EP2327638A1 - Device for packaging two products to be mixed and for distributing the mix of these two products - Google Patents
Device for packaging two products to be mixed and for distributing the mix of these two products Download PDFInfo
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- EP2327638A1 EP2327638A1 EP20090306161 EP09306161A EP2327638A1 EP 2327638 A1 EP2327638 A1 EP 2327638A1 EP 20090306161 EP20090306161 EP 20090306161 EP 09306161 A EP09306161 A EP 09306161A EP 2327638 A1 EP2327638 A1 EP 2327638A1
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- Prior art keywords
- bottle
- product
- products
- cavity
- receiving
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0053—Syringes, pipettes or oral dispensers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
- B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2065—Connecting means having aligning and guiding means
Definitions
- the present invention relates, in general, a device for packaging two products to be mixed, including at least one liquid product, and for dispensing the mixture of these products.
- this invention relates to a combined device for the extemporaneous preparation of drugs in the liquid state, and the secure collection of liquid preparations thus produced.
- the problem underlying the invention is set out below with reference to this particular application.
- Oral medication in the form of tablets in the solid state is often difficult for children and for the elderly, this for reasons of palatability in particular, the tablets are often too big.
- the doses to be prescribed are not uniform, and the current tablets do not allow a custom dose adjustment.
- the liquid forms of the drugs make it possible to improve the palatability and to personalize the doses, according to the age and the weight of the patients in particular.
- the liquid forms are quite complicated to implement, this mainly for reasons of stability of the active ingredient in the liquid.
- extemporaneous liquid preparations consist of a mixture of two components, such as mixing a powder with a liquid or mixing a liquid with another liquid, in order to prepare a reconstituted liquid medicine which may be a suspension or a solution, said drug can be taken in a more or less long time after its reconstitution.
- the present invention is in the field of the extemporaneous preparation of such liquid medicaments.
- the mixture is produced thanks to a voluntary action of the user, and it is not possible to eliminate the disadvantages of traditional extemporaneous preparations: risk of contamination for sterile products, risk of loss of part of the components, risk of using only one component and, in general, difficulties in implementing implementation or exploitation of the method to be followed to achieve the correct mixture.
- Packaging and dispensing assemblies have also been proposed, which make it possible to carry out the extemporaneous mixing of the components by a screwing or unscrewing movement.
- the principle of these devices is based on the presence of a lid closing a first bottle, which is opaque that is pushed back by screwing this bottle on the opening of another bottle, which then establishes a communication between the two bottles and allows the mixing of their respective contents.
- the lid is free or secured to the first bottle by means of a hinge.
- here can be cited the French patents N os 2478607 and 2506726 .
- This latter type of embodiment is rather difficult to handle, and it involves risks of leakage of the products during the supply of a bottle on the other, as well as at the time of distribution of the mixture produced. In addition, it is limited in its applications to the mixing of liquid products between them
- the subject of the invention is a device for packaging two products to be mixed, of which at least one liquid product, and distribution of the mixture of these products, this device being essentially characterized in that it comprises a vial having two open ends, the vial comprising a central body receiving a first product, an end with an orifice receiving a cap which contains a second product to mix with the first, and another end opposite to the previous one with an orifice receiving a removable cap and provided for the removal of the mixture after removal of the capsule.
- the device of the invention is in the form of a bottle or a small bottle with two orifices, one of which receives a stopper designed to contain the liquid or solid product to be mixed with the liquid product contained in the body of the bottle, or conversely while the other orifice is provided for dispensing the mixture obtained inside the vial.
- the bottle is thus unique, and the device can be used as follows: the cap located at one end of the bottle is first actuated, so as to release the product it contains and thus allow the mixture of this product with the other product contained in the body of the bottle; then, the bottle is turned over, and the capsule at its other end is removed, to take an appropriate amount of the drug or other reconstituted product.
- the plug provided at the first end of the bottle is provided with a central cavity engaged in the opening of this end and initially containing the second product, said cap carrying a movable part. axially and adapted, when depressed, to open the bottom of the cavity to release the second product.
- the cap is equipped with a tamper-evident tongue, the presence of which keeps said part away from the bottom of the cavity, and the removal of which permits the depression of this part in order to open the bottom of the cavity for release the second product.
- This cap may be a screw cap or a cap latched on the bottle.
- this end may also carry, or itself to form, a section reducer with a central orifice of diameter corresponding to that of a metering syringe used for the sampling of the mixing safely and sterile, without risk of leakage.
- the device shown in the drawing and generally designated by the reference numeral 1 consists mainly of a bottle 2 open at both ends, a plug 3 placed at one end of the bottle 2, and a capsule 4 mounted to the other end of this bottle 2.
- the bottle 2 has a central body 5, preferably made of a transparent material. At one end, the bottle 2 has a first circular opening 6. This end may be provided with a thread 7 (in the case of a screwed cap 3). At its other end, also open, the bottle 2 may be provided with an external thread 8 (in the case of a screwed cap).
- the cap 3 has an outer skirt 9, provided with an internal thread cooperating with the external thread 7 of the bottle 2.
- the cap 3 also has a central portion 10 in the form of a pot, which is engaged in the circular opening 6 of the bottle 2 and which delimits a cavity 11.
- An annular seal 14 is inserted between the top of the plug 3 and the central portion 13 of the piece 12.
- a tamper-evident tab 15 is provided at the base of the piece 12, around the lower zone of the outer skirt 9 of the cap 3. The initial presence of the tamper-evident tab 15 keeps the central portion 13 of the piece 12 away. of the bottom 16 of the cavity 11.
- This cavity 11 is intended to receive one of the two products (liquid or solid) to be mixed, while the central body 5 of the bottle 3 is provided to receive the other product (liquid or solid). As we understand, the two products remain well separated from each other, as long as the bottom 16 of the cavity 11 is in place.
- the bottle 2 receives a section reducer 17, reported and welded, which defines a central orifice 18 of circular shape.
- the diameter of the central orifice 18 corresponds to that of a metering syringe 19, known per se.
- the capsule 4 initially caps the gear 17, on which it is mounted (thread 8).
- the tamper-evident tab 15 is torn off ( figure 4 ) and the part 12, released axially on a certain stroke, is depressed ( figure 5 ) in order to open the bottom 16 of the cavity 11.
- the product initially contained in this cavity 11 then falls into the central body 5 of the bottle 2, where it mixes with the product already contained in said central body 5.
- the mixture of the two products is made homogeneous by shaking the device.
- the device is turned over and the capsule 4 is removed, as shown in figure 6 .
- the dosing syringe 19 is then introduced into the orifice 18, and used to collect a determined quantity of the extemporaneous preparation produced ( figure 7 ). After dosing, the syringe 19 is removed ( figure 8 ), and used to administer the drug. Finally, the capsule 4 is put back in place, at least if the device is not empty.
- the device is particularly well suited for extemporaneous preparations of liquid drugs from two liquid products, or a solid and a liquid, the term "liquid” designating both aqueous products and oily products or the gels. These may be oral or intravenous preparations.
- This device is also usable for the preparation of food supplements, or for any other similar preparations, which require the separate storage of two products including at least one liquid, then the mixing of these products and the distribution, with or without precise dosing, of the mixture made.
- the use with a dosing syringe and a section reducer adapted to such a syringe is not mandatory, and one can also consider that the second end of the bottle does not include a section reducer and receives a pacifier or be put directly in the mouth to drink or swallow the contents, any form of sampling of this content being conceivable.
- the invention is not limited to the sole embodiment of this device of conditioning of two products to be mixed, and distribution of the mixture of these products, which has been described above, as an example; it embraces, on the contrary, all variants of implementation and application respecting the same principle.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
La présente invention concerne, de façon générale, un dispositif de conditionnement de deux produits à mélanger, dont au moins un produit liquide, et de distribution du mélange de ces produits. A titre d'application particulière, mais non limitative, cette invention a pour objet un dispositif combiné destiné à la préparation extemporanée de médicaments à l'état liquide, et au prélèvement sécurisé des préparations liquides ainsi réalisées. La problématique à la base de l'invention est exposée ci-dessous en se référant à cette application particulière.The present invention relates, in general, a device for packaging two products to be mixed, including at least one liquid product, and for dispensing the mixture of these products. As a particular application, but not limited to, this invention relates to a combined device for the extemporaneous preparation of drugs in the liquid state, and the secure collection of liquid preparations thus produced. The problem underlying the invention is set out below with reference to this particular application.
La prise orale de médicaments sous forme de comprimés à l'état solide est souvent difficile pour les enfants et pour des personnes âgées, ceci pour des raisons de palatabilité notamment, les comprimés étant souvent trop gros. De plus, les doses à prescrire ne sont pas uniformes, et les comprimés actuels ne permettent pas une adaptation personnalisée des doses.Oral medication in the form of tablets in the solid state is often difficult for children and for the elderly, this for reasons of palatability in particular, the tablets are often too big. In addition, the doses to be prescribed are not uniform, and the current tablets do not allow a custom dose adjustment.
Ainsi, les formes liquides des médicaments permettent d'améliorer la palatabilité et de personnaliser les doses, en fonction de l'âge et du poids des patients notamment. Cependant, du point de vue industriel, les formes liquides sont assez compliquées à mettre en oeuvre, ceci principalement pour des raisons de stabilité du principe actif dans le liquide.Thus, the liquid forms of the drugs make it possible to improve the palatability and to personalize the doses, according to the age and the weight of the patients in particular. However, from the industrial point of view, the liquid forms are quite complicated to implement, this mainly for reasons of stability of the active ingredient in the liquid.
Ces difficultés justifient l'intérêt des préparations liquides dites extemporanées. Celles-ci consistent en un mélange de deux composants, tels que le mélange d'une poudre avec un liquide ou le mélange d'un liquide avec un autre liquide, afin de préparer un médicament liquide reconstitué qui pourra être une suspension ou une solution, ledit médicament pouvant être pris dans un délai plus ou moins long après sa reconstitution. La présente invention se situe dans le domaine de la préparation extemporanée de tels médicaments liquides.These difficulties justify the interest of so-called extemporaneous liquid preparations. These consist of a mixture of two components, such as mixing a powder with a liquid or mixing a liquid with another liquid, in order to prepare a reconstituted liquid medicine which may be a suspension or a solution, said drug can be taken in a more or less long time after its reconstitution. The present invention is in the field of the extemporaneous preparation of such liquid medicaments.
Diverses propositions ont été déjà faites, pour la réalisation de ces préparations extemporanées. A titre d'exemples, on peut ici citer les brevets français Nos 1233412, 1486502, 1508658, 2190094, 2238644, 2427960 et 2628075.Various proposals have already been made for the production of these extemporaneous preparations. By way of examples, mention may be made of French Patents Nos . 1233412, 1486502, 1508658, 2190094, 2238644, 2427960 and 2628075.
Dans ces brevets, le mélange est réalisé grâce à une action volontaire de l'utilisateur, et on ne parvient pas à éliminer les inconvénients des préparations extemporanées traditionnelles : risque de contamination pour les produits stériles, risque de perte d'une partie des composants, risque de n'utiliser qu'un seul composant et, d'une façon générale, difficultés de mise en oeuvre ou d'exploitation de la méthode à suivre pour réaliser correctement le mélange.In these patents, the mixture is produced thanks to a voluntary action of the user, and it is not possible to eliminate the disadvantages of traditional extemporaneous preparations: risk of contamination for sterile products, risk of loss of part of the components, risk of using only one component and, in general, difficulties in implementing implementation or exploitation of the method to be followed to achieve the correct mixture.
Il a également été proposé des ensembles de conditionnement et de distribution, qui permettent de réaliser le mélange extemporané des composants par un mouvement de vissage ou de dévissage. D'une manière générale, le principe de ces dispositifs repose sur la présence d'un opercule fermant un premier flacon, opercule que l'on repousse en vissant ce flacon sur l'ouverture d'un autre flacon, ce qui établit alors une communication entre les deux flacons et permet le mélange de leurs contenus respectifs. Selon les cas, l'opercule est libre ou solidaire du premier flacon par l'intermédiaire d'une charnière. A titre d'exemples de tels ensembles, peuvent être ici cités les brevets français Nos
Ce dernier type de réalisation reste assez délicat à manipuler, et il comporte des risques de fuite des produits lors de l'amenée d'un flacon sur l'autre, ainsi qu'au moment de la distribution du mélange réalisé. De plus, il est limité, dans ses applications, au mélange de produits liquides entre euxThis latter type of embodiment is rather difficult to handle, and it involves risks of leakage of the products during the supply of a bottle on the other, as well as at the time of distribution of the mixture produced. In addition, it is limited in its applications to the mixing of liquid products between them
[Merci de confirmer, corriger et compléter cette « critique » des réalisations en question] Eléments attendus...[Please confirm, correct and complete this "critique" of the achievements in question] Expected elements ...
La présente invention vise à remédier à l'ensemble des inconvénients précédemment exposés. Elle a donc pour objectif de fournir un dispositif pour la préparation extemporanée de médicaments ou de compléments alimentaires ou analogues, sous la forme d'un ensemble de conditionnement, qui satisfasse ou mieux les exigences suivantes :
- Simplification des manipulations nécessaires pour effectuer le mélange convenable des composants, sans mise en contact cutané, oral ou respiratoire ;
- Si cela est souhaité, prélèvement sécurisé du mélange préparé, avec élimination du risque de fuite et précision du dosage ;
- Compatibilité avec toutes préparations extemporanées : mélange d'un liquide avec un autre liquide, de type aqueux ou huileux ou gel, ou d'un liquide avec un solide pouvant lui-même se présenter sous toute forme (poudre, granules, tablette, nanoparticules...) ;
- Simplification of the manipulations necessary to effect the proper mixing of the components, without putting skin, oral or respiratory contact into contact;
- If desired, secure collection of the prepared mixture, with elimination of the risk of leakage and precision of the dosage;
- Compatibility with all extemporaneous preparations: mixing a liquid with another liquid, aqueous or oily type or gel, or a liquid with a solid that can itself be in any form (powder, granules, tablet, nanoparticles. ..);
A cet effet, l'invention a pour objet un dispositif de conditionnement de deux produits à mélanger, dont au moins un produit liquide, et de distribution du mélange de ces produits, ce dispositif étant essentiellement caractérisé par le fait qu'il comprend un flacon ayant deux extrémités ouvertes, le flacon comportant un corps central recevant un premier produit, une extrémité avec un orifice recevant un bouchon qui contient un second produit à mélanger avec le premier, et une autre extrémité opposée à la précédente avec un orifice recevant une capsule amovible et prévu pour le prélèvement du mélange après retrait de la capsule.For this purpose, the subject of the invention is a device for packaging two products to be mixed, of which at least one liquid product, and distribution of the mixture of these products, this device being essentially characterized in that it comprises a vial having two open ends, the vial comprising a central body receiving a first product, an end with an orifice receiving a cap which contains a second product to mix with the first, and another end opposite to the previous one with an orifice receiving a removable cap and provided for the removal of the mixture after removal of the capsule.
Ainsi, le dispositif de l'invention se présente comme un flacon ou une petite bouteille à deux orifices, dont l'un reçoit un bouchon conçu pour contenir le produit liquide ou solide à mélanger au produit liquide contenu dans le corps du flacon, ou inversement tandis que l'autre orifice est prévu pour la distribution du mélange obtenu à l'intérieur du flacon. Le flacon est ainsi unique, et le dispositif peut s'utiliser comme suit : le bouchon situé à une extrémité du flacon est d'abord actionné, de manière à libérer le produit qu'il contient et à permettre ainsi le mélange de ce produit avec l'autre produit contenu dans le corps du flacon ; ensuite, le flacon est retourné, et la capsule située à son autre extrémité est retirée, pour prélever une quantité appropriée du médicament ou autre produit reconstitué.Thus, the device of the invention is in the form of a bottle or a small bottle with two orifices, one of which receives a stopper designed to contain the liquid or solid product to be mixed with the liquid product contained in the body of the bottle, or conversely while the other orifice is provided for dispensing the mixture obtained inside the vial. The bottle is thus unique, and the device can be used as follows: the cap located at one end of the bottle is first actuated, so as to release the product it contains and thus allow the mixture of this product with the other product contained in the body of the bottle; then, the bottle is turned over, and the capsule at its other end is removed, to take an appropriate amount of the drug or other reconstituted product.
Dans une forme de réalisation préférée du dispositif de l'invention, le bouchon prévu à la première extrémité du flacon est muni d'une cavité centrale engagée dans l'ouverture de cette extrémité et contenant initialement le second produit, ledit bouchon portant une pièce déplaçable axialement et apte, lorsqu'elle est enfoncée, à ouvrir le fond de la cavité pour libérer le second produit. Avantageusement, le bouchon est équipé d'une languette d'inviolabilité, dont la présence maintient ladite pièce éloignée du fond de la cavité, et dont le retrait autorise l'enfoncement de cette pièce en vue de l'ouverture du fond de la cavité pour libérer le second produit. Ce bouchon peut être un bouchon vissé ou un bouchon encliqueté sur le flacon.In a preferred embodiment of the device of the invention, the plug provided at the first end of the bottle is provided with a central cavity engaged in the opening of this end and initially containing the second product, said cap carrying a movable part. axially and adapted, when depressed, to open the bottom of the cavity to release the second product. Advantageously, the cap is equipped with a tamper-evident tongue, the presence of which keeps said part away from the bottom of the cavity, and the removal of which permits the depression of this part in order to open the bottom of the cavity for release the second product. This cap may be a screw cap or a cap latched on the bottle.
En ce qui concerne l'autre extrémité du flacon, recevant la capsule, cette extrémité peut porter aussi, ou former elle-même, un réducteur de section avec un orifice central de diamètre correspondant à celui d'une seringue doseuse utilisable pour le prélèvement du mélange de façon sécurisée et stérile, sans risque de fuite.As regards the other end of the vial, receiving the capsule, this end may also carry, or itself to form, a section reducer with a central orifice of diameter corresponding to that of a metering syringe used for the sampling of the mixing safely and sterile, without risk of leakage.
De toute façon, l'invention sera mieux comprise à l'aide de la description qui suit, en référence au dessin schématique annexé représentant, à titre d'exemple, une forme d'exécution de ce dispositif de conditionnement de deux produits à mélanger et de distribution du mélange de ces produits :
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Figure 1 est une vue d'ensemble, extérieure, d'un dispositif conforme à la présente invention, avec indication d'une seringue doseuse utilisable avec ce dispositif ; -
Figure 2 est une vue en coupe longitudinale du dispositif de lafigure 1 ; -
Figure 3 est une vue en coupe, à échelle agrandie, de l'extrémité de ce dispositif comportant le bouchon ; -
Figure 4 à 8 sont des schémas illustrant l'utilisation du dispositif des figures précédentes.
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Figure 1 is an overall view, external, of a device according to the present invention, with indication of a dosing syringe usable with this device; -
Figure 2 is a longitudinal sectional view of the device of thefigure 1 ; -
Figure 3 is a sectional view, on an enlarged scale, of the end of this device comprising the plug; -
Figure 4 to 8 are diagrams illustrating the use of the device of the preceding figures.
Le dispositif, représenté au dessin et désigné globalement par le repère 1 se compose principalement d'un flacon 2 ouvert à ses deux extrémités, d'un bouchon 3 placé à une extrémité du flacon 2, et d'une capsule 4 montée à l'autre extrémité de ce flacon 2.The device, shown in the drawing and generally designated by the
Le flacon 2 possède un corps central 5, de préférence réalisé dans une matière transparente. A une extrémité, le flacon 2 possède une première ouverture circulaire 6. Cette extrémité peut être munie d'un filetage 7 (dans le cas d'un bouchon 3 vissé). A son autre extrémité, également ouverte, le flacon 2 peut être muni d'un filetage extérieur 8 (dans le cas d'une capsule vissée).The
En se référant plus particulièrement aux
Une pièce 12, d'allure générale cylindrique, coiffe le bouchon 3 et s'engage aussi, par une partie centrale 13 saillante, dans la cavité 11 délimitée par la partie centrale 10 dudit bouchon 3. Un joint annulaire d'étanchéité 14 est inséré entre le sommet du bouchon 3 et la partie centrale 13 de la pièce 12.A
Une languette d'inviolabilité 15 est prévue à la base de la pièce 12, autour de la zone inférieure de la jupe extérieure 9 du bouchon 3. La présence initiale de la languette d'inviolabilité 15 maintient la partie centrale 13 de la pièce 12 éloignée du fond 16 de la cavité 11.A tamper-
Cette cavité 11 est prévue pour recevoir l'un des deux produits (liquide ou solide) à mélanger, tandis que le corps central 5 du flacon 3 est prévu pour recevoir l'autre produit (liquide ou solide). Comme on le comprend, les deux produits restent bien séparés l'un de l'autre, aussi longtemps que le fond 16 de la cavité 11 est en place.This
A son autre extrémité, dans l'exemple illustré, le flacon 2 reçoit un réducteur de section 17, rapporté et soudé, qui délimite un orifice central 18 de forme circulaire. Le diamètre de l'orifice central 18 correspond à celui d'une seringue doseuse 19, connue en soi. La capsule 4 coiffe initialement le réducteur 17, sur lequel elle est montée (filetage 8).At its other end, in the illustrated example, the
Au moment de l'utilisation, la languette d'inviolabilité 15 est arrachée (
Ensuite, le dispositif est retourné et la capsule 4 est retirée, comme le montre la
Le dispositif, précédemment décrit, est particulièrement bien adapté pour les préparations extemporanées de médicaments liquides à partir de deux produits liquides, ou d'un solide et d'un liquide, le terme « liquide » désignant aussi bien les produits aqueux que les produits huileux ou les gels. Il peut s'agir de préparations à usage oral ou à usage intraveineux. Ce dispositif, est aussi utilisable pour la préparation de compléments alimentaires, ou pour toutes autres préparations analogues, qui nécessitent le stockage séparé de deux produits dont au moins un liquide, puis le mélange de ces produits et la distribution, avec ou sans dosage précis, du mélange réalisé. Ainsi, l'utilisation avec une seringue doseuse et un réducteur de section adapté à une telle seringue n'est nullement obligatoire, et l'on peut tout aussi bien envisager que le deuxième extrémité du flacon ne comporte pas de réducteur de section et reçoive une tétine ou soit directement mise à la bouche pour boire ou avaler le contenu, toute forme de prélèvement de ce contenu étant envisageable.The device, previously described, is particularly well suited for extemporaneous preparations of liquid drugs from two liquid products, or a solid and a liquid, the term "liquid" designating both aqueous products and oily products or the gels. These may be oral or intravenous preparations. This device is also usable for the preparation of food supplements, or for any other similar preparations, which require the separate storage of two products including at least one liquid, then the mixing of these products and the distribution, with or without precise dosing, of the mixture made. Thus, the use with a dosing syringe and a section reducer adapted to such a syringe is not mandatory, and one can also consider that the second end of the bottle does not include a section reducer and receives a pacifier or be put directly in the mouth to drink or swallow the contents, any form of sampling of this content being conceivable.
Comme il va de soi, et comme se résulte de ce qui précède, l'invention ne se limite pas à la seule forme d'exécution de ce dispositif de conditionnement de deux produits à mélanger, et de distribution du mélange de ces produits, qui a été décrite ci-dessus, à titre d'exemple ; elle en embrasse, au contraire, toutes les variantes de réalisation et d'application respectant le même principe. C'est ainsi, notamment, que l'on ne s'éloignerait pas du cadre de l'invention par des modifications du détail des formes, et assemblages des composants du dispositif, par exemple en modifiant le volume du flacon, en remplaçant le bouchon vissé par un bouchon encliqueté ou par des aménagements tels que l'ajout ou la suppression de joints d'étanchéité entre ces composants ou encore par des accessoires, encore par des accessoires complémentaires, propres à faciliter l'utilisation du dispositif ; ainsi, il est envisageable d'adapter sur le bouchon ou le flacon lui-même une « étiquette intelligente », qui constitue une sorte d'alarme visuelle permettant de mesurer le temps passé depuis la mise en contact des deux liquides ou du liquide avec le solide.As is obvious, and as results from the foregoing, the invention is not limited to the sole embodiment of this device of conditioning of two products to be mixed, and distribution of the mixture of these products, which has been described above, as an example; it embraces, on the contrary, all variants of implementation and application respecting the same principle. This is so, in particular, that one would not depart from the scope of the invention by changes in the detail of the shapes, and assemblies of the components of the device, for example by changing the volume of the bottle, replacing the cap screwed by an interlocking plug or by arrangements such as adding or removing seals between these components or by accessories, further by additional accessories, to facilitate the use of the device; thus, it is conceivable to adapt to the cap or the bottle itself an "intelligent label", which constitutes a kind of visual alarm for measuring the time spent since the two liquids or the liquid come into contact with the solid.
Claims (5)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT93061612T PT2327638E (en) | 2009-11-30 | 2009-11-30 | Device for packaging two products to be mixed and for distributing the mix of these two products |
DK09306161T DK2327638T3 (en) | 2009-11-30 | 2009-11-30 | Apparatus for packaging two products to be mixed and for dispensing the mixture of these products |
ES09306161T ES2394408T3 (en) | 2009-11-30 | 2009-11-30 | Device for the conditioning of two products to be mixed, and for the distribution of the mixture of these two products |
EP20090306161 EP2327638B1 (en) | 2009-11-30 | 2009-11-30 | Device for packaging two products to be mixed and for distributing the mix of these two products |
PL09306161T PL2327638T3 (en) | 2009-11-30 | 2009-11-30 | Device for packaging two products to be mixed and for distributing the mix of these two products |
US12/952,384 US20110147333A1 (en) | 2009-11-30 | 2010-11-23 | Device for packaging two products to be mixed and for dispensing the mixture of these products |
CA 2722979 CA2722979A1 (en) | 2009-11-30 | 2010-11-29 | Device for packaging two products to be mixed and for distributing the mixture of these products |
US15/840,821 US20190380910A1 (en) | 2009-11-30 | 2017-12-13 | Device for packaging two products to be mixed and for dispensing the mixture of these products |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20090306161 EP2327638B1 (en) | 2009-11-30 | 2009-11-30 | Device for packaging two products to be mixed and for distributing the mix of these two products |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2327638A1 true EP2327638A1 (en) | 2011-06-01 |
EP2327638B1 EP2327638B1 (en) | 2012-09-19 |
Family
ID=42074535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20090306161 Not-in-force EP2327638B1 (en) | 2009-11-30 | 2009-11-30 | Device for packaging two products to be mixed and for distributing the mix of these two products |
Country Status (7)
Country | Link |
---|---|
US (2) | US20110147333A1 (en) |
EP (1) | EP2327638B1 (en) |
CA (1) | CA2722979A1 (en) |
DK (1) | DK2327638T3 (en) |
ES (1) | ES2394408T3 (en) |
PL (1) | PL2327638T3 (en) |
PT (1) | PT2327638E (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3053848A1 (en) | 2015-02-09 | 2016-08-10 | Rovipharm | Device comprising a first compartment intended for being mounted on a second compartment with a view to mixing the contents of each of the compartments and vial therewith |
FR3077806A1 (en) * | 2018-02-13 | 2019-08-16 | Rovipharm | DEVICE FOR PACKAGING AND TAKING BY PIPETTE OF 2 MIXED PRODUCTS TO BE MOUNTED ON THE BOTTLE OF A BOTTLE |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG192310A1 (en) | 2012-02-02 | 2013-08-30 | Becton Dickinson Holdings Pte Ltd | Adaptor for coupling to a medical container |
EP2809293B1 (en) | 2012-02-02 | 2018-05-09 | Becton Dickinson Holdings Pte. Ltd. | Adaptor for coupling with a medical container |
SG192312A1 (en) | 2012-02-02 | 2013-08-30 | Becton Dickinson Holdings Pte Ltd | Adaptor for coupling to a medical container |
JP1526207S (en) | 2013-08-05 | 2015-06-15 |
Citations (3)
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FR2294937A1 (en) * | 1974-12-18 | 1976-07-16 | Neve Rene | Two-compartment bottle for two-component pharmaceutical prods. - which must be kept apart until the moment of injection |
FR2344466A2 (en) * | 1975-05-21 | 1977-10-14 | Tuboplast France | Container for pharmaceutical products separated until required - sterile mixing by internal plunger piercing dividing membrane |
US20020087141A1 (en) * | 2001-01-03 | 2002-07-04 | Freddy Zinger | Fluid transfer device |
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US3404811A (en) * | 1966-12-02 | 1968-10-08 | Cernei Jose | Container for maintaining in separate condition liquids which are to be mixed together and which may be manipulated to commingle such liquids |
US3425598A (en) * | 1967-06-14 | 1969-02-04 | Gerald Kobernick | Dispensing container having a membrane puncturing means |
US3735900A (en) * | 1971-05-13 | 1973-05-29 | Prod Res & Chem Corp | Dual ingredient storage, intermixing and dispensing storage |
US3946732A (en) * | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US4479578A (en) * | 1981-04-09 | 1984-10-30 | The West Company | Single barrel two-compartment medicament container assembly |
US4648532A (en) * | 1986-05-09 | 1987-03-10 | Green Russell D | Mixing and discharge capsule |
FR2603869B1 (en) * | 1986-09-12 | 1988-11-18 | Oreal | ASSEMBLY FOR SEPARATELY PACKAGING TWO PRODUCTS AND FOR DISTRIBUTING SIMULTANEOUSLY AFTER THEIR CONTACT |
DK235589D0 (en) * | 1989-05-12 | 1989-05-12 | Wolff & Kaaber | METHOD AND APPARATUS FOR MIXING A SOLID AND LIQUID COMPONENT |
US5246142A (en) * | 1991-09-26 | 1993-09-21 | Dipalma Elio | Device for storing two products separately and subsequently mixing them |
US5335773A (en) * | 1993-07-02 | 1994-08-09 | Habley Medical Technology Corporation | Multi-pharmaceutical storage, mixing and dispensing vial |
FR2750397B1 (en) * | 1996-06-28 | 1998-08-07 | Oreal | DEVICE FOR THE SEPARATE STORAGE OF AT LEAST TWO PRODUCTS, THEIR MIXTURE AND THE DISTRIBUTION OF THE MIXTURE THUS OBTAINED AND METHOD FOR MANUFACTURING |
US5927549A (en) * | 1998-03-20 | 1999-07-27 | Aptargroup, Inc. | Dispensing structure with frangible membrane for separating two products |
FR2789979B1 (en) * | 1999-02-22 | 2001-05-04 | Oreal | PACKAGING FOR MIXING A MULTI-COMPONENT PRODUCT |
WO2003093128A1 (en) * | 2002-04-30 | 2003-11-13 | Bormioli Rocco & Figlio S.P.A. | Capsule containing a mixer substance for bottles containing pressurised liquids |
US7252091B1 (en) * | 2006-04-26 | 2007-08-07 | Jim Wayne | Hair colorant applicator |
US7740134B2 (en) * | 2006-05-18 | 2010-06-22 | Theodore Sweeney & Company | Infusion cap with reservoir shiftable downwardly |
US7568576B2 (en) * | 2006-08-25 | 2009-08-04 | Theodore Sweeney & Company, Inc. | Infusion cap |
-
2009
- 2009-11-30 ES ES09306161T patent/ES2394408T3/en active Active
- 2009-11-30 DK DK09306161T patent/DK2327638T3/en active
- 2009-11-30 EP EP20090306161 patent/EP2327638B1/en not_active Not-in-force
- 2009-11-30 PL PL09306161T patent/PL2327638T3/en unknown
- 2009-11-30 PT PT93061612T patent/PT2327638E/en unknown
-
2010
- 2010-11-23 US US12/952,384 patent/US20110147333A1/en not_active Abandoned
- 2010-11-29 CA CA 2722979 patent/CA2722979A1/en not_active Abandoned
-
2017
- 2017-12-13 US US15/840,821 patent/US20190380910A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2294937A1 (en) * | 1974-12-18 | 1976-07-16 | Neve Rene | Two-compartment bottle for two-component pharmaceutical prods. - which must be kept apart until the moment of injection |
FR2344466A2 (en) * | 1975-05-21 | 1977-10-14 | Tuboplast France | Container for pharmaceutical products separated until required - sterile mixing by internal plunger piercing dividing membrane |
US20020087141A1 (en) * | 2001-01-03 | 2002-07-04 | Freddy Zinger | Fluid transfer device |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3053848A1 (en) | 2015-02-09 | 2016-08-10 | Rovipharm | Device comprising a first compartment intended for being mounted on a second compartment with a view to mixing the contents of each of the compartments and vial therewith |
FR3032433A1 (en) * | 2015-02-09 | 2016-08-12 | Rovipharm | DEVICE COMPRISING A FIRST COMPARTMENT TO BE MOUNTED ON A SECOND COMPARTMENT FOR MIXING THE CONTENT OF EACH COMPARTMENT |
FR3077806A1 (en) * | 2018-02-13 | 2019-08-16 | Rovipharm | DEVICE FOR PACKAGING AND TAKING BY PIPETTE OF 2 MIXED PRODUCTS TO BE MOUNTED ON THE BOTTLE OF A BOTTLE |
Also Published As
Publication number | Publication date |
---|---|
PL2327638T3 (en) | 2013-02-28 |
ES2394408T3 (en) | 2013-01-31 |
DK2327638T3 (en) | 2013-01-07 |
EP2327638B1 (en) | 2012-09-19 |
PT2327638E (en) | 2012-12-20 |
CA2722979A1 (en) | 2011-05-30 |
US20110147333A1 (en) | 2011-06-23 |
US20190380910A1 (en) | 2019-12-19 |
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