EP2285825A4 - Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor - Google Patents

Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor

Info

Publication number
EP2285825A4
EP2285825A4 EP09743099A EP09743099A EP2285825A4 EP 2285825 A4 EP2285825 A4 EP 2285825A4 EP 09743099 A EP09743099 A EP 09743099A EP 09743099 A EP09743099 A EP 09743099A EP 2285825 A4 EP2285825 A4 EP 2285825A4
Authority
EP
European Patent Office
Prior art keywords
forming non
uses therefor
hydrophobic protein
protein nanoparticles
immunogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09743099A
Other languages
German (de)
French (fr)
Other versions
EP2285825B1 (en
EP2285825A1 (en
Inventor
Omathanu P Perumal
Satheesh K Podaralla
Radhey S Kaushik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
South Dakota State University
University of South Dakota
Original Assignee
South Dakota State University
University of South Dakota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by South Dakota State University, University of South Dakota filed Critical South Dakota State University
Publication of EP2285825A1 publication Critical patent/EP2285825A1/en
Publication of EP2285825A4 publication Critical patent/EP2285825A4/en
Application granted granted Critical
Publication of EP2285825B1 publication Critical patent/EP2285825B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP09743099.5A 2008-05-09 2009-05-11 Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor Active EP2285825B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12713408P 2008-05-09 2008-05-09
PCT/US2009/002935 WO2009137112A1 (en) 2008-05-09 2009-05-11 Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor

Publications (3)

Publication Number Publication Date
EP2285825A1 EP2285825A1 (en) 2011-02-23
EP2285825A4 true EP2285825A4 (en) 2012-11-28
EP2285825B1 EP2285825B1 (en) 2020-07-15

Family

ID=41264904

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09743099.5A Active EP2285825B1 (en) 2008-05-09 2009-05-11 Method of forming non-immunogenic hydrophobic protein nanoparticles and uses therefor

Country Status (12)

Country Link
US (2) US8669225B2 (en)
EP (1) EP2285825B1 (en)
JP (2) JP5546532B2 (en)
KR (1) KR101616771B1 (en)
CN (1) CN102066399B (en)
AU (1) AU2009244742B2 (en)
BR (1) BRPI0908686B8 (en)
CA (1) CA2723563C (en)
HK (1) HK1158221A1 (en)
IL (1) IL209155A (en)
RU (1) RU2010146684A (en)
WO (1) WO2009137112A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2170283T3 (en) 2007-06-22 2019-04-15 Univ Texas CREATION OF STABLE SUBMICRON Peptide OR PROTEIN PARTICLES BY THIN FILM FREEZING
US20140234420A1 (en) * 2008-05-09 2014-08-21 Omathanu P. Perumal Method of Treating Skin Disorders using Nanoscale Delivery Devices and Transdermal Enhancing Compositions
US9233110B2 (en) 2008-05-09 2016-01-12 Omathanu P. Perumal Protein nanocarriers for topical delivery
CA2723563C (en) * 2008-05-09 2017-12-12 South Dakota State University Method of forming non-immunogenic hydrophobic protein nanoparticles, and uses therefor
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
US8779094B2 (en) 2008-11-16 2014-07-15 Board Of Regents, The University Of Texas System Low viscosity highly concentrated suspensions
BR112012033806B1 (en) 2010-06-30 2019-10-15 Unilever N.V. COMPOSITION IN THE FORM OF PARTICULATE UNDERSTANDING HYDROPHobic POLYMER AND PHENOLIC COMPOUND, METHOD FOR PREPARING COMPOSITION AND USE OF COMPOSITION
ES2724176T3 (en) * 2010-07-16 2019-09-06 Univ Navarra Nanoparticles for encapsulation of compounds, their obtaining and uses
CN102120823B (en) * 2011-01-06 2016-08-03 鲁传华 The synthesis of water solublity zein and the utilization in pharmaceutical preparation
WO2012116272A2 (en) * 2011-02-25 2012-08-30 South Dakota State University Polymer conjugated protein micelles
CA2829629A1 (en) * 2011-03-10 2012-09-13 Board Of Regents, The University Of Texas System Protein nanoparticle dispersions
CA2883080A1 (en) * 2011-08-26 2013-03-07 Vecoy Nanomedicines Ltd. Pathogen and substance traps
EP2625966A1 (en) 2012-02-13 2013-08-14 Bionanoplus, S.L. Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
US20150323530A1 (en) * 2012-07-04 2015-11-12 Empire Technology Development Llc Quantum dot-protein complexes, films, and methods of use
KR102045732B1 (en) * 2012-12-28 2019-11-18 엘지디스플레이 주식회사 Method Of Fabricating Water-Soluble Nano Particle Using Temperature-Sensitive Surfactan
BR112015030525B1 (en) * 2013-06-04 2023-01-24 South Dakota State University NANOPARTICLE
IL228528A (en) 2013-09-17 2015-01-29 Technion Res & Dev Foundation Potato protein nanoparticles
US20170252446A1 (en) * 2014-10-09 2017-09-07 Andreas Voigt Use of meso- and nanoporous material for surfactant trapping in nanoparticle suspensions
WO2018071864A1 (en) 2016-10-13 2018-04-19 Thomas Jefferson University Delivery compositions, and methods of making and using same
US11318095B2 (en) * 2017-06-02 2022-05-03 Teika Pharmaceutical Co., Ltd. Micelle for solubilizing a sparingly water-soluble ingredient and solution comprising the same
TWI642685B (en) * 2017-07-26 2018-12-01 中原大學 Novel peptide and application thereof
CN109432433A (en) * 2018-10-30 2019-03-08 中国药科大学 A kind of preparation method and purposes of nano-carrier
CN109730976B (en) * 2018-12-24 2020-06-09 华中科技大学 Method for preparing albumin nanoparticles based on free radical oxidation
CN110251487B (en) * 2019-08-01 2021-11-02 郑州大学 Preparation method and application of alcohol soluble protein nanoparticles for improving drug-loading rate and oral bioavailability of docetaxel
CN112121019B (en) * 2020-09-23 2022-05-31 合肥工业大学 Antioxidant starch-based dextrin composite nano-particles and preparation method and application thereof
CN115025054B (en) * 2022-06-09 2023-12-22 四川普锐特药业有限公司 Preparation method of nano composition taking lactoferrin as carrier

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Publication number Priority date Publication date Assignee Title
WO1996031231A1 (en) * 1995-04-04 1996-10-10 Elan Corporation, Plc Controlled release biodegradable nanoparticles containing insulin

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CA2723563C (en) * 2008-05-09 2017-12-12 South Dakota State University Method of forming non-immunogenic hydrophobic protein nanoparticles, and uses therefor
US9233110B2 (en) * 2008-05-09 2016-01-12 Omathanu P. Perumal Protein nanocarriers for topical delivery

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Publication number Priority date Publication date Assignee Title
WO1996031231A1 (en) * 1995-04-04 1996-10-10 Elan Corporation, Plc Controlled release biodegradable nanoparticles containing insulin

Non-Patent Citations (3)

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See also references of WO2009137112A1 *

Also Published As

Publication number Publication date
BRPI0908686B1 (en) 2020-09-29
BRPI0908686B8 (en) 2021-05-25
EP2285825B1 (en) 2020-07-15
IL209155A0 (en) 2011-01-31
JP5546532B2 (en) 2014-07-09
US20110091565A1 (en) 2011-04-21
KR101616771B1 (en) 2016-04-29
HK1158221A1 (en) 2012-07-13
RU2010146684A (en) 2012-06-20
AU2009244742B2 (en) 2014-11-06
CA2723563C (en) 2017-12-12
US9616021B2 (en) 2017-04-11
IL209155A (en) 2016-07-31
AU2009244742A1 (en) 2009-11-12
CN102066399B (en) 2014-11-26
KR20110036704A (en) 2011-04-08
US8669225B2 (en) 2014-03-11
JP2014177474A (en) 2014-09-25
EP2285825A1 (en) 2011-02-23
JP5851550B2 (en) 2016-02-03
JP2011519932A (en) 2011-07-14
WO2009137112A1 (en) 2009-11-12
CA2723563A1 (en) 2009-11-12
CN102066399A (en) 2011-05-18
US20140308351A1 (en) 2014-10-16

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