EP1675604A1 - Capsulated herbal composition as auxilary medicament against diabetes mellitus type (i) and (ii) - Google Patents
Capsulated herbal composition as auxilary medicament against diabetes mellitus type (i) and (ii)Info
- Publication number
- EP1675604A1 EP1675604A1 EP04769072A EP04769072A EP1675604A1 EP 1675604 A1 EP1675604 A1 EP 1675604A1 EP 04769072 A EP04769072 A EP 04769072A EP 04769072 A EP04769072 A EP 04769072A EP 1675604 A1 EP1675604 A1 EP 1675604A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- root
- mixture
- tincture
- temperature
- fact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Definitions
- This invention refers to the field of pharmacy, and more closely, it refers to the medicament against diabetes mellitus type I and II, and even more precisely, it refers to the medicament against diabetes mellitus type based on a herbal composition as an active substance.
- the subject invention is marked with the classification symbol A 61 K 35/78- Medical preparations containing substances or products of their reactions with undefined composition, whereby substances from herbs are in question.
- a technical problem, the solution of which is disclosed in this patent application, consists in finding cheaper and simplier way of obtaining and optimisation of proces of production substance that is disclosed within patent application with publication No. WO 99/55351.
- Unexpectitly, obtained composition has shown improved efficiency in treatment of diabetes mellitus type II in comparation with composition described in aforsaid patent application. Also surprisigly, in contrast to composition dislosed in WO 99/55351, according to present invention obtained composition has biological activity against diabetes mellitus type I as well.
- 99/55351 comprises evaporation in the vacuum in the timely linear temperature gradient, following with, by liquid air, freezing of evaporated suspension on -186°C, with lyophilization as last step in process. It was been found that amount of obtained active substance substantially vary with small variation of timely linear temperature gradient substantially. Further, freezing of evaporated suspension on -186°C causes quality problems (namely obtained active substance in hygroscopic) and cost of production final product becomes unexpectedly high. Finally, implementetion of high pressures can cause plastic deformation of particles and deformation of intramolecular forces. As consequence biological activity can be damaged and quality fluctuation of final product, that was noticed, will be developed.
- zeolite as compound in pharmaceutical preperation disclosed in WO 99/55351 often comprises Pb2 ⁇ s. Purification of zeolite from Pb2 ⁇ 5 traces makes final product production cost higher.
- zeolite was changed by root of chicory, and instead of natural miccrocellulose in pharmaceutical preparation, according to the invention, pulvis powder of herbal composition described in patent application WO 99/55351 was charged.
- active substance is obtained from extract made from herbal composition that comprises following usitnjeni and dried ingredients:
- centaury Plant of centaury (Centaurii umbellatum, Gentianaceae) 10-15% by weight (wt.) root of dandelion (Teraxacum officinale, Asteraceae) 6-12 % by wt. fruit of juniper (Juniperi communis L., Cupresaceae) 5-8% by wt. plant of nettle (Urticae dioidca L, Urticaceae) 5- 10% by wt. root of nettle (Urticae dioica L, Urticaceae) 5-10% by wt. root of chicory (Cichorium intybus L, Cichoriaceae) 12-20% by wt.
- the active substance from the herbal composition is obtained in the following way: the herbal composition which is made of dried and ground to 40 ⁇ 5 mesh ingredients is to be covered in 60% ethanol at the room temperature. For the purpose of extraction, the mixture is left to rest for 28 days in a covered container, at the room temperature and pressure.
- the herbal tincture is then obtained by decanting the liquid above the sediment.
- the alcoholic tincture obtained in that way was exposed to whirling spray granulation, with spraying with anhydrous gas under pressure 1-3 barr, during 30-40 minutes.
- Temperature of gas is at least 10°C higher than entering temperature of the tincture. Gas was provided by two-phase nozzle. Entering tempeature of tincture is, in prefe ed embodyment of the invention, 25 ⁇ 5° C, and temperature of the gas is 48 ⁇ 3° C.
- Gas used for spraying can be oxigen.
- Active substance obtained by aforesaid process has to be mixed, until homogeneous mixture, with pulvis powder of herbal composition, root of chicory and Mg-stearate to for obtaining pharmaceutical preparation.
- Steps needed for active principle preparation and for preparation of pharmaceutical preparation are as follows:
- centaury Centaurii umbellatum, Gentianaceae 10- 15% by weight (wt.) root of dandelion (Taraxacum officinale, Asteraceae) 6- 12 % by wt. fruit of juniper (Juniperi communis L, Cupresaceae) 5-8 % by wt. plant of nettle (Urticae dioica L, Urticaceae) 5-10 % by wt. root of nettle ( Urticae dioica L, Urticaceae) 5- 10 % by wt. root of chicory (Cichorium intybus L, Cichoriaceae) 12-20 % by wt.
- Obtained alcoholic tincture is entered to apparatus for whirling spray granulation on temperature of 25 ° C.
- apparatus alcoholic tincture is to be sprayed with anhydrous air, which has a temperature around 48 ° C. Air was provided in the apparatus with two phase nozzle.
- apparatus alcoholic tincture has to be increased in density for factor 5. Spaying with air is applied under pressure of 3 barr. All procedure can be done with WSG-GLATT-50. 282 mg of alcoholic extract produces 56,4 mg dried powder of active substance.
- capsules can consist 200 mg or 480 mg pharmaceutical preparation described above.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HRP20030816AA HRP20030816B1 (en) | 2003-10-10 | 2003-10-10 | Capsulated herbal composition as auxilary medicament against diabetes mellitus type (i) and (ii) |
PCT/HR2004/000033 WO2005034973A1 (en) | 2003-10-10 | 2004-10-04 | Capsulated herbal composition as auxilary medicament against diabetes mellitus type (i) and (ii) |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1675604A1 true EP1675604A1 (en) | 2006-07-05 |
Family
ID=46210920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04769072A Withdrawn EP1675604A1 (en) | 2003-10-10 | 2004-10-04 | Capsulated herbal composition as auxilary medicament against diabetes mellitus type (i) and (ii) |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1675604A1 (en) |
HR (1) | HRP20030816B1 (en) |
WO (1) | WO2005034973A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2904935A1 (en) * | 2006-08-18 | 2008-02-22 | Centre Nat Rech Scient | ANTIDIABETIC COMPOSITION CAPABLE OF STIMULATING THE SECRETION OF INSULIN AND INTENDED FOR THE TREATMENT OF DIABETES TYPE 2 (NON-INSULIN-DEPENDENT DIABETES). |
HRP20070230B1 (en) * | 2007-05-18 | 2010-05-31 | Leko Vlado | Herbal composition for the prevention and treatmentofdiabetes mellitus type (i) and type (ii) |
CN103223016B (en) * | 2013-05-06 | 2014-09-17 | 长春三德天晟科技有限公司 | Ginseng, mulberry leaf and chicoric acid composition for treating diabetes |
CN108524571A (en) * | 2018-07-21 | 2018-09-14 | 安溪县凤城建金产品外观设计服务中心 | The technique of active ingredient in a kind of milfoil by restricted-access media |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999055351A1 (en) * | 1998-04-23 | 1999-11-04 | Vladimir Leko | Herbal composition and medicament against diabetes mellitus type ii manufactured thereof |
DE19927537A1 (en) * | 1999-06-16 | 2000-12-21 | Merck Patent Gmbh | Spray drying plant and method of using it |
-
2003
- 2003-10-10 HR HRP20030816AA patent/HRP20030816B1/en not_active IP Right Cessation
-
2004
- 2004-10-04 WO PCT/HR2004/000033 patent/WO2005034973A1/en active Application Filing
- 2004-10-04 EP EP04769072A patent/EP1675604A1/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO2005034973A1 * |
Also Published As
Publication number | Publication date |
---|---|
HRP20030816A2 (en) | 2005-06-30 |
WO2005034973A1 (en) | 2005-04-21 |
HRP20030816B1 (en) | 2012-05-31 |
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Legal Events
Date | Code | Title | Description |
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Effective date: 20051109 |
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TCAT | At: translation of patent claims filed | ||
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RBV | Designated contracting states (corrected) |
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Effective date: 20070926 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 36/14 20060101AFI20090306BHEP Ipc: A61K 36/45 20060101ALI20090306BHEP Ipc: A61K 36/282 20060101ALI20090306BHEP Ipc: A61P 3/10 20060101ALI20090306BHEP Ipc: A61K 36/48 20060101ALI20090306BHEP Ipc: A61K 36/60 20060101ALI20090306BHEP Ipc: A61K 36/84 20060101ALI20090306BHEP |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20100501 |