EP1569684A4 - Utilisation de fragments hmgb en tant qu'agents anti-inflammatoires - Google Patents
Utilisation de fragments hmgb en tant qu'agents anti-inflammatoiresInfo
- Publication number
- EP1569684A4 EP1569684A4 EP03789973A EP03789973A EP1569684A4 EP 1569684 A4 EP1569684 A4 EP 1569684A4 EP 03789973 A EP03789973 A EP 03789973A EP 03789973 A EP03789973 A EP 03789973A EP 1569684 A4 EP1569684 A4 EP 1569684A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- hmgb
- fragments
- inflammatory agents
- inflammatory
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42784602P | 2002-11-20 | 2002-11-20 | |
US42784102P | 2002-11-20 | 2002-11-20 | |
US427846P | 2002-11-20 | ||
US427841P | 2002-11-20 | ||
PCT/US2003/037507 WO2004046345A2 (fr) | 2002-11-20 | 2003-11-20 | Utilisation de fragments hmgb en tant qu'agents anti-inflammatoires |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1569684A2 EP1569684A2 (fr) | 2005-09-07 |
EP1569684A4 true EP1569684A4 (fr) | 2006-08-02 |
Family
ID=32329191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03789973A Withdrawn EP1569684A4 (fr) | 2002-11-20 | 2003-11-20 | Utilisation de fragments hmgb en tant qu'agents anti-inflammatoires |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1569684A4 (fr) |
JP (1) | JP2006510619A (fr) |
AU (1) | AU2003294488B2 (fr) |
CA (1) | CA2506328A1 (fr) |
NZ (1) | NZ540067A (fr) |
WO (1) | WO2004046345A2 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
WO2005025604A2 (fr) * | 2003-09-10 | 2005-03-24 | The General Hospital Corporation | Utilisation de hmgb et fragments de hmgb pour faire diminuer la reponse immunitaire specifique |
CA2538763C (fr) | 2003-09-11 | 2015-05-05 | Critical Therapeutics, Inc. | Anticorps monoclonaux diriges contre hmgb1 |
US20080305073A1 (en) * | 2004-07-02 | 2008-12-11 | Barone Domenico G | Therapeutic Agents for the Treatment of Hmgb1-Related Pathologies |
WO2006012373A2 (fr) * | 2004-07-20 | 2006-02-02 | Critical Therapeutics, Inc. | Polytherapies hmgb |
MX2007002557A (es) * | 2004-09-03 | 2007-10-10 | Creabilis Therapeutics Spa | Uso de polipeptidos obtenidos a traves de mutaciones sistematicas de aminoacidos unicos de bloque-a humano y no humano de hmgb1 para prevenir y/o antagonizar las patologias inducidas por hmgb1. |
WO2007001422A2 (fr) * | 2004-10-22 | 2007-01-04 | Medimmune, Inc. | Anticorps d'affinité élevée contre la hmgb1 et procédés d'utilisation |
EP2364998A1 (fr) * | 2005-06-16 | 2011-09-14 | The Feinstein Institute for Medical Research | Anticorps contre le HMGB1 et fragments associés |
EP1909834A2 (fr) * | 2005-07-18 | 2008-04-16 | Critical Therapeutics, Inc. | Utilisation d'antagonistes hmgb1 pour traiter des etats inflammatoires de la peau |
WO2007031100A1 (fr) * | 2005-09-14 | 2007-03-22 | Ostini, Marco | Immunothérapie active pour inflammation systémique potentiellement mortelle |
AU2006312847A1 (en) * | 2005-11-09 | 2007-05-18 | Pharmexa A/S | Therapeutic vaccines targeting HMGB1 |
US8546547B2 (en) * | 2006-09-15 | 2013-10-01 | Creabilis Therapeutics S.P.A. | Polymer conjugates of Box-A of HMGB1 and Box-A variants of HMGB1 |
US8604178B2 (en) | 2006-09-18 | 2013-12-10 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses |
JP5225109B2 (ja) | 2007-02-15 | 2013-07-03 | 国立大学法人 熊本大学 | ヒトhmgb−1に特異的に結合する抗体を有効成分として含有する治療剤 |
CN102083962B (zh) | 2008-04-30 | 2013-03-27 | 吉诺米克斯股份有限公司 | 生物体内功能性细胞的高效采集方法 |
CN102711777B (zh) | 2009-10-28 | 2015-04-15 | 吉诺米克斯股份有限公司 | 利用骨髓间充质干细胞和/或多能干细胞的血中动员的组织再生促进剂 |
DK2525817T3 (en) | 2010-01-21 | 2017-10-02 | Univ Arkansas | Vaccine vectors and methods for enhancing immune responses |
JP5746333B2 (ja) | 2010-06-09 | 2015-07-08 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | カンピロバクター感染を減少させるワクチン及び方法 |
EP3358011B1 (fr) | 2011-04-26 | 2020-03-04 | StemRIM Inc. | Peptide permettant d'induire la régénération d'un tissu et son utilisation |
DK2913059T3 (en) * | 2012-10-25 | 2018-06-25 | Genomix Co Ltd | Hitherto UNKNOWN PROCEDURE FOR TREATMENT OF SPINE INJURY USING HMGB1 FRAGMENT |
BR112015009037A2 (pt) | 2012-10-25 | 2017-11-14 | Genomix Co Ltd | composição farmacêutica para uso no tratamento de infarto do miocárdio e uso de um peptídeo de fragmento de hmgb1 |
KR20150134319A (ko) | 2013-01-28 | 2015-12-01 | 에베크 인코포레이티드 | 인간화 항 hmgb1 항체 또는 그의 항원 결합성 단편 |
PT2956165T (pt) | 2013-02-14 | 2019-11-29 | Texas A & M Univ Sys | Composições e métodos de potenciação das respostas imunitárias frente a eimeria ou limitação de uma infeção por eimeria |
US10376571B2 (en) | 2013-03-15 | 2019-08-13 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to enteric pathogens |
EP3452069A4 (fr) | 2016-05-03 | 2020-02-12 | The Board of Trustees of the University of Arkansas | Vecteur vaccinal de levure comprenant des polypeptides immunostimulants et antigéniques et ses procédés d'utilisation |
WO2018139562A1 (fr) | 2017-01-27 | 2018-08-02 | 株式会社ジェノミックス | Agent thérapeutique pour les cardiomyopathies, l'infarctus du myocarde ancien et l'insuffisance cardiaque chronique |
US11746136B2 (en) | 2017-03-15 | 2023-09-05 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
US11298403B2 (en) | 2017-12-01 | 2022-04-12 | StemRIM Inc. | Therapeutic agent for inflammatory bowel disease |
EP3750553A4 (fr) * | 2018-02-08 | 2022-01-12 | Stemrim Inc. | Agent thérapeutique contre le psoriasis |
CN112823038A (zh) * | 2018-10-05 | 2021-05-18 | 国家儿童医院研究所 | 用于移除生物膜的hmgb1蛋白衍生物 |
CN111743890A (zh) * | 2019-03-26 | 2020-10-09 | 深圳先进技术研究院 | 水绫霉素或其衍生物的用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1033401A2 (fr) * | 1999-02-26 | 2000-09-06 | Genset | Marqueurs de séquence exprimées et protéines humaines codées |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
-
2003
- 2003-11-20 AU AU2003294488A patent/AU2003294488B2/en not_active Ceased
- 2003-11-20 NZ NZ540067A patent/NZ540067A/en not_active IP Right Cessation
- 2003-11-20 CA CA002506328A patent/CA2506328A1/fr not_active Abandoned
- 2003-11-20 WO PCT/US2003/037507 patent/WO2004046345A2/fr active IP Right Grant
- 2003-11-20 EP EP03789973A patent/EP1569684A4/fr not_active Withdrawn
- 2003-11-20 JP JP2004554020A patent/JP2006510619A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1033401A2 (fr) * | 1999-02-26 | 2000-09-06 | Genset | Marqueurs de séquence exprimées et protéines humaines codées |
Non-Patent Citations (4)
Title |
---|
DAILEY LISA ET AL: "Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 186, no. 3, March 2001 (2001-03-01), pages 315 - 328, XP002373261, ISSN: 0021-9541 * |
DATABASE Geneseq [online] 6 October 2000 (2000-10-06), "Human secreted protein, SEQ ID NO: 7904.", XP002373264, retrieved from EBI accession no. GSN:AAG03823 Database accession no. AAG03823 * |
ROGALLA P ET AL: "Mapping and molecular characterization of five HMG1-related DNA sequences", CYTOGENETICS AND CELL GENETICS, vol. 83, no. 1-2, 1998, pages 124 - 129, XP009063822, ISSN: 0301-0171 * |
YANG HUAN ET AL: "Reversing established sepsis with antagonists of endogenous high-mobility group box 1.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, no. 1, 6 January 2004 (2004-01-06), pages 296 - 301, XP002373262, ISSN: 0027-8424 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003294488B2 (en) | 2007-05-24 |
AU2003294488A1 (en) | 2004-06-15 |
NZ540067A (en) | 2007-05-31 |
JP2006510619A (ja) | 2006-03-30 |
EP1569684A2 (fr) | 2005-09-07 |
WO2004046345A2 (fr) | 2004-06-03 |
WO2004046345A3 (fr) | 2004-12-02 |
CA2506328A1 (fr) | 2004-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20050616 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060630 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: O'KEEFE, THERESA, L. Inventor name: NEWMAN, WALTER |
|
17Q | First examination report despatched |
Effective date: 20080818 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20081230 |