EP1701937A4 - Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide - Google Patents

Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

Info

Publication number
EP1701937A4
EP1701937A4 EP03768046A EP03768046A EP1701937A4 EP 1701937 A4 EP1701937 A4 EP 1701937A4 EP 03768046 A EP03768046 A EP 03768046A EP 03768046 A EP03768046 A EP 03768046A EP 1701937 A4 EP1701937 A4 EP 1701937A4
Authority
EP
European Patent Office
Prior art keywords
nitrophenyl
dihydroxy
acrylamide
cyano
diethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP03768046A
Other languages
German (de)
French (fr)
Other versions
EP1701937A1 (en
Inventor
Mukarram Siddiqui Moham Jaweed
Rashid Abdul Rehman Khan
Ram Prasad Yadav
Zakir Gafoor Shaikh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JAWEED MUKARRAM, SIDDIQUI MOHAMMED
Khan Rashid Abdul Rehman
Shaikh Zakir Gafoor
YAVAD, RAM PRASAD
Wockhardt Ltd
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of EP1701937A1 publication Critical patent/EP1701937A1/en
Publication of EP1701937A4 publication Critical patent/EP1701937A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
EP03768046A 2003-12-29 2003-12-29 Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide Ceased EP1701937A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/006200 WO2005066117A1 (en) 2003-12-29 2003-12-29 Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

Publications (2)

Publication Number Publication Date
EP1701937A1 EP1701937A1 (en) 2006-09-20
EP1701937A4 true EP1701937A4 (en) 2007-05-02

Family

ID=34746624

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03768046A Ceased EP1701937A4 (en) 2003-12-29 2003-12-29 Stable polymorphs of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

Country Status (5)

Country Link
EP (1) EP1701937A4 (en)
AU (1) AU2003292465A1 (en)
BR (1) BR0318690A (en)
CA (1) CA2551791A1 (en)
WO (1) WO2005066117A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1945607B1 (en) * 2005-11-09 2009-10-14 USV Limited A process for the preparation of highly pure (e) n,n-diethyl-2-cyano-3-(3,4-dihydroxy- 5-nitro phenyl) acrylamide (entacapone)
US20080300420A1 (en) * 2006-01-02 2008-12-04 Sanmar Speciality Chemicals Ltd. Process for the Preparation of Entacapone Form-A
US7932415B2 (en) * 2006-02-06 2011-04-26 Orion Corporation Process for manufacturing entacapone
GB0610207D0 (en) * 2006-05-23 2006-07-05 Pliva Istrazivanje I Razvoj D New forms of active pharmaceutical ingredient
WO2008023380A1 (en) * 2006-08-24 2008-02-28 Srinivasa Reddy Battula Improved and simplified procedure for the preparation of (e) n,n-diethyl-2-cyano-3(3,4-dihydroxy-5-nitrophenyl)acrylamide
ES2306587B1 (en) * 2006-11-15 2009-08-07 Quimica Sintetica, S.A. NEW CRYSTAL FORM OF ENTACAPONA AND PROCEDURE FOR OBTAINING.
ES2319024B1 (en) 2007-02-13 2009-12-11 Quimica Sintetica, S.A. PROCEDURE FOR OBTAINING ENTACAPONA SUBSTANTIALLY FREE OF ISOMERO Z, ITS SYNTHESIS INTERMEDIATES AND NEW CRYSTAL FORM.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2200109A (en) * 1986-11-28 1988-07-27 Orion Yhtymae Oy Catechol derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2238047B (en) * 1989-11-03 1993-02-10 Orion Yhtymae Oy Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2200109A (en) * 1986-11-28 1988-07-27 Orion Yhtymae Oy Catechol derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954, ISSN: 0340-1022, ISBN: 978-3-540-36760-4, DOI: 10.1007/3-540-69178-2_5 *
CHRISTIAN NÄTHER: "Grundlagen der Einkristallstrukturanalyse und der Pulverbeugung mit Röntgen-und Neutronenstrahlung", 1 January 2004 (2004-01-01), pages 1 - 58, XP055157521, Retrieved from the Internet <URL:http://www.christian.naether.uni-kiel.de/pdf/Wien_2004_Stunde 1 und 2.pdf> [retrieved on 20141209] *
No further relevant documents disclosed *
See also references of WO2005066117A1 *

Also Published As

Publication number Publication date
AU2003292465A1 (en) 2005-08-12
WO2005066117A1 (en) 2005-07-21
CA2551791A1 (en) 2005-07-21
EP1701937A1 (en) 2006-09-20
BR0318690A (en) 2006-12-26

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Owner name: WOCKHARDT LIMITED

Owner name: JAWEED MUKARRAM, SIDDIQUI MOHAMMED

Owner name: KHAN, RASHID ABDUL REHMAN

Owner name: YAVAD, RAM PRASAD

Owner name: SHAIKH, ZAKIR GAFOOR

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