EP1704095A1 - Device for making secure tubes - Google Patents

Device for making secure tubes

Info

Publication number
EP1704095A1
EP1704095A1 EP05717423A EP05717423A EP1704095A1 EP 1704095 A1 EP1704095 A1 EP 1704095A1 EP 05717423 A EP05717423 A EP 05717423A EP 05717423 A EP05717423 A EP 05717423A EP 1704095 A1 EP1704095 A1 EP 1704095A1
Authority
EP
European Patent Office
Prior art keywords
securing
biological samples
container
collection
samples according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05717423A
Other languages
German (de)
French (fr)
Inventor
Nicolas Bara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1704095A1 publication Critical patent/EP1704095A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D55/00—Accessories for container closures not otherwise provided for
    • B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/08—Coverings or external coatings
    • B65D23/0885—Rigid shells for receiving the bottle or part of it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D55/00—Accessories for container closures not otherwise provided for
    • B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
    • B65D55/024—Closures in which a part has to be ruptured to gain access to the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2401/00—Tamper-indicating means
    • B65D2401/10—Tearable part of the container
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/901—Tamper-resistant structure

Definitions

  • the present invention relates to the field of collecting and preserving biological samples.
  • the present invention relates more particularly to a sleeve device for securing cryotubes which may contain for example blood or tissue samples.
  • a cryotube is a cylindrical plastic container conventionally composed of two basic parts: the tube and the plug. The tightness of assembly of these two parts (generally by screwing) allows, inside the cryotube, the conservation of samples with variable temperatures which can go down according to the models up to -196 ° C (liquid nitrogen), hence the term "cryo" tube.
  • the present invention adds a third piece to the tube-plug couple: a security sleeve.
  • this piece will be called “sleeve”.
  • cryotubes corresponding to the prior art do not respond or very incompletely or partially to all of these safety requirements. Securing cryotubes is becoming increasingly important given the increasing central role played by analyzes in the forensic field, for example. DNA analysis, for example, takes the place of evidence in more and more cases. The use of secure containers (sampling, traceability and preservation) is henceforth required if the user (justice in this case) wishes to have physically and legally reliable samples.
  • the object of the invention is therefore to provide the maximum degree of security corresponding to the guaranteed levels described above.
  • the present invention is of the type described above and is remarkable, in its broadest sense, in that it concerns a device for securing a container for collecting and storing biological samples comprising a plug, characterized in that it comprises at least one means such that, after engagement of said device, access to the contents of said device necessarily entails an irreversible physical transformation and can be observed with the naked eye of said container (and not the stopper), said physical transformation consisting of example but not necessarily breaking or tearing said means.
  • said security device can be engaged at any time, at the user's choice.
  • said means is integral with said device.
  • said means is a breakable tab.
  • said device is inseparable from the container.
  • the engagement of said device is by irreversible depression of the container in said device.
  • said device and said container are of different material.
  • said device is composed of a material allowing the etching of indelible and unit identification.
  • said device is composed of a material allowing the reading of high contrast etching.
  • the means is a definitively fixed and non-replaceable tab of the device and the plug.
  • said joining of the tongue is done by tamper-proof adhesive tape.
  • said fastening of the tongue is done through a weld.
  • said device further comprises a housing for inserting a physical element containing at least one information associated with the content.
  • said insertion is done without masking said identification etching and irreversibly
  • FIG. 1 is a representation of the tube; brought to contain the samples; - Figures 2 and 3 show the security sleeve with or without the cap according to the invention; FIG.
  • FIG. 4 represents the plug associated with the securing sleeve provided with the securing tab according to the invention
  • - Figure 5 shows the plug associated with the security sleeve provided with the securing tongue according to the invention in the closed position
  • - Figure 6 shows the engagement of the tube in the sleeve according to a first notch
  • - Figure 7 shows the engagement of the tube in the sleeve according to a second notch
  • - Figure 8 shows the sleeve after breaking of the breakable safety tab
  • - Figure 9 shows the sleeve after placement of the safety tab.
  • the tube 1 to receive the sample is a container PolyPropylene (PP) can withstand cold. It is provided with an external screw thread 2 and a definitive engagement system with two levels of the sleeve (one-way assembly).
  • PP PolyPropylene
  • the first notch 3 is a mounting notch for securing the sleeve to the tube permanently (one way).
  • the second notch 4 is a detent of the device inviolabilisation by securing tabs through the sleeve. This first level of security will be called
  • the sleeve 7 is made of any rigid material, for example polyamide
  • the sleeve has for example labeling areas, or laser marking.
  • the bottom of the sleeve is flat and smooth to be etched on the bottom of the sleeve.
  • the sleeve is further provided with a hooking system 9 for automatic screwing.
  • It also has a side drawer for collecting a physical element carrying information relating to the sample, for example a radio frequency chip (RFID). It is lateral so as not to hide the marking areas under the sleeve.
  • RFID radio frequency chip
  • this element is a breakable lug 11 integral with the sleeve.
  • the characteristics of the tab are such that it breaks when the cap is opened, if the security system is engaged, as shown in FIG.
  • the sleeve also contains a zone 12 capable of receiving and holding in a vertical position without any allowance an optional tongue secured together with the sleeve and the plug.
  • This tongue may be secured to the sleeve by various means, such as for example by welding, or with an inviolable adhesive tape of known type.
  • the cap is a styling screw cap provided with a flexible seal to ensure sealing in liquid nitrogen, or in nitrogen vapor.
  • an automatic screwing device with higher notching and with a device allowing, for example, the clipping of a color code in the form of a circular disc.
  • the device can receive by clipping a tab support 13 representing the security level of the second degree.
  • the stopper also has a passage groove 14 intended to allow the passage without over-thickness of the tongue in the closed position as in FIG.
  • the cap also has inside an internal clipping member adapted to receive sample handling accessories directly inside the tube for example to facilitate the extraction of samples and their use.
  • the "tube-sleeve-plug" assembly is used for the purpose of securing the manipulation of the samples. The modes of use may then depend on the level of security required.
  • a first mode of use in the case of a standard laboratory, the cap is screwed onto a tube and the sleeve is engaged on the first catch 3 as in FIG. 6. The user can then unscrew the stopper, put the sample inside the tube, screw the cap and engage itself the first degree of inviolability by engaging the second notch 4 as in Figure 7. It can be noted that in this mode of use, the level of sterility of the tube is guaranteed by the tube supplier. On the other hand, after engagement with the second detent, any opening of the tube will cause breakage of the breakable tab 11 and may be identified as in FIG. 8.
  • the user receives the cap device closed with the second notch 4 engaged as in Figure 7, which guarantees emptiness and sterility level before use, in the case where the breakable tab 11 is intact.
  • the inviolabilisation is ensured by the second-level safety device by means of the tongue 13 secured together with the sleeve and the plug as in the figure.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention concerns the field of collecting and preserving biological samples. The invention more particularly concerns a sleeve device (7) for making secure cryogenic tubes (1) capable of containing blood or tissue samples. It concerns a device for making secure a container for collecting and preserving biological samples comprising a plug characterized in that it comprises at least means such that, after said device is locked, any access to the contents of the device inevitably produces an irreversible physical transformation of the device (and not of the plug) visible to the naked eye, said physical transformation consisting for example, but not necessarily, of a breakage or a tear of said means.

Description

DISPOSITIF DE SÉCURISATION DE TUBES DEVICE FOR SECURING TUBES
La présente invention se rapporte au domaine du recueil et de la conservation d'échantillons biologiques.The present invention relates to the field of collecting and preserving biological samples.
La présente invention se rapporte plus particulièrement à un dispositif de manchon permettant de sécuriser des cryotubes pouvant contenir par exemple des échantillons sanguins ou tissulaires.The present invention relates more particularly to a sleeve device for securing cryotubes which may contain for example blood or tissue samples.
Un cryotube est un contenant en plastique cylindrique composé classiquement de deux pièces élémentaires : le tube et le bouchon. L'étanchéité d'assemblage de ces deux pièces (généralement par vissage) permet, à l'intérieur du cryotube, la conservation d'échantillons à des températures variables pouvant descendre suivant les modèles jusqu'à —196°C (azote liquide), d'où le terme de « cryo » tube.A cryotube is a cylindrical plastic container conventionally composed of two basic parts: the tube and the plug. The tightness of assembly of these two parts (generally by screwing) allows, inside the cryotube, the conservation of samples with variable temperatures which can go down according to the models up to -196 ° C (liquid nitrogen), hence the term "cryo" tube.
L'art antérieur connaît déjà des tubes pouvant contenir des échantillons destinés à être congelés sous azote liquide.The prior art already knows tubes that may contain samples intended to be frozen under liquid nitrogen.
La présente invention adjoint une troisième pièce au couple tube-bouchon : un manchon de sécurisation. Dans toute la suite, cette pièce sera appelée « manchon ».The present invention adds a third piece to the tube-plug couple: a security sleeve. In the following, this piece will be called "sleeve".
La sécurisation des tubes de recueil et de conservation d'échantillons inclut les éléments suivants : garantie de l'intégrité physique de l'échantillon une fois le tube fermé (inviolabilisation de haut niveau de sécurité, témoin de viol définitif et non remplaçable solidarisé au contenant et non au bouchon) ; garantie de l'intégrité du tube vide : bonne fermeture, de la stérilité et de la vacuité de l'intérieur du cryotube avant utilisation ; garantie de l'identification unique et inaltérable du tube et donc de l'échantillon qu'il contient (échantillon non identifié = échantillon perdu) ; garantie de l'anonymat de l'échantillon.The securing of the sample collection and preservation tubes includes the following elements: guarantee of the physical integrity of the sample once the tube is closed (inviolabilisation of high level of security, witness of definitive and non-replaceable rape secured to the container and not to the stopper); guarantee of the integrity of the empty tube: good closure, sterility and vacuity inside the cryotube before use; guarantee of the unique and unalterable identification of the tube and therefore of the sample it contains (unidentified sample = lost sample); guarantee of the anonymity of the sample.
Les cryotubes correspondant à l'art antérieur ne répondent pas ou de manière très incomplète ou partielle à l'ensemble de ces exigences de sécurité. La sécurisation des cryotubes est de plus en plus importante étant donné le rôle central croissant joué par les analyses dans le domaine médico-légal par exemple. Les analyses ADN par exemple tiennent lieu de preuves dans de plus en plus d'affaires. L'utilisation de contenants sécurisés (échantillonnage, traçabilité et conservation) est donc désormais requise si l'utilisateur (la justice en l'occurrence) souhaite disposer d'échantillons physiquement et juridiquement fiables. Le but de l'invention est donc de fournir le degré maximal de sécurisation correspondant aux niveaux garantie décrits ci-dessus.Cryotubes corresponding to the prior art do not respond or very incompletely or partially to all of these safety requirements. Securing cryotubes is becoming increasingly important given the increasing central role played by analyzes in the forensic field, for example. DNA analysis, for example, takes the place of evidence in more and more cases. The use of secure containers (sampling, traceability and preservation) is henceforth required if the user (justice in this case) wishes to have physically and legally reliable samples. The object of the invention is therefore to provide the maximum degree of security corresponding to the guaranteed levels described above.
Pour ce faire, la présente invention est du type décrit ci-dessus et elle est remarquable, dans son acception la plus large, en ce que elle concerne un dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques comportant un bouchon, caractérisé en ce que il comporte au moins un moyen tel que, après enclenchement dudit dispositif, tout accès au contenu dudit dispositif entraîne nécessairement une transformation physique irréversible et constatable à l'œil nu dudit contenant (et non du bouchon), ladite transformation physique consistant par exemple mais pas nécessairement en une rupture ou une déchirure dudit moyen.To do this, the present invention is of the type described above and is remarkable, in its broadest sense, in that it concerns a device for securing a container for collecting and storing biological samples comprising a plug, characterized in that it comprises at least one means such that, after engagement of said device, access to the contents of said device necessarily entails an irreversible physical transformation and can be observed with the naked eye of said container (and not the stopper), said physical transformation consisting of example but not necessarily breaking or tearing said means.
De préférence, ledit dispositif de sécurisation peut être enclenché à tout moment, au choix de l'utilisateur.Preferably, said security device can be engaged at any time, at the user's choice.
Avantageusement, ledit moyen est solidaire dudit dispositif. De préférence, que ledit moyen est une patte sécable.Advantageously, said means is integral with said device. Preferably, said means is a breakable tab.
De préférence, ledit dispositif est indissociable du contenant. Avantageusement, l'enclenchement dudit dispositif se fait par enfoncement irréversible du contenant dans ledit dispositif .Preferably, said device is inseparable from the container. Advantageously, the engagement of said device is by irreversible depression of the container in said device.
De préférence, ledit dispositif et ledit contenant sont de matière différente.Preferably, said device and said container are of different material.
Avantageusement, ledit dispositif est composé d'une matière permettant le gravage d'identification indélébile et unitaire. Selon une variante, ledit dispositif est composé d'une matière permettant la lecture du gravage contraste élevé.Advantageously, said device is composed of a material allowing the etching of indelible and unit identification. According to a variant, said device is composed of a material allowing the reading of high contrast etching.
Selon un mode de réalisation, le moyen est une languette solidarisable de manière définitive et non remplaçable du dispositif et du bouchon.According to one embodiment, the means is a definitively fixed and non-replaceable tab of the device and the plug.
Selon un mode de mise en œuvre, ladite solidarisation de la languette se fait grâce à bande adhésive inviolable par déchirure. Selon un autre mode de mise en œuvre, ladite solidarisation de la languette se fait grâce à une soudure. Avantageusement, ledit dispositif comporte en outre un logement permettant d'insérer un élément physique contenant au moins une information associée au contenu.According to one mode of implementation, said joining of the tongue is done by tamper-proof adhesive tape. According to another mode of implementation, said fastening of the tongue is done through a weld. Advantageously, said device further comprises a housing for inserting a physical element containing at least one information associated with the content.
De préférence, ladite insertion se fait sans masquer ledit gravage d'identification et de manière irréversiblePreferably, said insertion is done without masking said identification etching and irreversibly
De préférence, ladite insertion se fait de manière irréversible . On comprendra mieux l'invention à l'aide de la description, faite ci-après à titre purement explicatif, d'un mode de réalisation de l'invention, en référence aux figures annexées où : - la figure 1 est une représentation du tube amené à contenir les échantillons ; - les figures 2 et 3 représentent le manchon de sécurisation avec ou sans le bouchon selon l'invention ; - la figure 4 représente le bouchon associé au manchon de sécurisation muni de la languette de sécurisation selon l'invention ; - la figure 5 représente le bouchon associé au manchon de sécurisation muni de la languette de sécurisation selon l'invention en position fermée; - la figure 6 représente l'enclenchement du tube dans le manchon selon un premier cran ; - la figure 7 représente l'enclenchement du tube dans le manchon selon un second cran; - la figure 8 représente le manchon après cassure de la patte sécable de sécurité ; - la figure 9 représente le manchon après mise en place de la languette de sécurité.Preferably, said insertion is irreversible. The invention will be better understood by means of the description, given below for purely explanatory purposes, of one embodiment of the invention, with reference to the appended figures in which: FIG. 1 is a representation of the tube; brought to contain the samples; - Figures 2 and 3 show the security sleeve with or without the cap according to the invention; FIG. 4 represents the plug associated with the securing sleeve provided with the securing tab according to the invention; - Figure 5 shows the plug associated with the security sleeve provided with the securing tongue according to the invention in the closed position; - Figure 6 shows the engagement of the tube in the sleeve according to a first notch; - Figure 7 shows the engagement of the tube in the sleeve according to a second notch; - Figure 8 shows the sleeve after breaking of the breakable safety tab; - Figure 9 shows the sleeve after placement of the safety tab.
Illustré figure 1, le tube 1 apte à recevoir les échantillon est un contenant en PolyPropylene (PP) pouvant résister au froid. Il est pourvu d'un pas de vis extérieur 2 et d'un système d'enclenchement définitif à deux niveaux du manchon (one-way assembly) .Illustrated Figure 1, the tube 1 to receive the sample is a container PolyPropylene (PP) can withstand cold. It is provided with an external screw thread 2 and a definitive engagement system with two levels of the sleeve (one-way assembly).
Le premier cran 3 est un cran de montage servant à solidariser le manchon au tube de manière définitive (one way) .The first notch 3 is a mounting notch for securing the sleeve to the tube permanently (one way).
Le deuxième cran 4 est un cran d'enclenchement du dispositif l'inviolabilisation par pattes secables grâce au manchon. Ce premier niveau de sécurité sera appeléThe second notch 4 is a detent of the device inviolabilisation by securing tabs through the sleeve. This first level of security will be called
« sécurisation de premier degré » ou « inviolabilité de premier degré » . Les éventuelles collerettes 5 du tube possèdent des saignées 6 nécessaires au passage des différents dispositifs d'inviolabilisation en position enclenchée."First degree security" or "first degree inviolability". The possible flanges 5 of the tube have grooves 6 necessary for the passage of the different inviolabilisation devices in the engaged position.
Illustré figure 2 et 3 , le manchon 7 est constitué d'une matière rigide quelconque, par exemple de polyamideIllustrated in FIGS. 2 and 3, the sleeve 7 is made of any rigid material, for example polyamide
(PA) . Il faut noter qu'il n'est pas en contact avec les échantillons. Les spécifications des tubes et des manchons sont alors très différentes, et parfois divergentes. Ceci permet d'ajouter librement, directement sur le manchon, tout additif de marquage ou de sécurisation. Ainsi, les marquages par étiquettes dans l'azote liquide n'étant pas satisfaisant, il est possible de marquer le manchon au laser pour une authentification inaltérable. De préférence, pour les manipulations, il est plus pratique de voir l'échantillon ou son niveau. Un marquage de volume ou autre 8 est alors gravé dans le moule directement sur le manchon. Ce système permet d'éviter des étapes de marquage coûteuses .(PA). It should be noted that it is not in contact with the samples. The specifications of the tubes and sleeves are then very different, and sometimes divergent. This allows to freely add, directly on the sleeve, any marking additive or securing. Thus, labeling labels in liquid nitrogen is not satisfactory, it is possible to mark the laser sleeve for unalterable authentication. Preferably, for manipulations, it is more convenient to see the sample or its level. A volume marking or other 8 is then etched in the mold directly on the sleeve. This system avoids expensive marking steps.
La manchon possède par exemple des zones d'étiquetage, ou de marquage laser.The sleeve has for example labeling areas, or laser marking.
Le fond du manchon est plat et lisse pour pouvoir être gravé sur la partie inférieure du manchon.The bottom of the sleeve is flat and smooth to be etched on the bottom of the sleeve.
Le manchon est par ailleurs pourvu d'un système d'accroché 9 pour un vissage automatique.The sleeve is further provided with a hooking system 9 for automatic screwing.
Il possède en outre un tiroir latéral pour venir recueillir un élément physique porteur d'informations relatives à l'échantillon, par exemple une puce radio fréquence (RFID) . Il est latéral pour ne pas cacher les zones de marquage sous le manchon.It also has a side drawer for collecting a physical element carrying information relating to the sample, for example a radio frequency chip (RFID). It is lateral so as not to hide the marking areas under the sleeve.
Il comprend en outre un élément essentiel de sécurisation sous forme d'élément dont la rupture est irréversible représentant le premier degré de sécurisation.It further comprises an essential element of securing element form whose break is irreversible representing the first degree of security.
De préférence, cet élément est une patte sécable 11 solidaire du manchon. Les caractéristiques de la patte sont telles qu'elle se casse à l'ouverture du bouchon, si le système de sécurisation est enclenché, comme illustré figurePreferably, this element is a breakable lug 11 integral with the sleeve. The characteristics of the tab are such that it breaks when the cap is opened, if the security system is engaged, as shown in FIG.
8.8.
Le manchon contient par ailleurs une zone 12 apte à accueillir et retenir en position verticale sans surépaisseur une éventuelle languette solidarisée conjointement au manchon et au bouchon.The sleeve also contains a zone 12 capable of receiving and holding in a vertical position without any allowance an optional tongue secured together with the sleeve and the plug.
Cette languette pourra être solidarisé au manchon par différents moyens, comme par exemple par soudure, ou grâce à une bande adhésive inviolable de type connu.This tongue may be secured to the sleeve by various means, such as for example by welding, or with an inviolable adhesive tape of known type.
Illustré figure 4, le bouchon est un bouchon à vis coiffant pourvu d'un joint souple pour assurer l'étanchéité dans l'azote liquide, ou dans la vapeur d'azote.Illustrated in Figure 4, the cap is a styling screw cap provided with a flexible seal to ensure sealing in liquid nitrogen, or in nitrogen vapor.
Il est muni d'un dispositif de vissage automatique par crantage supérieur et d'un dispositif permettant par exemple le clipsage d'un code couleur sous forme de disque circulaire.It is provided with an automatic screwing device with higher notching and with a device allowing, for example, the clipping of a color code in the form of a circular disc.
Selon un mode de réalisation particulier illustré figure 4, le dispositif peut recevoir par clipsage un support languette 13 représentant le niveau de sécurité de deuxième degré.According to a particular embodiment illustrated in FIG. 4, the device can receive by clipping a tab support 13 representing the security level of the second degree.
Le bouchon possède par ailleurs une saignée de passage 14 destinée à permettre le passage sans surépaisseur de la languette en position refermée comme sur la figure 5.The stopper also has a passage groove 14 intended to allow the passage without over-thickness of the tongue in the closed position as in FIG.
Selon un mode de réalisation, le bouchon possède par ailleurs à l'intérieur un organe de clipsage interne apte à recevoir des accessoires de manipulation des échantillons directement à l'intérieur du tube afin par exemple de faciliter l'extraction des échantillons et leur utilisation.According to one embodiment, the cap also has inside an internal clipping member adapted to receive sample handling accessories directly inside the tube for example to facilitate the extraction of samples and their use.
Il possède enfin également sur sa partie inférieure un logement 15 pour accueillir la patte sécable de sécurisation de premier degré 11 en position enclenchée. L'ensemble « tube-manchon-bouchon » est utilisé à des fins de sécurisation de la manipulation des échantillons. Les modes d'utilisation peuvent alors dépendre du niveau de sécurité requis.Finally, it also has on its lower part a housing 15 to accommodate the breakable tab of first degree security 11 in the engaged position. The "tube-sleeve-plug" assembly is used for the purpose of securing the manipulation of the samples. The modes of use may then depend on the level of security required.
Selon un premier mode d'utilisation, dans le cas d'un laboratoire standard, le bouchon est vissé sur tube et le manchon enclenché sur le premier cran 3 comme sur la figure 6. L'utilisateur peut alors dévisser le bouchon, mettre l'échantillon à l'intérieur du tube, revisser le bouchon et enclencher lui-même le premier degré d'inviolabilité en enclenchant le deuxième cran 4 comme sur la figure 7. On peut noter que dans ce mode d'utilisation, le niveau de stérilité du tube est garanti par le fournisseur du tube. Par contre, après enclenchement sur le deuxième cran, toute ouverture du tube provoquera la cassure de la patte sécable 11 et pourra être repérée comme sur la figure 8. Selon un second mode d'utilisation de l'invention, dans le cas de tubes à usage médico-légal, l'utilisateur reçoit le dispositif bouchon fermé avec le deuxième cran 4 enclenché comme sur la figure 7, ce qui lui garantit la vacuité et le niveau stérilité avant toute utilisation, dans le cas où la patte sécable 11 est intacte.According to a first mode of use, in the case of a standard laboratory, the cap is screwed onto a tube and the sleeve is engaged on the first catch 3 as in FIG. 6. The user can then unscrew the stopper, put the sample inside the tube, screw the cap and engage itself the first degree of inviolability by engaging the second notch 4 as in Figure 7. It can be noted that in this mode of use, the level of sterility of the tube is guaranteed by the tube supplier. On the other hand, after engagement with the second detent, any opening of the tube will cause breakage of the breakable tab 11 and may be identified as in FIG. 8. According to a second mode of use of the invention, in the case of Forensic use, the user receives the cap device closed with the second notch 4 engaged as in Figure 7, which guarantees emptiness and sterility level before use, in the case where the breakable tab 11 is intact.
Après utilisation et l'introduction des échantillons dans le tube, 1 ' inviolabilisation est assurée par le dispositif de sécurité de deuxième niveau à l'aide de la languette 13 solidarisée conjointement au manchon et au bouchon comme sur la figure .After use and the introduction of the samples into the tube, the inviolabilisation is ensured by the second-level safety device by means of the tongue 13 secured together with the sleeve and the plug as in the figure.
L'invention est décrite dans ce qui précède à titre d'exemple. Il est entendu que l'homme du métier est à même de réaliser différentes variantes de l'invention sans pour autant sortir du cadre du brevet. The invention is described in the foregoing by way of example. It is understood that the skilled person is able to realize different variants of the invention without departing from the scope of the patent.

Claims

REVENDICATIONS
1. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques comportant un bouchon, caractérisé en ce que il comporte au moins un moyen tel que, après enclenchement dudit dispositif, tout accès au contenu dudit dispositif entraîne nécessairement une transformation physique irréversible et constatable à l'œil nu dudit contenant (et non du bouchon), ladite transformation physique consistant par exemple mais pas nécessairement en une rupture ou une déchirure dudit moyen.1. Device for securing a container for collecting and storing biological samples comprising a plug, characterized in that it comprises at least one means such that, after engagement of said device, any access to the contents of said device necessarily entails an irreversible physical transformation and visible to the naked eye of said container (and not the stopper), said physical transformation consisting for example but not necessarily in a break or a tear of said means.
2. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ledit dispositif de sécurisation peut être enclenché à tout moment, au choix de l'utilisateur.2. Device for securing the collection and storage of biological samples according to claim 1, characterized in that said securing device can be engaged at any time, at the user's discretion.
3. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ledit moyen est solidaire dudit dispositif.3. Device for securing the collection and preservation of biological samples container according to claim 1, characterized in that said means is integral with said device.
4. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ledit moyen est une patte sécable.4. Device for securing the collection container and conservation of biological samples according to claim 1, characterized in that said means is a breakable tab.
5. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ledit dispositif est indissociable du contenant. 5. Device for securing the collection container and conservation of biological samples according to claim 1, characterized in that said device is inseparable from the container.
6. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que l'enclenchement dudit dispositif se fait par enfoncement irréversible du contenant dans ledit dispositif.6. Device for securing the collection and storage of biological samples according to claim 1, characterized in that the engagement of said device is by irreversible depression of the container in said device.
7. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ledit dispositif et ledit contenant sont de matière différente.7. Device for securing the collection and preservation of biological samples container according to claim 1, characterized in that said device and said container are of different material.
8. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ledit dispositif est composé d'une matière permettant le gravage d'identification indélébile et unitaire.8. Device for securing the collection and preservation of biological samples according to claim 1, characterized in that said device is composed of a material for indelible and unit identification etching.
9. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 8, caractérisé en ce que ledit dispositif est composé d'une matière permettant la lecture du gravage contraste élevé.9. Device for securing the collection container and conservation of biological samples according to claim 8, characterized in that said device is composed of a material for reading the high contrast etching.
10. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que le moyen est une languette solidarisable de manière définitive et non remplaçable du dispositif et du bouchon. 10. Device for securing the collection and storage of biological samples container according to claim 1, characterized in that the means is a definitively fixed and non-replaceable tab of the device and the plug.
11. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ladite solidarisation de la languette se fait grâce à bande adhésive inviolable par déchirure. 11. Device for securing the collection container and conservation of biological samples according to claim 1, characterized in that said fastening of the tongue is done with tamper-proof adhesive tape by tearing.
12. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ladite solidarisation de la languette se fait grâce à une soudure.12. Device for securing the collection container and conservation of biological samples according to claim 1, characterized in that said fastening of the tongue is done through a weld.
13. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 1, caractérisé en ce que ledit dispositif comporte en outre un logement permettant d'insérer un élément physique contenant au moins une information associée au contenu.13. Device for securing the collection and preservation of biological samples container according to claim 1, characterized in that said device further comprises a housing for inserting a physical element containing at least one information associated with the content.
14. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon les revendications 8 et 13, caractérisé en ce que ladite insertion se fait sans masquer ledit gravage d'identification et de manière irréversible. 14. Device for securing the collection and preservation of biological samples according to claims 8 and 13, characterized in that said insertion is done without masking said identification etching and irreversibly.
15. Dispositif de sécurisation de contenant de recueil et conservation d'échantillons biologiques selon la revendication 13, caractérisé en ce que ladite insertion se fait de manière irréversible. 15. Device for securing the collection container and conservation of biological samples according to claim 13, characterized in that said insertion is irreversibly.
EP05717423A 2004-01-15 2005-01-14 Device for making secure tubes Withdrawn EP1704095A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0400358A FR2865190B1 (en) 2004-01-15 2004-01-15 DEVICE FOR SECURING TUBES
PCT/FR2005/000090 WO2005073102A1 (en) 2004-01-15 2005-01-14 Device for making secure tubes

Publications (1)

Publication Number Publication Date
EP1704095A1 true EP1704095A1 (en) 2006-09-27

Family

ID=34707872

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05717423A Withdrawn EP1704095A1 (en) 2004-01-15 2005-01-14 Device for making secure tubes

Country Status (6)

Country Link
US (1) US7950540B2 (en)
EP (1) EP1704095A1 (en)
JP (1) JP4699387B2 (en)
CA (1) CA2553319A1 (en)
FR (1) FR2865190B1 (en)
WO (1) WO2005073102A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912727B1 (en) 2007-02-19 2013-07-19 Cryo Bio System PACKAGING TUBE OF A PREDETERMINED VOLUME OF BIOLOGICAL SUBSTANCE TO BE PRESERVED AT LOW TEMPERATURE AND SYSTEM COMPRISING SAME
ES2888824T3 (en) * 2015-10-05 2022-01-07 C Change Surgical Llc Use of sterile cuff in the production of surgical crushed ice
CN109124696B (en) * 2018-10-16 2023-11-28 上海导向医疗***有限公司 Detachable sample collector assembly and biopsy rotary cutting device
US11882824B2 (en) 2019-03-08 2024-01-30 Fisher Bioservices Inc. Cryogenic vial sleeve and related systems and methods

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1162615A (en) * 1913-10-18 1915-11-30 William A Findlay Non-refillable bottle.
US2763395A (en) * 1952-06-06 1956-09-18 Airkem Inc Diffuser devices
US3794098A (en) * 1972-06-05 1974-02-26 M Versen Tire repair or installation method and seal device therefor
GB2089327B (en) * 1980-12-06 1984-08-30 Glyndon Plastics Ltd Tamperproof enclosure
US4724972A (en) * 1986-02-25 1988-02-16 Paul Marcus Tamper evident container
US4872563A (en) 1988-05-31 1989-10-10 Pro-Tech-Tube, Inc. Protective enclosure for hazardous material primary containers
BR9202197A (en) 1991-06-12 1993-02-02 Ppg Industries Inc STERILIZABLE AND SUBSTANTIALLY HERMETICALLY CLOSED GLASS TRECIPIENT AND PROCESS FOR CONTAINER PRODUCTION
US5230427A (en) * 1991-06-12 1993-07-27 Ppg Industries, Inc. Sterilizable hermetically-sealed substantially glass container
DE9300042U1 (en) * 1992-01-08 1993-03-11 H. Obrist & Co Ag, Reinach Plastic threaded part for mounting on a tube neck
US5257704A (en) * 1992-05-08 1993-11-02 Revlon Consumer Products Corporation Tamperproof lipstick seal
US5605230A (en) * 1994-10-11 1997-02-25 Elr, Inc. Sealed label having anti-counterfeit construction
GB2366790A (en) * 2000-08-10 2002-03-20 Robinson & Sons Ltd Tamper evident closure
US6821268B2 (en) * 2002-03-30 2004-11-23 Bracco Diagnostics Inc. Tamper evident overap of a container

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005073102A1 *

Also Published As

Publication number Publication date
JP2007525384A (en) 2007-09-06
WO2005073102A1 (en) 2005-08-11
FR2865190A1 (en) 2005-07-22
US20080093362A1 (en) 2008-04-24
JP4699387B2 (en) 2011-06-08
FR2865190B1 (en) 2006-03-10
US7950540B2 (en) 2011-05-31
CA2553319A1 (en) 2005-08-11

Similar Documents

Publication Publication Date Title
FR2820120A1 (en) CAP WITH POURING ORIFICE CLOSED BY A LID AND LID INVIOLABILITY SYSTEM
FR2597072A1 (en) CONTAINER TIP ENSURING THE IMPOSSIBILITY OF FILLING AFTER EXHAUSTION OF THE INITIAL LOAD
EP1704095A1 (en) Device for making secure tubes
FR3035572A1 (en) DISMOUNTABLE-REMONTABLE SCREWABLE PUMP
FR2978187A1 (en) ANTI-THEFT DEVICE FOR A LIQUID CONTAINER
EP2324929A1 (en) Storage and dispensing system for a pasty fluid or a liquid
FR2808662A1 (en) Applicator system especially for make-up has reservoir perforated by applicator tip prior to first use
WO2005089840A1 (en) Tamper-proof device for syringe and syringe comprising one such device
EP1461263B1 (en) Closure device and container equipped therewith
FR2983046A3 (en) Device for distributing liquid i.e. body lotion, has sleeve rotated along rotation ring and pipe to move plunger toward bottom part of container to push liquid to flow to applicator head through channel of inlet opening and axial passage
WO2020127132A1 (en) Cap for rigid container
FR2795056A1 (en) CONTAINER FOR RECEIVING AN ARTICLE
FR2861702A1 (en) Flask for holding a biological sample comprises cap enclosing color-coded identification and electronic label with memory and contact-less emitter
FR3038213A1 (en) POWDER-TYPE COSMETIC HOUSING
FR2688762A1 (en) Container obturating device with tamper indicator
WO2005026004A1 (en) Resealable opening system for cans
FR3014856A1 (en) DISPOSITION OF A CONTAINER HAVING A COLLAR
EP1317385A1 (en) Screw cap with clip-on means
EP4147992B1 (en) Integrity protection system for sensitive assets
FR2649077A1 (en) BONGE SHUTTER
EP0537282B1 (en) Device for storing two components separately and bringing them together for use
FR2934506A1 (en) Liquid reagent product containing container for cartridge of analyzing assembly in analyzing apparatus, has closure plug whose bottom wall closes end of skirt, where wall has slot permitting passage of probe or needle of analyzing apparatus
EP1044670B1 (en) Bag system with integrated safety means
WO1998030333A1 (en) Liquid perfume sample
EP3174815B1 (en) Device for extracting a straw from a container, system and method

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060712

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100803

18RA Request filed for re-establishment of rights before grant

Effective date: 20110118