EP2403471A2 - Procédé de fabrication de cosmétiques - Google Patents

Procédé de fabrication de cosmétiques

Info

Publication number
EP2403471A2
EP2403471A2 EP10706555A EP10706555A EP2403471A2 EP 2403471 A2 EP2403471 A2 EP 2403471A2 EP 10706555 A EP10706555 A EP 10706555A EP 10706555 A EP10706555 A EP 10706555A EP 2403471 A2 EP2403471 A2 EP 2403471A2
Authority
EP
European Patent Office
Prior art keywords
components
granules
product
component
processed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10706555A
Other languages
German (de)
English (en)
Inventor
Rudolf Erwin Berghoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Linde GmbH
Original Assignee
Linde GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200910012069 external-priority patent/DE102009012069A1/de
Priority claimed from DE200910012068 external-priority patent/DE102009012068A1/de
Application filed by Linde GmbH filed Critical Linde GmbH
Priority to EP10706555A priority Critical patent/EP2403471A2/fr
Publication of EP2403471A2 publication Critical patent/EP2403471A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium

Definitions

  • the invention relates to a method for producing a cosmetic or pharmaceutical product, wherein a plurality of components are processed into the product, wherein at least one component is sprayed in the liquid state, cooled and transferred to a granulate and that the granules are processed with the other components to the product becomes.
  • fat-containing components are mixed and processed with other components necessary for the product, in particular auxiliaries and active ingredients, often also with aqueous components.
  • auxiliaries and active ingredients often also with aqueous components.
  • aqueous and greasy components do not dissolve or only barely intertwine and therefore form a dispersion after mixing.
  • suitable emulsifiers and stabilizers are used.
  • melt crystallization process in which a melt is fed to the head of a cooling tube and divided into uniform drops. The drops fall down and are brought into contact with a cold gas stream, whereby the drops crystallize to a granulate with a diameter of up to 2 mm.
  • This melt crystallization process is also referred to as prilling.
  • the individual product components should be distributed as finely as possible.
  • Granules produced by the method described above are not or only partially suitable for cosmetic products because of their particle size. Furthermore, it is more convenient for the production of cosmetics to provide the individual product components as an amorphous structure instead of a crystalline granule.
  • Object of the present invention is to provide a process for the preparation of cosmetic or pharmaceutical products, which allows a finer dispersion of the individual product components and higher stability of the product.
  • the sprayed component should be converted into a very fine granules, which if possible has an amorphous structure state.
  • This object is achieved by a method for producing a cosmetic or pharmaceutical product, wherein a plurality of components are processed into the product, wherein at least one component is sprayed in the liquid state, cooled and transferred to a granulate and wherein the granules with the other components to the Product is processed, wherein the at least one component in the liquid state is cooled in a flash by direct heat exchange with a cryogenic liquid gas, preferably with liquid nitrogen.
  • cosmetic product is to be understood as meaning all types of care, cleansing and decorative cosmetics. This includes, for example, agents for cleaning skin, hair or teeth, such as
  • Cosmetic product is intended to cover fat-containing products such as creams, ointments, pastes, emulsions and suspensions.
  • granules is intended to include in particular a particulate, powdered or granular material.
  • At least one of the components used for the cosmetic or pharmaceutical product is first brought into the liquid state of aggregation.
  • the component is this, if it is not already present in the liquid state, either melted or dissolved in a solvent such as water or oil, or in other formulation ingredients. Subsequently, the liquid thus obtained is sprayed, these in the finest
  • Droplet is parted. These smallest liquid droplets are suddenly cooled by direct heat exchange with a cryogenic liquid gas, that is, by contact with a cryogenic liquid, so that the droplets without agglomeration turn into the solid state and form a granular or powdery phase.
  • a cryogenic liquid gas that is, by contact with a cryogenic liquid
  • the fine liquid droplets are cooled about 100 to 1000 times faster than by heat exchange with a cold gas. Due to the sudden cooling, the droplets preferably solidify in the desired amorphous structure and not in a crystalline structure.
  • the at least one component is preferably sprayed in such a way that a fine spray mist results.
  • the spray and the cryogenic liquid gas are strongly mixed with each other.
  • crystalline beads of the same size as possible should be produced.
  • the drops fall as undisturbed down in the cooling tube.
  • the drops should be cooled by the supplied cold gas in the known prilling method, but not be swirled or torn, otherwise beads of different sizes would arise.
  • the component to be granulated is sprayed in such a way that the strongest possible interaction with the cryogenic liquid results in order to achieve the fastest possible solidification.
  • a cryogenic liquid gas ie a cryogenic liquid
  • the strong swirling of the droplets with the cryogenic liquid is achieved on the one hand by the use of a cryogenic liquid gas, ie a cryogenic liquid.
  • the component Before spraying the component, it must be liquefied, if not already in the liquid state. This can be done for example by melting or by dissolving in a solvent. In case of melting the
  • the heating takes place for reasons of energy saving, preferably only up to the minimum temperature required for the subsequent spraying process. If the component is instead dissolved in a solvent, advantageously only the minimum amount of solvent required is used.
  • the method according to the invention gives a particulate, pourable material, which can be processed quickly and easily.
  • the granules are mixed with the other components and optionally subjected to further processing steps, such as heating.
  • the individual components in the cosmetic or pharmaceutical product distributed much finely dispersed than in the conventional production method. The homogeneity and stability of the products is significantly improved.
  • the component is placed under elevated pressure in the liquid state, passed to a spray nozzle and sprayed. It is also possible to supply the liquid component by means of a propellant gas to a nozzle, via which the component is radiated and finely distributed.
  • the liquid component can be brought together in this case substantially without pressure with the propellant gas.
  • the propellant gas used is preferably gaseous nitrogen.
  • Other sputtering or spraying techniques may be used.
  • the spraying of the liquefied component can be carried out with one- or two-component nozzles.
  • pressures between 20 and 70 bar are necessary, and for very small particle sizes even up to 300 bar.
  • the liquid can be pumped at low pressures between approx. 2 and 8 bar.
  • the pressure of the gas stream, which causes the atomization is usually higher by about 1 to 2 bar.
  • the at least one component is cooled by direct heat exchange with liquid nitrogen.
  • the droplets solidify very quickly to fine granules.
  • the granules are stable and have an amorphous structure, so that agglomeration into larger clusters or growth to larger particles is prevented.
  • the lipophilic components in particular the oil, fat and / or wax-containing components
  • the term "wax” is intended to cover in particular animal and vegetable waxes, including liquid waxes such as jojoba oil.
  • fusible components may well be other fusible components before merging with the other components to be pulverized according to the invention.
  • the invention makes it possible to significantly reduce the proportion of emulsifiers and stabilizers in comparison to a conventionally produced product. In some cases it is even possible to completely dispense with emulsifiers and stabilizers. In this way, on the one hand, the manufacturing costs can be reduced, on the other hand, a high-quality, consumer-friendly product is produced. In particular, consumers who are allergic to certain additives, benefit from the products according to the invention.
  • a temperature of less than 25 0 C preferably in the temperature range from 0 0 C to 15 0 C, made.
  • the components are frequently heated and mixed and processed at temperatures between 40 0 C and 80 0 C, thereby significant energy savings can be achieved.
  • temperatures lower than 0 ° C may be desirable.
  • the invention is based essentially on the conversion of one or more liquid, pasty or solid components into a particulate, granular or pulverulent state.
  • the component can be better mixed with the other components and gives a much finer dispersion.
  • Particularly difficult to mix products, such as water-oil components can be much easier to convert into emulsions, without the individual phases grow together to larger areas.
  • At least one component is converted into a granulate which essentially has particle sizes between 1 micrometer and 1000 micrometers, preferably between 1 micrometer and 300 micrometers.
  • the component is atomized or sprayed so finely in the liquid state of aggregation that corresponding small droplets form, which are subsequently shock-cooled according to the invention and converted into the solid state of aggregation.
  • the fat components of a cosmetic product to be produced are brought into a fine amorphous granules having a particle size of less than 300 micrometers.
  • This fine fat granules facilitates the preparation of the desired emulsions or suspensions making up the product.
  • the distribution of the fat in the other components is much more homogeneous than in the usual manufacturing processes, in which the fat is mixed in the liquid state with the other components.
  • the invention has numerous advantages compared to the known production methods for cosmetic or pharmaceutical products.
  • Granules have very uniform particle sizes and is thus mixed very homogeneously with the other components, so that the end product has a significantly higher stability.
  • the granulate according to the invention is pourable, easy to dose and thus easier, faster and cheaper to further process. Due to the fine dispersion of the individual components in the product, it is possible to reduce the proportion of emulsifiers and stabilizers, in some cases even completely to dispense with these. Products made in this way have a higher quality. For example, care products produced according to the invention are more skin-friendly and more cost-effective to manufacture.
  • the invention brings in the cosmetic industry in the production of emulsions and suspensions of all kinds advantages.
  • Some preferred applications are the production of • Silane or silicone emulsions: These are used in cosmetics in the form of a gel or as an emulsion in particular in skin creams and sunscreen products.
  • Gels are dimensionally stable, easily deformable, finely dispersed systems of at least one solid and one aqueous phase. Gels are used, for example, as a carrier medium for ointments and creams or as a hair gel.
  • Oil-water emulsions such as those used in sprayable sunscreens.
  • Figure a device for carrying out the method according to the invention.
  • the figure shows a device for the production of fine oil or fat particles, which are then processed with other components to cosmetics.
  • the liquid fat or the oil are kept in a storage container 1. When using fat, this is previously heated to just above its melting point and thereby liquefied.
  • the oil or fat is conveyed by means of a pump 2 at a pressure between 1, 5 and 8 bar via a line 3 to a two-fluid nozzle 4.
  • the two-fluid nozzle 4 is also supplied via line 5 gaseous nitrogen as Zerstäubergas.
  • the liquid fat or oil is mixed with the sputtering gas and blasted as a two-phase flow in a product container 11.
  • the liquid fat or oil is present in this two-phase mixture as finely divided droplets 6, preferably with a droplet size between 10 and 500 microns.
  • the droplet size can be controlled by varying the pressure of the atomizing gas and / or the flow rate of liquid fat or oil.
  • the cooling of the fat or oil droplets takes place by heat exchange with cryogenic nitrogen.
  • liquid nitrogen is fed via line 7 to a ring line 8.
  • the ring line 8 is arranged concentrically around the two-fluid nozzle 4 and has on its underside a plurality of outlet openings 9, from which fine jets 10 of liquid nitrogen are ejected.
  • the jets of cryogenic nitrogen are oriented obliquely downwards and inwards and undergo heat exchange with the fat or oil droplets 6, whereby the fat or oil droplets 6 solidify into small particles 12 and collect at the bottom of the product container 11.
  • the liquid nitrogen used as the cooling medium evaporates and is sucked off together with the atomizing gas through a trigger 13.
  • the generated solid fat or oil particles are then used as starting material for the production of cosmetics.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un procédé de fabrication d'un produit cosmétique ou pharmaceutique, plusieurs composants étant transformés en ce produit. Au moins un composant (1) est pulvérisé (6) à l'état liquide, refroidi brusquement et transformé en un granulat (12). Le granulat (12) est transformé en ledit produit avec les autres composants.
EP10706555A 2009-03-06 2010-03-04 Procédé de fabrication de cosmétiques Withdrawn EP2403471A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10706555A EP2403471A2 (fr) 2009-03-06 2010-03-04 Procédé de fabrication de cosmétiques

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE200910012069 DE102009012069A1 (de) 2009-03-06 2009-03-06 Verfahren zur Herstellung von Kosmetika
DE200910012068 DE102009012068A1 (de) 2009-03-06 2009-03-06 Verfahren zur Herstellung von Kosmetika
EP09004501A EP2226062A1 (fr) 2009-03-06 2009-03-27 Procédé de fabrication de cosmétique
EP10706555A EP2403471A2 (fr) 2009-03-06 2010-03-04 Procédé de fabrication de cosmétiques
PCT/EP2010/001361 WO2010099966A2 (fr) 2009-03-06 2010-03-04 Procédé de fabrication de cosmétiques

Publications (1)

Publication Number Publication Date
EP2403471A2 true EP2403471A2 (fr) 2012-01-11

Family

ID=42710047

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10706555A Withdrawn EP2403471A2 (fr) 2009-03-06 2010-03-04 Procédé de fabrication de cosmétiques

Country Status (3)

Country Link
US (1) US20120052102A1 (fr)
EP (1) EP2403471A2 (fr)
WO (1) WO2010099966A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBS20110076A1 (it) * 2011-05-25 2012-11-26 K190 S R L Apparato e procedimento per la preparazione di gelato o prodotti alimentari affini
DE202016106243U1 (de) * 2016-09-21 2016-11-17 Dressler Group GmbH & Co. KG Vorrichtung zur Herstellung von pulverförmigen Kunststoffen mit möglichst kugelförmiger Struktur
CN110269523B (zh) * 2019-06-26 2020-11-24 广东美的厨房电器制造有限公司 炸油器具及加热设备

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DE2256790A1 (de) * 1972-11-20 1974-06-06 Air Prod Gmbh Verfahren und vorrichtung zum tiefgefrieren von wasserhaltigen extrakten, suspensionen u. dgl
DE2731318A1 (de) * 1977-07-12 1979-02-01 Bayer Ag Spruehgranulate
US4952224A (en) * 1989-04-17 1990-08-28 Canadian Oxygen Limited Method and apparatus for cryogenic crystallization of fats
JPH06323712A (ja) * 1993-04-20 1994-11-25 E I Du Pont De Nemours & Co 霧化した極低温液滴の閉じ込め帯域を用いて凍結粒子を製造する方法および装置
DE19600324A1 (de) * 1996-01-08 1997-07-10 Basf Ag Granulate für kosmetische und pharmazeutische Zubereitungen
GB9702886D0 (en) * 1996-09-28 1997-04-02 Agglomeration Technology Ltd Spray crystallised products and processes
AU5131699A (en) * 1998-07-31 2000-02-21 Eli Lilly And Company Cryogranulation of activated protein c
AU5745599A (en) * 1998-09-15 2000-04-03 Henkel Kommanditgesellschaft Auf Aktien Method for producing nanoparticles
US7262224B2 (en) * 1999-11-30 2007-08-28 Hanna Isul Skin Therapy, Inc. Cosmetic rejuvenating and healing product, method of its manufacture and uses thereof
GB0120552D0 (en) * 2001-08-23 2001-10-17 Boc Group Plc Cryogenic crystallisation of solid fats
US20030082222A1 (en) * 2001-10-22 2003-05-01 Kao Corporation Cosmetic particle and method of production thereof
US20040146553A1 (en) * 2002-12-23 2004-07-29 Aventis Pharma S.A. Compositions for oral administration of active principles requiring masking of taste
DE10320609A1 (de) * 2003-05-08 2004-12-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Sprühgefriergranulate mit verbesserter Homogenität der Eigenschaftsverteilung und Verfahren zu deren Herstellung
GB0326491D0 (en) * 2003-11-13 2003-12-17 Boc Group Plc Cooling of liquids
BRPI0417264A (pt) * 2003-12-19 2007-03-06 Alk Abello As processos para a preparação de uma batelada de um ingrediente farmacêutico ativo, um recipiente compreendendo criogránulos de um produto alérgeno, e um criogránulo de um produto alérgeno
EP1923188A1 (fr) 2006-11-14 2008-05-21 Linde Aktiengesellschaft Dispositif de production de particule

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Also Published As

Publication number Publication date
WO2010099966A2 (fr) 2010-09-10
US20120052102A1 (en) 2012-03-01
WO2010099966A3 (fr) 2011-12-29

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