Definitions

• 2- Arylpropionic acids include: Ibuprofen, Carprofen, Fenbufen, Fenoprofen, Flurbiprofen, Ketoprofen, Ketorolac, Loxoprofen, Naproxen, Tiaprofenic acid and Suprofen.
• N-Arylanthranilic acids include: Mefenamic acid and Meclofenamic acid.
• Pyrazolidine derivatives include: Phenylbutazone, Azapropazone, Metamizole, Oxyphenbutazone and Sulfinprazone.
• Oxicams include: Piroxicam, Lornoxicam, Meloxicam and Tenoxicam.
• WO 2005/011636 discloses a non-emulsion based spray drying process for forming "solid amorphous dispersions" of drugs in polymers.
• a polymer and a low-solubility drug are dissolved in a solvent and spray-dried to form dispersions in which the drug is mostly present in an amorphous form rather than in a crystalline form.
• Unpublished co-pending applications (GB 0501835 of 28 January 2005 and GB 0613925 filed on 13 July 2006) describe how materials which will form a nano- dispersion in water can be prepared, preferably by a spray-drying process. In the first of these applications the water insoluble materials is dissolved in the solvent- phase of an emulsion.
• the products obtainable by the process aspects of the present invention are suitable for use in the preparation of medicaments for treatment of pain.
• Sonication is also a particularly preferred way of reducing the droplet size for emulsion systems.
• a Hert Systems Sonicator XL operated at level 10 for two minutes is suitable.
• the carrier material is water soluble, which includes the formation of structured aqueous phases as well as true ionic solution of molecularly mono-disperse species.
• Alkoxylated nonionics especially the PEG/PPG PluronicTM materials
• phenol- ethoxylates especially TRITONTM materials
• alkyl sulphonates especially SDS
• ester surfactants preferably sorbitan esters of the SpanTM and TweenTM types
• cationics especially cetyltrimethylammonium bromide - CTAB
• Particularly preferred solvents are alcohols, particularly ethanol and halogenated solvents, more preferably chlorine-containing solvents, most preferably solvents selected from (di- or trichloromethane).
• 0.20 g Paracetamol, 0.40 g Klucel EF, 0.10 g Pluronic Fl 27, 0.10 g Tween 80, and 0.20 g Mannitol are all dispersed into 50 ml absolute ethanol.
• the ethanol suspension is stirred intensively with a magnetic bar for about half hour before added 30 ml distilled water. A clear solution is obtained. ⁇

Landscapes

• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Priority Applications (1)

Applications Claiming Priority (4)

Publications (1)

Family

ID=40429822

Family Applications (1)

Country Status (1)

• 2007
  • 2007-07-13 EP EP07766448A patent/EP2046295A1/de not_active Ceased

Non-Patent Citations (1)

Similar Documents

Legal Events