EP2023874A4 - Methods for identifying agents and their use for the prevention of restenosis - Google Patents

Methods for identifying agents and their use for the prevention of restenosis

Info

Publication number
EP2023874A4
EP2023874A4 EP07809331A EP07809331A EP2023874A4 EP 2023874 A4 EP2023874 A4 EP 2023874A4 EP 07809331 A EP07809331 A EP 07809331A EP 07809331 A EP07809331 A EP 07809331A EP 2023874 A4 EP2023874 A4 EP 2023874A4
Authority
EP
European Patent Office
Prior art keywords
restenosis
prevention
methods
identifying agents
identifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07809331A
Other languages
German (de)
French (fr)
Other versions
EP2023874A2 (en
Inventor
Eric J Kunkel
Evangelos Hytopoulos
Ivan Plavec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioseek LLC
Original Assignee
Bioseek LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioseek LLC filed Critical Bioseek LLC
Publication of EP2023874A2 publication Critical patent/EP2023874A2/en
Publication of EP2023874A4 publication Critical patent/EP2023874A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061Muscle cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064Endothelial cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/323Arteriosclerosis, Stenosis
EP07809331A 2006-06-02 2007-06-04 Methods for identifying agents and their use for the prevention of restenosis Withdrawn EP2023874A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81050806P 2006-06-02 2006-06-02
US93803107P 2007-05-15 2007-05-15
PCT/US2007/013230 WO2007143211A2 (en) 2006-06-02 2007-06-04 Methods for identifying agents and their use for the prevention of restenosis

Publications (2)

Publication Number Publication Date
EP2023874A2 EP2023874A2 (en) 2009-02-18
EP2023874A4 true EP2023874A4 (en) 2009-07-08

Family

ID=38802134

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07809331A Withdrawn EP2023874A4 (en) 2006-06-02 2007-06-04 Methods for identifying agents and their use for the prevention of restenosis

Country Status (4)

Country Link
US (2) US8697387B2 (en)
EP (1) EP2023874A4 (en)
JP (1) JP2009542583A (en)
WO (1) WO2007143211A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2135078B1 (en) * 2007-03-09 2013-08-21 DiscoveRx Corporation Methods for identifying agents and their use for the prevention or stabilization of fibrosis
EP2152944A4 (en) 2007-03-30 2010-12-01 Bioseek Inc Methods for classification of toxic agents and counteragents
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
CA3186201A1 (en) * 2009-05-20 2010-11-25 Lyra Therapeutics, Inc. Self-expandable medical device comprising polymeric strands and coatings thereon
US10265281B2 (en) 2012-11-02 2019-04-23 Murray And Poole Enterprises Ltd Treatment or prevention of cardiovascular events via the administration of a colchicine derivative
JP2015035196A (en) * 2012-11-03 2015-02-19 有限会社 ミクロデント N calculating device
EA039635B1 (en) * 2012-11-05 2022-02-18 Марри Энд Пул Энтерпрайзес, Лтд. Treatment or prevention of cardiovascular events using a colchicine derivative
PL2986280T3 (en) 2013-04-16 2021-10-25 Murray & Poole Enterprises, Ltd. Sustained-release formulations of colchicine and methods of using same
KR101778439B1 (en) 2015-04-27 2017-09-14 울산대학교 산학협력단 composition for improving immunity and anti-cancer activity comprising natural killer cell activator
EP3405214B1 (en) * 2016-01-22 2023-07-05 Puyo, Carlos A. Anti-neutrophil activity on innate immune response
US11058690B2 (en) * 2017-01-22 2021-07-13 Beijing Weilanzhiyuan Medical Technology Co., Ltd. Use of cytochrome bc1 complex inhibitor in preparing pharmaceutical composition
GB201720320D0 (en) 2017-12-06 2018-01-17 Univ Of Sussex Tissue repair
KR20210062449A (en) * 2019-11-21 2021-05-31 연세대학교 산학협력단 Vascular leakage blocking effect of primaquine diphosphate and its targets usp1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005093561A1 (en) * 2004-02-27 2005-10-06 Bioseek, Inc. Biological dataset profiling of asthma and atopy

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3006812A (en) * 1960-09-21 1961-10-31 Lab Francais Chimiotherapie N-desacetyl colchiceine for the treatment of gout
US6004346A (en) 1990-02-28 1999-12-21 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5498238A (en) 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US6060451A (en) 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
US5891108A (en) 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
SE9600216D0 (en) 1996-01-18 1996-01-18 Hans Arne Hansson Control of healing processes
WO1997045424A1 (en) 1996-05-31 1997-12-04 C & C Research Laboratories Aromatic amidine derivatives useful as selective thrombin inhibitors
US5985833A (en) 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6147109A (en) 1997-10-14 2000-11-14 The General Hospital Corporation Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors
US6280411B1 (en) 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
AU760735B2 (en) 1998-09-28 2003-05-22 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
US6168619B1 (en) * 1998-10-16 2001-01-02 Quanam Medical Corporation Intravascular stent having a coaxial polymer member and end sleeves
US6801859B1 (en) * 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US7912651B2 (en) 2000-03-06 2011-03-22 Bioseek Llc Function homology screening
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
US7266458B2 (en) 2000-03-06 2007-09-04 Bioseek, Inc. BioMAP analysis
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
WO2002066092A2 (en) * 2001-02-23 2002-08-29 Angiogene Inc. Drug eluting device for treating vascular diseases
WO2004045474A1 (en) * 2002-11-15 2004-06-03 Gmp Cardiac Care, Inc. Rail stent
US20050058688A1 (en) * 2003-02-22 2005-03-17 Lars Boerger Device for the treatment and prevention of disease, and methods related thereto
EP1625394A4 (en) 2003-04-23 2008-02-06 Bioseek Inc Methods for analysis of biological dataset profiles
EP1620722A4 (en) 2003-04-23 2008-01-30 Bioseek Inc Methods for characterizing signaling pathways and compounds that interact therewith
JP2007503841A (en) 2003-09-03 2007-03-01 バイオシーク インコーポレイティッド Cell-based assay for determining drug action
US20070155020A1 (en) * 2005-12-19 2007-07-05 Intel Corporation Detection of chemical analytes by array of surface enhanced Raman scattering reactions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005093561A1 (en) * 2004-02-27 2005-10-06 Bioseek, Inc. Biological dataset profiling of asthma and atopy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BERG E L ET AL: "Biological complexity and drug discovery: a practical systems biology approach Selected Systems Biology papers from the International Conference on Foundations of Systems Biology in Engineering (FOSBE 2005)", 20051209, vol. 152, no. 4, 9 December 2005 (2005-12-09), pages 201 - 206, XP006025688 *
JASCHKE ET AL: "Local statin therapy differentially interferes with smooth muscle and endothelial cell proliferation and reduces neointima on a drug-eluting stent platform", CARDIOVASCULAR RESEARCH, OXFORD UNIVERSITY PRESS, vol. 68, no. 3, 1 December 2005 (2005-12-01), pages 483 - 492, XP005151508, ISSN: 0008-6363 *
MINTZER R J ET AL: "Differential effects of IFN-beta1b on the proliferation of human vascular smooth muscle and endothelial cells.", JOURNAL OF INTERFERON & CYTOKINE RESEARCH : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR INTERFERON AND CYTOKINE RESEARCH NOV 1998, vol. 18, no. 11, November 1998 (1998-11-01), pages 939 - 945, XP008106305, ISSN: 1079-9907 *
PAN SHIOW-LIN ET AL: "Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats.", BIOCHEMICAL PHARMACOLOGY, vol. 65, no. 11, 1 June 2003 (2003-06-01), pages 1897 - 1905, XP002527931, ISSN: 0006-2952 *

Also Published As

Publication number Publication date
EP2023874A2 (en) 2009-02-18
US8697387B2 (en) 2014-04-15
US20140288032A1 (en) 2014-09-25
WO2007143211A3 (en) 2008-11-06
WO2007143211A2 (en) 2007-12-13
JP2009542583A (en) 2009-12-03
US20090304769A1 (en) 2009-12-10

Similar Documents

Publication Publication Date Title
EP2023874A4 (en) Methods for identifying agents and their use for the prevention of restenosis
TWI561237B (en) Substituted dihydropyrazolones and their use
IL196956A0 (en) Aza-benzofuranyl compounds and methods of use
GB0718972D0 (en) Compounds and methods of making the compounds
EP1994181A4 (en) Identification and use of novopeptides for the treatment of cancer
EP1988084A4 (en) Metal complex and use thereof
HK1208000A1 (en) Thioninium compounds and their use
EP2023718A4 (en) Creatine-ligand compounds and methods of use thereof
IL195400A0 (en) Aldh-2 inhibitors in the treatment of addiction
ZA200902189B (en) Phenylpropionamide compounds and the use thereof
EP2135078A4 (en) Methods for identifying agents and their use for the prevention or stabilization of fibrosis
IL197060A0 (en) Aza-benzothiophenyl compounds and methods of use
IL194028A0 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
HK1137756A1 (en) Substituted dihydropyrazolones and use thereof as hif-prolyl-4 -hydroxylase inhibitors hif--4-
EP2018163A4 (en) Imaging agents and methods
EP2049141A4 (en) Treatment for intimal hyperplasia and related conditions
PL3216457T3 (en) Compounds and methods for the prevention or treatment of restenosis
GB0611115D0 (en) Compounds and their use
EP2077262A4 (en) Iminopyridine derivative and use thereof
EP2097378A4 (en) Novel seh inhibitors and their use
EP2069371A4 (en) Organo-arsenoxide compounds and use thereof
ZA200900896B (en) Aza-benzofuranyl compounds and methods of use
GB0619611D0 (en) Compounds and their use
GB0608797D0 (en) Novel agents and the use thereof
ZA200901009B (en) Aza-benzothiophenyl compounds and methods of use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20081216

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

RIC1 Information provided on ipc code assigned before grant

Ipc: A61F 2/06 20060101ALI20090330BHEP

Ipc: A61F 2/00 20060101ALI20090330BHEP

Ipc: A61F 13/00 20060101AFI20090330BHEP

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/50 20060101ALI20090527BHEP

Ipc: A61F 2/06 20060101ALI20090527BHEP

Ipc: A61F 2/00 20060101ALI20090527BHEP

Ipc: A61F 13/00 20060101AFI20090330BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20090605

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20090930

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100413