EP2091969A4 - Polypeptide mit verbesserten entzündungshemmenden und verminderten zytotoxischen eigenschaften und damit im zusammenhang stehende verfahren - Google Patents

Polypeptide mit verbesserten entzündungshemmenden und verminderten zytotoxischen eigenschaften und damit im zusammenhang stehende verfahren

Info

Publication number
EP2091969A4
EP2091969A4 EP07812601A EP07812601A EP2091969A4 EP 2091969 A4 EP2091969 A4 EP 2091969A4 EP 07812601 A EP07812601 A EP 07812601A EP 07812601 A EP07812601 A EP 07812601A EP 2091969 A4 EP2091969 A4 EP 2091969A4
Authority
EP
European Patent Office
Prior art keywords
polypeptides
inflammatory
enhanced anti
cytotoxic properties
decreased cytotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP07812601A
Other languages
English (en)
French (fr)
Other versions
EP2091969A2 (de
Inventor
Falk Nimmerjahn
Yoshikatsu Kaneko
Jeffrey V Ravetch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2006/041791 external-priority patent/WO2007055916A2/en
Priority claimed from PCT/US2007/008396 external-priority patent/WO2007117505A2/en
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of EP2091969A2 publication Critical patent/EP2091969A2/de
Publication of EP2091969A4 publication Critical patent/EP2091969A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP07812601A 2006-10-27 2007-07-03 Polypeptide mit verbesserten entzündungshemmenden und verminderten zytotoxischen eigenschaften und damit im zusammenhang stehende verfahren Ceased EP2091969A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2006/041791 WO2007055916A2 (en) 2005-11-07 2006-10-27 Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
PCT/US2007/008396 WO2007117505A2 (en) 2006-04-05 2007-04-03 Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
PCT/US2007/072771 WO2008057634A2 (en) 2006-10-26 2007-07-03 Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods

Publications (2)

Publication Number Publication Date
EP2091969A2 EP2091969A2 (de) 2009-08-26
EP2091969A4 true EP2091969A4 (de) 2010-05-12

Family

ID=39367532

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07812601A Ceased EP2091969A4 (de) 2006-10-27 2007-07-03 Polypeptide mit verbesserten entzündungshemmenden und verminderten zytotoxischen eigenschaften und damit im zusammenhang stehende verfahren

Country Status (3)

Country Link
EP (1) EP2091969A4 (de)
AU (1) AU2007317755A1 (de)
WO (1) WO2008057634A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8470318B2 (en) 2005-11-07 2013-06-25 The Rockefeller University Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
US20080206246A1 (en) * 2006-04-05 2008-08-28 Ravetch Jeffrey V Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
CN101432301B (zh) 2006-04-05 2014-01-08 洛克菲勒大学 具有增强的抗炎性和降低的细胞毒性特性的多肽以及相关方法
CN101981200A (zh) 2008-03-27 2011-02-23 诺维信公司 从含木素纤维素材料产生发酵产物
MX2010011598A (es) 2008-04-22 2010-12-15 Univ Rockefeller Metodos para identificar compuestos anti-inflamatorios.
EP2233499A1 (de) 2009-03-26 2010-09-29 CSL Behring AG Antikörperzusammensetzung mit veränderter Fab-Sialylierung
EP2233502A1 (de) * 2009-03-27 2010-09-29 Deutsches Rheuma-Forschungszentrum Berlin Sialylierte antigenspezifische Antikörper zur Behandlung oder Vorbeugung von ungewollten entzündlichen Immunreaktionen und Verfahren zu deren Herstellung
US9187568B2 (en) 2009-05-07 2015-11-17 Stallergenes S.A. Use of IgG1 immunoglobulins and/or ligands of the CD32 receptor for treating inflammatory diseases and manifestations via the mucosal route
EP2459590B1 (de) 2009-07-30 2015-04-22 F.Hoffmann-La Roche Ag Enzymatische antikörperverarbeitung
CN102947333A (zh) 2010-05-07 2013-02-27 瑞士杰特贝林生物制品有限公司 抗体组合物
WO2012012590A2 (en) 2010-07-23 2012-01-26 Novozymes A/S Processes for producing fermentation products
EA201300418A1 (ru) 2010-10-05 2013-09-30 Ф.Хоффманн-Ля Рош Аг Антитела к человеческому tweak и варианты их применения
AU2011329053A1 (en) * 2010-11-15 2013-06-06 Biogen Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
AR085302A1 (es) 2011-02-24 2013-09-18 Sanofi Sa Metodo de produccion de anticuerpos sialilados
EP2702077A2 (de) 2011-04-27 2014-03-05 AbbVie Inc. Verfahren zur steuerung des galactosylierungsprofil von rekombinant exprimierten proteinen
EP2710032B1 (de) 2011-05-20 2019-12-25 Momenta Pharmaceuticals, Inc. Modifizierte glykoproteine
WO2013050335A1 (en) 2011-10-05 2013-04-11 F. Hoffmann-La Roche Ag Process for antibody g1 glycoform production
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
EP4234577A3 (de) 2012-04-25 2023-10-18 Momenta Pharmaceuticals, Inc. Modifizierte glykoproteine
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014052360A2 (en) * 2012-09-26 2014-04-03 Momenta Pharmaceuticals, Inc. Glycoprotein preparations
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US10450361B2 (en) 2013-03-15 2019-10-22 Momenta Pharmaceuticals, Inc. Methods related to CTLA4-Fc fusion proteins
US10464996B2 (en) 2013-05-13 2019-11-05 Momenta Pharmaceuticals, Inc. Methods for the treatment of neurodegeneration
EP3052640A2 (de) 2013-10-04 2016-08-10 AbbVie Inc. Verwendung von metallionen zur modulation von proteinglykosylierungsprofilen rekombinanter proteine
EP3058084A4 (de) 2013-10-16 2017-07-05 Momenta Pharmaceuticals, Inc. Sialylierte glycoproteine
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
SG11202005654QA (en) 2017-12-19 2020-07-29 Univ Rockefeller HUMAN IgG Fc DOMAIN VARIANTS WITH IMPROVED EFFECTOR FUNCTION

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039488A1 (en) * 1995-06-06 1996-12-12 Genentech, Inc. Process for controlling sialylation of proteins produced by mammalian cell culture
WO2000063403A2 (en) * 1999-04-15 2000-10-26 Crucell Holland B.V. Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein
WO2004058944A2 (en) * 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
WO2005063808A1 (en) * 2003-12-31 2005-07-14 Merck Patent Gmbh Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS
WO2007005786A2 (en) * 2005-06-30 2007-01-11 Centocor, Inc. Methods and compositions with enhanced therapeutic activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656466B1 (en) 1995-06-06 2003-12-02 Genetech, Inc. Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
US7064191B2 (en) * 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039488A1 (en) * 1995-06-06 1996-12-12 Genentech, Inc. Process for controlling sialylation of proteins produced by mammalian cell culture
WO2000063403A2 (en) * 1999-04-15 2000-10-26 Crucell Holland B.V. Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein
WO2004058944A2 (en) * 2002-12-23 2004-07-15 Bristol-Myers Squibb Company Product quality enhancement in mammalian cell culture processes for protein production
WO2005063808A1 (en) * 2003-12-31 2005-07-14 Merck Patent Gmbh Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS
WO2007005786A2 (en) * 2005-06-30 2007-01-11 Centocor, Inc. Methods and compositions with enhanced therapeutic activity

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DALZIEL MARTIN ET AL: "Lectin analysis of human immunoglobulin G N-glycan sialylation", GLYCOCONJUGATE JOURNAL, vol. 16, no. 12, December 1999 (1999-12-01), pages 801 - 807, XP002575135, ISSN: 0282-0080 *
JASSAL R ET AL: "Sialylation of human IgG-Fc carbohydrate by transfected rat alpha2,6-sialyltransferase.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 17 AUG 2001, vol. 286, no. 2, 17 August 2001 (2001-08-17), pages 243 - 249, XP002574380, ISSN: 0006-291X *
KANEKO Y ET AL: "ANTI-INFLAMMATORY ACTIVITY OF IMMUNOGLOBULIN G RESULTING FROM FC SIALYLATION", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 313, no. 5787, 1 August 2006 (2006-08-01), pages 670 - 673, XP008076047, ISSN: 0036-8075 *
KANEKO Y ET AL: "ANTI-INFLAMMATORY ACTIVITY OF IMMUNOGLOBULIN G RESULTING FROM FC SIALYLATION", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 313, no. 5787, 1 August 2006 (2006-08-01), pages 670 - 673, XP008076047, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1129594 *
NIMMERJAHN FALK ET AL: "The antiinflammatory activity of IgG: the intravenous IgG paradox", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 204, no. 1, January 2007 (2007-01-01), pages 11 - 15, XP002575137, ISSN: 0022-1007 *
RAJU T SHANTHA ET AL: "Glycoengineering of therapeutic glycoproteins: In vitro galactosylation and sialylation of glycoproteins with terminal N-acetylglucosamine and galactose residues", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, PA.; US, vol. 40, no. 30, 31 July 2001 (2001-07-31), pages 8868 - 8876, XP002461128, ISSN: 0006-2960 *
SCALLON ET AL: "Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 44, no. 7, November 2006 (2006-11-01), pages 1524 - 1534, XP005792683, ISSN: 0161-5890 *
See also references of WO2008057634A2 *
WANG W-C ET AL: "THE IMMOBILIZED LEUKOAGGLUTININ FROM THE SEEDS OF MAACKIA-AMURENSIS BINDS WITH HIGH AFFINITY TO COMPLEX-TYPE ASN-LINKED OLIGOSACCHARIDES CONTAINING TERMINAL SIALIC ACID-LINKED .ALPHA.-2 3 TO PENULTIMATE GALACTOSE RESIDUES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 263, no. 10, 5 April 1988 (1988-04-05), pages 4576 - 4585, XP002575136, ISSN: 0021-9258 *
WANG W-C ET AL: "THE IMMOBILIZED LEUKOAGGLUTININ FROM THE SEEDS OF MAACKIA-AMURENSIS BINDS WITH HIGH AFFINITY TO COMPLEX-TYPE ASN-LINKED OLIGOSACCHARIDES CONTAINING TERMINAL SIALIC ACID-LINKED ALPHA-2 3 TO PENULTIMATE GALACTOSE RESIDUES", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 10, 1988, pages 4576 - 4585, XP002575136, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2008057634A3 (en) 2008-12-04
AU2007317755A1 (en) 2008-05-15
WO2008057634A2 (en) 2008-05-15
EP2091969A2 (de) 2009-08-26

Similar Documents

Publication Publication Date Title
ZA200808900B (en) Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
EP2091969A4 (de) Polypeptide mit verbesserten entzündungshemmenden und verminderten zytotoxischen eigenschaften und damit im zusammenhang stehende verfahren
ZA201004045B (en) Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
IL237314A0 (en) Modified insulin polypeptides and their uses
IL185563A0 (en) Gip analog and hybrid polypeptides with selectable properties
ZA200810323B (en) Fkbp-l and uses thereof
EP2089480A4 (de) Antimikrobielle materialien und beschichtungen
IL193198A0 (en) Long-actine polypeptides and methods of producing and administering same
IL194751A0 (en) Drugs and uses
ZA200902161B (en) Antiobodies and immunoconjugates and uses therefor
ZA200904061B (en) Fuel composition and its use
SI2064327T1 (sl) DBAIT in njegova uporaba
ZA201002802B (en) Functionalised materials and uses thereof
HK1133552A1 (en) Carboranylporphyrins and uses thereof
GB0621513D0 (en) Novel polypeptides and uses thereof
SI2068909T1 (sl) Modificirani fgf-21 polipeptidi in njihova uporaba
GB0607798D0 (en) Novel polypeptides and use thereof
IL197920A0 (en) Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
ZA200904583B (en) Dual composition with warming and analgesic effects
EP1977996A4 (de) Phosphat-metall-haltiger komplex und diesen enthaltendes dichtes material
EP2097085A4 (de) Therapeutische materialien und verfahren
PL2032708T3 (pl) Rekombinowane nowirabdowirusy i ich zastosowania
GB0701295D0 (en) Z-stilbenes derivatives and the pharmaceutical composition thereof
GB0907108D0 (en) Mutants and uses therefor
IL192800A0 (en) Fgf2-binding peptides and uses thereof

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20090519

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: RAVETCH, JEFFREY V.

Inventor name: NIMMERJAHN, FALK

Inventor name: KANEKO, YOSHIKATSU

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE ROCKEFELLER UNIVERSITY

A4 Supplementary search report drawn up and despatched

Effective date: 20100414

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1135408

Country of ref document: HK

17Q First examination report despatched

Effective date: 20100719

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20130201

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1135408

Country of ref document: HK