EP1605893A4 - Inhibition d'apoptose induite par un anticorps tansmembranaire - Google Patents
Inhibition d'apoptose induite par un anticorps tansmembranaireInfo
- Publication number
- EP1605893A4 EP1605893A4 EP04718110A EP04718110A EP1605893A4 EP 1605893 A4 EP1605893 A4 EP 1605893A4 EP 04718110 A EP04718110 A EP 04718110A EP 04718110 A EP04718110 A EP 04718110A EP 1605893 A4 EP1605893 A4 EP 1605893A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- apoptosis
- trans
- membrane
- induced inhibition
- antibody induced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45198003P | 2003-03-05 | 2003-03-05 | |
US451980P | 2003-03-05 | ||
PCT/US2004/006911 WO2004078146A2 (fr) | 2003-03-05 | 2004-03-05 | Inhibition d'apoptose induite par un anticorps tansmembranaire |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1605893A2 EP1605893A2 (fr) | 2005-12-21 |
EP1605893A4 true EP1605893A4 (fr) | 2008-08-13 |
Family
ID=32962675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04718110A Withdrawn EP1605893A4 (fr) | 2003-03-05 | 2004-03-05 | Inhibition d'apoptose induite par un anticorps tansmembranaire |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1605893A4 (fr) |
JP (1) | JP2006522122A (fr) |
KR (1) | KR20060006775A (fr) |
CA (1) | CA2518119A1 (fr) |
WO (1) | WO2004078146A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004049479A1 (de) * | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
EP1937814A4 (fr) | 2005-09-01 | 2010-05-05 | Ca Nat Research Council | Anticorps protéiques anti-apoptotiques |
IT1392238B1 (it) * | 2008-12-02 | 2012-02-22 | Fond Santa Lucia | Uso della caspasi-3 per la malattia dell'alzheimer |
CA2758378A1 (fr) * | 2009-04-14 | 2010-10-21 | Trojan Technologies Ltd. | Molecules therapeutiques antennapedia-anticorps et leurs procedes d'utilisation |
EP2968546B1 (fr) * | 2013-03-15 | 2023-09-20 | Omeros Corporation | Méthodes de génération d'anticorps porteurs de peptide bioactif et compositions les comprenant |
US10456475B2 (en) | 2015-02-03 | 2019-10-29 | Kennsaw State University Research and Service Foundation, Inc. | Cell penetrating protein adaptor molecules and their application in research and medicine |
US10435446B2 (en) | 2015-06-03 | 2019-10-08 | Kennesaw State University Research and Service Foundation Inc. | Cell penetrating protein adaptor molecules and their application in research and medicine |
MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
EP3411387A4 (fr) | 2016-02-03 | 2019-12-04 | Kennesaw State University Research And Services Foundation Inc. | Molécules signal utiles en tant qu'agents de pénétration cellulaire |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001060866A1 (fr) * | 2000-02-15 | 2001-08-23 | The Secretary Of State For Defence | Conjugue antiviral contenant un facteur permettant la translocation d'une proteine a travers une membrane cellulaire et presentant un fragment d'anticorps monocatenaire dirige contre une proteine virale |
US6316003B1 (en) * | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
US20020143142A1 (en) * | 1998-03-31 | 2002-10-03 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
EP1488804A1 (fr) * | 2002-03-22 | 2004-12-22 | Bipha Corporation | Complexes peptide hydrophile - immunoglobuline |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2813630B2 (ja) * | 1987-02-20 | 1998-10-22 | ジェネンテク,インコーポレイテッド | ヒト免疫不全ウイルスのエンベロープポリペプチドおよびその抗体 |
US5242824A (en) * | 1988-12-22 | 1993-09-07 | Oncogen | Monoclonal antibody to human carcinomas |
CA2395053C (fr) * | 1999-12-06 | 2012-05-29 | Agensys, Inc. | Nouveaux antigenes transmembranaires du type serpentin exprimes dans des cancers humains et utilisations de ces antigenes |
EP1317414A2 (fr) * | 2000-09-08 | 2003-06-11 | Merck Frosst Canada & Co. | Dipeptides a gamma cetoacide servant d'inhibiteurs de caspase-3 |
JP2002355077A (ja) * | 2001-02-23 | 2002-12-10 | Takeda Chem Ind Ltd | カスパーゼ3阻害剤 |
-
2004
- 2004-03-05 JP JP2006509211A patent/JP2006522122A/ja active Pending
- 2004-03-05 EP EP04718110A patent/EP1605893A4/fr not_active Withdrawn
- 2004-03-05 CA CA002518119A patent/CA2518119A1/fr not_active Abandoned
- 2004-03-05 WO PCT/US2004/006911 patent/WO2004078146A2/fr active Application Filing
- 2004-03-05 KR KR1020057016454A patent/KR20060006775A/ko not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6316003B1 (en) * | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
US20020143142A1 (en) * | 1998-03-31 | 2002-10-03 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
WO2001060866A1 (fr) * | 2000-02-15 | 2001-08-23 | The Secretary Of State For Defence | Conjugue antiviral contenant un facteur permettant la translocation d'une proteine a travers une membrane cellulaire et presentant un fragment d'anticorps monocatenaire dirige contre une proteine virale |
EP1488804A1 (fr) * | 2002-03-22 | 2004-12-22 | Bipha Corporation | Complexes peptide hydrophile - immunoglobuline |
Non-Patent Citations (4)
Title |
---|
MULLER SYBILLE ET AL: "TransMabs: cell-penetrating antibodies, the next generation", EXPERT OPINION ON BIOLOGICAL THERAPY, ASHLEY, LONDON, GB, vol. 5, no. 2, 1 February 2005 (2005-02-01), pages 237 - 241, XP008093137, ISSN: 1471-2598 * |
ROJAS M ET AL: "GENETIC ENGINEERING OF PROTEINS WITH CELL MEMBRANE PERMEABILITY", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 16, no. 4, 1 April 1998 (1998-04-01), pages 370 - 375, XP001118371, ISSN: 1087-0156 * |
STEIN S ET AL: "A disulfide conjugate between anti-tetanus antibodies and HIV (37-72)Tat neutralizes tetanus toxin inside chromaffin cells", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 458, no. 3, 24 September 1999 (1999-09-24), pages 383 - 386, XP004260296, ISSN: 0014-5793 * |
ZHAO Y ET AL: "MTS-conjugated-antiactive caspase 3 antibodies inhibit actinomycin D-induced apoptosis.", APOPTOSIS : AN INTERNATIONAL JOURNAL ON PROGRAMMED CELL DEATH DEC 2003, vol. 8, no. 6, December 2003 (2003-12-01), pages 631 - 637, XP002485667, ISSN: 1360-8185 * |
Also Published As
Publication number | Publication date |
---|---|
CA2518119A1 (fr) | 2004-09-16 |
JP2006522122A (ja) | 2006-09-28 |
WO2004078146A2 (fr) | 2004-09-16 |
WO2004078146A3 (fr) | 2006-01-05 |
KR20060006775A (ko) | 2006-01-19 |
EP1605893A2 (fr) | 2005-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20051004 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
PUAK | Availability of information related to the publication of the international search report |
Free format text: ORIGINAL CODE: 0009015 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/554 20060101ALI20060202BHEP Ipc: G01N 33/541 20060101ALI20060202BHEP Ipc: G01N 33/533 20060101ALI20060202BHEP Ipc: A61K 51/10 20060101ALI20060202BHEP Ipc: A61K 39/44 20060101ALI20060202BHEP Ipc: A61K 39/395 20060101ALI20060202BHEP Ipc: C07K 16/28 20060101ALI20060202BHEP Ipc: C07K 16/00 20060101AFI20060202BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: MORGAN, ALTON C., JR.,INNEXUS BIOTECHNOLOGY, INC. Inventor name: ZHAO, YUNFENG,C/O LSU HEALTH SCIENCE CENTER Inventor name: BROWN, THOMAS, L. Inventor name: MULLER, SYBILLE Inventor name: KOHLER, HEINZ |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20080710 |
|
17Q | First examination report despatched |
Effective date: 20081223 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090703 |