EP1723127A4 - Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof - Google Patents

Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof

Info

Publication number
EP1723127A4
EP1723127A4 EP05749117A EP05749117A EP1723127A4 EP 1723127 A4 EP1723127 A4 EP 1723127A4 EP 05749117 A EP05749117 A EP 05749117A EP 05749117 A EP05749117 A EP 05749117A EP 1723127 A4 EP1723127 A4 EP 1723127A4
Authority
EP
European Patent Office
Prior art keywords
making
methods
cell proliferation
analogs exhibiting
exhibiting inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05749117A
Other languages
German (de)
French (fr)
Other versions
EP1723127A2 (en
Inventor
Duane D Miller
James T Dalton
Veeresa Gududuru
Eunju Hurh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ohio State University Research Foundation
University of Tennessee Research Foundation
Original Assignee
Ohio State University Research Foundation
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohio State University Research Foundation, University of Tennessee Research Foundation filed Critical Ohio State University Research Foundation
Publication of EP1723127A2 publication Critical patent/EP1723127A2/en
Publication of EP1723127A4 publication Critical patent/EP1723127A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
EP05749117A 2004-02-11 2005-02-11 Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof Withdrawn EP1723127A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54372404P 2004-02-11 2004-02-11
US55580304P 2004-03-24 2004-03-24
PCT/US2005/004759 WO2005086638A2 (en) 2004-02-11 2005-02-11 Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof

Publications (2)

Publication Number Publication Date
EP1723127A2 EP1723127A2 (en) 2006-11-22
EP1723127A4 true EP1723127A4 (en) 2009-10-28

Family

ID=34976061

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05749117A Withdrawn EP1723127A4 (en) 2004-02-11 2005-02-11 Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof

Country Status (8)

Country Link
EP (1) EP1723127A4 (en)
JP (1) JP2007522247A (en)
AU (1) AU2005220705A1 (en)
BR (1) BRPI0507612A (en)
CA (1) CA2559333A1 (en)
EA (1) EA200601471A1 (en)
IL (1) IL177444A0 (en)
WO (1) WO2005086638A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101395146B1 (en) * 2011-02-09 2014-05-16 부산대학교 산학협력단 New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof
WO2014066613A2 (en) * 2012-10-26 2014-05-01 Zhejiang University Sphingolipid metabolite mimetics
AU2014233168B2 (en) * 2013-03-15 2018-11-22 Cancer Research Technology, Llc Methods and compositions for Gamma-glutamyl cycle modulation
WO2023170024A1 (en) * 2022-03-11 2023-09-14 University Of Copenhagen Camk2 modulators and their use in medicine
CN115894398B (en) * 2022-12-02 2024-03-12 青岛科技大学 Fluothiazole amide-containing insecticidal acaricide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310370A1 (en) * 1987-09-30 1989-04-05 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallgeric and anti-inflammatory agents
US4962096A (en) * 1987-03-24 1990-10-09 Nippon Chemiphar Co., Ltd. Heterocyclic glycerol derivatives and their use as anti-hypertensive agents
US5149704A (en) * 1991-05-03 1992-09-22 Abbott Laboratories Platelet activating antagonists
WO1993001167A1 (en) * 1991-07-10 1993-01-21 Rhone-Poulenc Rorer S.A. Pyrrolidine and thiazolidine derivatives, preparation thereof and drugs containing same
FR2700168A1 (en) * 1993-01-07 1994-07-08 Rhone Poulenc Rorer Sa Derivatives of thiazolidine, their preparation and the drugs containing them.
US5811429A (en) * 1995-12-15 1998-09-22 Bayer Aktiengesellschaft Bicyclic heterocyclic compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962096A (en) * 1987-03-24 1990-10-09 Nippon Chemiphar Co., Ltd. Heterocyclic glycerol derivatives and their use as anti-hypertensive agents
EP0310370A1 (en) * 1987-09-30 1989-04-05 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallgeric and anti-inflammatory agents
US5149704A (en) * 1991-05-03 1992-09-22 Abbott Laboratories Platelet activating antagonists
WO1993001167A1 (en) * 1991-07-10 1993-01-21 Rhone-Poulenc Rorer S.A. Pyrrolidine and thiazolidine derivatives, preparation thereof and drugs containing same
FR2700168A1 (en) * 1993-01-07 1994-07-08 Rhone Poulenc Rorer Sa Derivatives of thiazolidine, their preparation and the drugs containing them.
US5811429A (en) * 1995-12-15 1998-09-22 Bayer Aktiengesellschaft Bicyclic heterocyclic compounds

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AITKEN, R. ALAN ET AL: "Effect of added benzoic acid on the phase-transfer-catalyzed permanganate oxidation of organosulfur compounds", XP002541379, retrieved from STN Database accession no. 1997:505484 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CAPET, MARC ET AL: "Preparation and formulation of 2- aryl-3-(ureidoacetyl)thiazolidine-4-carboxylates and analogs as CCK receptor and gastrin receptor ligands", XP002541376, retrieved from STN Database accession no. 1994:217658 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DUBROEUCQ, MARIE-CHRISTINE ET AL: "Preparation and formulation of N-[(phenylureido)acetyl]thiazolidine-4-carboxylates and analogs as gastrin and CCK antagonists", XP002541377, retrieved from STN Database accession no. 1995:664908 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HALL, G. E. ET AL: "Chemistry of micrococcin P. VIII. A method for the degradation of thiazole-4-carboxylic acids", XP002541380, retrieved from STN Database accession no. 1966:465478 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HOOPER, FLORENCE E. ET AL: "Synthesis of thiazolebarbituric acids. XIII", XP002541381, retrieved from STN Database accession no. 1934:14056 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MIYAKE, AKIRA ET AL: "Antibiotics. I. Acidomycin. Isolation and chemical structure", XP002541382, retrieved from STN Database accession no. 1955:64797 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MUSSER, JOHN HENRY ET AL: "2-Aryl-substituted heterocyclic compounds as antiallergic and anti-inflammatory agents", XP002541383, retrieved from STN Database accession no. 1989:553787 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SUMMERS, JAMES B. ET AL: "Preparation of N-benzoylphenyl 2-(3-pyridinyl)-4-aminomethylthiazolidines and related compounds as platelet activating factor antagonists", XP002541378, retrieved from STN Database accession no. 1993:59704 *
DATABASE CROSSFIRE BEILSTEIN BEILSTEIN INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, FRANKFURT AM MAIN. DE; XP002541384, Database accession no. 219563 *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 56, 484-5 CODEN: JACSAT; ISSN: 0002-7863, 1934 *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 56, 1934, pages 484 *
JOURNAL OF THE CHEMICAL SOCIETY [SECTION] C: ORGANIC , (6), 1357-60 CODEN: JSOOAX; ISSN: 0022-4952, 1966 *
PHARMACEUTICAL BULLETIN , 1, 84-8 CODEN: PHBUA9; ISSN: 0369-9471, 1953 *
SYNTHESIS , (7), 787-791 CODEN: SYNTBF; ISSN: 0039-7881, 1997 *
SZILAGYI, LASZLO ET AL: "Comments on the putative stereoselectivity in cysteine-aldehyde reactions. Selective C(2) inversion and C(4) epimerization in thiazolidine-4-carboxylic acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 101(2), 427-32 CODEN: JACSAT; ISSN: 0002-7863, 1979, XP002541375 *

Also Published As

Publication number Publication date
JP2007522247A (en) 2007-08-09
EA200601471A1 (en) 2007-10-26
BRPI0507612A (en) 2007-07-03
CA2559333A1 (en) 2005-09-22
WO2005086638A3 (en) 2005-11-24
EP1723127A2 (en) 2006-11-22
IL177444A0 (en) 2006-12-10
WO2005086638A2 (en) 2005-09-22
AU2005220705A1 (en) 2005-09-22

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20060911

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: DALTON, JAMES, T.

Inventor name: HURH, EUNJU

Inventor name: GUDUDURU, VEERESARXBIO, INC

Inventor name: MILLER, DUANE, D.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION

Owner name: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20090929

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20091227