EP2147092A4 - Antibiotikaresistenz-freie listeria-stämme und verfahren zur konstruktion und verwendung davon - Google Patents

Antibiotikaresistenz-freie listeria-stämme und verfahren zur konstruktion und verwendung davon

Info

Publication number
EP2147092A4
EP2147092A4 EP08742912A EP08742912A EP2147092A4 EP 2147092 A4 EP2147092 A4 EP 2147092A4 EP 08742912 A EP08742912 A EP 08742912A EP 08742912 A EP08742912 A EP 08742912A EP 2147092 A4 EP2147092 A4 EP 2147092A4
Authority
EP
European Patent Office
Prior art keywords
constructing
methods
same
antibiotic resistance
listeria strains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08742912A
Other languages
English (en)
French (fr)
Other versions
EP2147092A2 (de
Inventor
Yvonne Paterson
Thorsten Verch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/785,249 external-priority patent/US7855064B2/en
Priority claimed from US11/818,965 external-priority patent/US7858097B2/en
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of EP2147092A2 publication Critical patent/EP2147092A2/de
Publication of EP2147092A4 publication Critical patent/EP2147092A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP08742912A 2007-04-16 2008-04-15 Antibiotikaresistenz-freie listeria-stämme und verfahren zur konstruktion und verwendung davon Withdrawn EP2147092A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/785,249 US7855064B2 (en) 2004-08-13 2007-04-16 Antibiotic resistance free vaccines and methods for constructing and using same
US11/818,965 US7858097B2 (en) 2004-08-13 2007-04-27 Antibiotic resistance free Listeria strains and methods for constructing and using same
PCT/US2008/004861 WO2008130551A2 (en) 2007-04-16 2008-04-15 Antibiotic resistance free listeria strains and methods for constructing and using same

Publications (2)

Publication Number Publication Date
EP2147092A2 EP2147092A2 (de) 2010-01-27
EP2147092A4 true EP2147092A4 (de) 2010-06-09

Family

ID=39876122

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08742912A Withdrawn EP2147092A4 (de) 2007-04-16 2008-04-15 Antibiotikaresistenz-freie listeria-stämme und verfahren zur konstruktion und verwendung davon

Country Status (2)

Country Link
EP (1) EP2147092A4 (de)
WO (1) WO2008130551A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
EP2288379A4 (de) * 2008-05-19 2012-08-08 Advaxis Doppeltes freisetzungssystem für heterologe antigene
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9084747B2 (en) 2009-11-11 2015-07-21 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of HER2/NEU over-expressing tumors
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
WO2012138377A2 (en) * 2010-10-01 2012-10-11 Trustees Of The University Of Pennsylvania The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
EP2683400A4 (de) 2011-03-11 2014-09-17 Advaxis Adjuvanzien auf listerien-basis
SG11201405605VA (en) 2012-03-12 2014-10-30 Advaxis Inc SUPPRESSOR CELL FUNCTION INHIBITION FOLLOWING <i>LISTERIA</i> VACCINE TREATMENT
WO2015126921A1 (en) 2014-02-18 2015-08-27 Advaxis, Inc. Biomarker directed multi-target immunotherapy
WO2015164121A1 (en) 2014-04-24 2015-10-29 Advaxis, Inc. Recombinant listeria vaccine strains and methods of producing the same
MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
MA42841A (fr) * 2015-09-15 2018-07-25 Advaxis Inc Procédé de fabrication d'une formulation immunothérapeutique comprenant une souche de listeria de recombinaison
SG10202105561PA (en) 2016-11-30 2021-07-29 Advaxis Inc Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof
MX2020003100A (es) 2017-09-19 2020-08-20 Advaxis Inc Composiciones y metodos para la liofilizacion de bacterias o cepas de listeria.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017856A2 (en) * 2004-08-13 2006-02-16 The Trustees Of The University Of Pennsylvania Methods for constructing antibiotic resistance free vaccines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099848A (en) * 1997-11-18 2000-08-08 The Trustees Of The University Of Pennsylvania Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017856A2 (en) * 2004-08-13 2006-02-16 The Trustees Of The University Of Pennsylvania Methods for constructing antibiotic resistance free vaccines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRUHN ET AL: "Listeria as a vaccine vector", MICROBES AND INFECTION, ELSEVIER, PARIS, FR LNKD- DOI:10.1016/J.MICINF.2007.05.010, vol. 9, no. 10, 7 May 2007 (2007-05-07), pages 1226 - 1235, XP022244468, ISSN: 1286-4579 *
VERCH THORSTEN ET AL: "Listeria monocytogenes-based antibiotic resistance gene-free antigen delivery system applicable to other bacterial vectors and DNA vaccines", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US LNKD- DOI:10.1128/IAI.72.11.6418-6425.2004, vol. 72, no. 11, 1 November 2004 (2004-11-01), pages 6418 - 6425, XP002508995, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
WO2008130551A2 (en) 2008-10-30
EP2147092A2 (de) 2010-01-27
WO2008130551A3 (en) 2008-12-24

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Legal Events

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Extension state: AL BA MK RS

A4 Supplementary search report drawn up and despatched

Effective date: 20100511

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 35/74 20060101ALI20100504BHEP

Ipc: C12N 1/21 20060101AFI20091119BHEP

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Effective date: 20101112