EP1728857A3 - Liver tissue source - Google Patents

Liver tissue source Download PDF

Info

Publication number
EP1728857A3
EP1728857A3 EP06120178A EP06120178A EP1728857A3 EP 1728857 A3 EP1728857 A3 EP 1728857A3 EP 06120178 A EP06120178 A EP 06120178A EP 06120178 A EP06120178 A EP 06120178A EP 1728857 A3 EP1728857 A3 EP 1728857A3
Authority
EP
European Patent Office
Prior art keywords
tissue
cells
donor
source
cadaveric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06120178A
Other languages
German (de)
French (fr)
Other versions
EP1728857A2 (en
Inventor
Lola M. Reid
Edward L. Dept. of Drug & Disposition Lecluyse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Priority claimed from EP01903136A external-priority patent/EP1252293B1/en
Publication of EP1728857A2 publication Critical patent/EP1728857A2/en
Publication of EP1728857A3 publication Critical patent/EP1728857A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Abstract

The instant invention provides, for the first time, the use of cadaveric organs from donors with non-beating hearts as a source of functional cells such as progenitor or stem cells for various medical purposes. More specifically, a method is disclosed whereby a tissue source of progenitor cells is obtained comprising harvesting tissue from a donor, wherein the donor has a non-beating heart for as long as about thirty hours postmortem and processing the cadaveric tissue to provide progenitor cells. The instant progenitors are used for various medical purposes as means of cell therapy, gene therapy, artificial organs, bioreactors, organ regeneration and the like.
Figure imgaf001
EP06120178A 2000-01-19 2001-01-19 Liver tissue source Withdrawn EP1728857A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17679800P 2000-01-19 2000-01-19
EP01903136A EP1252293B1 (en) 2000-01-19 2001-01-19 Liver tissue source

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP01903136A Division EP1252293B1 (en) 2000-01-19 2001-01-19 Liver tissue source
EP01903136A Division-Into EP1252293B1 (en) 2000-01-19 2001-01-19 Liver tissue source

Publications (2)

Publication Number Publication Date
EP1728857A2 EP1728857A2 (en) 2006-12-06
EP1728857A3 true EP1728857A3 (en) 2007-04-11

Family

ID=37772789

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06120178A Withdrawn EP1728857A3 (en) 2000-01-19 2001-01-19 Liver tissue source

Country Status (1)

Country Link
EP (1) EP1728857A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008107652A1 (en) 2007-03-02 2008-09-12 Smith & Nephew Plc Apparatus and method for filter cleaning by ultrasound, backwashing and filter movement during the filtration of biological samples
JP5629683B2 (en) 2008-07-25 2014-11-26 スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ Separator controller
CN110913691A (en) * 2017-04-06 2020-03-24 北卡罗来纳大学教堂山分校 Low temperature preservation method
US11697799B2 (en) * 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003142A1 (en) * 1991-08-07 1993-02-18 Albert Einstein College Of Medicine Proliferation of hepatocyte precursors
EP0682106A2 (en) * 1994-04-11 1995-11-15 Research Development Corporation Of Japan Liver parenchymal cells having clonal growth ability, method for obtaining same, method for culturing same, and culturing system of primary hepatocytes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003142A1 (en) * 1991-08-07 1993-02-18 Albert Einstein College Of Medicine Proliferation of hepatocyte precursors
EP0682106A2 (en) * 1994-04-11 1995-11-15 Research Development Corporation Of Japan Liver parenchymal cells having clonal growth ability, method for obtaining same, method for culturing same, and culturing system of primary hepatocytes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BRILL S ET AL: "Hepatic progenitor populations in embryonic, neonatal, and adult liver", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY & MEDICINE, vol. 204, no. 3, 1 December 1993 (1993-12-01), pages 261 - 269, XP002040996, ISSN: 0037-9727 *
HALDER SUNIL K ET AL: "Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells", ENDOCRINOLOGY, vol. 139, no. 7, July 1998 (1998-07-01), pages 3316 - 3328, XP002404505, ISSN: 0013-7227 *
JOSEPH J M ET AL: "Transplantation of encapsulated bovine chromaffin cells in the sheep subarachnoid space: A preclinical study for the treatment of cancer pain", CELL TRANSPLANTATION, vol. 3, no. 5, 1994, pages 355 - 364, XP002404503, ISSN: 0963-6897 *
M AGELLI ET AL: "Putative liver progenitor cells: conditions for long-term survival in culture", JOURNAL OF HISTOTECHNOLOGY, vol. 29, 1997, pages 205 - 217, XP002123294, ISSN: 0147-8885 *
MUGISHIMA H ET AL: "BONE MARROW FROM CADAVER DONORS FOR TRANSPLANTATION", BLOOD, vol. 65, no. 2, 1985, pages 392 - 396, XP002404502, ISSN: 0006-4971 *
SUSICK R ET AL: "Hepatic progenitors and strategies for liver cell therapies", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. BIOARTIFICIAL ORGANS III: TISSUE SOURCING, IMMUNOISOLATION, AND CLINICAL TRIALS NEW YORK ACADEMY OF SCIENCES {A}, 2 EAST 63RD STREET, NEW YORK, NY, 10021, USA SERIES : ANNALS OF THE NEW YORK ACADEMY OF SCIE, 2001, & CONFERENCE ON BIOARTIFICIAL ORGANS, III: TISSUE SOURCING, IMMUNOISOLATION, AND CLINICAL TRIALS; DAVOS, SWITZERLAND; OCTOBER 07-11, 2000, pages 398 - 419, XP002420108, ISSN: 1-57331-342-4 1-57331-343-2 *
YAN Z B ET AL: "A STUDY OF CADAVERIC FETAL ADRENAL USED FOR ADRENAL TRANSPLANTATION TO TREAT ADDISON'S DISEASE THIRTEEN CASES REPORTED", TRANSPLANTATION PROCEEDINGS, vol. 22, no. 1, 1990, & FIFTEENTH CONGRESS OF THE SCANDINAVIAN TRANSPLANTATION SOCIETY, HELSINKI, FINLAND, MAY 18-20, 1989., pages 280 - 282, XP002404504, ISSN: 0041-1345 *

Also Published As

Publication number Publication date
EP1728857A2 (en) 2006-12-06

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