EP1878732A4 - HIGHLY SELECTIVE Rho-KINASE INHIBITOR - Google Patents
HIGHLY SELECTIVE Rho-KINASE INHIBITORInfo
- Publication number
- EP1878732A4 EP1878732A4 EP06732284A EP06732284A EP1878732A4 EP 1878732 A4 EP1878732 A4 EP 1878732A4 EP 06732284 A EP06732284 A EP 06732284A EP 06732284 A EP06732284 A EP 06732284A EP 1878732 A4 EP1878732 A4 EP 1878732A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- group
- hydrogen atom
- highly selective
- compound
- kinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005126423 | 2005-04-25 | ||
PCT/JP2006/308574 WO2006115247A1 (en) | 2005-04-25 | 2006-04-24 | HIGHLY SELECTIVE Rho-KINASE INHIBITOR |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1878732A1 EP1878732A1 (en) | 2008-01-16 |
EP1878732A4 true EP1878732A4 (en) | 2008-08-27 |
EP1878732B1 EP1878732B1 (en) | 2009-02-25 |
Family
ID=37214861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06732284A Not-in-force EP1878732B1 (en) | 2005-04-25 | 2006-04-24 | HIGHLY SELECTIVE Rho-KINASE INHIBITOR |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090306053A1 (en) |
EP (1) | EP1878732B1 (en) |
JP (1) | JP4257383B2 (en) |
AT (1) | ATE423779T1 (en) |
CA (1) | CA2610166C (en) |
DE (1) | DE602006005351D1 (en) |
WO (1) | WO2006115247A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5220414B2 (en) | 2005-08-30 | 2013-06-26 | 旭化成ファーマ株式会社 | Sulfonamide compounds |
US8415372B2 (en) | 2007-02-27 | 2013-04-09 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
US7964613B2 (en) | 2007-02-28 | 2011-06-21 | Asahi Kasei Pharma Corporation | Sulfonamide compound |
AU2008272396B2 (en) | 2007-07-02 | 2011-09-08 | Asahi Kasei Pharma Corporation | Sulfonamide Compound and Crystal Thereof |
US8951997B2 (en) | 2009-06-19 | 2015-02-10 | D. Western Therapeutics Institute, Inc. | Substituted isoquinoline derivative |
JP5864046B2 (en) * | 2011-08-12 | 2016-02-17 | 浜松ホトニクス株式会社 | 11C-labeled isoquinoline derivative, production method thereof, precursor thereof, PET probe using the same, and tissue imaging method |
CN104557897B (en) * | 2014-04-10 | 2017-10-27 | 中山大学 | The synthesis and its application of Fasudil lipoic acid dyad |
CN109134433B (en) * | 2017-06-16 | 2021-05-25 | 成都先导药物开发股份有限公司 | Compound for inhibiting ROCK and application thereof |
US11248004B2 (en) | 2018-11-06 | 2022-02-15 | Cervello Therapeutics, Llc. | Substituted isoquinolines as rock kinase inhibitors |
KR20210093269A (en) * | 2018-11-06 | 2021-07-27 | 써벨로 테라퓨틱스, 엘엘씨 | ROCK Kinase Inhibitors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5993054A (en) * | 1982-11-18 | 1984-05-29 | Asahi Chem Ind Co Ltd | Isoquinolinesulfonic acid amide derivative |
JPS61227581A (en) | 1985-04-02 | 1986-10-09 | Asahi Chem Ind Co Ltd | Isoquinoline derivative bearing sulfone group |
US4678783B1 (en) * | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
WO1990005723A1 (en) | 1988-11-24 | 1990-05-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Trans-4-amino(alkyl)-1-pyridylcarbamoyl-cyclohexane compounds and their medicinal use |
EP0885888B1 (en) * | 1996-02-02 | 2003-08-13 | Dr.HIDAKA Hiroyoshi | Isoquinoline derivatives and drugs |
JPH1087491A (en) * | 1996-07-26 | 1998-04-07 | Asahi Chem Ind Co Ltd | Transcription control factor inhibitor |
JPH10310576A (en) * | 1997-03-10 | 1998-11-24 | Hiroyoshi Hidaka | Isoquinoline sulfone amide derivative and drug containing the same as an active ingredient |
WO1999020620A1 (en) * | 1997-10-22 | 1999-04-29 | Nippon Shinyaku Co Ltd | Isoquinoline derivative and drug |
JP4212149B2 (en) | 1998-06-11 | 2009-01-21 | 株式会社デ・ウエスタン・セラピテクス研究所 | Medicine |
US7094789B2 (en) * | 2002-07-22 | 2006-08-22 | Asahi Kasei Pharma Corporation | 5-substituted isoquinoline derivatives |
JP2004155661A (en) * | 2002-11-01 | 2004-06-03 | Asahi Kasei Pharma Kk | Prophylactic drug for sudden death |
-
2006
- 2006-04-24 EP EP06732284A patent/EP1878732B1/en not_active Not-in-force
- 2006-04-24 DE DE602006005351T patent/DE602006005351D1/en active Active
- 2006-04-24 CA CA2610166A patent/CA2610166C/en not_active Expired - Fee Related
- 2006-04-24 AT AT06732284T patent/ATE423779T1/en not_active IP Right Cessation
- 2006-04-24 WO PCT/JP2006/308574 patent/WO2006115247A1/en active Application Filing
- 2006-04-24 US US11/919,176 patent/US20090306053A1/en not_active Abandoned
- 2006-04-24 JP JP2007514721A patent/JP4257383B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
No further relevant documents disclosed * |
Also Published As
Publication number | Publication date |
---|---|
ATE423779T1 (en) | 2009-03-15 |
JPWO2006115247A1 (en) | 2008-12-18 |
CA2610166A1 (en) | 2006-11-02 |
JP4257383B2 (en) | 2009-04-22 |
US20090306053A1 (en) | 2009-12-10 |
DE602006005351D1 (en) | 2009-04-09 |
WO2006115247A1 (en) | 2006-11-02 |
EP1878732B1 (en) | 2009-02-25 |
EP1878732A1 (en) | 2008-01-16 |
CA2610166C (en) | 2010-07-27 |
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