EP2473040A4 - Inhibiting the invasion and metastasis of cancer cells - Google Patents

Inhibiting the invasion and metastasis of cancer cells

Info

Publication number
EP2473040A4
EP2473040A4 EP10800596.8A EP10800596A EP2473040A4 EP 2473040 A4 EP2473040 A4 EP 2473040A4 EP 10800596 A EP10800596 A EP 10800596A EP 2473040 A4 EP2473040 A4 EP 2473040A4
Authority
EP
European Patent Office
Prior art keywords
metastasis
invasion
inhibiting
cancer cells
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10800596.8A
Other languages
German (de)
French (fr)
Other versions
EP2473040A1 (en
Inventor
Pui-Kwong Chan
May Sung Mak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacific Arrow Ltd
Original Assignee
Pacific Arrow Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/541,713 external-priority patent/US8735558B2/en
Application filed by Pacific Arrow Ltd filed Critical Pacific Arrow Ltd
Publication of EP2473040A1 publication Critical patent/EP2473040A1/en
Publication of EP2473040A4 publication Critical patent/EP2473040A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP10800596.8A 2009-07-16 2010-07-16 Inhibiting the invasion and metastasis of cancer cells Withdrawn EP2473040A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22604309P 2009-07-16 2009-07-16
US12/541,713 US8735558B2 (en) 2005-02-14 2009-08-14 Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
PCT/US2010/042240 WO2011009032A1 (en) 2009-07-16 2010-07-16 Inhibiting the invasion and metastasis of cancer cells

Publications (2)

Publication Number Publication Date
EP2473040A1 EP2473040A1 (en) 2012-07-11
EP2473040A4 true EP2473040A4 (en) 2013-06-12

Family

ID=43449819

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10800596.8A Withdrawn EP2473040A4 (en) 2009-07-16 2010-07-16 Inhibiting the invasion and metastasis of cancer cells

Country Status (3)

Country Link
EP (1) EP2473040A4 (en)
CN (1) CN102548405A (en)
WO (1) WO2011009032A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727561B2 (en) 2001-08-31 2010-06-01 Pacific Arrow Limited Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof
US7488753B2 (en) 2003-10-09 2009-02-10 Pacific Arrow Limited Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
US8614197B2 (en) 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups
US8735558B2 (en) 2005-02-14 2014-05-27 Pacific Arrow Limited Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof
US9382285B2 (en) 2004-09-07 2016-07-05 Pacific Arrow Limited Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
US8586719B2 (en) 2005-04-27 2013-11-19 Pacific Arrow Limited Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents
US9499577B2 (en) 2009-07-16 2016-11-22 Pacific Arrow Limited Natural and synthetic compounds for treating cancer and other diseases
US20120277308A1 (en) * 2010-07-16 2012-11-01 Pacific Arrow Limited compounds for treating cancer and other diseases
US9434677B2 (en) * 2009-07-16 2016-09-06 Pacific Arrow Limited Natural and synthetic compounds for treating cancer and other diseases
CN103833818B (en) * 2014-01-30 2016-01-20 苏州大学 The antitumor drug of a kind of Sasanguasaponin compound, its preparation method, application and preparation thereof
CN104059123B (en) * 2014-01-30 2016-03-02 苏州大学 The antitumor drug of a kind of Sasanguasaponin compound, its preparation method, application and preparation thereof
CN103739657B (en) * 2014-01-30 2017-01-04 苏州大学 A kind of Sasanguasaponin compound, its preparation method, the antitumor drug applying and prepare
CN103739660B (en) * 2014-01-30 2016-08-17 苏州大学 A kind of compound, its extracting method, its application preparing antitumor drug and antitumor drug of preparation thereof
CN103739659B (en) * 2014-01-30 2016-08-17 苏州大学 A kind of compound, its extracting method, its application preparing antineoplastic and antineoplastic of preparation thereof
CN103755770B (en) * 2014-01-30 2016-03-23 苏州大学 The antitumor drug of a kind of Sasanguasaponin compound, its preparation method, application and preparation thereof
CN104055786B (en) * 2014-07-02 2016-12-07 中南民族大学 The application in preparation preventing and treating tumour medicine of medicagenic acid-3-O-β-D-pyranglucoside, medicagenic acid and salt thereof
CN107281203A (en) * 2016-03-30 2017-10-24 南京惠宝生物医药有限公司 Application of the Horse chest Nut P.E in preventing and treating medicine for senile dementia is prepared
IT201700088474A1 (en) * 2017-08-02 2019-02-02 Novamont Spa HERBICIDE COMPOSITIONS BASED ON PELARGONIC ACID
CN107629104A (en) * 2017-09-18 2018-01-26 昆明贝泰妮生物科技有限公司 Triterpenoid saponin medical compounds and its preparation and application
CN108840899B (en) * 2018-07-25 2020-11-10 浙江大学 Pentacyclic triterpenoid compound and derivative and application thereof
CN109970839B (en) * 2019-04-16 2022-03-01 沈阳药科大学 Triterpenoid saponin compound and preparation method and medical application thereof
CN110585222B (en) * 2019-10-12 2023-05-09 西南医科大学 Application of aescin compound in preparation of medicines
CN113072608B (en) * 2020-01-03 2022-06-07 沈阳药科大学 Triterpenoid saponin compound and application thereof
CN111233963B (en) * 2020-03-02 2020-11-13 河南中医药大学 Active monomer for treating esophageal cancer, and composition and application thereof
CN114409721B (en) * 2022-01-24 2023-07-18 大连理工大学 Pentacyclic triterpene derivative containing electrophilic warhead, and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6616943B2 (en) * 2001-08-31 2003-09-09 Fountain Silver Limited Composition comprising Wenguanguo extracts and methods for preparing same
CN101242850B (en) * 2003-10-09 2013-03-20 太平洋艾瑞有限公司 Composition, function and use of xanthoceras sorbifolia extract and compound isolated from same, method for preparing same
US8614197B2 (en) * 2003-10-09 2013-12-24 Pacific Arrow Limited Anti-tumor compounds with angeloyl groups

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
OHTSUKI ET AL: "Acylated triterpenoid saponins from Schima noronhae and their cell growth inhibitory activity", JOURNAL OF NATURAL PRODUCTS, vol. 71, no. 5, 20 March 2008 (2008-03-20), pages 918 - 921, XP002694762 *
See also references of WO2011009032A1 *
SHARMA ET AL: "Lanthadenes and their esters as potential antitumor agents", JOURNAL OF NATURAL PRODUCTS, vol. 71, no. 7, 14 June 2008 (2008-06-14), pages 1222 - 1227, XP002694763 *

Also Published As

Publication number Publication date
EP2473040A1 (en) 2012-07-11
WO2011009032A9 (en) 2012-05-24
WO2011009032A1 (en) 2011-01-20
CN102548405A (en) 2012-07-04

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20120330

AK Designated contracting states

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/704 20060101ALI20130425BHEP

Ipc: A61K 31/56 20060101ALI20130425BHEP

Ipc: C07J 17/00 20060101AFI20130425BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20130513

17Q First examination report despatched

Effective date: 20150527

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20151208