EP2214756A1 - Dispositif d'injection pour injecter un fluide sans aiguille - Google Patents

Dispositif d'injection pour injecter un fluide sans aiguille

Info

Publication number
EP2214756A1
EP2214756A1 EP08852368A EP08852368A EP2214756A1 EP 2214756 A1 EP2214756 A1 EP 2214756A1 EP 08852368 A EP08852368 A EP 08852368A EP 08852368 A EP08852368 A EP 08852368A EP 2214756 A1 EP2214756 A1 EP 2214756A1
Authority
EP
European Patent Office
Prior art keywords
injection device
chamber
medium
nozzle
needleless
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08852368A
Other languages
German (de)
English (en)
Inventor
Bernd STÖRMER-TALLEUR
Stephan Theuer
Dirk Schulz
Benedikt Lenzner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Painless Tech GmbH
Original Assignee
Painless Tech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200710055405 external-priority patent/DE102007055405A1/de
Priority claimed from DE200810011310 external-priority patent/DE102008011310A1/de
Application filed by Painless Tech GmbH filed Critical Painless Tech GmbH
Publication of EP2214756A1 publication Critical patent/EP2214756A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3142—Modular constructions, e.g. supplied in separate pieces to be assembled by end-user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod

Definitions

  • Injection device for needle-free injection of a medium
  • the invention describes an injection device consisting of an injector and an ampoule unit for needle-free injection of a medium.
  • DE 699 28 012 T2 discloses an injection device
  • DE 101 37 961 A1 relates to an ampoule for an injection device
  • DE 201 05 183 U1 relates to an ampoule for a needleless injection device
  • EP 1 762 261 B1 discloses a device for administering an injectable product
  • EP 0 114 145 A2 discloses a syringe for medical use.
  • FIG. 1 shows in cross-section an ampoule unit according to WO 2007/065544.
  • the embodiment shows the structural structure of the ampoule unit 1.
  • This consists of a filled with the medium 3 main body 4, which is completely covered by a jacket in the longitudinal axial direction.
  • a nozzle 13 preferably a steel nozzle
  • a sealing element 15 preferably made of silicone
  • a cap 14 At the outlet of the steel nozzle 13 is screwed a cap 14, wherein between the inner wall of the cap 14th and the outlet of the steel nozzle 13 in turn a cap seal 20 (made of sterile material) is located.
  • such an ampoule unit as shown in FIG. 1 is screwed on in order to apply the medium 3 (or to inject it under the skin) after removal of the cap 14 and the cap seal 20 after placement on a specific skin area.
  • Object of the invention of the present application is now to improve the filling of the injection device, in particular to allow a nearly gas-free filling. Further, it is an object of the invention to further develop the injection device to make it usable for other medical or non-medical purposes (eg cosmetic purposes) and also to allow different types of media to be delivered shortly before injection or are mixed together only during the injection, can be administered with the injection device according to the invention
  • Figure 2a shows an exploded view of the device according to the invention
  • Figure 2b and Figure 2c show the ampoule unit according to the invention in various embodiments.
  • a seal 16 which, as shown in Figures 2, has a conical cross-section and the space between the base body 4 (preferably made of glass or a similar material, eg Topaz) and a filling nozzle 18 is located.
  • This filling connection 18 has a cylindrical part 25 which is sealingly disposed in the ampoule unit 1 according to the invention and also has another funnel-shaped widened end 26.
  • a filling device eg. As a filling needle, the injected medium introduced into the interior of the base body 4 and the injection device according to the invention is erected vertically, so all bubbles or similar air bubbles are due to the conical surface up and through the filler neck 18.
  • the filling nozzle 18 may be made of plastic or of a metal, for. As stainless steel, be manufactured and if this filling tube mechanically after filling a constriction 27 (Einkränkung, squeezing or the like.) Exists, the interior of the ampoule unit according to the invention is completely closed off from the outside, with a narrowing of the diameter of the filling at several points is quite advantageous to obtain a reliable absolute conclusion of the interior of the device according to the invention from the outside.
  • the filling nozzle 18 shown in Figure 2 remains after filling in place and is used during the injection process to form the known from the prior art piston rod, driven by spring force together with the adjacent seal 16 located in the main body medium to squeeze the inside of the ampoule unit.
  • the filling nozzle has several constrictions, it can also be used as a predetermined breaking point to detach the filling funnel from the filler neck after filling.
  • FIGS 3 and 4 now show a further embodiment of the ampoule unit according to the invention over the prior art. It can be seen particularly well how in the rear part of the ampoule unit, a piston 28 (in the figures, a displacement piston) is shown, which is surrounded by its front end within the body and in its central region by a seal 30, wherein the by the ampoule unit according to the invention
  • a piston 28 in the figures, a displacement piston
  • Frizu-de medium such as a lubricating film 29 between the piston 28 and the base body 4 and the seal 30 is located.
  • the base body 4 is made of glass (eg borosilicate glass), then this base body 4 can also be coated from the inside with a lubricant in order to give it a streak-free, transparent impression.
  • glass eg borosilicate glass
  • the seal 30 shown in FIG. 3 can have on its top side a ring 31 projecting upwards, which serves as a stop for the abutment located on the piston and if the seal is designed to be particularly soft in this area, a rather soft impact is also produced ,
  • FIGS. 3 and 4 it is also shown that the seal 30 is pressed by means of a screw-on cover 32 against which the shrink sleeve or the base body is pressed.
  • FIG. 5 shows the device according to the invention with a further embodiment.
  • the base body 4 is not, as in the prior art, formed by a glass material, but by a material called Topaz.
  • the properties and production of this material are known from documents of TOPAS Advanced Polymers GmbH, Frankfurt and Ticon GmbH, Frankfurt (a company of Celanese AG), and in particular available at http://www.topas.com. At this point it is omitted to list all the details of this topaz material here.
  • these mechanical, chemical and other mechanical properties of the topaz material must be assumed to be known, especially since it is a standard material which can be obtained from various sources, in particular via the above-mentioned source.
  • the Topas material is a Cyclo Olefin Copolymer (COC) and the essential chemical, physical and other material properties of this material have been known since 2000.
  • COC Cyclo Olefin Copolymer
  • the wall thickness a of the main body 4 ie topaz
  • the wall thickness b of the casing 5 is less than the wall thickness b of the casing 5.
  • the main body continues to be made of a plastic or glass, but on the inside coated with the Topas material, which z. B. by damping or by a low-plasma application method is possible.
  • a particular advantage may be that the topaz material does not have to be depyrolesed first.
  • Figures 6 and 7 show a development of the known single-chamber injection device to a two-chamber injection device.
  • parts shown in Figs. 6 and 7 are shown separately, but they are interchangeable or bolted together, e.g. B. in particular via the outer or inner thread shown in both figures A-A and B-B.
  • FIG. 6 now shows the basic structure of the ampoule unit already mentioned, wherein a volume is formed in the interior of the main body 4, which is referred to below as the first chamber 50.
  • This first chamber is filled with a desired medium, for. B. a powdery, liquid-soluble active ingredient.
  • FIG. 7 likewise shows a hollow-cylindrical body 35, the interior of which forms a second chamber 51.
  • connection consists of a hollow needle 36.
  • This hollow needle is closed at one end by a check valve 32, which opens into the first chamber.
  • the other end of the hollow needle runs (as in a needle usual) pointed (see Figure 6) and when both parts of the two-chamber injection device according to the invention are connected to each other, which is pointed tapered part to a seal 38, which is destructible (or open) of the tip of the hollow needle.
  • the second chamber is closed by a further seal 39 and this seal can be pressed by a piston 40 through the cylindrical part, thus passing the medium, which lies inside the second chamber 51, through the hollow needle to press into the interior of the first chamber.
  • the two media in both chambers can be coordinated so that they can mix for a specific medical purpose or can also react and thus have the desired properties after mixing or after reaction has occurred. It is also quite possible and desirable if both media of a different consistency, for.
  • the medium in the first chamber is powdery and the medium in the second chamber is liquid, so that when the liquid is brought into the powder, the powder dissolves there and the substance to be applied is formed.
  • the injection device according to the invention according to FIGS. 6 and 7 has two locking pins 41, 42. If the first locking pin 42 is released, it is possible to actuate the piston 40 manually, so that with the propulsion of the piston, the medium in the second chamber is driven, so that the tip of the hollow needle opposite seal 38 is opened or is pierced and thus the medium from the second chamber can pass through the hollow needle into the interior of the first chamber.
  • the manual propulsion of the seal can also be limited so far, until the interior of the first chamber is filled by the medium from the second chamber.
  • the check valve 32 shown in Figure 6 is formed in the manner of a rubber-like closure and provided with an incision, so that when pressure from the outside (ie from the interior of the first chamber), the valve closes, but at pressure from the inside (ie from the hollow needle off) the valve opens.
  • Both chambers 50, 51 can - as already mentioned - with different media, in particular different consistency, filled. So it is particularly advantageous, the first chamber with a medium (preparation) in powdered form, z. B. lyophilate to fill and the second chamber with a liquid medium, for. B. to fill a solution with isotonic NaCl (0.9%) or with a pH buffered solution so that powder and liquid mix together before application or extremely fast (less than 5 seconds, preferably faster than 1 second) can be used to subcutaneously administer certain medical agents to a patient.
  • a medium preparation
  • a liquid medium for. B. to fill a solution with isotonic NaCl (0.9%) or with a pH buffered solution so that powder and liquid mix together before application or extremely fast (less than 5 seconds, preferably faster than 1 second) can be used to subcutaneously administer certain medical agents to a patient.
  • the nozzle not only has a single central outlet opening (as in the cited prior art), but has a plurality of outlet openings 53 and - as Figure 8 shows in a particular example, these openings on an imaginary Ring 44 are (see Figure 8b) and thus make it possible that the medium to be applied penetrates through the illustrated outlet openings at different points through the skin of the patient.
  • the advantage of multiple outlet openings is that the total exit area becomes relatively large, while the individual nozzles are still very small.
  • the cross section also shows that the front nozzle tip is formed in the manner of a hemisphere, which is a very preferred embodiment.
  • the size and shape of the passage surfaces of the nozzles is adapted to both the particular application and on the medium, thus achieving the desired distribution of media under the skin of the patient.
  • FIGS. 9 shows a further embodiment of a needleless injection device according to the invention.
  • both springs 55, 56 have different error constants, so that the spring-way characteristic not, as usual in a spring, linear, but also over two different linear gradients - Fig. 10a - can and even progressively - Fig. 10b - run.
  • the strong spring predominates in its action, this can serve to penetrate the skin layer of a patient, and when the second spring, which is weaker than the first spring, comes into effect thereafter, the medium becomes active from the injection device according to the invention is not brought deep under the skin, but the injection volume is relatively flat under the skin and the penetration depth of the injection volume can be determined by the strength of the second spring, while the First spring is designed primarily to first overcome the resistance that forms the natural skin through their closure.
  • FIG. 10a A typical spring characteristic of such a two-spring system is shown in FIG. 10a, FIG. 13 shows a possibility of the profile of the injected medium beneath the skin, it being understood that this medium forms relatively broadly below the skin, but not as shown in FIG. 1 1 - penetrates into the lower skin layers.
  • Figure 12 shows another - independent - training of the invention.
  • the aim in an optimal intradermal administration of the injection is in the foreground.
  • intradermally means that a visible wheal remains after the injection, ie the injection charge lies relatively flat in and / or under the dermis and has a significantly larger surface diameter than height in cross section (see FIGS. 13a, 13b).
  • the ampoule unit according to the invention already described is provided at its front end with a header which is either firmly applied there or there can be placed or released again, for. B. by screwing etc.
  • This attachment has an edge that projects beyond the front surface of the nozzle, z. B. by about 0.2 to 0.8 mm.
  • the attachment consists of a (circular) ring whose diameter essentially determines the later wheal diameter and whose height h is approximately 0.2 to 0.6 mm above the front nozzle surface as illustrated.
  • the Austriebsfeder is relatively weak in such an embodiment, so that when the injection device, the skin of the one who is to receive the injection, bulges in the centering and the upper side very close to the outlet opening of the nozzle moves, if not even touched. Due to the curvature, the skin is slightly biased in this area and can be easily penetrated by the injection, by the curvature itself but also supports the wheal formation and the spring constant of the exit spring must therefore not as strong as in an injection device in which the injection is to be transported into deeper skin layers.
  • an injection device for the needle-free injection of a medium is already generally known from WO 2007/065542.
  • the embodiment shown there is very well suited for the use of a needle-free injection of a medium.
  • a triggering device is arranged, which only - comparable to a conventional ballpoint pen with conventional rear arranged Pressure mechanism - must be depressed so as to allow the release (activation) of the triggering device and thus the activation of the spring drive.
  • the needle-free injection device already known from WO 2007/065542 is provided with an enclosure in its part facing away from the outlet end. Since the injection device has an approximately circular diameter in this region, the housing also has a corresponding diameter, which, however, is somewhat larger. ßer than the outer diameter of the injection device, so that with its inner surface, the outer surface of the injection device in the surrounding area (slidably) encloses, but is still displaceable in the longitudinal direction of the injection device. As can be seen in Figure 14, the housing also encloses the trigger element. Thus, if the housing is moved in the direction of the outlet end, the triggering element is also pressed inwards at the same time and the entire triggering of the needle-free injection is activated.
  • an opening is provided in the upper part of the housing in which a ring-like securing element, which as such is already known from WO 2007/065542, is inserted. Only when this fuse element is pulled out of the housing, the functionality of the needle-free injection device is given.
  • the user can now detect the entire needle-free injection device by attacking only the housing or its surface and puts the injection device with its outlet end on the respective skin area (pad), where the injection is to take place. Now the user needs the needle-free injection device only the enclosure - of course, after removal of the fuse element - to push towards the skin and thus the needle-free injection is always under the same conditions, which means always with the same contact pressure of the injection device on the respective skin area.
  • the desired injection result is reliably achieved and since only a time of about 10 to 500 milliseconds, preferably about 50 to 100 milliseconds is needed for the entire injection is itself when, due to a possible pain reflex, the user jerkily removes the injection device from the skin, the entire injection already takes place, because the anxiety / pain reflection time is much greater than the actual injection time.
  • the respective contact pressure (force) of the injection device on the skin can be substantially determined by also adjusting the pressure (force) required for the triggering. The higher the pressure required to trigger the trigger element, the higher the pressure of the entire injection device on the respective skin area.
  • the release of the drive element is accomplished by pivoting or twisting a blocking element (8).
  • This blocking element cooperates with the triggering element, which in turn is wedge-shaped. Due to the position of the blocking element to the wedge-like surface of the triggering element on the one hand or by the surface friction conditions of blocking element on the one hand and surface of the wedge-like triggering element on the other hand, the respective force (pressure), with the triggering itself, are very precise and above all be set repeatable, so that all identical injection devices with the corresponding design at the same pressure force, so trigger at the same force with displacement of the housing.
  • FIG. 15a but more precisely 15b, now show a very advantageous embodiment of the outlet end, ie the end of the injection device on which the nozzle unit is formed.
  • the nozzle is surrounded by a casing, preferably a shrink sleeve, which has a first section in a front region, in which the outer diameter of the casing tapers and, as shown, tapered so that sets a circular arc cross section R2 (or deviations thereof).
  • This section is followed by another section, in which the external thread is formed (preferably a M8x1 thread), on which the attachment can be screwed.
  • joins another third section in which the front end of the shell again linearly, ie tapered conically.
  • the first section is preferably about 1 mm long and starts at a distance of 4 mm from the nozzle end.
  • the second section is preferably 2 mm long and the third section adjoining the second section is about 1 mm long.
  • the diameter of the third section in the outlet area is about 6 mm.
  • the material of the shrink sleeve is preferably a plastic, very particularly preferred here is polycarbonate.
  • FIG. 15 has the particular advantage that a bursting of the ampoule during the injection, that is to say when a particularly high pressure acts inside the ampoule, can thus be avoided very reliably and, in particular, can be achieved by the design as shown in FIG 15, the notch stresses are reduced so that the overall material reliability is improved.
  • a further variant of the invention which may be independent of the previously described embodiments and variants of the invention, but may also form an advantageous embodiment of the invention together with the previous embodiments and variants, is disclosed in FIGS. 16, 17 and 18.
  • a displacement piston can be introduced, for example via a ring seal in the ampoule. Then, if a sufficiently large pressure in the ampoule is reached, the medium, which is located in the ampoule, can escape at the contact surface between the ring seal and the piston. This then has the consequence that the pressure in the ampoule drops, which in turn can lead to a certain pressure, which is required to inject a medium easily and reliably at a desired depth, needlelessly under the skin is not achieved.
  • a pressure drop should be avoided by occurring overflows or leaks when inserting a displacement piston.
  • FIG. 16 shows a solution according to the invention to this problem.
  • a piston rod 18 is in a clamped tube seal 16 having a sealing flange 61, a stretchable tube 62 and a tip 63.
  • the tip 63 is preferably formed so that it fits positively into the inner part of a nozzle 13 and thus a complete displacement of a medium, which is located in the interior of a base body 4, achieved.
  • other embodiments of the tip 63 can be used, for example, a rounded tip or a tip, which results from a conclusion of the expandable tube 62, wherein the conclusion of a Is formed manner that the piston rod can not come into contact with a medium which may be located in the interior of the base body 4.
  • the nozzle 13 is closed with a cap 14, which has a cap seal 20 on the inside.
  • a shrink sleeve 5 surrounds the main body 4, a sealing element 15 and the nozzle 13.
  • the shrink sleeve 5 is connectable for example via a screw connection with a lid or an injector 32.
  • the hose seal 16 is inserted into the body of the ampoule and the piston rod 18 is received by the expandable hose 62.
  • the piston rod 18 moves toward the nozzle 13, for example, caused by a spring force, the expandable tube 16 is stretched and a medium located within the body is squeezed out of the nozzle.
  • At least the part of the piston 18 which is located within the base body 4 is completely enclosed by the hose seal 16. In this way, it is excluded that a medium which is located within the base body 4, can come into contact with the piston.
  • FIG. 17 shows the arrangement according to FIG. 16, wherein the piston rod 18 is now completely, that is, inserted up to a stop, into the main body 4.
  • the stretchable tube 16 is stretched, reducing the wall thickness of the stretchable tube 16.
  • a lubricating film 64 may form between the clamped tube seal 16 and the base body 4.
  • FIG. 18 a shows the hose seal 16, which has the sealing flange 61, the tip 63 and the expandable hose 62.
  • the hose seal is here in the unstretched state.
  • FIG. 18b shows the hose seal 16 according to FIG. 18a in an expanded state.
  • the hose seal 16 is used to receive the piston 18 and the sealing of the piston input on the base body 4, in particular during the introduction of the piston 18.
  • the tip 63 is preferably formed so that it can adapt to form a fit to the interior of the nozzle 13 and so complete displacement can be achieved.
  • the expandable tube 62 is used to receive the movable piston 18 and the formation of a lubricating film 64.
  • the sealing flange 61 can be pressed against the base body 4 and thus serves to seal the piston input of the base body 4.
  • the lubricating film allows sliding of the piston 18 and of the expandable tube 62 which surrounds the piston 18, along an inner side of the main body 4.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif d'injection constitué d'un injecteur et d'une unité d'ampoule, pour injecter un fluide sans aiguille. Un dispositif d'injection sans aiguille est doté d'une première chambre dont l'intérieur débouche dans une buse et d'une deuxième chambre dont l'intérieur est séparé de l'intérieur de la première chambre, les intérieurs des deux chambres pouvant être reliés l'un à l'autre pour ainsi permettre un mélange et/ou une réaction des substances présentes dans les chambres, une substance de préférence pulvérulente étant placée dans la première chambre et une substance de préférence liquide étant placée dans la deuxième chambre, la substance liquide étant de préférence transportée dans la première chambre pour mélanger/faire réagir les deux substances.
EP08852368A 2007-11-19 2008-11-18 Dispositif d'injection pour injecter un fluide sans aiguille Withdrawn EP2214756A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE200710055405 DE102007055405A1 (de) 2007-11-19 2007-11-19 Injektionsvorrichtung zur nadelfreien Injektion eines Mediums
DE200810011310 DE102008011310A1 (de) 2008-02-27 2008-02-27 Injektionsvorrichtung zur nadelfreien Injektion eines Mediums
DE102008044830 2008-08-28
PCT/EP2008/065766 WO2009065835A1 (fr) 2007-11-19 2008-11-18 Dispositif d'injection pour injecter un fluide sans aiguille

Publications (1)

Publication Number Publication Date
EP2214756A1 true EP2214756A1 (fr) 2010-08-11

Family

ID=40288810

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08852368A Withdrawn EP2214756A1 (fr) 2007-11-19 2008-11-18 Dispositif d'injection pour injecter un fluide sans aiguille

Country Status (3)

Country Link
US (1) US9533098B2 (fr)
EP (1) EP2214756A1 (fr)
WO (1) WO2009065835A1 (fr)

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US10220149B2 (en) 2010-09-17 2019-03-05 Daicel Corporation Syringe

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EP2279021B1 (fr) * 2008-04-18 2013-02-13 Kuros Biosurgery AG Dispositif de distribution, ensemble contenant le dispositif, et procédé d'utilisation du dispositif
CN105530974A (zh) * 2013-09-09 2016-04-27 Lts勒曼治疗***股份公司 蛋白无针皮下注射
KR101862201B1 (ko) * 2017-08-31 2018-05-29 제이에스케이바이오메드(주) 역류방지밸브가 구비된 마이크로젯 약물 주사 장치
CN110743634B (zh) * 2019-09-20 2021-06-01 华南农业大学 一种微流控设备

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US10220149B2 (en) 2010-09-17 2019-03-05 Daicel Corporation Syringe
US10569021B2 (en) 2010-09-17 2020-02-25 Daicel Corporation Syringe
US10821232B2 (en) 2010-09-17 2020-11-03 Daicel Corporation Syringe

Also Published As

Publication number Publication date
US9533098B2 (en) 2017-01-03
US20110009815A1 (en) 2011-01-13
WO2009065835A1 (fr) 2009-05-28

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