EP1997826A3 - Synthetic ligands for immunoglobulins and pharmaceutical compositions containing them - Google Patents

Synthetic ligands for immunoglobulins and pharmaceutical compositions containing them Download PDF

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Publication number
EP1997826A3
EP1997826A3 EP08009793A EP08009793A EP1997826A3 EP 1997826 A3 EP1997826 A3 EP 1997826A3 EP 08009793 A EP08009793 A EP 08009793A EP 08009793 A EP08009793 A EP 08009793A EP 1997826 A3 EP1997826 A3 EP 1997826A3
Authority
EP
European Patent Office
Prior art keywords
immunoglobulins
pharmaceutical compositions
compositions containing
synthetic ligands
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08009793A
Other languages
German (de)
French (fr)
Other versions
EP1997826A2 (en
Inventor
Antonio Verdoliva
Maria Rossi
Vincenzo Manfredi
Menotti Ruvo
Maurizio Colombo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecnogen SpA
Original Assignee
Tecnogen SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecnogen SpA filed Critical Tecnogen SpA
Publication of EP1997826A2 publication Critical patent/EP1997826A2/en
Publication of EP1997826A3 publication Critical patent/EP1997826A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A peptide comprising the sequence of formula:

         X1-Arg-Thr-Tyr-     (S)

where:
X1 is the residue of an amino acid, of an amino acid derivative, of a carboxylic acid, or of some other derivative capable of binding covalently to the amino group of arginine, comprising at least one aromatic group.
Pharmaceutical composition comprising the aforesaid peptide.
Use of the aforesaid peptide for production of a pharmaceutical composition for the treatment of allergic diseases.
EP08009793A 2007-06-01 2008-05-29 Synthetic ligands for immunoglobulins and pharmaceutical compositions containing them Withdrawn EP1997826A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI20071119 ITMI20071119A1 (en) 2007-06-01 2007-06-01 NEW SYNTHETIC LIGANDS FOR IMMUNOGLOBULINES AND PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM

Publications (2)

Publication Number Publication Date
EP1997826A2 EP1997826A2 (en) 2008-12-03
EP1997826A3 true EP1997826A3 (en) 2009-07-29

Family

ID=38537513

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08009793A Withdrawn EP1997826A3 (en) 2007-06-01 2008-05-29 Synthetic ligands for immunoglobulins and pharmaceutical compositions containing them

Country Status (2)

Country Link
EP (1) EP1997826A3 (en)
IT (1) ITMI20071119A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102016961B1 (en) * 2011-02-09 2019-09-02 노보자임스 에이/에스 Peptide for use in the treatment of skin conditions
JP5982676B2 (en) * 2011-02-28 2016-08-31 学校法人 いわき明星大学 Biotinylated peptide compound having anti-PAF activity
GB2513405A (en) 2013-04-26 2014-10-29 Adc Biotechnology Ltd Method of synthesising ADCs using affinity resins
GB201419185D0 (en) 2014-10-28 2014-12-10 Adc Biotechnology Ltd Method of synthesising ADCs using affinity resin
GB201419184D0 (en) 2014-10-28 2014-12-10 Adc Biotechnology Ltd Method of synthesising biomolecule-effector/reporter-conjugates using affinity resins

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0752425A2 (en) * 1995-06-21 1997-01-08 TECNOGEN Società Consortile per azioni Peptide ligands for the constant region of immunoglobulins
WO1998005347A1 (en) * 1996-07-22 1998-02-12 The Trustees Of Columbia University In The City Of New York Compounds that inhibit interaction between signal-transducing proteins and the glgf (pdz/dhr) domain and uses thereof
WO1998026794A1 (en) * 1996-12-16 1998-06-25 Tecnogen S.C.P.A. Pharmaceutical composition containing an inhibitor of immunoglobulin-receptor interaction
US20010045384A1 (en) * 2000-04-28 2001-11-29 Bozidar Stipanovic Simulated activity of protein a displayed by ligands attached to a cellulose bead surface
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
US20030143158A1 (en) * 2000-12-23 2003-07-31 Wescott Charles R. Fibrin binding moieties useful as imaging agents
WO2005001480A1 (en) * 2003-06-27 2005-01-06 Proteome Systems Intellectual Property Pty Ltd Method of isolating a protein
US20060073563A1 (en) * 2004-09-02 2006-04-06 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0752425A2 (en) * 1995-06-21 1997-01-08 TECNOGEN Società Consortile per azioni Peptide ligands for the constant region of immunoglobulins
WO1998005347A1 (en) * 1996-07-22 1998-02-12 The Trustees Of Columbia University In The City Of New York Compounds that inhibit interaction between signal-transducing proteins and the glgf (pdz/dhr) domain and uses thereof
WO1998026794A1 (en) * 1996-12-16 1998-06-25 Tecnogen S.C.P.A. Pharmaceutical composition containing an inhibitor of immunoglobulin-receptor interaction
US20010045384A1 (en) * 2000-04-28 2001-11-29 Bozidar Stipanovic Simulated activity of protein a displayed by ligands attached to a cellulose bead surface
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
US20030143158A1 (en) * 2000-12-23 2003-07-31 Wescott Charles R. Fibrin binding moieties useful as imaging agents
WO2005001480A1 (en) * 2003-06-27 2005-01-06 Proteome Systems Intellectual Property Pty Ltd Method of isolating a protein
US20060073563A1 (en) * 2004-09-02 2006-04-06 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VERDOLIVA A ET AL: "Affinity purification of polyclonal antibodies using a new all-D synthetic peptide ligand: comparison with protein A and protein G", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER, AMSTERDAM, NL, vol. 271, no. 1-2, 20 December 2002 (2002-12-20), pages 77 - 88, XP004393927, ISSN: 0022-1759 *

Also Published As

Publication number Publication date
EP1997826A2 (en) 2008-12-03
ITMI20071119A1 (en) 2008-12-02

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