EP2088989A1 - Procédé de renforcement de l'activité de bronzage de substances auto-bronzantes - Google Patents

Procédé de renforcement de l'activité de bronzage de substances auto-bronzantes

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Publication number
EP2088989A1
EP2088989A1 EP07846682A EP07846682A EP2088989A1 EP 2088989 A1 EP2088989 A1 EP 2088989A1 EP 07846682 A EP07846682 A EP 07846682A EP 07846682 A EP07846682 A EP 07846682A EP 2088989 A1 EP2088989 A1 EP 2088989A1
Authority
EP
European Patent Office
Prior art keywords
oxygen
self
tanning
preparation
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07846682A
Other languages
German (de)
English (en)
Inventor
Thomas Rudolph
Philipp Buehle
Hansjuergen Driller
Herwig Buchholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP2088989A1 publication Critical patent/EP2088989A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/884—Sequential application

Definitions

  • the invention relates to a method for enhancing the tanning effect of at least one self-tanning substance by reducing or eliminating the presence of oxygen.
  • the epidermis contains in its lowest layer, the basal layer, in addition to the basal cells, individual pigment-forming cells, the melanocytes. UV light in these cells stimulates the production of melanin, which is transported to the keratinocytes (horny cells) where it becomes visible as a brown skin color.
  • Produced by the amino acid tyrosine, pigmentation is primarily initiated by UVB radiation and referred to as "indirect pigmentation.” Its development proceeds over several days, resulting in a few weeks of suntan on "direct pigmentation” associated with exposure to the sun is used, predominantly colorless melanin precursors by UVA radiation dark colored melanin oxidized.
  • An artificial tanning of the skin can be produced externally with the help of make-up and orally by taking carotenoids.
  • the artificial tanning of the skin which can be achieved by applying so-called self-tanner.
  • These compounds have as a chemical structural feature keto or aldehyde groups in the vicinity of alcohol functions. These ketols or aldols belong predominantly to the substance class of sugars.
  • An especially frequently used self-tanning substance is 1,3-dihydroxyacetone (DHA).
  • the compounds can be reacted with the proteins and amino acids of the dermal layer of the skin in the manner of a Maillard reaction, resulting in a not yet fully elucidated pathway polymers that give the skin a brownish hue. This reaction is completed in about 4 to 6 hours. The tan thus obtained is not washable and is removed only with the normal Hautabschuppung.
  • the self-tanning substances are usually used as a solution or
  • Emulsion sprayed on the skin or applied manually usually takes place only after a time delay by a very slow reaction of the self-tanner with the proteins of the skin, as described above. Therefore, it is all the more desirable, especially from the user's point of view, that the tanning per application of the self-tanning substance is intensified and that tanning takes place more rapidly overall.
  • the object of the present invention was accordingly to find a method for enhancing the tanning effect of self-tanning substances. It has now surprisingly been found that tanning enhancement occurs to a great extent when the air present during the application or permanent air or the oxygen contained therein is reduced or eliminated.
  • the tanning of the skin is usually more uniform and lasts longer.
  • there may also be an acceleration of the tanning effect in other words, that in an observed period, the tanning takes place earlier.
  • the term "tanning reinforcement" used in the invention is also be used in the invention.
  • a first aspect of the invention is therefore a method for enhancing the tanning effect of at least one self-tanning substance by reducing or eliminating the presence of oxygen.
  • Suitable measures for reducing the exposure to air or oxygen are, for example, the type of application, the composition of the preparation containing the at least one self-tanning substance or the composition of the environment, based on physical, chemical, biochemical or microbiological effects.
  • the type of application within the meaning of the invention includes the temporal nature of the application, as described in detail below, or the manner of applying the self-tanning substance or the treatment of the area to be tanned.
  • the oxygen in the form of pure oxygen but also in mixtures with other gases, for example as
  • Another object of the invention is therefore a method for enhancing the tanning effect of at least one self-tanning substance, wherein the reduction or elimination of the oxygen content during the application of the at least one
  • a tanning reactor is understood to mean, for example, a tanning cabin in which the cosmetic preparation comprising the at least one self-tanner substance is applied to the skin by means of nozzles, a tanning shower, a tanning bath or tanning systems such as the Airbrush tanning system of the Beauty-Form company, where the tanning system has a tanning system Spray mist of a tanning lotion that is applied to the skin.
  • the reduction or elimination of the oxygen content can be achieved by pretreatment of the skin to which the at least one self-tanning substance is applied.
  • This pretreatment can be carried out, for example, by application of a formulation containing at least one deoxygenating or oxygen-binding substance and / or at least one oxygen-consuming biochemical or microbiological component and / or at least one antioxidant.
  • a formulation containing at least one deoxygenating or oxygen-binding substance and / or at least one oxygen-consuming biochemical or microbiological component and / or at least one antioxidant.
  • component is used synonymously with substance.
  • kit is used synonymously with Set.
  • formulation synonymous means or preparation is used.
  • self-tanning substance is used in addition to the term self-tanning substance.
  • 1,3-dihydroxyacetone it is also used to mean dihydroxyacetone or the abbreviation DHA.
  • Inerted preparation means that measures have been taken for a preparation to reduce or eliminate the oxygen content of the preparation.
  • a suitable measure is a degassing, wherein the content of oxygen in the aqueous portion of the preparation, as described above, is less than or equal to 10 mg / l or preferably in the range between 0.1 to 7 mg / l.
  • the content of oxygen can be reduced by this measure also in the oil phase of the preparation.
  • Suitable oxygen-depleting or oxygen-binding substances are, for example, alkali, alkaline earth or ammonium sulfites, alkali, alkaline earth or ammonium hydrogen sulfites, alkali, alkaline earth or ammonium bisulfites, alkali, alkaline earth or ammonium polysulfites or dialkylhydroxylamines.
  • An alkyl group is, for example, an alkyl group having 1, 2, 3, 4, 5 or 6 C atoms, for example methyl, ethyl, isopropyl, n-propyl, isobutyl, n-butyl, tert-butyl, n-pentyl or n -Hexyl understood.
  • Dialkylhydroxylamines are, for example, dimethylhydroxylamine, methylethylhydroxylamine, diethylhydroxylamine, dipropylhydroxylamine, Dibutylhydroxylamine, dipentylhydroxylamine or dihexylhydroxylamine, which according to the invention preferably diethylhydroxylamine can be used.
  • Sodium bisulfite, sodium hydrogen sulfite, sodium sulfite, potassium hydrogen sulfite, potassium sulfite are particularly suitable according to the invention.
  • Ammonium hydrogen sulfite, ammonium sulfite, magnesium hydrogen sulfite or magnesium sulfite, with sodium bisulfite, sodium sulfite or potassium sulfite particularly preferred or sodium sulfite can be used with very particular preference.
  • the oxygen scavenging or deoxygenating substances as described above are typically used in the formulation for pretreatment in amounts of from 0.01% to 20% by weight, preferably in amounts of from 0.05% to 10% by weight.
  • the quantity refers to the total amount of formulation for pretreatment. The expert does not have any difficulties in selecting the quantities according to the intended effect of the preparation.
  • Suitable oxygen-consuming biochemical or microbiological components are, for example, superoxide dismutase, peroxidase and / or catalase, in each case as enzyme or isoenzyme.
  • the synergistic antioxidant effect of superoxide dismutase and peroxidase is from Int. J. Cos. Known in 2000, Lods, 85ff.
  • the oxygen-degrading activity of an isoenzyme of superoxide dismutase is known from WO 2005/017134.
  • Superoxide Dismutase, peroxidase and / or catalase can be used both as pure substance or as extract. Usual use concentrations are between 0.1 wt .-% and 10 wt .-%, preferably at 2 wt .-% based on the total amount of the preparation.
  • antioxidants eg amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles, (eg urocaninic acid) and their derivatives, peptides such as DL-carnosine, D-carnosine, L-carnosine and their derivatives (eg anserine), carotenoids, carotenes (eg ⁇ -carotene, ⁇ -carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives (eg dihydrolipoic acid), aurothioglucose, Propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl
  • vitamin C and derivatives eg ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate
  • tocopherols and derivatives eg Vitamin E acetate
  • vitamin A and derivatives eg vitamin A palmitate
  • benzylic benzylic resin rutinic acid and
  • Suitable antioxidants are also compounds of the general formulas A or B.
  • R 1 can be selected from the group consisting of -C (O) CH 3 , -CO 2 R 3 , -C (O) NH 2 and -C (O) N (R 4 ) 2 , XO or NH,
  • R 2 is linear or branched alkyl having 1 to 30 C atoms
  • R 3 is linear or branched alkyl having 1 to 20 C atoms
  • R 4 are each, independently of one another, H or linear or branched alkyl having 1 to 8 C atoms
  • R 5 is linear or branched alkyl having 1 to 8 C atoms or linear or branched alkoxy having 1 to 8 C atoms
  • R 6 is linear or branched Alkyl having 1 to 8 carbon atoms, preferably derivatives of 2- (4-hydroxy-3,5-dimethoxybenzylidene) malonic acid and / or 2- (4-hydroxy-3,5-dimethoxybenzyl) -malonic acid, particularly preferably 2 - (4-hydroxy-3,5-dimethoxybenzylidene) malonic acid bis- (2-ethylhexyl) ester (for example Oxynex ® ST Liquid) and / or 2- (4-hydroxy-3,5 dimethoxybenzy) malonic acid-bis - (2-ethylhexyl) ester (eg RonaCare ® AP).
  • mixtures suitable for pretreatment are, for example, mixtures comprising, as active ingredients, lecithin, L - (+) - ascorbyl palmitate and citric acid (for example (for example Oxynex ® AP), natural
  • Citric acid eg Oxynex ® K LIQUID
  • tocopherol extracts from natural sources L - (+) - ascorbyl palmitate, L - (+) - ascorbic acid and Citric acid (for example Oxynex ® L LIQUID), DL- ⁇ -tocopherol, L - (+) - ascorbyl palmitate, citric acid and lecithin (for example Oxynex ® LM) or butylhydroxytoluene (BHT), L - (+) - ascorbyl palmitate and citric acid (for example Oxynex ® 2004).
  • Oxynex ® K LIQUID Citric acid
  • tocopherol extracts from natural sources L - (+) - ascorbyl palmitate, L - (+) - ascorbic acid and Citric acid
  • DL- ⁇ -tocopherol for example Oxynex ® L LIQUID
  • citric acid and lecithin for example Oxynex ® LM
  • the antioxidants, as described above, according to the invention typically in amounts of 0.01 to 20 wt .-%, preferably in amounts of 0.05 wt .-% to 10 wt .-% based on the total amount in the formulation for pretreatment used.
  • the expert does not have any difficulty in selecting the quantities according to the intended effect of the preparation.
  • the application of the cosmetic preparation containing at least one deoxygenating or oxygen-binding substance and / or at least one oxygen-consuming biochemical or microbiological component and / or at least one antioxidant to the area, which is to be treated later with the formulation containing at least one self-tanning substance, should be rapid.
  • the application is preferably carried out within 1 to 15 minutes, of course, depending on the area of the area, with a
  • Preparations containing at least one antioxidant, as described above, are known in the art.
  • a preparation containing an antioxidant, a preparation containing an oxygen-binding or deoxygenating substance, a preparation containing the oxygen-consuming biochemical or microbiological component with a preparation containing at least one self-tanner substance can be combined.
  • the kit may also consist of the said preparations.
  • the kit can be offered in a package or separately, with the individual components of the kit, ie the preparations, as described above or consist of.
  • the reduction or elimination of the oxygen content can take place after the application of the at least one self-tanning substance.
  • a suitable measure for this purpose is, for example, a covering of the area treated with a preparation containing at least one self-tanning substance by cloths, films or other materials, wherein in particular the material used should have a low oxygen permeability.
  • a low oxygen permeability is defined as a value of less than 1000 cm 3 / (m 2 * bar * d), preferably less than 100 cm 3 / (m 2 * bar * d), more preferably less than 50 cm 3 / (m 2 bar). d).
  • the material used is permeable to water.
  • the gas permeability can be carried out according to the carrier gas method DIN 53380-3 or DIN 53380-S.
  • the sample is installed in a permeation cell to form the barrier between two separate chambers.
  • a measuring chamber is flowed through by the test gas, here oxygen, under test pressure.
  • a carrier gas for example nitrogen, which flows through the sample permeable test gas transported to the sensor.
  • the slides are ideally the size of a DIN A4 sheet.
  • the test is performed on three independent patterns per Permeationsraum.
  • the test temperatures are generally between -50 0 C and 50 0 C at pressures up to 100 bar.
  • films made of plastics or composite films are preferably used, for example polyethylene or polypropylene films, PVC, PVDC, PA, PET, EVOH films, but also special composite films such as the Escal TM film from Mitsubishi
  • PVOH or PA polyvinyl alcohol
  • the area treated with the at least one self-tanning substance should be covered for at least 10 minutes or more with the appropriately selected material as described above. It should be noted that the action taken, as described above, the concentration of oxygen above the skin and in the upper layers of the skin is reduced, or it may Presence of oxygen to a partial pressure less than the atmospheric oxygen partial pressure can be reduced.
  • the atmospheric oxygen partial pressure is physically defined as 159.21 mmHg at sea level.
  • Another object of the invention is therefore a kit containing a formulation containing at least one self-tanning substance and a film whose oxygen permeability has a value of less than 1000 cm 3 / (m 2 * bar * d).
  • the reduction or elimination of the oxygen content can be achieved by the type of formulation containing the at least one self-tanning substance.
  • the individual components of the preparation containing the at least one self-tanning substance can be degassed or rendered inert and then mixed together.
  • the content of oxygen in the aqueous portion of the preparation is less than or equal to 10 mg / l or preferably in the range between 0.1 and 7 mg / l.
  • the determination of the oxygen in the aqueous solution is carried out using the tritrimetric oxygen test of Merck KGaA, Darmstadt, Germany [1.11107.0001].
  • the dissolved oxygen oxidizes manganese (II) ions in alkaline solution to manganese (IV) oxide hydrates - a so-called "oxygen fixation" takes place.
  • the resulting iodine is titrated with a sodium thiosulfate solution against starch as an indicator until complete decolorization.
  • the Oxygen concentration results from the consumption of titration solution. This test is based on the iodometric determination according to Winkler.
  • the detection limit is 0.1 mg / l oxygen in the aqueous solution. An experimental description of this test method is given in a corresponding example in the examples section.
  • Degassing or inerting of the preparation is carried out, for example, by passing an inert gas stream through liquid individual components or liquid portions of the preparation.
  • the inert gas stream is nitrogen, argon, other inert gases or mixtures thereof.
  • Another object of the invention is therefore an inerted preparation containing at least one self-tanning substance.
  • the content of oxygen in the aqueous portion of the preparation is less than or equal to 10 mg / l.
  • the preparation of such an inerted preparation containing at least one self-tanning substance has been described above.
  • a further possibility of reducing or eliminating the oxygen content by the type of formulation containing the at least one self-tanning substance is, for example, the addition of at least one oxygen-binding component and / or at least one oxygen-consuming biochemical or microbiological component to this preparation.
  • oxygen scavenging or deoxygenating substances or components that can be used have been previously described for the preparation for pretreatment of the skin.
  • the addition of sodium sulfite or diethylhydroxylamine to the self-tanning preparation also applies here.
  • the oxygen-binding or deoxygenating compounds according to the invention are typically present in amounts of from 0.01 to 20% by weight, preferably used in amounts of 0.05 wt .-% to 10 wt .-% based on the total amount of the preparation.
  • the expert does not have any difficulties in selecting the quantities according to the intended effect of the preparation.
  • the oxygen-consuming biochemical or microbiological components that can be used have been previously described for the preparation for pretreatment of the skin.
  • the admixture of superoxide dismutase and / or peroxidase to the self-tanning preparation applies here.
  • the enzymes or isoenzymes can be used both as pure substance or extract. Usual use concentrations are between 0.1 wt .-% to 10% by weight, preferably at 2 wt .-% based on the total amount of the preparation.
  • Another object of the invention is therefore also a preparation containing at least one self-tanning substance and at least one oxygen-consuming biochemical or microbiological component, as described above.
  • the reinforcement according to the invention of the tanning action of the at least one self-tanning substance can of course also be achieved by any combination of the previously described measures.
  • An example of such a combination is the subsequent coverage of the skin area treated with an inerted preparation containing the at least one self-tanning substance.
  • the above-described method for enhancing the tanning effect and the necessary measures that can be taken apply or apply in general to all known self-tanning substances or to all cosmetic or dermatological self-tanning formulations comprising at least one self-tanning substance, mixtures of Self-tanning substances or combinations of self-tanning substances with effect enhancers, for example with flavonoids or other active ingredients, auxiliaries or additives.
  • 6-aldo-D-fructose ninhydrin also 5-hydroxy-1,4-naphthoquinone (juglone), which can be extracted from fresh walnuts shells,
  • Dihydroxyacetone phosphate Dihydroxyacetone phosphate, glyceraldehyde phosphate or erythrose.
  • trioses and tetroses are preferably used: 1 0 1, 3-dihydroxyacetone (DHA), glyceraldehyde, dihydroxyacetone phosphate, glyceraldehyde phosphate, erythrose and 1, 3,4-trihydroxy-2-butanone (erythrulose).
  • DHA 3-dihydroxyacetone
  • glyceraldehyde dihydroxyacetone phosphate
  • glyceraldehyde phosphate erythrose
  • 3,4-trihydroxy-2-butanone erythrulose
  • the tanning effect of 1, 3-dihydroxyacetone 15 and erythrulose is enhanced with the measures mentioned.
  • the tanning action of 1,3-dihydroxyacetone is intensified by the measures mentioned.
  • compositions according to the invention is typically used in amounts of 0.01 to 20 wt .-%, preferably in amounts of 0.05 wt .-% to 10 wt .-% based on the total amount of Used for preparation.
  • the expert does not have any difficulties in selecting the quantities according to the intended effect of the preparation.
  • 2 In a mixture of 2 Edhoffenrsubstanzen _ is the
  • Weight percent ratio preferably between 1:10 and 10: 1.
  • a preferred mixture of self-tanning substances is the mixture of DHA and erythrulose.
  • mixing ratios in weight percent of DHA: erythrulose of 2: 1 and 3: 1 are used.
  • the kit consisting of or containing preparations or even in the inerted preparation according to the invention are usually either topically applicable preparations, for example cosmetic, pharmaceutical or dermatological formulations.
  • the preparations in this case contain a cosmetically, pharmaceutically or dermatologically suitable carrier and, depending on the desired property profile, optionally further suitable ingredients.
  • the topical preparations are preferably used as a cosmetic or dermatological preparation, particularly preferably as a cosmetic preparation. "Topically applicable" means suitable for a local, in particular superficially applicable form.
  • compositions according to the invention or the preparations according to the invention as part of the kit may include vitamins, inorganic or organic UV filters. Particularly preferred are those UV filters whose physiological harmlessness has already been demonstrated. Both for UVA and UVB filters, there are many well-known and proven substances from the literature.
  • the preparations containing the at least one self-tanning substance or else the preparation for pretreatment may moreover comprise further anti-aging active ingredients, anti-cellulite active ingredients or customary skin-friendly or skin-care active ingredients. Skin-sparing or skin-care active ingredients can, in principle, be all active ingredients known to the person skilled in the art.
  • compositions or preparations may therefore contain as further ingredients preferably vitamins and / or vitamin derivatives selected from vitamin A, vitamin A propionate, vitamin A Palmitate, vitamin A acetate, retinol, vitamin B 1 thiamin chloride hydrochloride (vitamin Bi), riboflavin (vitamin B 2 ), nicotinamide, vitamin C (ascorbic acid), vitamin D, ergocalciferol (vitamin D 2 ), vitamin E, DL- ⁇ - tocopherol, tocopherol-E-acetate, tocopherol hydrogen succinate, vitamin Ki, esculin (vitamin P active ingredient), thiamine (vitamin Bi), nicotinic acid
  • Vitamins are used with compounds of formula I usually in weight percent ratios in the range of 1000: 1 to 1: 1000, preferably used in weight percent ratios of 100: 1 to 1: 100.
  • UV filters may therefore preferably be used as further ingredients, as described above, for example
  • Benzylidenecamphor derivatives such as 3- (4'-methylbenzylidene) -dl-camphor (for example Eusolex 6300), 3-benzylidenecamphor (for example Mexoryl® SD), polymers of N - ⁇ (2 and 4) - [(2-oxoborn-3- ylidene) methyl] benzyl ⁇ -acrylamide (eg Mexoryl® SW), N, N, N-trimethyl-4- (2-oxoborn-3-ylidenemethyl) anilinium methylsulfate (eg Mexoryl® SK) or (2-oxoborn-3-yl) yliden) toluene-4-sulfonic acid (eg
  • Benzoyl or dibenzoylmethanes such as 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione (eg Eusolex® 9020) or 4-isopropyldibenzoylmethane (eg Eusolex® 8020),
  • Benzophenones such as 2-hydroxy-4-methoxybenzophenone (eg Eusolex® 4360) or 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its sodium salt (eg Uvinul® MS-40),
  • Methoxycinnamic acid esters such as octyl methoxycinnamate (e.g., Eusolex®
  • 4-methoxycinnamic acid isopentyl ester e.g. as a mixture of isomers (e.g., Neo Heliopan® E 1000),
  • Salicylate derivatives such as 2-ethylhexyl salicylate (e.g., Eusolex® OS), 4-isopropylbenzyl salicylate (e.g., Megasol®) or 3,3,5-trimethylcyclohexyl salicylate (e.g., Eusolex® HMS),
  • 4-aminobenzoic acid and derivatives such as 4-aminobenzoic acid, 2-ethylhexyl 4- (dimethylamino) benzoate (e.g., Eusolex® 6007), ethoxylated 4-aminobenzoic acid ethyl ester (e.g., Uvinul® P25),
  • Phenylbenzimidazole sulfonic acids such as 2-phenylbenzimidazole-5-sulfonic acid and its potassium, sodium and triethanolamine salts (eg Eusolex® 232), 2,2- (1,4-phenylene) bisbenzimidazole-4,6-disulfonic acid or salts thereof (eg Neoheliopan® AP) or 2,2- (1,4-phenylene) bisbenzimidazole-6-sulfonic acid;
  • organic UV filters are usually incorporated in an amount of 0.5 to 10 weight percent, preferably 1-8 wt .-%, in cosmetic formulations. The quantities are based on the total amount of the formulation.
  • Organic UV filters are usually incorporated in an amount of 0.5 to 20 percent by weight, preferably 1 to 15 wt .-%, in cosmetic formulations. The quantities are based on the total amount of the formulation.
  • inorganic UV filters are those from the group of titanium dioxides such as coated titanium dioxide (eg Eusolex®T-2000, Eusolex ® T-AQUA, Eusolex ® T-AVO), zinc oxides (eg Sachtotec®), iron oxides or cerium oxides conceivable.
  • coated titanium dioxide eg Eusolex®T-2000, Eusolex ® T-AQUA, Eusolex ® T-AVO
  • zinc oxides eg Sachtotec®
  • iron oxides or cerium oxides conceivable.
  • These inorganic UV filters are usually incorporated in an amount of 0.5 to 20 percent by weight, preferably 2 to 10 wt .-%, in cosmetic preparations. The quantities are based on the total amount of the formulation.
  • UV filters can also be used in encapsulated form.
  • organic UV filters in encapsulated form.
  • hydrophilicity of the capsule wall can be adjusted independently of the solubility of the UV filter.
  • hydrophobic UV filters can also be incorporated into purely aqueous preparations.
  • the often perceived as unpleasant oily impression when applying the hydrophobic UV filter containing preparation is suppressed.
  • Certain UV filters in particular dibenzoylmethane derivatives, show only reduced photostability in cosmetic preparations.
  • these filters or compounds that affect the photostability of these filters such as cinnamic acid derivatives, the photostability of the entire formulation can be increased.
  • UV filters it is preferred if one or more of the above-mentioned UV filters are present in encapsulated form. It is advantageous if the capsules are so small that they can not be observed with the naked eye. To achieve the o.g. Effects it is still necessary that the capsules are sufficiently stable and donate the encapsulated active ingredient (UV filter) not or only to a small extent to the environment.
  • Suitable capsules may have walls of inorganic or organic polymers.
  • US Pat. No. 6,242,099 B1 describes the preparation of suitable capsules having walls of chitin, chitin derivatives or polyhydroxylated polyamines.
  • Capsules which are particularly preferred for use in accordance with the invention have walls which can be obtained by a SolGel process, as described in applications WO 00/09652, WO 00/72806 and WO 00/71084.
  • capsules whose walls are made up of silica gel (silica, undefined silicon oxide hydroxide) are preferred.
  • the production of such capsules is known to the skilled worker, for example, from the cited patent applications, whose contents are expressly also part of the subject of the present application.
  • the capsules are preferably contained in the preparations in amounts which ensure that the encapsulated UV filters are present in the preparation in the amounts indicated above. Therefore, the ingredients or preparations described above may preferably contain, as further ingredients, anti-aging active ingredients, anti-cellulite active ingredients or customary skin-friendly or skin-care active ingredients. Particularly preferred anti-aging agents are pyrimidinecarboxylic acids,
  • Aryloxime, bioflavonoids, bioflavonoid-containing extracts, chromones or retinoids Aryloxime, bioflavonoids, bioflavonoid-containing extracts, chromones or retinoids.
  • Pyrimidinecarboxylic acids occur in halophilic microorganisms and play a role in the osmoregulation of these organisms
  • Ectoine and ectoine derivatives such as hydroxyectoine can be used to advantage in medicines.
  • hydroxyectoine can be used for the manufacture of a medicament for the treatment of skin diseases.
  • Other fields of use of hydroxyectoine and other ectoin derivatives are typically in areas in which, for example, trehalose is used as an additive.
  • ectoine derivatives, such as hydroxyectoine can be used as a protective substance in dried yeast and bacterial cells. Even pharmaceutical products such as non-glycosylated, pharmaceutically active peptides and proteins such as t-PA can be protected with ectoine or its derivatives.
  • EP-A-0 671 161 describes in particular that ectoine and hydroxyectoine are used in cosmetic preparations such as powders, soaps and surfactant-containing
  • a pyrimidinecarboxylic acid according to the formula below is preferably used,
  • R 1 is a radical H or ds-alkyl
  • R 2 is a radical H or C 4 alkyl and R 3,
  • R 4 , R 5 and R 6 are each independently a radical from the group H, OH, NH 2 and C 1-4 -alkyl.
  • the preparations according to the invention contain such pyrimidinecarboxylic acids, preferably in amounts of up to 15% by weight.
  • the pyrimidinecarboxylic acids are preferably used in ratios by weight of 100: 1 to 1: 100 to the compounds of the formula I, weight percent ratios in the range from 1:10 to 10: 1 being particularly preferred.
  • 2-hydroxy-5-methyllaurophenone oxime which is also referred to as HMLO, LPO or F5
  • HMLO 2-hydroxy-5-methyllaurophenone oxime
  • Preparations containing 2-hydroxy-5-methyllaurophenone oxime are accordingly suitable for the treatment of skin diseases which are associated with inflammation.
  • the preparations preferably contain from 0.01 to 10% by weight of the aryloxime, and it is particularly preferred if the preparation contains from 0.05 to 5% by weight of aryloxime.
  • the quantities are based on the total amount of the formulation.
  • bioflavonoids are, for example, troxerutin, tiliroside, ⁇ -glucosylrutin, rutin or isoquercetin, the said selection not being intended to be restrictive.
  • Bioflavonoidumble extracts are for example Gingko Biloba or Emblica.
  • Known anti-aging substances are also chromones, as described, for example, in EP 1508327 or retinoids, for example retinol (vitamin A), retinoic acid, retinaldehyde or else synthetically modified compounds of vitamin A.
  • retinoids for example retinol (vitamin A), retinoic acid, retinaldehyde or else synthetically modified compounds of vitamin A.
  • the described chromones and retinoids are also effective anti-cellulite agents.
  • Another well known anti-cellulite drug is caffeine.
  • compositions may include or include, but are not limited to, the essential or optional ingredients or ingredients mentioned. Any compounds or components which may be used in the compositions are either known and commercially available or may be synthesized by known methods.
  • the preparations described above are suitable for external application, for example as a cream, lotion, gel, or as a solution which can be sprayed onto the skin.
  • Other applications are e.g. shower rooms. Any customary carrier substances, adjuvants and optionally further active ingredients can be added to the preparation.
  • Preferable excipients come from the group of preservatives, stabilizers, solubilizers or odor improvers.
  • Ointments, pastes, creams and gels may contain the usual excipients, e.g. animal and vegetable fats, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide or mixtures of these substances.
  • excipients e.g. animal and vegetable fats, waxes, paraffins, starch, tragacanth, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicic acid, talc and zinc oxide or mixtures of these substances.
  • Powders and sprays may contain the usual carriers, e.g. Lactose, talc, silicic acid, aluminum hydroxide, calcium silicate and polyamide powder or mixtures of these substances.
  • Sprays may additionally contain the usual propellants, e.g. Chlorofluorocarbons, propane / butane or dimethyl ether.
  • Solutions and emulsions may include the customary carriers such as solvents, solubilizers and emulsifiers, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol, dimethyl capramide, dimethyl isosorbide, oils, in particular cottonseed oil , Peanut oil, corn oil, olive oil, castor oil and sesame oil, glycerin fatty acid esters, polyethylene glycols and fatty acid esters of sorbitan or mixtures of these substances.
  • solvents such as solvents, solubilizers and emulsifiers, for example water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylglycol, dimethyl capr
  • Suspensions may be the customary carriers such as liquid diluents, for example water, ethanol or propylene glycol, suspending agents, for example ethoxylated isostearyl alcohols, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum metahydroxide,
  • liquid diluents for example water, ethanol or propylene glycol
  • suspending agents for example ethoxylated isostearyl alcohols, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystalline cellulose, aluminum metahydroxide,
  • Bentonite, agar-agar and tragacanth or mixtures of these substances Bentonite, agar-agar and tragacanth or mixtures of these substances.
  • Surfactant-containing cleaning products may include the usual excipients such as salts of fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, fatty acid hydrolysates, isothionates, imidazolinium derivatives, methyltauate, sarcosinates, fatty acid amide ether sulfates, alkyl amidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable and synthetic oils, lanolin derivatives, ethoxylated Glycerine fatty acid esters or mixtures of these substances.
  • excipients such as salts of fatty alcohol sulfates, fatty alcohol ether sulfates, sulfosuccinic acid monoesters, fatty acid hydrolysates, isothionates, imidazolinium derivatives, methyltauate, sarcosinates, fatty acid
  • Facial and body oils may contain the usual excipients such as synthetic oils such as fatty acid esters, fatty alcohols, silicone oils, natural oils such as vegetable oils and oily vegetable extracts, paraffin oils, lanolin oils or mixtures of these substances.
  • synthetic oils such as fatty acid esters, fatty alcohols, silicone oils, natural oils such as vegetable oils and oily vegetable extracts, paraffin oils, lanolin oils or mixtures of these substances.
  • the preferred formulations include in particular emulsions.
  • Emulsions are advantageous and contain z.
  • Oils such as triglycerides of capric or caprylic, further natural oils such. Castor oil;
  • Fats, waxes and other natural and synthetic fats preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty acids
  • Alcohols with low C-alkanoic acids or with fatty acids Alcohols with low C-alkanoic acids or with fatty acids
  • Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions is advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acid and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 3 to 30 carbon atoms.
  • ester oils can then advantageously be selected from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexadecyl stearate, 2 Octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semisynthetic and natural mixtures of such esters, eg. B. jojoba oil.
  • the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, silicone oils, dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides, in particular the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of one chain length from 8 to 24, in particular 12-18 C atoms.
  • the fatty acid triglycerides can be selected, for example, advantageously from the group of synthetic, semi-synthetic and natural oils, for. For example, olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
  • any mixtures of such oil and wax components are advantageous to use. It may also be advantageous, if appropriate, to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
  • the oil phase is advantageously selected from the group 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 2-15 -alkyl, caprylic capric triglyceride, dicapryl ether.
  • Particularly advantageous are mixtures of C 2 -i 5 alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C 2 -is-alkyl benzoate and isotridecyl isononanoate and mixtures of C 2-15 alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.
  • hydrocarbons paraffin oil, squalane and squalene are to be used advantageously in the context of the present invention.
  • the oil phase can also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils.
  • cyclomethicone octamethylcyclotetrasiloxane
  • silicone oil is used.
  • other silicone oils are - oU -
  • Hexamethylcyclotrisiloxan for example Hexamethylcyclotrisiloxan, polydimethylsiloxane, poly (methylphenylsiloxane).
  • mixtures of cyclomethicone and Iso tridecylisononanoat from cyclomethicone and 2-Ethylhexylisostearat.
  • aqueous phase of the preparations described above optionally contains advantageously alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether,
  • Silica aluminum silicates, polysaccharides or their derivatives, e.g. Hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the group of so-called Carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • Carbopols for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • mixtures of the abovementioned solvents are used.
  • alcoholic solvents water can be another ingredient.
  • Emulsions are advantageous and contain z.
  • the preparations described above contain hydrophilic surfactants.
  • the hydrophilic surfactants are preferably selected from the group of alkylglucosides, acyl lactylates, betaines and cocoamphoacetates.
  • alkylglucosides in turn are advantageously selected from the group of alkylglucosides, which are represented by the structural formula
  • R is a branched or unbranched alkyl radical
  • the value DP represents the degree of glucosidation of the alkylglucosides used in the invention and is defined as
  • Pi represent the proportion of products which are mono-, di-trisubstituted ... times glucosylated in weight percentages.
  • products having degrees of glucosylation of 1-2 in particular advantageously of 1, 1 to 1, 5, very particularly advantageous from 1, 2-1, 4, in particular selected from 1, 3.
  • the value DP takes into account the fact that alkylglucosides, as a rule, are mixtures of mono- and oligoglucosides.
  • Advantageously in accordance with the invention is a relatively high content of monoglucosides, typically of the order of 40-70% by weight.
  • alkyl glycosides are selected from the group octyl glucopyranoside, nonyl glucopyranoside, decyl glucopyranoside, undecyl glucopyranoside, dodecyl glucopyranoside, tetradecyl glucopyranoside and hexadecyl glucopyranoside.
  • acyl lactylates are advantageously selected from the group of substances which are defined by the structural formula
  • R 1 is a branched or unbranched alkyl radical having O1 _ 1 to 30 carbon atoms and M + from the group of alkali ions and the group of substituted with one or more alkyl and / or with one or more hydroxyalkyl radicals ammonium ions is chosen or corresponds to half the equivalent of an alkaline earth metal.
  • N advantageous, for example, sodium, for example the product Pathionic ® ISL from the American Ingredients Company.
  • the betaines are advantageously selected from the group of substances which are defined by the structural formula
  • R 2 is a branched or unbranched alkyl radical having 1 to 30 carbon atoms.
  • R 2 is a branched or unbranched alkyl radical having 6 to 12 carbon atoms.
  • Capramidopropylbetaine for example, is advantageous
  • Sodium for example, selected as inventively advantageous cocoamphoacetate as under the name Miranol ® Ultra C32 from Miranol Chemical Corp. is available.
  • the preparations described above are advantageously characterized in that the hydrophilic surfactant or surfactants in concentrations of 0.01-20 wt .-%, preferably 0.05-10 wt .-%, particularly preferably 0.1-5 wt .-%, in each case based on the total weight of the composition, is present or present.
  • the cosmetic and dermatological preparations described above are applied to the skin in a sufficient amount in the manner customary for cosmetics.
  • the cosmetic and dermatological preparations can be in various forms. So they can z.
  • a solution, an anhydrous preparation, an emulsion or microemulsion of the water-in-oil (W / O) type or of the oil-in-water (O / W) type a multiple emulsion, for example of the Waser type.
  • in-oil-in-water (W / O / W) a gel, a solid stick, an ointment or even an aerosol.
  • Ectoine in encapsulated form, e.g.
  • collagen matrices and other common encapsulating materials e.g. As encapsulated cellulose, in gelatin, wax matrices or liposomally encapsulated. In particular wax matrices as described in DE-OS 43 08 282, have been found to be favorable. Preference is given to emulsions. O / W emulsins are especially preferred. Emulsions, W / O emulsions and O / W emulsions are available in the usual way.
  • emulsifiers for example, the known W / O and O / W emulsifiers can be used. It is advantageous to use further customary co-emulsifiers in the preferred O / W emulsions according to the invention.
  • O / W emulsifiers are selected as co-emulsifiers, principally from the group of substances with HLB values of 11-16, very particularly advantageously with HLB values of 14.5-15.5, provided that the O / W Emulsifiers have saturated radicals R and R 1 . If the O / W emulsifiers have unsaturated radicals R and / or R 1 , or if isoalkyl derivatives are present, the preferred HLB value of such emulsifiers may also be lower or higher.
  • fatty alcohol ethoxylates from the group of ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols).
  • Particularly preferred are: polyethylene glycol (13) stearyl ether (steareth-13), polyethylene glycol (14) stearyl ether (steareth-14), polyethylene glycol (15) stearyl ether (steareth-15), polyethylene glycol (16) stearyl ether (steareth-16), polyethylene glycol (17) stearyl ether (steareth-17), polyethylene glycol (18) stearyl ether (steareth-18), polyethylene glycol (19) stearyl ether (Steareth-19), polyethylene glycol (20) stearyl ether (steareth-20), polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether (isosteareth-13), polyethylene glycol (14) - iso
  • the sodium laureth-11-carboxylate can be advantageously used.
  • the alkyl ether sulfate sodium laurethi sulfate can be advantageously used.
  • polyethylene glycol (30) cholesteryl ether can be advantageously used.
  • polyethylene glycol (25) soybean oil has been proven.
  • polyethylene glycol glycerol fatty acid esters from the group consisting of polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, polyethylene glycol (6) glyceryl caprate / citrate, polyethylene glycol (20 ) glyceryl oleate, polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate (cocoate).
  • polyethylene glycol (20) glyceryl laurate polyethylene glycol (21) glyceryl laurate
  • polyethylene glycol (22) glyceryl laurate polyethylene glycol (23) glyceryl laurate
  • polyethylene glycol (6) glyceryl caprate / citrate polyethylene glycol (20 ) glyceryl oleate
  • sorbitan esters from the group of polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, polyethylene glycol (20) sorbitan monooleate.
  • W / O emulsifiers can be used:
  • W / O emulsifiers are glyceryl monostearate, glyceryl monoisostearate, glyceryl monomyristate, glyceryl monooleate, diglyceryl monostearate, diglyceryl monoisostearate, propylene glycol monostearate, propylene glycol monoisostearate, propylene glycol monocaprylate, propylene glycol monolaurate, sorbitan monoisostearate, sorbitan monolaurate,
  • compositions or preparations described are present in various dosage forms commonly used for the given application.
  • a preparation as described above in particular as a lotion or emulsion, such as cream or milk (O / W, W / O, O / W / O, W / O / W), in the form of oily-alcoholic, oily aqueous or aqueous-alcoholic gels or solutions, be present as solid sticks or formulated as an aerosol.
  • the preparation may contain cosmetic adjuvants which are commonly used in this type of preparations, e.g. Thickeners, emollients, humectants, surfactants, emulsifiers, preservatives, antifoaming agents, perfumes, waxes, lanolin, propellants, and other ingredients commonly used in cosmetics.
  • cosmetic adjuvants which are commonly used in this type of preparations, e.g. Thickeners, emollients, humectants, surfactants, emulsifiers, preservatives, antifoaming agents, perfumes, waxes, lanolin, propellants, and other ingredients commonly used in cosmetics.
  • Preservatives which are preferably used are preservatives which are listed in the Cosmetics Ordinance, Appendix 6 as positive list or also antimicrobial pigments, as described, for example, in WO 2004/0092283 or WO 2004/091567. Suitable preservatives are therefore also alkyl esters of p-hydroxybenzoic acid, hydantoin derivatives, propionate salts or a variety of ammonium compounds.
  • Preservatives are used in amounts between 0.5 to 2 wt .-%. The quantities are based on the total amount of the formulation.
  • Emollients or plasticizers are often incorporated into cosmetic preparations. They are preferably used in 0.5 to 50 wt .-%, preferably between 5 and 30 wt .-% based on the total composition.
  • plasticizers can be classified into classes, such as the category of esters, fatty acids or fatty alcohols, polyols, hydrocarbons and oils containing at least one amide structure unit.
  • oils containing at least one amide structure unit together with their synthesis are described in particular in EP 1044676 and EP 0928608.
  • a particularly preferred compound is isopropyl N-lauroyl sarcosinate, which is commercially available under the product name Eldew SL-205 from Ajinomoto.
  • esters mono or diesters may be selected. Examples in this regard are dibutyl adipate, diethyl sebacate, diisopropyl dimerate or dioctyl succinate.
  • Branched fatty acid esters are, for example, 2-ethylhexyl myristate, isopropyl stearate or isostearyl palmitate.
  • Tribasic esters are, for example, trisopropyl trilinoleate or trilauryl citrate.
  • Straight-chain fatty acid esters are, for example, lauryl palmitate, myristyl lactate, oleyl eurcat or stearyl oleate.
  • Suitable fatty alcohols and acids are compounds having 10 to 20 carbon atoms. Particularly preferred compounds are cetyl, myristyl,
  • Palmitin or stearic alcohol or acid Palmitin or stearic alcohol or acid.
  • Suitable polyols are linear or branched-chain alkyl polyhydroxy compounds, for example propylene glycol, sorbitol or glycerol. However, it is also possible to use polymeric polyols, for example polypropylene glycol or polyethylene glycol. Butylene and propylene glycol are also particularly suitable compounds for enhancing the penetration.
  • hydrocarbons as plasticizers are compounds that generally have 12 to 30 carbon atoms. Specific examples are arylalkyl benzoates, alkyl benzoates, mineral oils, petrolatum, squalene or isoparaffins.
  • Additional emollients or water repellents are neopentanoate octyldodecyl preferably C1 2 to C 15 alkyl benzoates, dioctyladipate, octyl stearate, octyldodecanol, hexyl laurate, Cyclomethicone, Dicapryl ether, dimethicone, phenyl trimethicone, isopropyl myristate, Capriylic / capric glycerides, propylene glycol dicaprylate / dicaprate or decyl oleate.
  • Thickeners are generally used in amounts between 0.1 to 20 wt .-%, preferably between 0.5 to 10 wt .-%, based on the total amount.
  • Illustrative of these compounds are crosslinked polyacrylate materials, commercially available under the trademark Carbopol from BF Goodrich Company. It is also possible to use thickeners, such as xanthan gum, Carrageenan gum, gelatin gum, karaya gum, pectin gum or locust bean gum.
  • a compound may be both a thickener and a plasticizer.
  • these are silicone gums (kinematic viscosity> 10 centistokes), esters such as glycerol stearate or cellulose derivatives, for example hydroxypropyl cellulose.
  • dispersion or solubilizing agent an oil, wax or other fatty substance, a low monoalcohol or a low polyol or mixtures thereof.
  • Particularly preferred monoalcohols or polyols include ethanol, i-propanol, propylene glycol, glycerine and sorbitol.
  • a preferred embodiment of the invention is an emulsion which is present as a protective cream or milk and in addition to the compound or compounds of formula I, for example fatty alcohols, fatty acids, fatty acid esters, especially triglycerides of fatty acids, lanolin, natural and synthetic oils or waxes and emulsifiers in the presence of Contains water.
  • fatty alcohols for example fatty alcohols, fatty acids, fatty acid esters, especially triglycerides of fatty acids, lanolin, natural and synthetic oils or waxes and emulsifiers in the presence of Contains water.
  • oily lotions based on natural or synthetic oils and waxes, lanolin, fatty acid esters, in particular triglycerides of fatty acids, or oily alcoholic lotions based on a lower alcohol such as ethanol or a glycerol such as propylene glycol and / or a polyol such as Glycerol, and oils, waxes and fatty acid esters, such as triglycerides of fatty acids.
  • the preparations described above may also be present as an alcoholic gel containing one or more lower alcohols or polyols, such as Ethanol, propylene glycol or glycerin, and a thickening agent such as silica.
  • the oily-alcoholic gels also contain natural or synthetic oil or wax.
  • Phases A and B are heated to 65-7O 0 C. Subsequently, phase B is added with stirring to phase A. After homogenization, allow to cool to room temperature.
  • dihydroxyacetone a mixture of dihydroxyacetone and troxerutin may be used, e.g. 3 wt .-% mixture containing dihydroxyacetone and troxerutin in the ratio 2: 1.
  • Phase A is heated to 75 ° C and phase B to 80 0 C. While stirring, phase B is added slowly to phase A. After homogenization is cooled with stirring. At a temperature of 40 ° C., perfume substances can optionally be added.
  • Phase A is heated to 75 0 C and phase B to 80 0 C. While stirring, phase B is added slowly to phase A. After homogenization is cooled with stirring. At a temperature of 4O 0 C. optional perfume agents may be added.
  • Phase B is rendered inert in an ultrasonic bath until the oxygen content is less than 5 mg / L. If necessary, phase B in a further inerting pretreated by introducing nitrogen. Phases A and B are heated separately to 75 ° C. Phase C is added to phase B. The combined phases B and C are added to phase A with stirring. Homogenize and cool to 40 ° C before adding phases D and E.
  • the field on the left forearm is wrapped tightly with PE kitchen foil to prevent oxygen exposure. After 5 hours, the PE film is removed. Twenty-two hours after the start of the test it is found that oxygen reduction by covering the film results in a significantly stronger browning effect.

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Abstract

L'invention concerne un procédé de renforcement de l'activité de bronzage d'une substance auto-bronzante par la réduction ou l'élimination de la présente d'oxygène.
EP07846682A 2006-12-11 2007-11-20 Procédé de renforcement de l'activité de bronzage de substances auto-bronzantes Withdrawn EP2088989A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006058237A DE102006058237A1 (de) 2006-12-11 2006-12-11 Verfahren zur Verstärkung der Bräunungswirkung von Selbstbräunersubstanzen
PCT/EP2007/010020 WO2008071292A1 (fr) 2006-12-11 2007-11-20 Procédé de renforcement de l'activité de bronzage de substances auto-bronzantes

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EP2088989A1 true EP2088989A1 (fr) 2009-08-19

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EP (1) EP2088989A1 (fr)
DE (1) DE102006058237A1 (fr)
WO (1) WO2008071292A1 (fr)

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Publication number Priority date Publication date Assignee Title
US8747818B1 (en) * 2011-02-07 2014-06-10 Dennis Gross Self-tanning compositions

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
FR1281686A (fr) * 1961-02-22 1962-01-12 Baxter Laboratories Inc Procédé de fabrication de dihydroxyacétone par fermentation microbienne
LU71110A1 (fr) * 1974-10-15 1976-11-11
US4609544A (en) * 1983-07-05 1986-09-02 Repligen Corporation Process for tanning the skin
FR2657607B1 (fr) * 1990-01-30 1992-04-30 Durand Muriel Procede de protection de la dihydroxyacetone, dihydroxyacetone protegee par ce procede et produit cosmetique contenant une telle dihydroxyacetone protegee.
US5514437A (en) * 1994-03-29 1996-05-07 The Procter & Gamble Company Artificial tanning compositions having improved stability
EP0752843B1 (fr) * 1994-03-29 2000-12-06 The Procter & Gamble Company Compositions pour bronzage artificiel presentant un developpement ameliore de la couleur
FR2740042B1 (fr) * 1995-10-23 1997-11-14 Oreal Support, et composition contenant ce support et un actif cosmetique ou dermatologique stabilise
DE19603018C2 (de) * 1996-01-17 1998-02-26 Lancaster Group Gmbh Kosmetisches Selbstbräunungsmittel mit Lichtschutzwirkung
US6261541B1 (en) * 1996-11-25 2001-07-17 Schering-Plough Healthcare Products, Inc. Sunless tanning emulsions with disappearing color indicator
EP0884045A1 (fr) * 1997-06-06 1998-12-16 Pfizer Products Inc. Formulations autobronzantes de dihydroxyacetone à stabilité améliorée et conférant une administration accrue
CA2338124C (fr) * 2001-02-26 2010-08-03 Valerie Dumont Dicianna Composition autobronzante sous forme de substrat en feuilles

Non-Patent Citations (1)

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Title
See references of WO2008071292A1 *

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