EP1807040A1 - Additional improvements in powder compaction and enrobing - Google Patents
Additional improvements in powder compaction and enrobingInfo
- Publication number
- EP1807040A1 EP1807040A1 EP05729259A EP05729259A EP1807040A1 EP 1807040 A1 EP1807040 A1 EP 1807040A1 EP 05729259 A EP05729259 A EP 05729259A EP 05729259 A EP05729259 A EP 05729259A EP 1807040 A1 EP1807040 A1 EP 1807040A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- film
- powder
- dosage forms
- platen
- enrobed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/027—Particular press methods or systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
- B30B11/10—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable intermittently rotated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
Definitions
- This invention concerns the compacting of powder e.g. a powder containing a medicament, vitamin, dietary supplement etc, and such compacted powder being enrobed by a biodegradable and/or water soluble film, for example a non- gelatin film, such as hydroxypropyl methyl cellulose (HPMC) , to produce encapsulated bodies of compacted powder, suitable for dosage forms, e.g. for human ingestion.
- a biodegradable and/or water soluble film for example a non- gelatin film, such as hydroxypropyl methyl cellulose (HPMC)
- HPMC hydroxypropyl methyl cellulose
- the invention is applicable to all related dosage forms, including tablets and. capsules, but for simplicity all such forms will be as tablets.
- Tablets are a common type of dosage form and various means for improving their properties have been tried.
- Current methods for coating tablets, such as pharmaceutical tablets include the using ofvestcoaters or pan coaters, which spray low molecular weight , HPMC grades onto tablets so imparting a surface layer, which is uniform and smooth, but opaque and low gloss. It is possible for the tablets to have embossed lettering on them.
- This method of coating tablets is however time consuming and requires a high level of expertise to produce satisfactory results. Production complications such as tablet twinning are common, where two tablets become attached to one another during the spray coating operation.
- This high level of compaction can have an adverse effect on the disintegration and dissolution rates of active ingredients contained within the capsule, for example, leading to a delay in the release of a drug to a patient, whilst the tablet slowly dissolves in the stomach of the patient.
- An alternative to spray or pan coating is to use two-piece hard capsules. These are produced by a dipping process, typically a HPMC solution is used, producing half shells which interlock and thus produce an enclosed capsule. These capsules are typically opaque but glossy, and cannot have any form of embossment, as this would interfere with the overlap interlocking process.
- the nature of the capsule dictates that there will always be an airspace above the powder fill level. Additionally, it is not possible to compact the powder into these tablets, and this so limits the quantity of powder which can be encapsulated. It follows that this lack of compaction can effectively reduce the amount of e.g. medicament which can be encapsulated.
- the existence of the air space in the capsule and lack of compaction of the powder contained within the capsule leads to a capsule that is inevitably larger than necessary.
- apparatus for forming a film onto dosage forms comprising: a platen for holding oral dosage forms onto which a film is to be formed, directly;
- At least one film conditioning unit also referred to a "preconditioning unit”
- a barr-ier plate disposed between said film conditioning means and said target tablets such that, in use, the barrier protects the oral dosage forms from the effects of film condit ⁇ oning.
- a mettiod of forming a film directly onto a dosage form comprising:
- the barrier plate being disposed between a film conditioning unit and the oral dosage forms onto which the film is to be formed;
- apparatus for forming dosage forms coated with film comprising:
- a platen comprising a substantiaILIy flat platen surface providing a plurality of locations for accommodating dosage forms
- a film conditioning unit deployable to condition a film to impart to the film properties enabling the film to be formed onto dosage forms in said locations,- and
- a barrier disposed between the said, platen surface and said film conditioning unit, said barrier comprising an opening through which the film is formable when it has been conditioned.
- a method for forming dosage forms coated with film comprising:
- barrier disposed between said film and said dosage forms, said barrier being provided with an opening through which the film may be formed directly onto said dosage forms,- conditioning said film to impart properties enabling it to be formed;
- apparatus for forming a dosage forms coated with film comprising:
- One or more platens for holding dosage forms said platen being movable between a plurality of stations each performing steps in an enrobe process;
- one or more film lifters operable to separate waste film from said platen after the forming step.
- a method for forming dosage for-ms coated with film comprising:
- apparatus for forming a compacted powder slug coated with a film comprising:
- compaction equipment capable of a first enrobing step in which powder is compacted into a film formed in a plurality of pockets to provide a plurality of partially enrobed powder slugs
- enrobe equipment capable of a second enrobing step in which the partially enrobed powder slugs are enrobed, to produce completely enrobed powder slugs;
- a transfer and cutting tool comprising a cutter and a transfer gasket.
- a method for forming a compacted powder slug coated with a film comprising: performing a first enrobing step in which powder is compacted into a film formed in a plurality of pockets to provide a plurality of partially enrobed powder slugs,-
- a combined cutting and transfer tool for cutting tablets from a waste film web and holding the tablets for transfer, comprising:
- a cutter provided with a plurality of cutter holes extending between a cutting surface and non-cutting surface thereof;
- a transfer gasket provided proximate the non-cutting edge of the cutter, the transfer gasket comprising a plurality o f press-fit holes in locations linking to the holes in the cutter.
- a method for cutting and transferring tablets from a waste film using a combined cutting and transfer tool having a transfer gasket which follows a. cutter in the direction of the cut comprising:
- a method of ironing a plurality of enrobed dosage forms comprising:
- apparatus for forming compacted powder slugs coated with a film comprising:
- compaction equipment capable of performing a first enrobing step in which powder is compacted into a film formed in a pocket to provide a partially enrobed powder slug
- a jet sprayer operable to apply fluid to said powder slugs.
- apparatus for forming a compacted powder slug coated with a film comprising: a powder store;
- compaction equipment capable of compacting powder in a film formed into a pocket to produce a partiality enrobed powder slug
- a powder doser operable to deliver powder between the powder store and the compaction equipment, said powder doser being operable to collect powder from the powder store and to pre- compact the powder before transferring it to the compaction equipment, wherein said pre-compaction by said powder doser is performed to a lower pressure than said compaction by said compaction equipment.
- Another aspect of the invention provides an apparatus for forming a compacted powder slug coated with a film, comprising a platen having a pocket for receiving a vacuum formed film into the pocket and receiving a powder; and a mechanical means comprising a compression piston for compacting the powder in the pocket, the compression piston having a frront face with a concave recess and a square edge around the circumference of the front face.
- the pocket has a base formed by a lower piston, the lower piston having a front face with a concave recess and a square edge around the circumference of the front face.
- the front face of the lower piston further comprises at least two apertures to allow a vacuum to be formed in the pocket for vacuum forming the film.
- the platen further comprises an aperture to allow a vacuum to be formed between the platen and the film.
- An array of apertures are formed in the platen around the circumference of the pocket.
- the platen further comprises a recessed sur-face defining a raised edge forming the circumference of the pocket .
- the diametric clearance between the compression, piston and the pocket is a fra.ction of the film thickness.
- the diametric clearance between the compression piston and the pocket is at most 35 micrometres.
- the diametric clearance between the lower piston and. the pocket is a fraction of the film thickness.
- the diametric clearance between the lower piston and the pocket is at most 25 micrometres.
- the platen further comprises an array of pockets.
- a means for conditioning the film for temporarily retaining and heating, the means ffor conditioning comprising a heated plate having a surface with an array of apertures for forming a vacuum between the heated plate and the film may be pro-vided in the apparatus.
- the apparatus may further comprise a gasket for receiving and retaining the compacted powder slug to transport and release the compacted powder slug to a desired location.
- the gasket may comprise an aperture with a receiving side for receiving the compacted powder slug and an exit side, the receiving side having a greater diameter than the exit side.
- a film preconditioner for temporarily retaining and heating the film, said film preconditioner comprising a heated plate having a surface with an array of apertures for forming a vacuum between the heated plate and the fiLm, a platen having a pocket for receiving said preconditioned film into the pocket xmder vacuum, and receiving the powder; and a mechanical means for compacting the powder in said pocket.
- Another aspect of the invention provides an apparatus for forming a. compacted powder slug coated with a film comprising a platen comprising an array of pockets for receiving a vacuum formed film into the pockets, said pockets receiving the powder, the platen comprising at least one aperture proximate to said pockets to allow a vacuum to be formed between the platen and the film; and a mechanical means ⁇ or compacting the powder in said pocket.
- an array of apertures are formed in the pZLaten around the circumference of the pocket.
- An aspect of the invention provides an apparatus for forming a compacted powder slug coated with a film comprising a platen comprising an array of pockets for receiving a vacuum formed film into the pockets receiving the powder, "the platen having a recessed surface between a plurality of raised edge profiles each forming a circumference of a pocket; mechanical means for compacting the powder in said pocket; and a cutting sleeve moveable to interfere with saicL raised edge profile to cutt a film supported thereon.
- the apparatus may further comprise a turntable for holding the platen and transferring the platen during processing.
- the turntable may comprise four platens.
- the apparatus may further comprrise a vacuum for cleaning the platen.
- Another aspect of the invention provides an apparatus of any one of the preceding claims further comprising a dosator and a dosing unit for dosing the pocket with powder, the dosaator comprising a powder hopper for holding the powder, an ⁇ d a dosing head having dosing tubes for retaining powder from the powder hopper and transferring the powder to the pocket .
- the dosing head may have tamping pins within the tubes for pre- compacting the powder in the dosing tubes and transferring the powder from the tubes into the pocket .
- the apparatus may have a dosing unit having the mechanical means for compacting, and a dosing sledge for receiving the powder from the dosing tubes of the dosing head and dosing the pockets with the powder, the sledge moveable from a charging position to a dosing position.
- a ⁇ other aspect of the invention provides a.n apparatus for forming a compacted powder slug encapsulated with a film comprising a platen having a pocket for receiving a first vacuum formed film into the pocket and rece ⁇ ving a powder; a dosing means for placing the powder in a position suitable for compaction of the powder in the pocket having" the first vacuum formed film with powder; a compacting mech-anical means for compacting the powder; a turntable for holding the platen and rotatable to transfer the platen from one station to another station during processing, a station for a.pplying the film into the pocket of the platen and compacting the powder to partially enrobe the compacted powder, another station for applying a second vacuum formed film onto the partially enrobed compacted powder to completely coat the slug with film.
- the dosing means places the powder proximate the pocket in a position suitable for compact ion of the powder in the pocket having the first vacuum formed film with powder.
- the dosing means may dose the pockets having the first vacuum formed film with the powder.
- the apparatus may compare a vacuum for cleaning the platen, and another station for cleaning the platen.
- the number of platens in the turntable may correspond to the number of stations in the apparatus.
- the turntable may comprise four platens for processing in another embodiment.
- the apparatus during said compaction may process comprise a means for isolating the compaction pressure forces frrom the turntable assembly.
- Another aspect of the invention provides an appara_tus for forming a compacted powder slug coated with a film, comprising a platen having a pocket for receiving a vacuum formed film into the pocket and receiving a powder a mechanical means for comprssing the powder in the pocket; and a gaslket for receiving and retaining the comapcted powder slug to transport and release the compacted powder slug to a desired location.
- the gasket may comprise an aperature having a receiv ⁇ ng side for receiving the compacted powder slug and an exit side, the receiving side having a greater diameter the exit sicie.
- the gasket may comprise an array of apertures for receiving more than one compacted powder slug.
- One aspect of the invention concerns a novel method for compacting and enrobing a powder to produce capsuLes with enhanced properties.
- a non gelatin film layer is thermoformed tablet shaped pocket under the influence of heat and/or vacuum, and/or pressure.
- a pre-determined mass of powder is dosed into the film formed pocket, and compressed into a tablet shape e.g. with the aid of a piston or pistons.
- a partially enrobed "soft 1 tablet results from this process, which is then full ⁇ enrobed by a second sequence of events which involves the raising of the tablet above a platen which allows the remainder of the compressed tablet to be enrobed by a second film.
- Suitable tablet shaped pockets can be created by using e.g. a pair of pistons slideable within a cylinder, such pistons also having the advantage of being able to form pinch points between the platen and the top of cylinders which are useful for cutting away unwanted excess film from the (partially) enrobed tablets.
- One of the aims of the present invention is to produce tamper evident capsules.
- Another aim of preferred embodiments is to produce powder filled capsules whereby the powder is enrobed with a material which may or may not form a "skin tight wrap 1 .
- Another aim of preferred embodiments is to produce a capsule with a high gloss surface which is able to adopt an underlying embossment, e.g. to identify a pharmaceutical tablet.
- Another aim of preferred embodiments is to piroduce capsules which have a flange which is almost non-discernsble.
- Another aim of preferred embodiments is to enable the production of dosage forms in a wide variety of shapes and sizes, which , because of the nature of the processes involved and the properties of the product produced, includes shapes and sizes of dosage forms wtiich have not been previously possible to make or practical to use.
- Another aim of preferred embodiments is to produce capsules with favourable properties and which contain powder or other flowable solid material which is at a favourable state of compaction and/or composition, and/or the encapsulating medium of the capsule being fast dissolving or dissolvable (with control) pharmaceutical grade fi3_ms plasticised with pharmaceutical grade materials.
- Another aim of preferred embodiments is to produce capsules, which by their nature, are easy to swallow, and more easily can be conveyed to the site where it is desirable where the active ingredients are most advantageously released.
- Another aspect the present invention is a method of powder compaction to produce powder compacted slugs, which , for example can be enrobed to produce capsules which possess enhanced disintegration and dissolution properties over and above traditional tablets.
- Another aspect of the present invention is a method of producing a capsule, which, at the very least can perform the same function as a conventional coated tablet, but in which the conventional tablet pressing and coating stages are replaced by a single powder enrobing process.
- Another aspect of the present invention is a method of producing a capsule by enrobing powder, in which., because of the nature of capsule produced, certain ancillary ingredients necessary in conventional tablet production, can be omitted.
- certain ancillary ingredients necessary in conventional tablet production can be omitted.
- ingredients in a tablet which are added to give structural integrity can be omitted, because the active ingredients are in powder form, relatively loosely compacted are encapsulated within a film, such film which, now securely packages the powder/ingredients, thus giving integrity and forming a discrete effective dosage form.
- Another aspect of the invention provides a method of enrobing compacted powder, comprising vacuum forming" a film into a pocket compacting a powder in said pocket, resulting in a partially enrobed powder slug in a pocket. "Vacuum forming a second film over this powder slug to completely enrobe the powder slug, forms a discrete compacted powder filled capsule, suitable for use as a dosage form.
- in yet another aspect of the present invention provides a method of enrobing compacted powder using fzLlm or films, to form a compacted powder filled capsule, wherrein the film or films forming the wall of the compacted powder filled capsule used overlap each other.
- a further aspect of the present invention provides a method of forming and/or enrobing a compacted slug wherein the level of compaction of the compacted powcler is less than that necessary to reach the industry standard for the discrete slug of compacted powder to be described as a tablet.
- the films are caused to deform to conform with the external surface of the pocket and ttie compacted powder slug, the films effectively forming a secxire capsule, by being wrapped around the powder slug.
- Vacuum chamber or vacuum bed apparatus in which the films and powder are located in a suitably shaped support and exposed to conditions of vacuum (or substantially reduced pressure) can be modified and used for this purpose.
- Such apparatus may be based on commercially available vacuum chamber or vacuum bed apparatus, suitably modified.
- Vacuum forming techniques result in the compacted powder being completely enclosed and encapsulated within a film, leading to a capsule containing compacted powcler, such capsule having enhanced and controllable properties over dosage forms currently available, such as conventional tablets.
- the powders to be compacted are typically subjected to pressures between, but not limited to, 5-15 mega pascals.
- Examples of powders compacted and enrobed include paracetamol, ibuprofen, sorbital and multivitamin.
- Other powder fills which are contemplated are antacid, anti ⁇ inflammatory, anti-histamine antibiotic and anti-cholesterol drugs .
- the film should be a material which is suitable for human consumption and that has sufficient flexibility and plasticity to be vacuum formable. Some film materials have suitable properties in their natural condition, but commonly it will be necessary to pre-treat the film material so that it is -vacuum formable. For example, it may be necessary to expose the film material to a solvent therefor; for instance certain grades of polyvinyl alcohol (PVA) will vacuum form after application of a small amount of water to the surface thereof or when exposed to conditions of high humidity.
- PVA polyvinyl alcohol
- thermoplastic materials include modified cellulose materials, particularly hydroxypropyl methyl cellulose (HPMC) and hydroxypropyl cellulose (HPC) , ⁇ polyvinyl alcohol (PVA) , polyethylene oxide (PEO) , pectin, alginate, starches, and modified starches, and also protein f ⁇ lms such as soya and whey protein films.
- HPMC hydroxypropyl methyl cellulose
- HPC hydroxypropyl cellulose
- PVA polyvinyl alcohol
- PEO polyethylene oxide
- pectin pectin
- alginate starches
- starches starches
- modified starches and also protein f ⁇ lms
- protein f ⁇ lms such as soya and whey protein films.
- the currently preferred film material is HPMC . Suitable film materials are currently available.
- thermoplastic film When using thermoplastic film, the film is typically heated prior to application to pocket or compacted powder slug, so that the film is in a heat softened deformable condition. This can be achieved by exposing the film to a source of heat e.g. an infrared heater, infrared lamps, a heated plate a hot air source etc.
- a source of heat e.g. an infrared heater, infrared lamps, a heated plate a hot air source etc.
- a range of temperatures may be used, but by "way of exampLe only, where films of different thickness may be utilized for the first and second films in the process, a first film forming temperature of around 150 degrees celcius may be used and for the second film forming stage, a range of approximately 70-80 degrees celcius may be used.
- films may be caused to overlap, preferably a. minimum of 1.5mm-2mm.
- Compacted powder slugs may preferably have a sidewall height of about 3mm and films may be caused to overlap substantially completely over the sidewall area.
- the film material may include optional colourings, e.g. in the form of food dyes such as FD and C yellow number 5, and/or optional flavourings, e.g. sweeteners, and/or optional textures etc in known manner.
- optional colourings e.g. in the form of food dyes such as FD and C yellow number 5, and/or optional flavourings, e.g. sweeteners, and/or optional textures etc in known manner.
- the film material typically includes plastici-ser to give desired properties of flexibility to the film in known manner.
- plasticisers include alpha hydroxy acids such as lactic acid and salts thereof, maleic acid, benzyl alcotiol, certain lactones, diacetin, triacetin, propylene glycol, glycerin or mixtures thereof: .
- a typical thermoplastic film formulation is HPMC 72-77% by weight, plasticiser 28-23% by weight.
- the film formulation is HPMC 74% by weight, and plasticiser 26% by weight.
- the film suitably has a thickness in the range 20-200 microns, conveniently 50 to 100 microns, e.g. at about 80 microns, with appropriate film thickness depending on factors including the size and form of the tablet. Films of different thickness may be used, e.g. a film of greater tt ⁇ ickness may be used in the first stage of the enrobing process, say 125 microns thickness and a film of lesser thickness may be used in the second stage of the enrobing process, say 80 microns thickness.
- the thickness of the film formed in the pocket may be greater than that of the film which ⁇ s to cover the remainder of the compacted powder slug (in the second and final phase of enrobement of the compacted powcler) .
- Such differential thickness may give rise to certain advantageous structural features of the resultant capsule; the capsule my be generally more robust and so may be more safely stored and handled (generally thicker film on the capsule) , but such capsule also possessing a smaller area (window) of weaker, thinner film which can give rise to quicker reILease characteristics by the thinner film wall dissolving more quickly when exposed to any given solvent.
- An advantageous differential film thickness to form a capsule with walH of different thickness could be e.g. 70/90 micron film coordination to produce capsules which are robust but wliich release their contents quickly, through a window of thixiner film.
- films of different thickness may be used in the enrobing process, and to give a further examples, a filnn of greater thickness may be used in the first stage of the enrobing process, a maximum of 200 microns and a minimuirx of 70 microns but say preferably 125 microns thickness an ⁇ i a film of lesser thickness may be used in the second stage of the enrobing process, a maximum of 125 microns and a minimum of 50 microns, but say preferably 80 microns thickness.
- the spacing of the compacted powder slugs can be important . If the compacted powder slugs are positioned too closely together, the film is not able to fully thermoform between them. For example, a spacing between the adjacent compacted powder slugs of about 4mm has been found to give good results, the film being able to fully adopt the vertical sidewall of the compacted powder slug to a distance of about 2mm before it begins to curve away from tlhe side of the compacted powder slug.
- thermoform multiples of enrobed product limits the differential driving force available to deform the film to that of atmospheric pressure (1 Bar) .
- positive pressure alone or- in combination with vacuum to rapidly deform the film by increasing the pressure differential across the film surfaces provides the ability to form adjacent pockets with a deeper profile and /or reduced spacing of adjacent product.
- heated compressed air assists to minimize the cooling effect of thermodynamic expansion of a compressed gas.
- the method involves forming two separate overlapping half coatings of film, effectively on the compacted powder sILug.
- the method preferably involves, first forming a film in a pocket, then compacting a powder slug into the film lined pocket, thereby effectively coating/encapsulating a substantial portion of a powder slug within a film formed into a partial capsule, removing the remaining film material not coating the compacted powder slug e.g. by cutting, then coating half of the compacted powder slug, with overlapping portions of the two coatings sealed together to provide a sealed complete enclosure for the slug, and again removing remaining surplus film material not coated on the slug.
- InkJet formulation is preferably a solvent, rather than a diluted -version of the film. It is applied at sufficient quantity to partially dissolve the surface layer of the film.
- a currently preferred formulation has the the composition: Benzyl alcohol 62%, Denatured ethyl alcohol 31%, Potassium acetate 5%, DI water 2%.
- the adhesive material conveniently has the same composition as the film, but with a greater proportion of plasticiser, e.g.
- the adhesive material may be applied, e.g. by use of a roller, spraying etc.
- Another exemplary adhesive formuILation has the composition by weight %: HPMC 4%, lactic acid 77%, water 19%.
- the compacted powder slug and capsule conveniently include a generally cylindrical side wall portion, with two half coatings overlapping on this side wall. Tablets of circular symmetrical form with a circular cylindrical side wall are very common, but other forms e.g. generally oblong and oval, again including a generally cylindrical side wall, are also known. It may be also advantageous or desirable to apply adhesive material e.g. as described above, to the surface off compacted powder slug prior to the final stage of coating, to promote adhesion of the second portion of the film thereto. Again, this may be achieved by e.g. use of a roller, spraying etc.
- a plurality of tablets in an array may be conveniently coated simultaneously, using a suitably large sheet of film material.
- FIG. 1 shows in steps a-1 the basic compaction and enirobing apparatus and process in accordance with an embodiment of the invention
- FIG. 2 shows a variation of the method shown in FIG.l with steps al and bl in accordance with an embodiment of the invention.
- FIG. 3 shows a variation of the method shown in F 1 IG-I with steps a2 - d2 in accordance with an embodiment of the invention
- FIG.4 shows a variation of the method shown in FIG. 1 with steps a3 - g3 in accordance with an embodiment of the invention
- FIG. 4A shows a. schematic plan of turntable apparatus embodying the present invention
- FIG. 4B shows a film lifter assembly of a type used in the embodiment of Figure 4A;
- FIG.5 A-B shows a. top view (filmside) and bottom view, respectively, of a platen assembly in accordance with an embodiment of the invention
- FIG.6 A-B shows a cross-sectional view o ⁇ the platen assembly of FIG. 5A taken along the arrow shown in FIG.5A in accordance with an embodiment of the invention and FIG.6B shows the section indicated- by dashed circle in FIG.6A in 1 more detail;
- FIG.7 A-F show a lower piston in accordance with an embodiment of the invention, where FZG.7A and B show perspective views of the lower piston, FIG.7C shows plan view of a front face of: the lower piston, FIG.7D and E show cross-sectional views of the piston taken along Y-Y and X-X as shown in FIG.7C, and FIG.7F shows the section ⁇ ndicated by dashed circle in FIG.7B in more detail of the concave shape in front face of piston and square edges;
- FIG.8A-B shows a perspective view of a lowerrr platen in accordance with an embodiment of the invention, and FIG.8B shows the section indicated by dashed circle in FIG.8A in more detail of the recessed surface around the cavities and raised edge around cavities, also the vacuum holes around the cavities;
- FIG.9A-B shows a cross sectional view of tile lower platen of FIG.8A in accordance with an embodiment of the invention, and FIG.9B shows the section indicated k>y dashed circle in FIG.9A of the raised edges around the cavities;
- FIG.10-11 show perspective views of a slider mechanism for a dosing unit in accordance with an embodiment of the invention.
- FIG.12A-B respectively show front and rear perspective views of the dosing unit of FIG.11 engaged with a. portion of a dosator in accordance with an embodiment of the invention; FIG.13 Not used.
- FIG.14 Not used.
- FIG.15 A-C show perspective views of a compaction piston in accordance with an embodiment of the invention, and FIG.15C shows the section indicated by dashed circle In FIG.15A;
- FIG.16B shows a cross-sectioned view of the dosator, dosing and compaction units,-
- FIG.17 A-B shows a perspective view of a thermoformer in accordance with an embodiment of the invention, and.
- FIG.17B shows a perspective view of the underside of the assembled unit of the thermoformer of FIG.17A;
- FIG.18A shows an exemplary spacer plate in accordance with an embodiment of the present invention
- FIG. 18B (i) - (ii) show schematically how the a film may be formed through an opening in a spacer plate,-
- FIG.18C-E shows an exploded perspective view of a combined transfer and cutting tool according to an embodiment of the present invention
- FIG. 18D shows a perspective vie ⁇ w of the cutter of the combined transfer and cutting tool
- FIG. 18E shows tlie combined transfer and cutting tool in assembled form
- FIG.19A-C shows a perspective view of a dosator table in accordance with an embodiment of the invention
- FIG.19B shows the dosator powder bowl shown in FIG.19A in more detail
- FIG.19C shows the dosator head shown in FIG.19A in more detail;
- FIG.20A-C FIG 2OA shows a perspective view of a. dosing unit and rotor head assembly in accordance with an embodiment of the invention
- FIG.2OB shows a dosing unit shown in FIG.20A in more detail
- FIG.20C shows the dosator dosing head shown in FIG.19C charging the dosing unit shown in FIG.2OB;
- FIG.21A-C shows a perspective view of an inkjet assembly in accordance with an embodiment of the invention
- FIG.21D-F shows a perspective view of spray jet equipment according to an embodiment of the invention, from below, with a platen in spray position;
- FIG. 21E shows a further perspective view, from below, in the absence of a platen;
- FIG. 21F shows a schematic plan view of the spiray jets in operation;
- FIG.22 shows a perspective view of a vacuum for cleaning the platen and the pockets in accordance withi an embodiment of the invention;
- FIG.23 shows a perspective view of a turntable for holding the platen to transfer the platen from one processing station to another processing station in accordance with an embodiment of the invention
- FIG.24 shows a perspective view of a cam unit for raising and lowering the platen in relation to the turntable in accordance with an embodiment of the invention
- FIG.25A-E shows a tablet gasket in accordance with an embodiment of the invention
- FIG.25B shows a cross- sectional view taken along A-A of the gasket in FIG.25A
- FIG.25C shows a cross-sectional view of the gasket positioned in a transfer arm w ⁇ th tablets
- FIG.25D-E show cross-sectional views of the platen assembly and the gasket
- FIG. 26 shows an exemplary timing diagram of a system in accordance with an embodiment of the invention.
- FIG.l shows the mechanism of the basic steps of powcler compaction and enrobement via steps a-1: a.
- a first film (1) is laid upon a platen (2) .
- Lower piston (3), slideable in cylinder (4) incorporates vacuum port (5) .
- a quantity of powder (6) is introduced over tl ⁇ e pocket of film and upper.
- piston (9) moves downwarrd towards the lower piston (3) compressing a quantity of powder (6) .
- Lower piston (3) begins to move upwards, thereby also urging compacted powder slug (7) upwairds .
- Second vacuum is applied drawing second film (8) around and closely in association with the upper portion of compacted powder slug (7) , second film (8) thereby wrapping itself around the upper part of the compacted powder slug (7) .
- FIG. 1 Shows a fully enrobed tablet with ironed seams.
- FIG. 2 depicts a variation of the basic process described by FIG. 1.
- Steps a.1 and bl show a second pre-formed film pocl ⁇ et, formed by a second vacuum forming pocket (14) being lowered, onto the platen immediately above a partially enrobed, powder slug as shown in step f of FIG.l.
- lower piston (3) moves upwards thus pushing compacted partia_lly enrobed powder slug also upwards and into the cavity of the second pre-formed film pocket, thus capping the partially enrobed powder slug to form a fully enroled capsule, enrobed by two pockets of film.
- the capsule is then r-eleased, trimmed and ironed as mentioned previously.
- FIG.3 depicts a further variation of the basic process described by FIG.l.
- Step a2 shows a powder slug as in step f of FIG.l, and like FIG.2 a second pre-formed film pocket is introduced, but this time it is a shallow pocket, formed by a second shallow vacuum forming pocket (15) , such to only coat the top of the powder slug and to form a seal at the circumference of the very edge of the cylindric-a.1 portion of the powder slug.
- Steps a2-d2 show this revised prrocess. This process gives irise to a capsule with a d ⁇ fferent type of seal whicli gives rise to different properties in the capsule.
- FIG.4 depicts another variation of the process described by FIG.l.
- step f in duplicate, which is basically steps a3-c3 in FIG.4.
- the main differences at this point in FIG.4, are that the two opposing pockets filled with, compacted powder (16,17) axe half size in depth, and the top of the powder slugs are essentially flat, rather than rounded.
- Step c3 may include the laying down of an intermediate film on the surface of the half slug.
- Steps d3-f3 show the bringing together of 2 half slugs to form a single capsule, comprised of 2 parts.
- Step g3 shows a compartmentalized capsule.
- a capsule according to an embodiment of the present invention containing a powder with a low compaction could produce extremely favourable quick release characteristics, suitable, e.g. for a fast acting analgesic; the film can be both designed to be smooth/flexible, to allow the capsule to quickly and relatively painlessly travel to the intended site of drug delivery through the digestive tract, and also be designed to dissolve at or near the intended site of drug delivery.
- the lower compaction of the powder in the capsule can also aid smooth travel of the capsule in the digestive tract, as the contents of the capsule can be designed to be compressible and mobile, thus allowing the capsule to be bent and/or compressed as it travels through the body so that it can conform to the shape of a more restricted part of a passage, squeeze through it and so continue its journey through the digestive tract with less hindrance.
- dosage forms may find themselves especially useful where a patient finds difficulty in swallowing, has a painful or restricted digestive tract, or there is some other reason why a dosage form is required to be more mobile and less aggressive to the internals of the body.
- Film 1 - may be in the general region of 125 microns thickness, or more preferably about 120 microns, HPMC plasticised with lactic acid 15.25%, and triethylcitrate 10%, and processing aid microcrystalline cellulose 1%
- Film 2 is substantially the same as film 1. In certain embodiments, film 2 may be of lower thickness. The thickness can be in the region of 80 micron thickness, but is more preferably about 100 microns.
- Film 1 is thermoformed into single or multiple tablet/caplet shaped pockets in a platen, each pocket containing a lower piston that can be raised or lowered as necessary to suit standard sized tablets and caplets .
- the tablet shaped pocket also has a raised edge profile around the top perimeter of the pocket. This edge profile is raised lmm above the platen surface and has an upper flat with a land width of in th_Ls example 0.35mm or a predetermined dimension of similar order of magnitude.
- the vertical sidewall of these pockets is typically 3mm deep.
- thermoforming operation involves the film acting as a membrane dividing the two halves of a vacuum chamber, which are separately controlled.
- the chamber above the film contains a flat heated platen at a temperature of approximately 140-145 0 C. Vacuum is drawn above the film causing it to be held against the heated plate far a period of 1 to 5 seconds, preferably 1.2 seconds.
- the vacuum level in the lower chamber reaches at least 0.94 bar (-94kPa) the vacuum in the upper chamber is released to atmosphere or replaced by positive pressure for a 1.2 second duration.
- This applied pressure differential forces the film downwards away from the heated platen and onto the tablet pocket shaped tooling below. In this way the film adopts the shape of the tablet pockets in the lower tooling.
- thermoformer may additionally pre-heat the film (i.e. before the 1.2 second contact) .
- the heated thermoformer plate is positioned over the film without contacting the film for a predetermined period (e.g. 3 seconds) to
- a powder dosing and compaction assembly is then placed over the film formed pocket.
- a dosator deposits a dose of powder into a slider mechanism of the dosing and compaction assembly, which transfers the powder into the film pocket.
- compaction and cutting of the film is achieved via a compaction piston that advances to a fixed stop after the film is cut.
- the level of compaction is controlled by the mass of powder being deposited into the dosing sleeve, and the depth of the formed film cavity. As the compaction piston is advanced it causes a punch cut tharough the film as it interferes with the inside edge of the raised edge profile. The compaction and punch cut occi ⁇ r in one continuous movement to the fixed stop position.
- the fit tolerance between the cut piston and the internal dimensions of the raised edge pro profile are such that the diametric clearance no more than 35 microns.
- the apparatus is generally of stainless steel , with the piston crowns made of hardened steel.
- the equipment was machined and supplied by Midland Tool and Design, Birmingham, UK.
- the partly enrobed core is then raised upwards within the tooling, such that half of the formed tablet sidewall is above the raised edge profile.
- Glue is applied around the perimeter of the first for-med film adhering to the sidewall of the tablet and/or to the second film to be thermoformed.
- Typical glue Levels of the order of 20gsm are applied to its surface via some suitable device.
- glue is applied to the first film on the sidewalls, rather than to the second film.
- 15gsm is a minimum applicable amount of glue.
- the film is then thermoformed in the same manner described for the first film, except that the film is held above the tablets by a barrier (spacer) plate 188, such that the positioning of the film does not damage the top surface of the tablet.
- a barrier (spacer) plate 188 such that the positioning of the film does not damage the top surface of the tablet.
- a lower temperature say 50 -170 0 C, preferably 140-165 0 C
- the thermoformer plate contact heats the film for 1.5 seconds, thermoforms for 1.5 seconds. This over process limits the heat exposure of the powder surface) .
- the second cut is performed by a combined transfer and cutter tool designed such that a cutter part forms a punch cut on the outside edge of the raised edge profile of the lower tooling.
- a diametric fit tolerance for cutting is say 25 microns, with acceptable ranges between 17-36 microns, for the width of a lozenge shaped dosage form, and say 31 microns, with acceptable ranges between 20-42, for the length of a lozenge shaped dosage form.
- the waste film web is then removed and the fully enrobed powder core is pushed through a tight fitting tablet shaped ironing unit (heated orifices) at say 40- 60 0 C to ensure the overlap seal is formed.
- a dosing assembly is then placed over the film formed pocket.
- This consists of a location mask which sits on location dowels in the platen, and a dosing sleeve that rests directly above the film formed pocket, and sits on the raised edge profile.
- the dosing sleeve exactly matches the dimensions of the film formed pocket.
- a dose of powder is deposited into the dosing sleeve and fa.lls into the film pocket.
- the cut is achieved via the cut piston that acts through the dosing sleeve and sweeps any residual powder down into the film pocket below.
- the level of compaction is controlled by the mass of po-wder being deposited into the dosing sleeve.
- the cutting piston cuts through the film as it interferes with the inside of the raised edge profile.
- the cut piston continues to engage with the raised edge for a further 0.2mm, and in so doing compacts the powder further into the film shell.
- the fit tolerance between the cut piston and the internal dimensions of the raised edge proffile are such that the diametric clearance is no more than 25 microns.
- the apparatus is generally of stainless steel , with the piston crowns made of hardened steel.
- the equipment was machined and supplied by Midland Tool and Design, Birmingham .
- the tablet is thus pushed down by the cut piston into the confines of the pocket, and comes to rest on the lower piston.
- the location mask and dosing sleeve and the waste film web are then removed.
- the turntable is rotatable to cause each of a plurality of platens to move between four operating stations [1-4] .
- the films 480, 482 are supplied from known types of rolls and are indexed across the surface of the turntable in the direction of arrows 485 after each enrobe process.
- fresh film is supplied from up stream (the lower part of the page) and waste film webs, riddled with holes, move down stream (towards the top of the page) .
- the turntable is provided with a plurality film lifters 490 (see also Fig. 4B) .
- the film lifters are bars deployed beneath the films in the same plane as the platen surfaces and extending substantially across the breadth of the film transverse to its direction of flow.
- the lifters are moveable relative to the platen surfaces such that they can be below (or flush with) the platen surface, thereby allowing the films to rest on the platen surface, or above thie platen surface, causing the films are stripped from the platen surface.
- Moving the lifters in relation to a platen can be achieved by one more of (i) raising relevant lifters by means of the lifter drive mechanism 497 or (ii) lowering the platen. In this way it is possible to detach the waste film webs from the platen surfaces and lift the remainder off the films clear so the turntable can be rotated and or th.e film indexed onwards. It is preferred in the detaching step that the relative movement of the lifters and the platen may accentuated by a movement of the lifters and the platen in opposition directions .
- Station One [1] is the insitu compaction station at which the powder slugs are compacted into tne film pockets in the first of the two enrobe processes.
- a thermoformer 100 can move itself to a position over the first film 480 and the platen 22, as too can the powder dosing and compaction units 130a/b.
- a fresh portion of the film 480 is preconditioned by the thermoformer and "formed” into respective pockets (cavities) in the platen with the assistance of pressure and or vacuum.
- the film pockets are then filled by an insitu compaction step using compaction pistons as descrribed hereinbefore to produce partially enrobed powder slugs/tablets .
- the partially enrobed powder slugs are cut from the web of film by a continued movement of the compaction pistons before the lifters strip the waste film from the platen and the turntable rotates to take the platen to station [2] .
- Station [2] is provided with a precision jet spraying assembly 140 (based on well known inkj et technology) for applying adhesive to the partially emrobed powder slug.
- a precision jet spraying assembly 140 based on well known inkj et technology
- the adhesive is applied to the side walls and so the powder slugs are raised in relation to the platen by means of the lower pistons 24 and a piston drive mechanism described in more detail hereinafter.
- the turntable rotates to take the platen to station [3] .
- Station [3] performs the second enrobing step in which the second film is "formed” by directly onto the partially enrobed powder slugs which have been prepared with adhesive.
- a thermoformer 100 At station [3] there is provided a thermoformer 100, a transfer and cutter arm 460, and a barrier plate 495 (also referred to herein as "spacer plate") .
- the barrier plate is disposed between the film to be conditioned by the thermoformer and the partially enrobed powder slugs. Since the film needs to be formed directly onto the powder slugs the barrier plate is provided with an opening to allow the film to be formed though it with the assistance of pressure and /or vacuum.
- the barrier plate 495 locks the film 482 in position against the heated surface of the thermoformer 100 and protects the partially enrobed powder slugs from heat and / or physical damage.
- the waste film web is cut away from the completely enrobed powder slugs by action of a combined transfer and cutter tool 460.
- This arm performs the second film cutting action described in detail hereinbefore and is also used to transfer the completely enrobed powder slugs to an adjacent ironing tool 470.
- the transfer and cutter arm 460 is thus a single device operable to perform the cut and transfer operations at stage [3] .
- the cutter of the arm is provide outwardly facing bores with cutting edges and is provided on its inwardly facing surface with a transfer gasket.
- the cutter continues its motion toward the completely enrobed powder slugs so as to completely accommodate them in its bores and, further, to an extent which ensures they become press-fitted in to the transfer gasket from the cutter side.
- the transfer and cutter arm 460 can then swing to a position below the ironing tool 470 where upwardly mobile pusher fingers provided on a movable support are used to push the enrobed powder slugs out through the transfer gasket (opposite side to cutter) and up into the ironing tool 470.
- the fingers halt the upward movement for a period, to allow the seams of the enrobed slugs to be ironed, before continuing their upward movement and to push the finished powder slugs / tablets out above the ironing tool for collection.
- the platen is rotated to station [4] where it is cleaned by cleaning unit 400 ahead of a new process cycle.
- the various steps in the process are performed simultaneously on different platens. In other words four process cycles are performed simultaneously.
- the lifters are employed regularly in the sense that two stations [1] , [3] perform film forming steps between every rotation.
- FIG.5A-B Views of the complete platen and piston assembly 20 are shown in FIG.5A-B and FIG.5A-B.
- Each platen 22 consists of a stainless steel plate with a surface that contains a row of cavities 48.
- the cavities have vertical sidewalls and the same cross sectional shape as the tablets that are to be formed, see FIG.8A-B and 9A-B.
- the recessed surface 42 that protects the raised edge and supports the film above the edge prior to first thermoforming operation.
- each cavity is formed by the surface 32 of a piston 24.
- Each piston is a close fit (maximum diametric clearance of 25 microns) in its respective cavity and is held securely downwards into the bottom of the cavity by a. compression spring 29 fitted around the stem of the piston . The spring force presses the end of the stem onto the surface of a cam which is used to control the vertical position of the piston and hence the depth of the cavities.
- FIG.7A-F Details of the piston shape are shown in FIG.7A-F. Note the concave recess in the front face 32 of the piston 24 and the square edge 34 around the recessed face shown in FIG.7F.
- Both the pistons and the platen have small holes 36,46 (approximately 0.5mm diameter) in them to allow a vacuum to be created in and around the tablet cavities during the two thermoforming processes that form part of the process.
- the vacuum holes 46 in the platen are shown in FIG.8B and the vacuum holes 36 in the piston are shown in FIG.7A,B 7 C,D and F.
- the lower pistons of the platen are preferably stationary at the first station, they are used to raise the powder slugs for example at station [2] , for gluing, and at station [3] , for the second enrobe step.
- the described embodiment provides a rotatable powder dosing and compaction assembly 420, which assembly is provided with two powder dosing and compaction units 130a, 130b. Thus, in. use, when one unit 130 is filling the other is dispensing- and compacting.
- a dosator mechaizism supplies powder to each powder dosing" and compaction unit 130a, 130b from a bulk powder supply.
- A- powder dosing and compaction unit has three functions:
- each powder dosing and compaction unit 130 has a slider mechanism 50.
- a slider mechanism 50 consists of two shaped plates 52, 53 that fit together as shown in FIGs.10 and 11 to create cavities 54 of substantially the same dimension as the lightly pre- compacted slugs dispensed from the dosator head.
- the assembly of these two plates 52, 53 is mounted such they can slide relative to one another between position 'A' where the cavities are filled with powder (or pre-compacted powder slugs) and position 1 B 1 where the powder is drawn over the compaction chambers delimited at their lower extreme by the pistons 24 of the platen 22 and at their upper extreme by the pistons 82 of the compaction unit at the other end. This will be explain in more detail below with reference to FIG. 16.
- FIGS 11-14 The insitu (“in film”) compression of the powder is achieved by means of a row of pistons 82 that are mounted in the 'dosing piston holder' 70 above position 1 B 1 , as shown in FIGS 11-14.
- FIGs.l5A-C illustrate trie compression pistons 82; note the concave recess 92 in ttie ⁇ front face of the piston and the square edge 94 around the circumference of the face as shown in FIG.15C.
- the pistons can thus pass through the bores 54 formed by the plates 52, 53 at position B to compact the powder and and cut the film, as will be described hereinafter.
- thermoforming unit 100 consists of a flat heated plate 109 mounted in a chamber that leaves only the surface of the heated plate exposed.
- the thermoforming unit also has a heater cover 103, heater 105, top block and heated plate 109.
- the chamber is connected to a vacuum source and the vacuum is connected to the surface of the heated, plate by an array of small holes 108 (approximately 0.5inm diameter) .
- These holes are a feature for the two thermoforming processes that foirm part of the process . They prevent air bubbles being trapped between the film and the plate.
- thermoforming is most effective when there is adequate contact between the film to be preconditioned and the thermoformer plate 109.
- the thermoforming process is assisted at station [1] , by • bringing the powder dosing and compaction unit 130 over the thermoformer and clamping it onto the film, an ⁇ d at station [3] , by provision of an additional top clamping assembly.
- the process starts with thermoforming the film onto the platen 22.
- thermoforming unit 3.00 A sheet of film is placed over the platen 22 and the thermoforming unit 3.00 positioned over it.
- the thermoforming unit is then pressed onto the film and platen. This creates a split vacuum chamber with the film acting as a membrane that separates the upper chamber (thermoforming unit) and the lower chamber (platen) .
- the contact between the underside of th.e film and the upper surface of the platen may, optionally, be improved by the application of additional pressure on the thermoformer.
- this can be achieved by a mechanical clamping action of the powder dosing and compaction unit and at station [2] by separately providing any suitable top clamping assembly.
- thermoforming process is started by connecting a vacuum to the upper chamber. This pulls the film onto the heated plate, which is at a controlled temperature of typically 180 0 C .
- the values quoted for the temperature of the heated plate y the film heating time and the lower chamber vacuum level are typical but not exclusively definitive. The optimum values for these parameters are dependent on the physical characteristics of the film being used and thus on the film formulation. In general, different operating parameters will be required for different films.
- vacuum is also connected to the lower chamber to evacuate the cavities in the platen.
- the upper chamber is vented to atmosphere.
- the resulting pressure difference across the film forms it into the cavities in the platen.
- the tt ⁇ ermoforming unit is then I-Lfted off the platen to complete the thermoforming process.
- the powder dosing and compaction unit 130, 50, 70 is located over the platen 22.
- the cavities 54 in the plates 52, 53 are slid to position A in which they are accessible to the dosator head 124 and pause for a predetermined time to allow filling. Liglitly pre-compacted slugs are dispensed from the dosator head IL24, more than dosator cycles may .be required to fill the all of the cavities 54.
- the plates aire then slid to position ' B • so that the cavities 54 (now full, of powder) are directly above the cavities 48 in the platen .
- the action of the pistons 82 ensures that all the powder in the plate cavities 54 is be swept out and compacted into the film to form a plurality of partially enrobed powder slugs .
- the compaction pistons 82 ai ⁇ e pressed through the plates 52,53 to press the powder into the platen cavities l_Lned with film (i.e. into the film pockets) . Applying more force compacts the powder to form firm tablets within the film shells that have been formed into the platen cavities.
- the lower pistons 24 of the pla-ten 22 are stationary during the processes occurring at stat ion [1] •
- the size of the finished tablets is fixed by the depth of the film formed pocket and is independent of the quantity of powder transferred because the stroke length of the compaction pistons 82 is fixed. Provided the force applied to compact the powder is in excess of that required to achieve the full stroke then a range of tablet weights can be achieved in a fixed size of finished tablets.
- the next step is to cut the partially enrobed slugs from the waste film web (first film) .
- the last movement of the compact ⁇ on pistons makes them enter the top of the platen cavities.
- the pistons 82 enter about 0.1 - 0.4mm below the upper flat of the raised edge profile 44 of the platen cavities 48.
- the pistons 82 enter about 0.2mm below the upper flat of the raised edge profile 44.
- This punch cuts the film and thLUS severs the partially enrobed slugs from the sheet of fLlm they have been formed from.
- the film is shear cut between the piston flats and the inside edges of the cavities.
- the action of the compaction pistons entering the cavities in the platen is a beneficial feature of the preferred cutting process. It creates tablets with, ⁇ TQTY well defined edges and overall shape as compared to the alternative method of using separate compression and cut processes.
- the cutting tool is a hollow tablet shaped tool provided in a transfer and cutting arm.
- the cutter tool engages with the outside edge of the raised profiles of the platen cavities to achieve a shear cut.
- This transfer arm and cutting tool will be described in more detail hereinafter with reference to FIGs. 18C and E.
- the second film forming step is performed directly onto partially enrobed powder slugs.
- the partially enrobed powder slugs are raised proud of the platen surrface to facilitate enrobing.
- the powder slugs are raised just more than half the depth of their sidewalls so that at least the half remaining uncoated can be enrobed.
- selection of the amount slugs should be raised depends on a number of factors, including the geometries and process in the first enrobe step and the extent of overlap desired.
- a spacer plate 188 (see FIG 18A) is provided a predetermined distance, for example 5mm above the platen surface.
- the spacer plate 188 is in the same plane as the platen surface and is fixed in relation to the platen throughout the second enrobe step.
- the spacer plate is provided with an opening 1805 having a cross-sectional area large enough to expose the plurality of partially enrobed powder slugs held in the platen below plus an a small area of the platen surface bordering the partially enrobed powder slugs.
- This opening is preferably provided with a sealing member about its periphery to assist the seal in the thermoforming process.
- the spacer plate also has bores 1810 for fixing means, such as bolts, and bores 1808 for location lugs.
- the spacer plate 188 is secured in a position above the platen surface holding the raised, partially enrobed powder slugs 1815.
- the film 482 is provided on top of the spacer plate (as distinct from on top ,of the platen itself) .
- a ttiermoformer 100 is deployed over the film and clamps it to trie spacer plate-platen assembly.
- thie clamping effect can be enhanced by use of a further clamping assembly (referred to herrein as the "top clamping assembly") on top of the thermoformer 100. Steps corresponding to those described hereinbefore in relation to thie earlier thermoforming step are used to condition and form the film using vacuum and or pressure.
- FZG. 18 B(ii) shows that when the second film 482 is formed it is urged through the opening 1805 and down onto the raised, partially enrobed powder slugs below.
- the film is formed through the opening across the entire cross-sectional area of the opening so that the plurality of the partially enrobed powder slugs are enrobed in a single step.
- the spacer plate thus has a plurality of purposes and beneficial effects. For example, it has a function of keeping the thermoforming unit away from powder slugs, which would otherwise be exposed to hea.t capable of denaturing them. This ⁇ s the heat barrier function of the spacer plate.
- the spacer plate also provides protection for the powder slugs from the swings of the thermoformer and transfer arms. This is the physical barrier function of the spacer plate. In use, the powder slugs are only accessible to the transfer arm when trie locator lugs and tapered bores have ensured accurate placement .
- the second film covers approximately hal f the tablet sidewall if half the tablet is exposed above the platen and the film is cut at the outside edge of trie raised edge profile.
- the only extra film available for overlap is that resting on the upper horizontal flat of the raised edge profile before cutting.
- the extent of overlap is equal to the amount of enrobed sidewall exposed above the platen plus the width of the flat on the upper surface of the raised edge profile. This depends on precise tolerances and good association between the film and the surfaces onto which it i_s formed. A skilled person will therefore understand how the degree of overlap can be controlled in this second film process, and how, beforehand, the amount of side wall already enrobed can be controlled by the position of the lower pistons in the first step.
- Transfer Arm and Cutting Tool (“c-arm)
- FIG. 18C shows the transfer and cutting arm in exploded view.
- the transfer and cutting arm comprises a moveable support 1850, locator lugs 1855, a cutting tool 186, a transfer gasket 1860, a back plate 1859 and fixing means 1859.
- the cutting tool 186 has a cutting surface 1830 provided with a plurality of tablet shaped holes 1825. Each hole has a cutting edge 1840 on the cutting surface 1830 and runs through from the cutting surface to a non-cutting surface 1835.
- a transfer gasket 180 Abutting the non-cutting surface 1835 of the cutting tool 186 is a transfer gasket 180 (See FIGS. 18C) .
- the transfer gasket has another plurality of tablet shaped, holes 182. These holes are slightly smaller than the hioles of the cutting tool such that a tablet / compacted powcier slug fits tightly into a hole in the transfer gasket once forcibly pushed (press- fitted) at least part way into the hole.
- the transfer gaskiet is a slightly flexible but resilient material, sucli as PTFE (polytetrafluoroethyleme) or PETP (polyethylene terephthalate. ) , or less preferably silicon, in order to optimize the effectiveness of this i?ress-fitting function.
- PTFFJ tends to have the best resielent, smoothness and hardness for this gasket function. It Is therefore less likely to leave scarring on the enrobed dosage form.
- This material is also of a food/pharmaceutical grade (e.g. FDA approved) since the gasket is in contact with the tablets.
- the gasket function is shown in more detail FIG.25A-E.
- the gasket has an array of apertures 182 to receive the compacted powder slugs or tablets.
- the apertures are chambered or tapered (i.e. diameter of aperture 184 tablet enters is, for example, 7.6mm diameters while the other "top" side of aperture 183 is 6.9mm diameter) .
- Thiis configuration of the gasket also provides an ironing action on the tablet as the tablet enters via the wider aperture, paizses for transfer and exits via the narrower aperture.
- the recently enrobed, and thus over lapping half of the tablet lead in and out of the gasket.
- the transfer and cutting arm is shown in assembled form in FIG. 18E.
- the cutter surface can be seen exposed on the underside of the support.
- the arm In use , the arm is deployed to cut the completely enrobed powder slugs from the waste film web and transfer them to the ironing tool.
- the cutting action is has been described hereinbefore as a shear cut on the outsi ⁇ Le edge of the raised edge profile of the cavities 48.
- the arm advances further so that the enrobed slugs are accommodated within the cutter and provided to the transfer gasket for press-fit engagement therewith.
- the enrobed slugs may be removed from their press-fit engagement with the transfer gasket for example by finger pushers or the like.
- a tablet with a 4mm sidewall 187a and a table with a 3mm sidewall 187b is shown in the tablet gasket 180 in FIG.25C.
- FIG.25D shows how the transfer arm lowers and the second cutter tool 186 cuts tablet out of weio of second film
- FIG.25E shows the lower piston push tablets into tablet gasket in transfer arm.
- the powder dosa.tor assembly is configured as shown in FIG. 19A-C and FIG. 2 OA-C.
- FIG. 19A shows a dosator 120 with a dosator powder bowl 122 and a dosator dosing head 124.
- the dosator powder L>owl is shown in more detail in FIG. 19B, with an anti-cloggincj device 126 and a powder levelling device 125 or doctor.
- the dosator powder bowl rotates at a constant clockwise speed, and the powder is hopper feed to the dosator dosing head as shown in more detail in FIG. 19C.
- the dosator dosing head has dosing tubes 128 and a rotary head 127 to rotate the dosator dosing head.
- the dosing tubes may be configured with internal tamping pins (not shown) for pre-compacting the powder in the dosing tubes and transferring the powder from the tubes into the pocket.
- the dosator powder bowl rotates at a constant clockwise speed, and the dosator powder bowl is fed with powder through a hopper system.
- the powder is set to a specific height by the dosator levelling device, and. the dosator head rotates over the dosing bowl.
- the dosator tubes are charged by lowering the tube to a known depth into the dosator powder bowl.
- the internal tamping pins lightly pre-compact the powder, in order to avoid spillage and ease of handling later on in the process.
- the powder is r-etained in the tubes by the pre-compaction effect but there is a vacuum retention facility available if required, i.e. for ver ⁇ y fine fill powders. (Fill volume is varied by altering the depth that the tubes are lowered into the dosator powder bowl) . Then the dosator head rises and rotates through approximately 180° to a position over the dosing unit 130 shown in FIG.2OA-C and discussed in greater detail below. The dosator head is lowered to the top of the dosing unit cavities 54, and the lightly pre-compacted slugs are transferred using the internal tamping pins from the dosator tubes into alternate caviti_es of the dosing unit.
- the platen has twelve cavities of an eleven and half millimetre pitch. Since in this embodiment the dosator head .has six tubes, the dosing unit is charged in two cycles of the dosator head. After discharging the dosing unit the dosator head rises and rotates over the dosing powder bowl ready for the next cycle.
- the powder compaction and dosing assembly 130 is shown in FIG. 20A-C, and is configured in this embodiment with two dosing units 130a, 130b mounted on a rotor head assembly 131, as shown in FIG. 2OA.
- the rotor head is driven by a servo motor.
- FIG. 2OB shows a dosing unit in more detail.
- Each dosing unit has a dosing sledge 50 with dosing cavities 54 fox holding the powder upon discharge from the dosing tubes of the dosator dosing head.
- the dosing units also each house the compaction pistons 82.
- a pneumatic cylinder 50 may slide sledge from a charging position to dosing position and v ⁇ ce versa as explained hereinbefore.
- the final location in dosing position may be achieved by precision location pins actuated by pneumatic cy1inders.
- FIG. 2OC shows the dosator dosing head charging the dosing unit 130a in dosing position, and the dosing unit 130b preparing to dose the film pocket in the cavitd.es 48 of the platen 22.
- the dosator powder tubes 128 charge out the powder into the cavities • of the slider.
- the rotor head 131 rotates the dosing units 130a,130b.
- Dosing unit 130a assumes the dosing position and doses the pockets having the vacuum formed film. After, the compaction pistons are engaged and compress the powder in the pocket (in-situ) and cut the film as discussed above. While this is Ixappening, the other dosing unit 130b is being charged by the dosator ready for the next machine cycle. At any given time one dosing unit is in the powder charging position, while the other dosing unit is in the process position.
- adhesive is applied prior to the application of the second film onto the partially enrobed slug, i.e. to the first film and the powder slug.
- FIGs. 21D-F show a spray jet assembly 140, using inkjet technology, that may be used to sprray the glue into a pattern (or to spray ink for printing purposes) onto the partially enrobed slug.
- the exemplary spray jet device 140 is provided with a sprayer 142 having three heads 147 supplied with adhesive or other fluid.
- the location of the spray tieads 147 can be precisely controlled by the control electronics 144-148.
- the spray heads are controlled in a fixed configmration with respect to one another such that they sweep the line of partially enrobed powder slugs 145 raised proud of the platen 22 in the direction of arrows 149. In this way a predetermined amount of adhesive may be applied to the "whole circumference of the side wall of each of the partially enrobed slugs in a single sweep.
- a screen 143 (visible in FIG. 21B) may be xised to expose the partially enrobed slug and protect the platen 22.
- the spray process occurs at station [2] once the lower pistons 24 have moved the partially enrobed powder slugs upwards so that approximately half the depth of the side walls of each is above the platen surface.
- the cleaning unit 400 includes a vacuum nozzle unit 150 is applied to platen to disturb any waste powder in the cavities of the platen, as shown in FIG. 22. Air is forced throxigh the nozzles into the cavities of the platen when the vacuum, nozzle unit is oriented proximate the cavities and the platen hood 152 forms a seal with the platen to enable the cleaning process.
- FIG. 23 With reference to Figures 23 and 24, there is described the turntable assembly 300 for holding the platen and transferring the platen from one station to the next during processing.
- An indexing drive system 162 of the turn table is provide to rotate the platen through 90° for each process cycle -
- the platen may be held in the turntable by a lower platen retaining assembly 164 with a seal retaining ring that may be secured to the turntable.
- a platen may be raised from the turntable by a cam unit 170 shown in FIG.
- the cam unit 170 is preferably an eccentric cam unit, using for example a TOX unit (TOX is a trademark in certain countries of Tox Pressotechnik GmbH & Co. KG of Germany) .
- the platen is raised from the turntable to ensure that the turntable is not exposed to the compaction pressure forces during processing.
- each of the four platens may be processed simultaneously in four stations.
- the first station [1] may perform dosing, compaction and partial enrobement
- the second station [2] may perform the application of glue to the sidewall of the partially enrobed sli ⁇ g
- the third station [3] may perform the second film enrobement on the opposite side of the partially enrobed slug and. ironing
- the fourth station [-4] may be platen vacuum cleaning station using air jets and vacuum to dislodge and suck processing dust to clean the platen.
- Thee station [1] procedure of dosing, compaction and partial enrobement is as follows.
- the film indexes.
- the charged dosing unit 130a rotates through 180° to the process position and turntat>le 160 indexes through 90° to prOcess position.
- the platen 22 is lifted out of turntable and lower pistons 24 are set at the appropriate operating height using the eccentric cam.
- Trie film lifter assemblies lower.
- the thermoformer 100 rotates through 90° to process position.
- the powder dosing and compaction assembly comprising the closing unit clamps thermofforming unit, the film and the platen together and film is thenrmoformed into platen cavities. Tbie powder dosing and compaction assembly releases and lifts using its air spring pneumatic cylinder.
- thermoformer returns to the home position, and the powder dosing and compaction assembly returns to clamp the dosing unit to the platen. Precise location is achieved using the tapered lugs on the dosing unit and spring loaded tapered bushes on platen assembly.
- the dosing unit slider 132 is moved to the dosing position and charges the cavities 134.
- the compaction pistons compress the powder into the cavity to form the partially enrobed slug (or tablet) and subsequently cut the film in one action.
- the powder dosing and the compaction assembly releases.
- the powder dosing and compaction unit lifts using for example the air spring pneumatic cylinder.
- the film lifters lift, stripping the waste file from the platen, the platen drops back into the turntable accentuating the stripping effect.
- the spray jet 140 applies glue to the sidewalls of the partially enrobed slugs.
- This process begins with the turntable 160 indexing through 90° to process position [2] .
- the platen 22 is lifted out of turntable by the station 2 cam unit and by pneumatic cylinder 136 and precise location is achieved using the tapered lugs location on the underside of the inkjet main body and spring loaded tapered bushes on platen assembly.
- the lower pistons 24 are set at the appropriate operating height using the eccentric cam, as a result the tablets are moved up tlie cavities to the correct level for the glue application.
- a East outward stroke of print liead assembly 140 is gets to the start position.
- a slower constant speed inward stroke applies the desired glue pattern (logo) to tablets using the print head configuration.
- the platen drops back into the turntable and lower pistons return to home position when the station 2 cam unit is lowered. Ready for the turntable index.
- Tlie turntable 300 indexes through 90° to process position [3] and a transfer arm rotates through 90° to a position underneath the ironing tool.
- the platen is lifted out of turntable by the station 3 cam unit, and the lower pistons are set at the appropriate operating height ffor enrobing the partially enrobed slugs using the eccentric cam.
- the thermoformer unit 100 film and lifters lower- to apply second film to the spacer plate above the partialLy enrobed slugs.
- Tlie transfer arm assembly raises to mate with ironing unit using the air spring pneumatic cylinder and film indexes.
- the thermoformer rotates through 90° to process position, a finger pi ⁇ sher assembly pushes the tablets into ironing tool .
- a top clamping assembly clamps the thermoformer, film and spacer plate of the platen together.
- the transfer arm assembly lowers clear with ironing unit using the air spring pneumatic cylinder and rotates 90° to home position. Thie film is formed over the partially enrobed tablets and the ironing unit indexes is to next position.
- the top clamping assembly releases and the thermoformer returns to the home position.
- the finger pusher assembly evacuates the finished tablets from ironing tool and empties the row of cavities ready for a new batch of tablets to be ironed.
- a pick off heacl performs a pick and place operation to take the product out of the machine.
- the transfer arm indexes 90° to the cutting position above the platen.
- the top assembly clamps the transfer arm, its locating lugs mating with the spring loaded tapered bushes of the lower platen assembly. Finally the cut is executed at the very end of the stroke of the top clamping assembly.
- the top clamping assembly holds the transfer arm, spacer plate 188 assembly and platen together.
- the spacer plate 188 provides a gap between the thermoformer and the partially enrobed slugs to ensure that the thermofomer does not cause damage to the compacted slugs while retaining and heating - I.e. conditioning - the second film prior to thermoforming the second film onto the partially enrobed slugs.
- the lower pistons are reset to the maximum height using the eccentric cam, pulling or pushing/lifting the tablets from the lower platen into a PEPT gasket contained in the transfer arm.
- the top clamp assembly holds the transfer arm down "whilst the cut tablets are transferred from the platen 20 into the tablet gasket 180, contained in the arm, using the lower pistons of the lower platen assembly 20.
- the top clamping assembly then releases, the film lifters strip the waste film from the spacer plate 188 and platen, and the transfer arm lifts the cutter to clear the film and film lifters, using the air spring pneumatic cylinder.
- the platen drops back ⁇ into the turntable accentuating the stripping effect and lower pistons return to home position when the station 3 cam unit is lowered.
- the transfer arm indexes 90° to the home potion under the ironing tool and the finger pushers urge the enrobed slugs up from the transfer arm into the ironing tool .
- At station [4] is a platen vacuum 150 cleaning station, using airjets and vacuum to dislodge and suck dust, respectively.
- the turntable 160 indexes through 9O° to process position to begin.
- the platen 22 is liftecu out of turntable by the station 4 cam unit 170 by pneumatic cylinder.
- Initially lower pistons 24 remain at home positions, and the -vacuum head 152 is lowered to mate with platen.
- the vacuuming process begins, and the lower pistons are set to upper operating height using the pneumatic cylinder until the vacuuming process ends.
- the platen drops back into the turntable and lower pistons return to home position when the station 4 cam unit is lowered and the vacuum head is raised.
- FIG.18 A draft timing diagram 110 for the complete process is shown FIG.18 to help clarify the sequence of events for the thermoforming, dosing, compaction and cutting processes. It will be understood that the processes and apparatus as described above provide advantages. It will be appreciated that specific embodiments of the invention are discussed for illustrative purposes, and various modifications may be made without departing from the scope of the invention as defined by the appended claims.
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Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08155052A EP1944005A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155056A EP1944007A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155050A EP1944003A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155057A EP1944008A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155049A EP1944002A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155055A EP1944006A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155051A EP1944004A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2004/004097 WO2005030116A1 (en) | 2003-09-24 | 2004-09-24 | Improvements in powder compaction and enrobing |
PCT/GB2005/001077 WO2006032828A1 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
Related Child Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08155056A Division EP1944007A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155055A Division EP1944006A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155049A Division EP1944002A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155050A Division EP1944003A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155051A Division EP1944004A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155057A Division EP1944008A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
EP08155052A Division EP1944005A3 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1807040A1 true EP1807040A1 (en) | 2007-07-18 |
Family
ID=34962986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05729259A Withdrawn EP1807040A1 (en) | 2004-09-24 | 2005-03-22 | Additional improvements in powder compaction and enrobing |
Country Status (9)
Country | Link |
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EP (1) | EP1807040A1 (en) |
JP (1) | JP2008514253A (en) |
KR (1) | KR20070057977A (en) |
CN (1) | CN101065091A (en) |
AR (1) | AR049257A1 (en) |
AU (1) | AU2005286288A1 (en) |
CA (1) | CA2580889A1 (en) |
NO (1) | NO20071693L (en) |
WO (1) | WO2006032828A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100912351B1 (en) * | 2007-02-14 | 2009-08-14 | 한미약품 주식회사 | Method for preparing rapidly disintegrating formulation for oral administration and medicine packing machine for the same |
WO2009002084A2 (en) | 2007-06-27 | 2008-12-31 | Hanmi Pharm. Co., Ltd. | Method for preparing rapidly disintegrating formulation for oral administration and apparatus for preparing and packing the same |
TW201129386A (en) | 2009-11-05 | 2011-09-01 | Fmc Corp | Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients |
TWI461213B (en) | 2009-11-05 | 2014-11-21 | Fmc Corp | Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients |
EP2515943A4 (en) | 2009-12-22 | 2014-04-30 | Fmc Corp | Microcrystalline cellulose and calcium carbonate compositions useful as recompactible pharmaceutical excipients |
GB2538252B (en) * | 2015-05-12 | 2021-03-03 | Freeman Tech Limited | Compaction apparatus |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5614098A (en) * | 1979-07-13 | 1981-02-10 | Takeda Chem Ind Ltd | Externally lubricating tablet making machine |
DE3312634A1 (en) * | 1983-04-08 | 1984-10-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | IMPROVED METHOD AND DEVICES FOR POINTING MOLDING TOOLS WITH DROPLETS OF LIQUID OR SUSPENDED LUBRICANTS IN THE PRODUCTION OF FORMS IN THE PHARMACEUTICAL, FOOD OR CATALYST AREA |
JP3133899B2 (en) * | 1994-07-07 | 2001-02-13 | 株式会社三共製作所 | Tablet manufacturing method and device |
US5682733A (en) * | 1996-05-09 | 1997-11-04 | Perrone; Aldo | Apparatus for enrobing tablets |
DE69911048T2 (en) * | 1998-11-11 | 2004-07-08 | Bioprogress Technology International Inc. | DRUG DELIVERY SYSTEM BASED ON A CAPSULE |
GB0113403D0 (en) * | 2001-06-02 | 2001-07-25 | Bioprogress Tech Int Inc | Tablet enrobing |
PT1405621E (en) * | 2001-06-20 | 2011-05-31 | Takeda Pharmaceutical | Method of manufacturing tablet |
US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
BR0212951A (en) * | 2001-09-28 | 2004-10-26 | Mcneil Ppc Inc | Composite Dosage Forms |
US7169450B2 (en) * | 2002-05-15 | 2007-01-30 | Mcneil-Ppc, Inc. | Enrobed core |
GB0211620D0 (en) * | 2002-05-21 | 2002-07-03 | Bioprogress Technology Ltd | Powder compaction and enrobing |
-
2005
- 2005-03-22 KR KR1020077009326A patent/KR20070057977A/en not_active Application Discontinuation
- 2005-03-22 WO PCT/GB2005/001077 patent/WO2006032828A1/en active Application Filing
- 2005-03-22 JP JP2007532942A patent/JP2008514253A/en active Pending
- 2005-03-22 EP EP05729259A patent/EP1807040A1/en not_active Withdrawn
- 2005-03-22 AU AU2005286288A patent/AU2005286288A1/en not_active Abandoned
- 2005-03-22 CN CNA2005800400709A patent/CN101065091A/en active Pending
- 2005-03-22 CA CA002580889A patent/CA2580889A1/en not_active Abandoned
- 2005-03-23 AR ARP050101152A patent/AR049257A1/en unknown
-
2007
- 2007-03-30 NO NO20071693A patent/NO20071693L/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
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See references of WO2006032828A1 * |
Also Published As
Publication number | Publication date |
---|---|
AR049257A1 (en) | 2006-07-12 |
WO2006032828A1 (en) | 2006-03-30 |
AU2005286288A1 (en) | 2006-03-30 |
KR20070057977A (en) | 2007-06-07 |
CN101065091A (en) | 2007-10-31 |
NO20071693L (en) | 2007-06-20 |
JP2008514253A (en) | 2008-05-08 |
CA2580889A1 (en) | 2006-03-30 |
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