EP1620039A4 - Magnetically controllable drug and gene delivery stents - Google Patents

Magnetically controllable drug and gene delivery stents

Info

Publication number
EP1620039A4
EP1620039A4 EP04750256A EP04750256A EP1620039A4 EP 1620039 A4 EP1620039 A4 EP 1620039A4 EP 04750256 A EP04750256 A EP 04750256A EP 04750256 A EP04750256 A EP 04750256A EP 1620039 A4 EP1620039 A4 EP 1620039A4
Authority
EP
European Patent Office
Prior art keywords
gene delivery
magnetically controllable
controllable drug
delivery stents
stents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04750256A
Other languages
German (de)
French (fr)
Other versions
EP1620039A2 (en
Inventor
Robert J Levy
Michael Chorny
Ilia Fishbein
Ivan Alferiev
Gennady Friedman
Kenneth A Barbee
Benjamin B Yellen
Zachary G Forbes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drexel University
Childrens Hospital of Philadelphia CHOP
Original Assignee
Drexel University
Childrens Hospital of Philadelphia CHOP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drexel University, Childrens Hospital of Philadelphia CHOP filed Critical Drexel University
Priority to EP11003742.1A priority Critical patent/EP2365007B1/en
Priority to EP15002247.3A priority patent/EP2974699A1/en
Publication of EP1620039A2 publication Critical patent/EP1620039A2/en
Publication of EP1620039A4 publication Critical patent/EP1620039A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/10—Acylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/009—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof magnetic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Nanotechnology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
EP04750256A 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents Withdrawn EP1620039A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11003742.1A EP2365007B1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents
EP15002247.3A EP2974699A1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46350503P 2003-04-16 2003-04-16
US54512704P 2004-02-17 2004-02-17
US54623304P 2004-02-20 2004-02-20
PCT/US2004/011861 WO2004093643A2 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP11003742.1A Division EP2365007B1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents
EP15002247.3A Division EP2974699A1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents

Publications (2)

Publication Number Publication Date
EP1620039A2 EP1620039A2 (en) 2006-02-01
EP1620039A4 true EP1620039A4 (en) 2010-08-04

Family

ID=33314244

Family Applications (3)

Application Number Title Priority Date Filing Date
EP04750256A Withdrawn EP1620039A4 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents
EP15002247.3A Withdrawn EP2974699A1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents
EP11003742.1A Expired - Lifetime EP2365007B1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP15002247.3A Withdrawn EP2974699A1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents
EP11003742.1A Expired - Lifetime EP2365007B1 (en) 2003-04-16 2004-04-16 Magnetically controllable drug and gene delivery stents

Country Status (4)

Country Link
EP (3) EP1620039A4 (en)
AU (1) AU2004231992B2 (en)
CA (2) CA2821376A1 (en)
WO (1) WO2004093643A2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US7635734B2 (en) 2004-02-17 2009-12-22 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
US9694103B2 (en) 2003-04-16 2017-07-04 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
DE10350248A1 (en) * 2003-10-28 2005-06-16 Magnamedics Gmbh Thermosensitive, biocompatible polymer carriers with variable physical structure for therapy, diagnostics and analytics
US8465453B2 (en) 2003-12-03 2013-06-18 Mayo Foundation For Medical Education And Research Kits, apparatus and methods for magnetically coating medical devices with living cells
US20090118817A1 (en) 2005-06-16 2009-05-07 Mayo Foundation For Medical Education And Research Magnetic Medical Apparatus, Kits, and Methods
US8562505B2 (en) 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US9028829B2 (en) 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
AU2007240758C1 (en) * 2006-04-21 2013-06-27 Drexel University Magnetic targeting and sequestering of therapeutic formulations
WO2008034066A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
US8052744B2 (en) 2006-09-15 2011-11-08 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
WO2008034050A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis containing magnetic induction particles
WO2008034030A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Magnetized bioerodible endoprosthesis
DE602007010669D1 (en) 2006-12-28 2010-12-30 Boston Scient Ltd HREN FOR THIS
US8182859B2 (en) 2007-03-30 2012-05-22 Boston Scientific Scimed, Inc. Using magnetism to prepare a medical device
DE102007032688A1 (en) 2007-07-13 2009-01-22 Biotronik Vi Patent Ag Implant and system of an implant and an excitation device
WO2009010303A2 (en) * 2007-07-18 2009-01-22 Neue Magnetodyn Gmbh System for administering active substances to an organism, devices for use in said type of system and method for producing said type of devices
DE102008006402A1 (en) * 2008-01-28 2009-07-30 Magnamedics Gmbh Coated instruments for invasive medicine
GB0808090D0 (en) * 2008-05-02 2008-06-11 Iti Scotland Ltd Use of magnetic proteins in medicine
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
EP2370055A2 (en) * 2008-11-30 2011-10-05 University Of The Witwatersrand, Johannesburg Polymeric pharmaceutical dosage form in sustained release
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
CN102379762B (en) * 2011-08-02 2015-03-25 上海微创医疗器械（集团）有限公司 Biodegradable stent with groove and preparation method thereof
GB201116879D0 (en) * 2011-09-30 2011-11-16 Magnus Stent Ic Endoprosthesis
US11285211B2 (en) 2015-04-01 2022-03-29 Yale University Iron platinum particles for adherence of biologics on medical implants
CA3069671A1 (en) * 2017-06-30 2019-01-03 Otomagnetics, Inc. Magnetic nanoparticles for targeted delivery
US11648135B2 (en) 2017-09-13 2023-05-16 Boston Scientific Scimed, Inc. Coated stent
US11357620B1 (en) * 2021-09-10 2022-06-14 California LASIK & Eye, Inc. Exchangeable optics and therapeutics
WO2024113032A1 (en) * 2022-12-01 2024-06-06 Dias Maues Chrisiane System for the release and delivery of drugs targeted at specific target tissue using a multifunctional matrix of magnetic nanoparticles and application aimed at endovascular and intraorgan platforms and devices made of graphene

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775500A1 (en) * 1995-11-23 1997-05-28 Cordis Corporation Medical device visible when using magnetic resonance imaging
US20020133219A1 (en) * 2001-03-15 2002-09-19 Robert Barry Magnetic stent
US20020133225A1 (en) * 2001-03-13 2002-09-19 Gordon Lucas S. Methods and apparatuses for delivering a medical agent to a medical implant
WO2004069169A2 (en) * 2003-01-31 2004-08-19 Scimed Life Systems, Inc. Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959078A (en) 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
US4247406A (en) 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US5512329A (en) 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
JPS6210104A (en) * 1985-07-05 1987-01-19 Nitto Boseki Co Ltd Production of novel photopolymer
US5129877A (en) 1988-04-29 1992-07-14 University Of Georgia Research Foundation, Inc. Receptor-mediated delivery system
US5071909A (en) 1989-07-26 1991-12-10 Millipore Corporation Immobilization of proteins and peptides on insoluble supports
US5414075A (en) 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
ATE156706T1 (en) 1993-03-17 1997-08-15 Silica Gel Gmbh SUPERPARAMAGNETIC PARTICLES, METHOD FOR THE PRODUCTION AND USE OF THE SAME
US5665333A (en) * 1995-01-17 1997-09-09 Homola; Andrew M. Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth
US5921244A (en) * 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
US6465178B2 (en) * 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US6315709B1 (en) 1998-08-07 2001-11-13 Stereotaxis, Inc. Magnetic vascular defect treatment system
AU3471400A (en) * 1999-01-19 2000-08-07 Children's Hospital Of Philadelphia, The Compositions and methods for controlled delivery of virus vectors
US6296604B1 (en) 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6375606B1 (en) 1999-03-17 2002-04-23 Stereotaxis, Inc. Methods of and apparatus for treating vascular defects
DE10030632A1 (en) * 2000-06-29 2002-01-10 Basf Ag Antistatic polyoxymethylene molding compounds
US6939375B2 (en) * 2000-12-22 2005-09-06 Avantac Vascular Corporation Apparatus and methods for controlled substance delivery from implanted prostheses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775500A1 (en) * 1995-11-23 1997-05-28 Cordis Corporation Medical device visible when using magnetic resonance imaging
US20020133225A1 (en) * 2001-03-13 2002-09-19 Gordon Lucas S. Methods and apparatuses for delivering a medical agent to a medical implant
US20020133219A1 (en) * 2001-03-15 2002-09-19 Robert Barry Magnetic stent
WO2004069169A2 (en) * 2003-01-31 2004-08-19 Scimed Life Systems, Inc. Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same

Also Published As

Publication number Publication date
WO2004093643B1 (en) 2005-06-16
CA2522625C (en) 2013-10-01
AU2004231992B2 (en) 2011-04-21
CA2821376A1 (en) 2004-11-04
WO2004093643A2 (en) 2004-11-04
EP2365007A3 (en) 2012-05-30
EP2365007B1 (en) 2015-09-02
AU2004231992A1 (en) 2004-11-04
WO2004093643A3 (en) 2005-04-28
CA2522625A1 (en) 2004-11-04
EP1620039A2 (en) 2006-02-01
EP2365007A2 (en) 2011-09-14
EP2974699A1 (en) 2016-01-20

Similar Documents

Publication Publication Date Title
EP1620039A4 (en) Magnetically controllable drug and gene delivery stents
EP1680008A4 (en) Fixed stent delivery devices and methods
EP1804767A4 (en) Biocompatible drug delivery apparatus and methods
IL174690A0 (en) Enhanced drug delivery
IL172223A0 (en) Drug delivery systems for tumor targeting ngr-molecules and uses thereof
EP1638639A4 (en) Drug delivery device and method
GB0307082D0 (en) Drug delivery device and method
EP1793865A4 (en) Gene or drug delivery system
AU2003300202A1 (en) Drug delivery balloon catheter
EP1648327A4 (en) Oral devices and methods for controlled drug delivery
EP1667696A4 (en) Probiotic storage and delivery
IL174748A0 (en) Nanoparticles for drug delivery
PT2260892E (en) Multireservoir implantable drug delivery pumps
EP1594883A4 (en) Covalent modification of rna for in vitro and in vivo delivery
PL372323A1 (en) Implantable drug delivery system
AU2003210497A8 (en) Gene delivery system and methods of use
EP1516597A4 (en) Drug eluting stent
EP1509278A4 (en) Implantable medication delivery device
AU2003231994A8 (en) Nanoparticle delivery systems and methods of use thereof
SI1631255T1 (en) Drug delivery system
EP1781354A4 (en) An occludable intravascular catheter for drug delivery and method of using the same
GB0308986D0 (en) Nasal drug delivery
HK1080015A1 (en) Drug delivery assembly
EP1549380A4 (en) Drug delivery system and method
AU2011203100B2 (en) Magnetically controllable drug and gene delivery stents

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20051116

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
RIN1 Information on inventor provided before grant (corrected)

Inventor name: FRIEDMAN, GENNADY

Inventor name: FISHBEIN, ILIA

Inventor name: BARBEE, KENNETH, A.

Inventor name: FORBES, ZACHARY, G.

Inventor name: LEVY, ROBERT, J.

Inventor name: CHORNY, MICHAEL

Inventor name: ALFERIEV, IVAN,1341 BLACKWOOD CLEMENTON ROAD 963

Inventor name: YELLEN, BENJAMIN, B.

A4 Supplementary search report drawn up and despatched

Effective date: 20100705

17Q First examination report despatched

Effective date: 20101004

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140805