EP1695072A1 - Adaptateur pour capnometre nanoelectronique - Google Patents

Adaptateur pour capnometre nanoelectronique

Info

Publication number
EP1695072A1
EP1695072A1 EP04815114A EP04815114A EP1695072A1 EP 1695072 A1 EP1695072 A1 EP 1695072A1 EP 04815114 A EP04815114 A EP 04815114A EP 04815114 A EP04815114 A EP 04815114A EP 1695072 A1 EP1695072 A1 EP 1695072A1
Authority
EP
European Patent Office
Prior art keywords
capnometer
sensor
nanostructure
recognition material
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04815114A
Other languages
German (de)
English (en)
Other versions
EP1695072A4 (fr
Inventor
Alexander Star
Jeffrey Wyatt
Vikram Joshi
Joseph R. Stettner
George Gruner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanomix Inc
Original Assignee
Nanomix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/940,324 external-priority patent/US20050129573A1/en
Application filed by Nanomix Inc filed Critical Nanomix Inc
Priority claimed from PCT/US2004/042998 external-priority patent/WO2005062031A1/fr
Publication of EP1695072A1 publication Critical patent/EP1695072A1/fr
Publication of EP1695072A4 publication Critical patent/EP1695072A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath

Definitions

  • the present invention relates to an apparatus and method for mainstream patient airway medical monitoring, such as by using a capnometer.
  • Mainstream devices make use of a sensor located at the patient airway by means of an airway adapter.
  • sidestream device requires connection of a sample line to the airway, and a sensor located away from the patient.
  • each may be subject to certain limitations that may compromise the effectiveness of C0 2 monitoring.
  • a comparison of exemplary limitations of prior-art apparatus and methods are listed below:
  • Mainstream • Secretions and humidity block the sensor. • A heating element is used to negate condensation. • A bulky device is at the patient airway. • The sensor must be sterilized and calibrated after each use. • The sensor is not usable with non-intubated patients.
  • a nanoelectronic capnometer system having aspects of the invention offers: (i). performance that matches or exceeds that of infrared technology, (ii) plug-and-pJay simplicity in a disposable package, (iii) the small size and low power consumption needed for wireless integration and (iv) the ability to incorporate arrays of sensors on a single chip.
  • This C " 0 2 sensing technology offers an order of magnitude reduction in the cost of the sensor component.
  • the capnometer comprises a nanoelectronic gas sensor integrated into an airway adapter for mainstream capnometry.
  • the nanoelectronic sensor may comprise a solid-state nanotube or other nanostructure sensor, for example, as described in the parent Application No. 10/940,324.
  • the capnometer apparatus may further comprise an appropriate adapter fitting that maximizes sensor performance. Both the adaptor fitting and the sensor may be incorporated into a compact and relatively low-cost assembly. Instead of sterilizing the capnometer after use, the sensing unit may be discarded, thereby avoiding difficulties and costs associated with sterilization.
  • the nanoelectronic gas sensor may be configured to respond to a chemical of interest, for example, carbon dioxide, oxygen or anesthesia gases. It may be integrated into a fitting designed to be inserted into an intubated or no ⁇ -intubated patient airstream, such as, for example, during anesthesia application and/or respiratory monitoring.
  • the nanoelectronic gas sensor itself may comprise a small packaged solid-state device incorporating a nanstructure sensor that is exposed to airflow on the inside of the tube and electronically connected to the outside of the tube.
  • the fitting together with the enclosed nanosensor may be designed as a disposable device.
  • a potentially reusable external electronics package that contains signal processing electronics may be socketed or snapped into place to make a secure connection with the sensor.
  • This electronics module may include a microprocessor, memory cell, power supply (including a battery) and a. wired or wireless connection to a monitor where the sensor output is stored and/or displayed. Being extremely small with a nanometer-scale active sensing area, the sensor may readily be protected from contamination, and can therefore be located in the more desirable mainstream configuration for faster response times.
  • the low cost of the chip-scale sensor can make it possible to dispose the sensor and its associated adaptor after each use, thereby eliminating the problem of disinfection.
  • the capnometer adaptor with its sensor may be very compact, cost- effective and convenient to use in a clinical setting. It is anticipated, therefore, that the invention will greatly facilitate and enhance the beneficial practice of capnography.
  • the invention comprises: an airway adaptor having ' at least one channel configured to permit the passage of respiratory gas; at least one solid-state nanostructure sensor arranged adjacent the airway adaptor in communication with the passage, the sensor having a sensitivity to at least one gaseous constituent of exhaled breath; electronic circuitry connected to the solid state sensor and configured to receive at least a signal indicative of the concentration of the at least one gaseous constituent of exhaled breath; and an output device connected to the electronic circuitry and configured to provide at least one of a qualitative and a quantitative measure of the concentration of the at least one gaseous constituent of exhaled breath.
  • the at least one gaseous constituent of exhaled breath includes carbon dioxide and the solid- state sensor incorporates a nanostructure as a sensing element responsive to the at least one gaseous constiuent.
  • the at least solid-state nanostructure sensor comprises: a substrate; a first nanostructure over the substrate; at least two conducting elements in electrical communication with the first nanostructure; and at least one recognition material operatively associated with the first nanostructure, the at least one recognition material configured for interacting with carbon dioxide.
  • the airway adaptor is configured to be mated so as to transmit at least a portion of the exhalation flow of at least a one of: a respirator/resuscitation system, a endotracheal ventilator system, an sleep apnea treatment system, a sleep apnea diagnostic system, an anesthesia system, a cardiac function diagnostic system, a metabolic function measuring system, an asthma monitoring system, and a gastro-intestinal testing system.
  • FIGS. 1A and 1B are schematic diagrams showing a wired capnometer sensor and adapter system from side and tube views, respectively.
  • FIG. 2 is a schematic diagram showing a wireless capnometer sensor and adapter system from an end view relative to the tube fitting.
  • FIG. 3 is a schematic diagram showing a wired capnometer sensor and adapter system with all electronics remote from the sensor, from an end view relative to the tube fitting.
  • FIG. 4 is a schematic diagram showing a capnometer sensor and adaptor with remote electronics, wherein the sensor is disposed directly in the airstream of the adaptor fitting.
  • FIG. 5 is a schematic showing an exemplary alternative structure for an adaptor and sensor of the type shown in FIG.
  • FIG. 6 is a schematic diagram showing a side view of a capnometer sensor and adapter generally similar to that shown in Figs. 1A and 1B, but having a sensor arranged adjacent a secondary parallel lumen in communication with the airway passage.
  • FIG. 7 is a schematic diagram showing a side view of a capnometer sensor and adapter generally similar to that shown in Fig. 6, but having inlet and outlet ends of the secondary parallel lumen projecting into airway passage into the exhalation flow path.
  • FIG. 8 is a schematic diagram showing an exemplary nanostructure sensor for use with the invention.
  • FIG. 9 is a plot showing the response of an exemplary nano-electronic carbon dioxide sensor to a range of low concentrations of carbon dioxide in air.
  • FIG. 10 is a plot showing the response of an exemplary nano-electronic carbon dioxide sensor to a wide range concentrations of carbon dioxide in air.
  • FIG. 11 is a plot showing the response of an exemplary capnometer having aspects of the invention to simulated human breathing.
  • FIGS. 12A, 12B and 12C depict exemplary configurations of a capnometer adaptor, in which the output device is mounted to the adapter housing and displays a quantitative bar graph.
  • FIG. 13 depicts an exemplary configuration of a capnometer adaptor, in which the output device is mounted to the adapter housing and displays a both a digital reading and a quantitative bar graph.
  • FIG. 12A, 12B and 12C depict exemplary configurations of a capnometer adaptor, in which the output device is mounted to the adapter housing and displays a both a digital reading and a quantitative bar graph.
  • FIGS. 15A and 15B depict exemplary configurations of a capnometer adaptor, in which either one or both of the sensor and the electronic circuitry is separately detachable from the airway adaptor housing.
  • FIGS. 1-7 depict a number of different embodiments, in which the same or generally similar elements are identified by numbers, in which the last digit corresponds to the equivalent or corresponding element, as much as possible, in each figure, with the digits preceding the last digit corresponding to the figure number of each example embodiment. Referring to FIGS.
  • the unit may be configured like conventional airway adapters, with an input and output for connecting tubing to an air channel 19 running through a housing 14.
  • One opening of housing 14 may be fed by the patient's respiration and the other opening may be connected to the breathing or anesthesia circuit.
  • the adapter 10 may be connected to a power and signal cable 15. Cable 15 may be used to relay gas monitoring data to the display unit, as well as powering the sensor.
  • the cable may be directly connected to an electronics module 11. This module may be configured for signal processing, analysis, and delivery of data values/waveforms to users.
  • Module 11 contain a microprocessor with embedded software and backup battery power.
  • the electronics module may be located above and connected by connector 17 to a solid-state sensor 12 (e.g., a nanoelectronic capnometer sensor such as is disclosed in Application No. 10/940,324).
  • Module 11 may be configured to readily detach and reattach, facilitating replacement of the sensor-containing adapter 14.
  • Electronics module 11 and sensor 12 may be provided on a single unitary semiconductor device, for example, a silicon chip, if desired.
  • The, nanoelectronic sensor 12 may be disposed in fluid communication with respired air passing through channel 19. In order to provide a sample volume to the capnometer, a small window or opening 13 may be provided between the sensor 12 and channel 19.
  • the sample window may be provided with membranes and/or filters 18 to reduce condensation, block patient secretions, and overall maintain stability of the sensor.
  • membranes and/or filters 18 to reduce condensation, block patient secretions, and overall maintain stability of the sensor.
  • a gas-permeable hydrophobic membrane e.g. a PFC membrane
  • the active sensing area of a nanotube sensor is extremely small, so one may readily protect the sensor from contamination in the patient airstream. For example, very little power is required to heat the sensor to a stable temperature at which condensation is prevented.
  • the senor may be protected from non-volatile contaminants by a simple mechanical filter and/or gas permeable membrane, which need only be large enough to minimize the likelihood of excessive filter blockage during the anticipated life of the sensor.
  • filter units may be removed and disposed between use, and then replaced with a new filter unit.
  • the unit 10 may be comprised primarily of a mechanically stable housing 14. Housing 14 may be comprised of any suitable plastic or other material with similar chemical and physical properties for use in medical tube fittings, as known in the art.
  • the capnometer sensor 12 may be based on nanoscale components as described in the parent patent application Serial No.
  • Sensing of other gases may also be achieved using a suitably configured nanotube sensor, for example, a sensor as described in U.S. provisional applications Serial No. 60/457,697 filed March 2003 and Serial No. 60/468,621 filed May 2003, and U.S. non-provisional applications Serial No. 10/177,929 filed June, 2002, Serial No. 10/656,898 filed September 5, 2003, Serial No. 10/655,529 filed September 4, 2003, Serial No. 10/388,701 filed March 14, 2003, and Serial No. 10/345,783 filed January 16, 2003; each of which is incorporated herein by reference.
  • Sensing for two or more gases may be accomplished using one or more sensors like sensor 12.
  • a single sensor may include a plurality of nanotube sensors, each configured to sense a different gas.
  • a plurality of nanotube sensors may be each configured to sense the same gas, for purposes of redundancy. It should be appreciated that the extremely small scale of a nanotube sensor makes it possible to cost-effectively incorporate numerous nanometer-scale sensors in a single gas sensing unit 12, which may essentially consist of a very compact silicon chip or other device.
  • one or more nanotube sensing devices may be assembled together into a sensing unit with multiple sensors. Since each device may be quite small, space and/or cost need not be limiting concerns.
  • FIG. 2 shows a wireless unit 20 without a need for a power or signal cable.
  • an on-board miniature battery 23 may provide sufficient power for its lifetime.
  • Housing 24 and channel 29 may be configured similarly as in capnometer 10.
  • a capnometer 30 may be designed to function with all electronics 31 separate from the sensor 32, as shown in FIG. 3.
  • the sensor 32 has a cable that connects it to the electronics module 31 , which is located remotely.
  • module 31 may be incorporated into a display and base station 36, which may be reused with different capnometer units 30.
  • Base station 36 may then incorporate more complex hardware and software for capnography, for example, display or analysis systems.
  • Signal and power cord 35 to the sensor may be removably connected to unit 30, allowing only the sensor unit 30 to be discarded and replaced.
  • FIGS. 4 and 5 show exemplary embodiments of this type.
  • FIG. 4 shows a capnometer sensing and airflow adaptor unit 40, comprising a tubular adaptor 44 with internal air channel 49.
  • Nanoelectric unit 42 may be mounted to the wall of channel 49, and connected to a cable connector 47 mounted on the outside of adaptor 44 by a wire.
  • sensing unit 42 may comprise a nanotube device as described above. It may be protected from contamination by a suitable filter and/or gas-permeable membrane (not shown) disposed around or over the sensor. For example, one may encapsulate sensor 12 in a gas-permeable membrane material, and/or a suitable filter and/or membrane may be separately mounted in channel 49. Alternatively, one may dispose the sensing unit more directly in the airstream. For example, FIG.
  • Ribs 58 may be molded integrally with sensor 52 and/or adaptor housing 54, with a molded-in connection to cable 55.
  • ribs 58 and sensor 52 may comprise a sub-assembly that is later ⁇ assembled in housing 54. Such a sub- assembly may attach to a molded-in electrical connector (not shown) passing through the wall of housing 54. It should be apparent that either design would virtually eliminate the possibility for inaccurate sensor readings from outside air leakage.
  • Ribs 58 or any other suitable mounting structures for sensor 52 may also be used to hold protective filters and membranes around sensor 52.
  • FIG. 6 is a schematic diagram showing a side view of a capnometer sensor and adapter 30 generally similar to that shown in Figs. 1A and 1B, but having a sensor 62 arranged adjacent a secondary parallel lumen 66 in communication with the airway passage 69. Window or opening 63 communicates to parallel lumen 66 directly, and is in only indirect communication with passage 69.
  • FIG. 7 is a schematic diagram showing a side view of a capnometer sensor and adapter generally similar to that shown in Fig.
  • Embodiments of this invention include a new sensing technology for carbon dioxide (CO 2 ) that uses nanoelectronic components.
  • CO 2 carbon dioxide
  • a tiny, low-cost nanosensor chip can offer: (i) performance that matches or exceeds that of infrared technology,
  • Fig 8. shows an electronic system 800 for detecting carbon dioxide 801 ,• comprising a nanostructure sensing device 802.
  • Device 802 comprises a substrate 804, and a nanostructure 806 disposed over the substrate.
  • the nanostructure may contact the substrate as shown, or in the alternative, may be spaced a distance away from the substrate, with or without a layer of intervening material.
  • nanostructure 806 may comprises a carbon nanotube.
  • nanostructure 806 may comprise boron, boron nitride, and carbon boron nitride, silicon, germanium, gallium nitride, zinc oxide, indium phosphide, molybdenum disulphide, silver, or any other suitable material.
  • nanostructure 806 comprises an interconnected network of smaller nanostructures.
  • nanostructure 806 may comprise a plurality of nanotubes forming a mesh.
  • Two conductive elements 808, 810 may be disposed over the substrate and electrically connected to nanostructure 806.
  • Elements 808, 810 may comprise metal electrodes in direct contact with nanostructure 806.
  • a conductive or semi-conducting material may be interposed between elements 808, 810 and nanostructure 806.
  • a functionalization material 815 reactive with carbon dioxide is disposed on nanostructure sensing device 802 and in particular, on nanostructure 806.
  • Material 815 may be deposited in a continuous layer, or in a discontinuous layer. Material 815 may comprise more than one material and/or more than one layer of material.
  • Device 802 may further comprise a gate 812.
  • Device 802 may further comprise a layer of inhibiting material 814 covering regions adjacent to the connections between the conductive elements 808, 810 and the first nanostructure 806.
  • the inhibiting material may be impermeable to at least one chemical species, such as carbon dioxide.
  • the inhibiting material may comprise a passivation material as known in the art, such as silicon dioxide. Further details concerning the use of inhibiting materials in a NTFET are described in prior Application No. 10/280,265, filed October 26, 2002, which is incorporated by reference herein.
  • system 800 may further comprise a second nanostructure sensing device (not shown) like device 802. It may be advantageous to provide the second device with ' a functionalization layer that incorporates a material different from that incorporated into layer 815.
  • System 800 may further include a nanostructure sensing device circuit 816.
  • Circuit 816 may include one or more electrical supplies 818, a meter 820 in electrical communication with the electrical supply or supplies 818, and electrical connections 822 between the first nanostructure sensing device 802 and both the electrical supply and the meter.
  • System may further comprise a signal control and processing unit (not shown) as known in the art, in communication with the first nanostructure sensing device circuit.
  • the carbon nanotube acts not as the sensing element itself but as a sensitive transducer.
  • a useful nanotube network device architecture has been described in commonly-owned Application Serial No. 10/177,929, filed on June 21, 2002, which is included by reference herein.
  • the nanotube transducers can be chemically functionalized to provide desired sensitivity and selectivity. They can even be made sensitive to a variety of inert gases.
  • the functionalization approach relies on the ability of basic inorganic compounds and organic polymers as well as aromatic compounds with electron-donating functionalities to provide electrons to nanotubes, thus resulting in n-doping of NTF.ETs.
  • Sensitivity to C0 2 can be achieved through functionalization also.
  • the functionalization layer has two main functions: 1) it selectively recognizes carbon dioxide molecules and 2) upon the binding of C0 2 it generates an amplified signal that is transferred to the carbon nanotube transducer.
  • Basic inorganic compounds e.g., sodium carbonate
  • pH-sensitive polymers such as polyaniline, poly(ethyleneimine), poly(o- phenylenediamine), poly(3-methylthiophene), and polypyrrole
  • aromatic compounds benzylamine, naphthalenemethylamine, antracene amine, pyrene amine, etc.
  • the functionalization layer can be constructed using certain polymeric materials such as polyethylene glycol, poly(vinyl alcohol) and polysaccharides, including various starches as well as their components amylose and amylopectin.
  • Materials in the functionalization layer- may be deposited on the NTFET using various different methods, depending on the material to be deposited. For example, inorganic materials, such as sodium carbonate, may be deposited by drop casting from 1mM solution in light alcohols. The functionalized sensor may then be dried by ' blowing with nitrogen or other suitable drying agent.
  • Polymeric materials may be deposited by dip coating. A typical procedure may involve soaking of the chip with the carbon nanotube device in 10% polymeric solution in water for 24 hours, rinsing with water several times, and blowing the chip dry with nitrogen.
  • FIG. 9 is a plot showing the response of an exemplary nano-electronic carbon . dioxide sensor to a range of low concentrations of carbon dioxide in air. The response to CO 2 gas is fast and reproducible at different concentrations.
  • FIG. 10 is a plot showing the response of an exemplary nano-electronic carbon dioxide sensor to a wide range concentrations of carbon dioxide in air.
  • FIG. 11 is a capnogram plot showing the response of an exemplary capnometer having aspects of the invention to simulated human breathing. The performance of the sensor at this clinically relevant condition shows the great potential for these sensors in capnography and anesthesia medical applications.
  • Capnometers having aspect of the invention may be included in many different sorts of medically useful system, both as permanent, semi-disposable, or completely disposable components. Likewise, a variety of different arrangements of the sensors, signal and power circuitry and data display and recordation subsystems are practical.
  • FIGS. 12A, 12B and 12C depict exemplary configurations of capnometer adaptors 120, 121 , and 122 having aspects of the invention, in which the output device is mounted to the adapter housing and displays a quantitative bar graph.
  • FIG. 13 depicts exemplary configurations of a capnometer adaptor 130 having aspects of the invention, in which the output device is mounted to the adapter housing and displays a both a digital reading and a quantitative bar graph.
  • FIG. 14 depicts exemplary configurations of a capnometer adaptor 140 having aspects of the invention, in which capnometer adaptor is configured to mate with a nasal canula, and to communicate with external data logging circuitry (not shown).
  • capnometer adaptors 150, 151 depict exemplary configurations of capnometer adaptors 150, 151 having aspects of the invention.
  • both of the sensor and the electronic circuitry are separately detachable from the airway adaptor housing.
  • the electronic circuitry is separately detachable from the airway adaptor housing without removing the sensor.
  • capnometers having aspects of the invention may include a wide variety of data acquisition, storage, processing and output devices.
  • the capnometer signal may be used to determine respiration rate, and inhaled gas composition, in addition to exhaled breath composition, such as end-tidal C02 values.
  • a real-time and continuous profile of breath composition may be determined and displayed, e.g as a plot of C02 concentration versus time.
  • Capnometers having aspects of the invention can be embedded into standard embodiments for breath monitoring commonly found in emergency medicine, ex: airway adapters, masks, ambubags, and laryngeal masks etc.
  • the construction of the sensor assembly is flexible to address most airway monitoring environments.
  • the sensor may be used in hospital, prehospital, and out-of-hospital settings, so as to provide highly valuable monitoring information to all health care providers whether they are doctors, nurses, respiratory technicians or EMTs.
  • the capnometers having aspects of the invention could provide significant healthcare benefits are: Endotracheal Tube Verification Breathing Quality Assessment Intra and Inter-Hospital Transport Adequacy of CPR
  • Table 1 shows example specifications of a disposable capnometer adapter having aspects of the invention, configured to provide a typical Emergency Medical Services/Emergency Department with a small, noninvasive, and disposable in-line sensor that continuously monitors varying C02 levels and delivers accurate measurement of end tidal carbon dioxide concentrations.
  • the device may have a bar graph to continuously track C02 concentration.
  • the operating lifetime of the sensor, 6 hours, is more than sufficient to accommodate long transport times.
  • Example: Technology Nanotube Sensor Display Bar Graph Range 0-6% (0-48 mm Hg) Resolution 1% (8 mm Hg) Response Time 500 ms Shelf Life 1 Year Use Life 6 Hours nal applications include:
  • Anesthesia-Capnography used to monitor adequacy of ventilation, verification of proper intubation and quality of respiration during surgical procedures requiring anesthesia. It also applies to post-op, intensive care and critical care monitoring.
  • An end tidal C02 value is a predictor of cardiac output and an indicator of adequate respiration. Many situations in the EMS could benefit from reporting of this value: cardiac arrest, respiratory arrest, trauma, seizures, shock, diabetic ketoacidosis, asthma, intra/inter hospital transport and most importantly, endotracheal tube placement.
  • JCAHO Joint Commission on Accreditation of Healthcare Organizations
  • Asthma Monitoring of C02 can assess the severity of a bronchospasm and notify successful medication or treatment. Sleep Apnea - The monitoring of C02 levels can be used to screen for apnea, the stoppage of breathing. In addition to diagnostic applications, C02 monitoring can show efficacy of therapeutic machines. Metabolic Testing - Various types of metabolic testing track expired C02 levels and volumes as a means to garner a metabolic assessment, including one's resting metabolic rate. Gastro-lntestinal Testing - C02 measurement is needed to monitor and capture alveolar respiratory gas as part of sampling for various breath testing: lactose/fructose intolerance, bacterial overgrowth, and H. Pylori (peptic ulcers).

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Abstract

Cette invention concerne un adaptateur de capnomètre (10) comprenant un capteur à nanostructure (12).
EP04815114A 2003-12-18 2004-12-20 Adaptateur pour capnometre nanoelectronique Withdrawn EP1695072A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53107903P 2003-12-18 2003-12-18
US56424804P 2004-04-20 2004-04-20
US10/940,324 US20050129573A1 (en) 2003-09-12 2004-09-13 Carbon dioxide nanoelectronic sensor
PCT/US2004/042998 WO2005062031A1 (fr) 2003-09-05 2004-12-20 Adaptateur pour capnometre nanoelectronique

Publications (2)

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EP1695072A1 true EP1695072A1 (fr) 2006-08-30
EP1695072A4 EP1695072A4 (fr) 2011-08-10

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CN109594100A (zh) * 2018-12-07 2019-04-09 东华大学 一种C3N4负载Cu/Sn合金材料及其制备和应用

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JP4926136B2 (ja) * 2008-07-18 2012-05-09 シャープ株式会社 呼気センシング装置
CN102821733B (zh) * 2010-03-26 2016-01-13 皇家飞利浦电子股份有限公司 用于监测进行中的心肺复苏的***
US9683957B2 (en) * 2013-05-29 2017-06-20 Csir Field effect transistor and a gas detector including a plurality of field effect transistors

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DE19831022A1 (de) * 1998-07-10 2000-01-13 Guenter Stemple Vorrichtung zur Bestimmung des Kohlendioxidgehaltes in ausgeatmeter Atemluft
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109594100A (zh) * 2018-12-07 2019-04-09 东华大学 一种C3N4负载Cu/Sn合金材料及其制备和应用

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EP1695072A4 (fr) 2011-08-10
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