EP2313098A4 - Methods and systems for evaluating memory agents - Google Patents

Methods and systems for evaluating memory agents

Info

Publication number
EP2313098A4
EP2313098A4 EP20090798843 EP09798843A EP2313098A4 EP 2313098 A4 EP2313098 A4 EP 2313098A4 EP 20090798843 EP20090798843 EP 20090798843 EP 09798843 A EP09798843 A EP 09798843A EP 2313098 A4 EP2313098 A4 EP 2313098A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
memory agents
evaluating memory
evaluating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP20090798843
Other languages
German (de)
French (fr)
Other versions
EP2313098A1 (en
Inventor
Timothy Tully
Lila Davachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dart Neuroscience LLC
Original Assignee
Dart Neuroscience LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dart Neuroscience LLC filed Critical Dart Neuroscience LLC
Publication of EP2313098A1 publication Critical patent/EP2313098A1/en
Publication of EP2313098A4 publication Critical patent/EP2313098A4/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
EP20090798843 2008-07-18 2009-07-17 Methods and systems for evaluating memory agents Ceased EP2313098A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8194508P 2008-07-18 2008-07-18
PCT/US2009/051082 WO2010009453A1 (en) 2008-07-18 2009-07-17 Methods and systems for evaluating memory agents

Publications (2)

Publication Number Publication Date
EP2313098A1 EP2313098A1 (en) 2011-04-27
EP2313098A4 true EP2313098A4 (en) 2011-12-21

Family

ID=41550744

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20090798843 Ceased EP2313098A4 (en) 2008-07-18 2009-07-17 Methods and systems for evaluating memory agents

Country Status (11)

Country Link
EP (1) EP2313098A4 (en)
JP (1) JP5789511B2 (en)
KR (1) KR20110049801A (en)
CN (1) CN102143749A (en)
AU (1) AU2009270697A1 (en)
BR (1) BRPI0916228A2 (en)
CA (1) CA2730940A1 (en)
IL (1) IL210696A (en)
MX (1) MX2011000652A (en)
SG (1) SG195572A1 (en)
WO (1) WO2010009453A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8277842B1 (en) 2012-01-20 2012-10-02 Dart Neuroscience (Cayman) Ltd. Enteric-coated HT-2157 compositions and methods of their use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053738A2 (en) * 1999-03-12 2000-09-14 Brown University Research Foundation Methods and compositions for regulating memory consolidation
WO2002013867A2 (en) * 2000-08-10 2002-02-21 Cold Spring Harbor Laboratory Augmented cognitive training
WO2004016227A2 (en) * 2002-08-19 2004-02-26 Helicon Therapeutics, Inc. Screening methods for cognitive enhancers
US20070135510A1 (en) * 2002-08-07 2007-06-14 Blackburn Thomas P Indolone Compounds Useful To Treat Cognitive Impairment

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770658B2 (en) * 1998-09-09 2004-08-03 Inflazyme Pharmaceuticals Ltd. Substituted γ-phenyl-Δ-lactams and uses related thereto
ES2323940T3 (en) * 2000-05-01 2009-07-28 Accera, Inc. USE OF MEDIUM CHAIN TRIGLICERIDS FOR THE TREATMENT AND PREVENTION OF ALZHEIMER'S DISEASE.
US20070179197A1 (en) * 2000-05-01 2007-08-02 Accera, Inc. Compositions and methods for improving or preserving brain function
JP2002020291A (en) * 2000-06-30 2002-01-23 Sumitomo Pharmaceut Co Ltd Therapeutic agent for cognitive dysfunction
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
EP1551855B1 (en) * 2002-06-25 2012-01-04 Helicon Therapeutics, Inc. Altering memory by affecting staufen function
AU2006326040B2 (en) * 2005-12-15 2012-02-09 Société des Produits Nestlé S.A. Compositions and methods for preserving brain function
EP2001293B9 (en) * 2006-04-03 2019-04-17 Accera, Inc. Use of ketogenic compounds for treatment of age-associated memory impairment
SG172602A1 (en) * 2006-05-19 2011-07-28 Helicon Therapeutics Inc Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
GB0611458D0 (en) * 2006-06-09 2006-07-19 Univ Cambridge Tech Assessment of functional status
JP2009541493A (en) * 2006-06-26 2009-11-26 ヘリコン セラピューティクス，インコーポレイテッド Method for modulating neurite outgrowth by use of a galanin-3 receptor antagonist

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053738A2 (en) * 1999-03-12 2000-09-14 Brown University Research Foundation Methods and compositions for regulating memory consolidation
WO2002013867A2 (en) * 2000-08-10 2002-02-21 Cold Spring Harbor Laboratory Augmented cognitive training
US20070135510A1 (en) * 2002-08-07 2007-06-14 Blackburn Thomas P Indolone Compounds Useful To Treat Cognitive Impairment
WO2004016227A2 (en) * 2002-08-19 2004-02-26 Helicon Therapeutics, Inc. Screening methods for cognitive enhancers

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
IMPEY S ET AL: "STIMULATION OF CAMP RESPONSE ELEMENT (CRE)-MEDIATED TRANSCRIPTION DURING CONTEXTUAL LEARNING", NATURE NEUROSCIENCE, NATURE AMERICA, INC, US, vol. 1, no. 7, 1 November 1998 (1998-11-01), pages 595 - 601, XP000900408, ISSN: 1097-6256, DOI: 10.1038/2830 *
JERRY CP YIN ET AL: "CREB and the formation of long-term memory", CURRENT OPINION IN NEUROBIOLOGY, vol. 6, no. 2, 1 April 1996 (1996-04-01), pages 264 - 268, XP055000872, ISSN: 0959-4388, DOI: 10.1016/S0959-4388(96)80082-1 *
LAMPRECHT R: "CREB: A MESSAGE TO REMEMBER", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHAUSER VERLAG, HEIDELBERG, DE, vol. 55, 1 January 1999 (1999-01-01), pages 554 - 563, XP000929860, ISSN: 1420-682X, DOI: 10.1007/S000180050314 *
See also references of WO2010009453A1 *
SILVA A J ET AL: "CREB AND MEMORY", ANNUAL REVIEW OF NEUROSCIENCE, ANNUAL REVIEWS INC., PALO ALTO, CA, US, vol. 21, 1 January 1998 (1998-01-01), pages 127 - 148, XP000900517, ISSN: 0147-006X, DOI: 10.1146/ANNUREV.NEURO.21.1.127 *
TULLY T ET AL: "Genetic dissection of consolidated memory in Drosophila", CELL, CELL PRESS, US, vol. 79, no. 1, 7 October 1994 (1994-10-07), pages 35 - 47, XP024245732, ISSN: 0092-8674, [retrieved on 19941007], DOI: 10.1016/0092-8674(94)90398-0 *
UKAI M ET AL: "EFFECTS OF GALANIN ON PASSIVE AVOIDANCE RESPONSE, ELEVATED PLUS-MAZE LEARNING, AND SPONTANEOUS ALTERNATION PERFORMANCE IN MICE", PEPTIDES, ELSEVIER, AMSTERDAM, vol. 16, no. 7, 1 January 1995 (1995-01-01), pages 1283 - 1286, XP002045936, ISSN: 0196-9781, DOI: 10.1016/0196-9781(95)02009-L *
YIN J C P ET AL: "CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila", CELL, CELL PRESS, US, vol. 81, 7 April 1995 (1995-04-07), pages 107 - 115, XP002205609, ISSN: 0092-8674, DOI: 10.1016/0092-8674(95)90375-5 *
YIN J C P ET AL: "Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila", CELL, CELL PRESS, US, vol. 79, no. 1, 7 October 1994 (1994-10-07), pages 49 - 58, XP024245733, ISSN: 0092-8674, [retrieved on 19941007], DOI: 10.1016/0092-8674(94)90399-9 *

Also Published As

Publication number Publication date
IL210696A0 (en) 2011-03-31
SG195572A1 (en) 2013-12-30
MX2011000652A (en) 2011-06-16
IL210696A (en) 2014-12-31
AU2009270697A1 (en) 2010-01-21
CN102143749A (en) 2011-08-03
WO2010009453A1 (en) 2010-01-21
JP2011528667A (en) 2011-11-24
EP2313098A1 (en) 2011-04-27
KR20110049801A (en) 2011-05-12
JP5789511B2 (en) 2015-10-07
CA2730940A1 (en) 2010-01-21
BRPI0916228A2 (en) 2015-11-03

Similar Documents

Publication Publication Date Title
HK1216040A1 (en) System and method for evaluating tissue
EP2281065A4 (en) Method for evaluating and comparing immunorepertoires
EP2245541A4 (en) Systems and methods for memory expansion
HK1148098A1 (en) Systems and methods for facilitating consumer-dispenser interactions
EP2308041A4 (en) Systems and methods for concept mapping
EP2310076A4 (en) Anchor systems and methods
ZA200906118B (en) Descenting systems and methods
EP2115594A4 (en) Memory system
EP2250564A4 (en) Memory system
EP2250567A4 (en) Memory system
EP2250565A4 (en) Memory system
EP2250489A4 (en) Systems and methods for providing environment monitoring
EP2248024A4 (en) Memory system
EP2248027A4 (en) Memory system
EP2200977A4 (en) F1f0-atpase inhibitors and related methods
EP2250566A4 (en) Memory system
EP2248022A4 (en) Memory system
EP2248026A4 (en) Memory system
IL202089A0 (en) Systems and methods for organ monitoring
EP2118756A4 (en) Memory system
GB2459741B (en) Debugging system and method
EP2111583A4 (en) Memory system
EP2335208A4 (en) Systems and methods for evaluating advertising metrics
IL213321A0 (en) Descenting systems and methods
GB2485925B (en) Connection methods and systems

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110209

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

AX Request for extension of the european patent

Extension state: AL BA RS

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20111118

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/497 20060101AFI20111114BHEP

Ipc: A61K 31/40 20060101ALI20111114BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1150537

Country of ref document: HK

17Q First examination report despatched

Effective date: 20130902

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20151012

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1150537

Country of ref document: HK