EP1765992A4 - Truncated galnact2 polypeptides and nucleic acids - Google Patents

Truncated galnact2 polypeptides and nucleic acids

Info

Publication number
EP1765992A4
EP1765992A4 EP05758682A EP05758682A EP1765992A4 EP 1765992 A4 EP1765992 A4 EP 1765992A4 EP 05758682 A EP05758682 A EP 05758682A EP 05758682 A EP05758682 A EP 05758682A EP 1765992 A4 EP1765992 A4 EP 1765992A4
Authority
EP
European Patent Office
Prior art keywords
polypeptides
nucleic acids
truncated galnact2
galnact2
truncated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05758682A
Other languages
German (de)
French (fr)
Other versions
EP1765992A2 (en
Inventor
Karl F Johnson
Xi Chen
Susann Taudte
Sami Saribas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Publication of EP1765992A2 publication Critical patent/EP1765992A2/en
Publication of EP1765992A4 publication Critical patent/EP1765992A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
EP05758682A 2004-06-03 2005-06-03 Truncated galnact2 polypeptides and nucleic acids Withdrawn EP1765992A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57653004P 2004-06-03 2004-06-03
US59858404P 2004-08-03 2004-08-03
PCT/US2005/019442 WO2005121331A2 (en) 2004-06-03 2005-06-03 Truncated galnact2 polypeptides and nucleic acids

Publications (2)

Publication Number Publication Date
EP1765992A2 EP1765992A2 (en) 2007-03-28
EP1765992A4 true EP1765992A4 (en) 2009-01-07

Family

ID=35945309

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05758682A Withdrawn EP1765992A4 (en) 2004-06-03 2005-06-03 Truncated galnact2 polypeptides and nucleic acids

Country Status (3)

Country Link
EP (1) EP1765992A4 (en)
JP (1) JP2008512085A (en)
WO (1) WO2005121331A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
BRPI0408358A (en) 2003-03-14 2006-03-21 Neose Technologies Inc branched water-soluble polymers and their conjugates
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
PL1615945T3 (en) 2003-04-09 2012-03-30 Ratiopharm Gmbh Glycopegylation methods and proteins/peptides produced by the methods
WO2006127896A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated factor ix
WO2004103275A2 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
WO2005070138A2 (en) 2004-01-08 2005-08-04 Neose Technologies, Inc. O-linked glycosylation of peptides
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
EP1799249A2 (en) 2004-09-10 2007-06-27 Neose Technologies, Inc. Glycopegylated interferon alpha
JP5948627B2 (en) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー Fibroblast growth factor (FGF) remodeling and carbohydrate pegylation
WO2006074467A2 (en) 2005-01-10 2006-07-13 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006127910A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated erythropoietin formulations
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20080280818A1 (en) 2006-07-21 2008-11-13 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As Methods for the purification of polypeptide conjugates
KR20150064246A (en) 2007-04-03 2015-06-10 바이오제너릭스 게엠베하 Methods of treatment using glycopegylated g―csf
WO2008143944A2 (en) * 2007-05-14 2008-11-27 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Methods of glycosylation and bioconjugation
ES2551123T3 (en) 2007-06-12 2015-11-16 Ratiopharm Gmbh Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
JP5358840B2 (en) * 2007-11-24 2013-12-04 独立行政法人産業技術総合研究所 Function activation / recovery method of GFP (green fluorescent protein)
RU2573587C2 (en) 2008-02-27 2016-01-20 Ново Нордиск А/С Conjugated factor viii molecules
CN103163300B (en) * 2013-03-01 2015-02-11 苏州大学 Anti-human N-acetamido galactosyl transferase 2 double-antibody sandwich enzyme-linked immuno sorbent assay (ELISA) kit
WO2018211529A1 (en) * 2017-05-19 2018-11-22 Council Of Scientific & Industrial Research A method for producing refolded recombinant humanized ranibizumab
CN114058602B (en) * 2020-07-30 2023-08-22 中国中医科学院中药研究所 Sinkiang lithospermum caffeic acid and rosmarinic acid glycosyltransferase, and coding gene and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892730B2 (en) * 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
AU2003228380A1 (en) * 2002-03-27 2003-10-13 Molex Incorporated Differential signal connector assembly with improved retention capabilities
ATE365794T1 (en) * 2002-11-08 2007-07-15 Glycozym Aps METHOD FOR IDENTIFYING AGENTS MODULATING THE FUNCTIONS OF POLYPEPTIDE GALNAC TRANSFERASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH AGENTS AND USE OF SUCH AGENTS FOR THE PRODUCTION OF MEDICINAL PRODUCTS

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BENNETT E P ET AL: "cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 271, no. 29, 19 July 1996 (1996-07-19), pages 17006 - 17012, XP002386961, ISSN: 0021-9258 *
BENNETT ERIC PAUL ET AL: "Cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminlytransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30472 - 30481, XP002504533, ISSN: 0021-9258 *
BOEGGEMAN E E ET AL: "The N-terminal stem region of bovine and human beta1,4-galactosyltransferase I increases the in vitro folding efficiency of their catalytic domain from inclusion bodies", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 30, no. 2, 1 August 2003 (2003-08-01), pages 219 - 229, XP004439531, ISSN: 1046-5928 *
DONADIO S ET AL: "Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells", BIOCHIMIE, MASSON, PARIS, FR, vol. 85, no. 3-4, 1 January 2003 (2003-01-01), pages 311 - 321, XP002397070, ISSN: 0300-9084 *
HOMA F L ET AL: "Isolation and expression of a cDNA clone encoding a bovine UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 268, no. 17, 15 June 1993 (1993-06-15), pages 12609 - 12616, XP002965844, ISSN: 0021-9258 *
KUROSAWA N ET AL: "Molecular cloning and expression of GalNAc alpha2,6-Sialyltransferase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 269, no. 2, 14 January 1994 (1994-01-14), pages 1402 - 1409, XP002486638, ISSN: 0021-9258 *
WANDALL H H ET AL: "Substrate specificities of three members of the human UPD-N-acetyl-alpha-D-galactosamine : Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, vol. 272, no. 38, 19 September 1997 (1997-09-19), pages 23503 - 23514, XP002904621, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
JP2008512085A (en) 2008-04-24
WO2005121331A3 (en) 2007-08-30
WO2005121331A2 (en) 2005-12-22
WO2005121331A8 (en) 2006-03-09
EP1765992A2 (en) 2007-03-28
WO2005121331A9 (en) 2006-06-01

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Inventor name: SARIBAS, SAMI

Inventor name: TAUDTE, SUSANN

Inventor name: CHEN, XI

Inventor name: JOHNSON, KARL F.

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/10 20060101ALI20071109BHEP

Ipc: C12N 15/00 20060101ALI20071109BHEP

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