EP1539206A1 - Kosmetische oder dermatologische zubereitungen mit einem gehalt an anti-freezing proteinen und/oder anti-freezing glycoproteinen - Google Patents
Kosmetische oder dermatologische zubereitungen mit einem gehalt an anti-freezing proteinen und/oder anti-freezing glycoproteinenInfo
- Publication number
- EP1539206A1 EP1539206A1 EP02774582A EP02774582A EP1539206A1 EP 1539206 A1 EP1539206 A1 EP 1539206A1 EP 02774582 A EP02774582 A EP 02774582A EP 02774582 A EP02774582 A EP 02774582A EP 1539206 A1 EP1539206 A1 EP 1539206A1
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- EP
- European Patent Office
- Prior art keywords
- skin
- freezing
- cosmetic
- preparations
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/0229—Sticks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- Cosmetic or dermatological preparations containing anti-freezing proteins and / or anti-freezing glycoproteins are included in Cosmetic or dermatological preparations containing anti-freezing proteins and / or anti-freezing glycoproteins
- the present invention relates to cosmetic or dermatological preparations containing one or more "anti-freezing proteins” (hereinafter also called AFP) and / or one or more "anti-freezing glycoproteins”. (hereinafter also called AFGP)
- AFP anti-freezing proteins
- AFGP anti-freezing glycoproteins
- the invention relates to cosmetic or dermatological preparations for the prophylaxis against degenerative skin symptoms and treatment of cold-related structural and cell damage in the skin which, in the event of clear, climate- and weather-induced temperature decreases in the cell and in the extracellular space, due to loss of the temperature optima of cellular enzymes, Changes in cell physiology cause, also for the prophylaxis and / or treatment of sensitive and dry skin, against itching and to protect the skin, lips and mouth and nose mucosa and the appendages of the skin against harmful environmental influences.
- the present invention relates to cosmetic preparations with effective protection against harmful environmental influences, such as cold, heat, strong temperature fluctuations, UV light, smog, oxidation processes in the skin, but also for additional protection of cosmetic preparations themselves or for additional protection the components of cosmetic preparations against harmful oxidation processes and influences due to unfavorable temperature changes
- Cosmetic skin care and skin protection should primarily be understood to mean that the natural function of the skin acts as a barrier against environmental influences (e.g. dirt, chemicals, microorganisms, micro-organisms, unphysiological temperatures) and against the loss of the body's own substances (e.g. water, natural fats, electrolytes) is strengthened, preserved or restored.
- environmental influences e.g. dirt, chemicals, microorganisms, micro-organisms, unphysiological temperatures
- the loss of the body's own substances e.g. water, natural fats, electrolytes
- the aim of skin care is also to compensate for the loss of fat and water in the skin caused by daily washing. This is especially important when the natural regeneration ability is insufficient.
- skin care products are intended to protect against environmental influences, especially sun and wind, and to delay skin aging.
- the chronological skin aging is e.g. B. caused by endogenous, genetically determined factors.
- the epidermis and dermis it occurs due to aging e.g. B. the following structural damage and malfunctions, which can also fall under the term "senile xerosis":
- Exogenous factors such as unphysiological temperatures, strong temperature fluctuations, wind, UV light and chemical noxious substances can be cumulatively effective.
- Exogenous factors such as unphysiological temperatures, strong temperature fluctuations, wind, UV light and chemical noxious substances can be cumulatively effective.
- the epidermis and dermis it comes in particular due to the exogenous factors mentioned for B. to the following structural damage and functional disorders in the skin:
- UVC range rays with a wavelength shorter than 290 nm
- UVB range rays in the range between 290 nm and 320 nm, the so-called UVB range, cause erythema simple sunburn or even more or less severe burns.
- the narrower range around 308 nm is given as a maximum of the erythema effectiveness of sunlight. .
- Numerous compounds are known for protection against UVB radiation, which are derivatives of 3-benzylidene camphor, 4-aminobenzoic acid, cinnamic acid, salicylic acid, benzophenone and also 2-phenylbenzimidazole.
- UVA range It is also important to have filter substances available for the range between about 320 nm and about 400 nm, the so-called UVA range, since their rays can cause reactions in light-sensitive skin. It has been proven that UVA radiation leads to damage to the elastic and collagen fibers of the connective tissue, which causes the skin to age prematurely, and that it is to be seen as the cause of numerous phototoxic and photoallergic reactions. The damaging influence of UVB radiation can be intensified by UVA radiation.
- UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products interfere with the skin's metabolism.
- Such photochemical reaction products are predominantly free radical compounds, for example hydroxy radicals. Even undefined radicals Due to their high reactivity, photo products that are created in the skin itself can display uncontrolled subsequent reactions.
- singlet oxygen a non-radical excited state of the oxygen molecule can occur with UV radiation, just as short-lived epoxies and many others.
- Singlet oxygen for example, is characterized by increased reactivity compared to the triplet oxygen that is normally present (radical ground state). However, there are also excited, reactive (radical) triplet states of the oxygen molecule.
- UV radiation also belongs to ionizing radiation. There is therefore a risk that ionic species also develop when exposed to UV, which in turn can then oxidatively intervene in the biochemical processes.
- antioxidants and / or free radical scavengers can be incorporated into the cosmetic or dermatological formulations.
- vitamin E a substance with a known antioxidant effect, in light protection formulations, but the effect achieved here also falls far short of the hoped-for effect.
- Antioxidants are mainly used as protective substances against the spoilage of the preparations containing them. Nevertheless, it is known that undesirable oxidation processes can also occur in human and animal skin.
- antioxidants and / or free radical scavengers can be incorporated into cosmetic or dermatological formulations.
- antioxidants and radical scavengers are known. So already in the US 4,144,325 and 4,248,861 and numerous other documents have suggested that vitamin E, a substance with a known antioxidant effect, be used in sunscreen formulations, but the effect achieved here still falls far short of the hoped-for effect.
- the object of the present invention was therefore to provide cosmetic, dermatological and pharmaceutical active ingredients and preparations and light protection formulations which serve to protect and treat light- and temperature-sensitive skin, in particular of skin areas which are intensively exposed to environmental influences, such as, for. B. Skin areas of the face, lips, nose, forehead, eyes, head, beaulleté and hands and arms.
- Another object of the present invention was therefore to avoid the disadvantages of the prior art and, in particular, to eliminate or prevent the damage caused by environmental noxes permanently, sustainably and without the risk of side effects.
- antifreezing proteins refers to proteins that enable an organism to functionally keep important cell structures functionally active even under extreme temperature conditions. In understanding this function, “antifreezing proteins” in this sense represent “antifreeze compounds” at the cellular level.
- the best studied antifreezing glycoproteins come from arctic fish such as Trematomas borgrevinki and Dissostichus mawsoni, and from Nordic fish such as Boreogadus saida and Gadus morhua.
- the best investigated type 1 antifreezing proteins come from the Pseudopleuronectes americanus, Myoxocephalus scorpius, Myoxocephalus aenaeus, Myoxocephalus scorpiodes ⁇ es type 2 from the Hemitripterus americanus, Osmerus mordax and Clupea harengus harengusi, rhodophila arcesarea, American type deracillus, and the type 3 American , lycodes polaris and the "Wolffish" Anarhichas lupus and type 4 from Myoxocephalus octodecimspinosis.
- AFPs are represented by the following amino acid sequences (source: Ananthanarayanan VS: Antifreeze proteins: structural diversity and mechanisms of action. Life Chem Rep 7: 1-32, 1989)
- Cosmetic or dermatological preparations according to the invention containing AFP and / or AFGP are extremely satisfactory preparations in every respect.
- the preparations according to the invention better protect against cold-related structural and cell damage in the skin, better maintain or restore the barrier properties of the skin, counteract dehydration better, act better against pigment disorders, work better against inflammatory skin conditions work better against skin aging and - protect the skin better from environmental influences than the preparations of the prior art.
- AFP and / or AFGP or cosmetic or topical dermatological preparations with an effective AFP and / or AFGP content is surprisingly an effective treatment, but also a prophylaxis against cold-related structural and cell damage in the skin, which helps significant, climate and weather-induced temperature decreases in the cell and in the extracellular space caused by changes in the temperature optima of cellular enzymes cause changes in cell physiology.
- AFP and / or AFGP or cosmetic or topical dermatological preparations with an effective AFP and / or AFGP content is surprisingly an effective treatment, but also a prophylaxis of deficient, sensitive or hypoactive skin conditions or deficient, sensitive or hypoactive conditions of skin appendages from signs of premature aging of the skin (eg wrinkles, age spots, telangiectasias) and / or skin appendages, of environmental ones (smoking, smog, reactive oxygen species, free radicals) and in particular light-related negative changes of the skin and skin appendages. - from light-related skin damage, pigmentation disorders, sensitive, irritated and itchy skin, from dry skin conditions and horny layer barrier disorders, - from hair loss and for improved hair growth
- Signs of aging such as B. wrinkles and reduced skin regeneration, inflammatory skin conditions as well as atopic eczema, seborrheic eczema, polymorphic light dermatosis, psoriasis, vitiligo to calm sensitive or irritated skin - to stimulate collagen, hyaluronic acid, elastin synthesis
- AFP and / or AFGP for the prophylaxis and treatment of inflammatory skin conditions - including atopic eczema - and / or for skin protection in the case of sensitive, determined and dry skin is also in accordance with the invention.
- cosmetic or dermatological preparations for the production of cosmetic or dermatological preparations for the treatment and / or prophylaxis of pigmentation disorders is also in accordance with the invention.
- AFP and / or AFGP for the production of cosmetic or dermatological preparations for increasing ceramide biosynthesis is also according to the invention.
- AFP and / or AFGP for the production of cosmetic or dermatological preparations for strengthening the barrier function of the skin is also according to the invention.
- Cosmetic or dermatological preparations according to the invention preferably contain 0.0001 to 50% by weight, particularly preferably 0.01 to 10% by weight, of the named th AFP and / or AFGP or a combination of two or more of the aforementioned AFP and / or AFGP, based on the total composition of the preparations.
- AFP and / or AFGP or cosmetic or topical dermatological preparations with an effective content of AFP and / or AFGP for cosmetic or dermatological treatment or prophylaxis of undesirable skin conditions.
- preparations containing the active compound combinations according to the invention, customary antioxidants can be used.
- the antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan, ⁇ -alanine) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L- Carnosine, D-carnosine, L-carosene and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. ⁇ -carotene, ß-carotene, lycopene) and their derivatives, lipoic acid and its derivatives (e.g.
- amino acids e.g. glycine, histidine, tyrosine, tryptophan, ⁇ -alanine
- imidazoles e.g. urocanic acid
- peptides such as D, L- Carnosine, D-carnosine, L-carosene and their derivatives (e.g
- thiols e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl- , Amyl, butyl and lauryl, palmitoyl, oleyl, ⁇ -linoleyl, cholesteryl and glyceryl esters
- salts dilaurylthiodipropionate, distearylthiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g.
- buthionine sulfoximines in very low tolerable doses (e.g. B. pmol to ⁇ mol / kg), further (metal) chelators (e.g. ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), ⁇ -hydroxy acids (e.g.
- citric acid citric acid, lactic acid, malic acid
- humic acid bile acid
- Bile extracts bilirubin, biliverdin, EDTA, EGTA and their derivatives
- unsaturated fatty acids and their derivatives eg ⁇ -linolenic acid, linoleic acid, oleic acid
- folic acid and their derivatives unsaturated fatty acids and their derivatives (eg ⁇ -linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, alanine diacetic acid, flavonoids, polyphenols, catechins, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), toeopherols and derivatives (e.g.
- vitamin E acetate vitamin E acetate
- the amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 1 to 10% by weight, based on the total weight of the preparation ,
- the active compounds according to the invention for. B. as a so-called solid lipid nanoparts with the help of melted waxes, which among other things, but not exclusively, can be selected from the group of ester waxes, triglyceride waxes or hydrocarbon waxes.
- the prophylaxis or the cosmetic or dermatological treatment with the active ingredient used according to the invention or with the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention is carried out in the usual manner, in such a way that the active ingredient or the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention are applied to the affected skin areas.
- the active ingredient used according to the invention can advantageously be incorporated into customary cosmetic and dermatological preparations, which can be in various forms. So you can z. B. a solution, an emulsion of the water-in-oil (W / O) or of the oil-in-water (O / W) type, or a multiple emulsions, for example of the water-in-oil-in-water type (W / O / W) or oil-in-water-in-oil (O ⁇ / V / O), a hydro-dispersion or lipodispersion, a gel, a Pickering emulsion, a solid stick or an aerosol.
- Emulsions according to the invention in the sense of the present invention, for. B.
- Medical topical compositions in the sense of the present invention generally contain one or more medicaments in an effective concentration.
- medicaments in an effective concentration.
- Cosmetic or topical dermatological compositions can accordingly In the sense of the present invention, depending on their structure, they are used, for example, as skin protection cream, cleansing milk, sunscreen lotion, nutritional cream, day or night cream, lip balm, nasal spray, etc. It may be possible and advantageous to use the compositions according to the invention as the basis for pharmaceutical formulations ,
- UV-A or UV-B filter substances are usually incorporated into day creams or makeup products.
- UV protective substances like antioxidants and, if desired, preservatives, also provide effective protection of the preparations themselves against spoilage.
- Cosmetic and dermatological preparations which are in the form of a sunscreen are also favorable.
- the preparations preferably contain, in addition to one or more active ingredients used according to the invention, at least one further UV-A and / or UV-B filter substance.
- the formulations may, although not necessary, optionally also contain one or more organic and / or inorganic pigments as UV filter substances, which may be present in the water and / or the oil phase.
- Preferred inorganic pigments are metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular oxides of titanium (TiO 2 ), zinc (ZnO), iron (e.g. Fe 2 O 3 ), zirconium (ZrO 2 ), silicon ( SiO 2 ), manganese (e.g. MnO), aluminum (Al 2 O 3 ), cerium (e.g. Ce 2 O 3 ), mixed oxides of the corresponding metals and mixtures of such oxides.
- such pigments can advantageously be surface-treated (“coated”), with an amphiphilic or hydrophobic character, for example, being formed or retained.
- This surface treatment can consist in that the pigments are coated with a thin film using methods known per se hydrophobic layer.
- TiO 2 pigments coated with aluminum stearate e.g. B. those available under the trade name MT 100 T from TAYCA.
- Another advantageous coating of the inorganic pigments consists of dimethylpolysiloxane (also: dimethicone), a mixture of fully methylated, linear siloxane polymers which are blocked at the end with trimethylsiloxy units.
- Zinc oxide pigments which are coated in this way are particularly advantageous for the purposes of the present invention.
- the inorganic pigments are also advantageous to coat with a mixture of dimethylpolysiloxane, in particular dimethylpolysiloxane with an average chain length of 200 to 350 dimethylsiloxane units, and silica gel, which is also referred to as simethicone. It is particularly advantageous if the inorganic pigments are additionally coated with aluminum hydroxide or aluminum oxide hydrate (also: alumina, CAS no .: 1333-84-2). Titanium dioxides coated with simethicone and alumina are particularly advantageous, the coating also being able to contain water. An example of this is the titanium dioxide available from Merck under the trade name Eusolex T2000.
- An advantageous organic pigment for the purposes of the present invention is 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol) [INCI: Bisoctyl-triazolj, which is available under the trade name Tinosorb® M from CIBA-Chemicals GmbH.
- Preparations according to the invention advantageously contain substances which absorb UV radiation in the UV-A and / or UV-B range, the total amount of the filter substances, for. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 20 wt .-%, in particular 1.0 to 15.0 wt .-%, based on the total weight of the preparations to cosmetic
- 0.1 wt .-% to 30 wt .-% preferably 0.5 to 20 wt .-%, in particular 1.0 to 15.0 wt .-%
- UV-A filter substances for the purposes of the present invention are dibenzoyl methane derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol brand ® 1789 and is sold by Merck under the trade name Eusolex® 9020.
- dibenzoyl methane derivatives in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol brand ® 1789 and is sold by Merck under the trade name Eusolex® 9020.
- UV-A filter substances are the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts, especially the corresponding sodium, potassium or triethanolammonium salts , in particular the phenylene-1,4-bis (2-benzimizazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt with the INCI name bisimidazylate, which, for example, under the trade name Neo Heliopan AP is available from Haarmann & Reimer.
- 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene and its salts especially the corresponding 10-sulfato compounds, especially the corresponding sodium, potassium or triethanolammonium salt
- benzene-1,4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid especially the corresponding sodium, potassium or triethanolammonium salt
- Advantageous UV filter substances in the sense of the present invention are also so-called broadband filters, i.e. Filter substances that absorb both UV-A and UV-B radiation.
- Advantageous broadband filters or UV-B filter substances are, for example, bis-resorcinyltriazine derivatives.
- Particularly advantageous preparations within the meaning of the present invention which are distinguished by a high or very high UV-A protection, preferably contain a plurality of UV-A and / or broadband filters, in particular dibenzoylmethane derivatives [for example 4- (tert-butyl) -4'-methoxydibenzoylmethane], benzotriazole derivatives [both for example 2,2'-methylene-bis- (6- (2H-benzotriazoI-2-yl) -4- (1, 1, 3,3-tetramethylbutyl) phenol)], phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and / or its salts, the 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene and / or its salts and / or the 2,4-bis - ⁇ [4- (2-ethylhexyloxy) -2
- UV filter substances which the structural motif
- UV filter substances for the purposes of the present invention, for example the s-triazine derivatives described in European patent application EP 570838 A1, the chemical structure of which is given by the generic formula
- R represents a branched or unbranched G, -C 18 -alkyl radical, a C 5 -C 12 -cycloalkyl radical, optionally substituted by one or more C., - C 4 -alkyl groups
- X represents an oxygen atom or an NH group
- R. a branched or unbranched CrC ⁇ alkyl radical, a C 5 -C 12 cycloalkyl radical, optionally substituted with one or more C, -C 4 alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula
- A represents a branched or unbranched G, -C 18 alkyl radical, a C 5 -C 12 cycloalkyl or aryl radical, optionally substituted by one or more C r C 4 alkyl groups,
- R 3 represents a hydrogen atom or a methyl group, n represents a number from 1 to 10,
- R 2 represents a branched or unbranched C 1 -C 18 alkyl radical, a C 5 -C 12 cycloalkyl radical, optionally substituted by one or more C 1 -C 4 alkyl groups, if X represents the NH group, and a branched or unbranched C 1 -C 18 alkyl radical, a C 5 -C 12 cycloalkyl radical, optionally substituted with one or more CC 4 alkyl groups, or a
- Hydrogen atom an alkali metal atom, an ammonium group or a group of the formula
- A represents a branched or unbranched CC ⁇ alkyl radical, a C 5 -C 12 cycloalkyl or aryl radical, optionally substituted by one or more C r C 4 alkyl groups,
- R 3 represents a hydrogen atom or a methyl group
- n represents a number from 1 to 10 when X represents an oxygen atom.
- a particularly preferred UV filter substance in the sense of the present invention is also an asymmetrically substituted s-triazine, the chemical structure of which is represented by the formula
- dioctylbutylamidotriazon (INCI: Dictylbutamidotriazone) and is available under the trade name UVASORB HEB from Sigma 3V.
- a symmetrically substituted s-triazine which is 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) tris-benzoic acid tris (2- ethylhexyl ester), synonymous: 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: octyl triazone) , which is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150.
- Also advantageous for the purposes of the present invention are 2,4-bis - ⁇ [4- (3-sulfonato) -2-hydroxypropyloxy) -2-hydroxy] phenyl ⁇ -6- (4-methoxyphenyl) -1, 3,5-triazine sodium salt, the 2,4-bis - ⁇ [4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy] phenyl ⁇ -6- (4-methoxyphenyl ) -1, 3,5-triazine, the 2,4-bis - ⁇ [4- (2-ethylhexyloxy) -2-hydroxy] phenyl ⁇ -6- [4- (2-methoxyethyl carboxyl ) -phenylamino] -1, 3,5-triazine, the 2,4-bis - ⁇ [4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxyJ-phenyl ⁇ -6- [ 4
- An advantageous broadband filter in the sense of the present invention is the 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol), which is available under the trade name Tinosorb® M from CIBA-Chemicals GmbH.
- Another advantageous broadband filter in the sense of the present invention is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1, 3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane.
- the UV-B and / or broadband filters can be oil-soluble or water-soluble.
- Advantageous oil-soluble UV-B and / or broadband filter substances are e.g. B .: ⁇ 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
- 4-aminobenzoic acid derivatives preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester; 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine;
- esters of benzalmalonic acid preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester;
- esters of cinnamic acid preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
- benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone
- Advantageous water-soluble UV-B and / or broadband filter substances are e.g.
- ⁇ salts of 2-phenylbenzimidazole-5-sulfonic acid such as its sodium, potassium or triethanolammonium salt, and the sulfonic acid itself;
- a concentratedre Lichtsehutzfiltersubstanz according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenylacrylate, obtainable (octocrylene) from BASF under the name Uvinul ® N 539th
- the preparations according to the invention advantageously contain the substances which absorb UV radiation in the UV-A and / or UV-B range in a total amount of, for. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 20 wt .-%, in particular 1.0 to 15.0 wt .-%, each based on the total weight of the preparations to cosmetic
- 0.1 wt .-% to 30 wt .-% preferably 0.5 to 20 wt .-%, in particular 1.0 to 15.0 wt .-%, each based on the total weight of the preparations to cosmetic
- the cosmetic and dermatological preparations according to the invention can contain cosmetic active ingredients, auxiliaries and / or additives, as are usually used in such preparations, e.g. B. antioxidants, preservatives, bactericides, perfumes, anti-foaming substances, dyes, pigments that have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other common ingredients a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.
- cosmetic active ingredients e.g. B. antioxidants, preservatives, bactericides, perfumes, anti-foaming substances, dyes, pigments that have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other common ingredients
- the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion
- the following can be used as solvents: • Water or aqueous solutions
- oils such as triglycerides of capric or caprylic acid, but preferably castor oil;
- Fats, waxes and other natural and synthetic fat bodies preferably esters of fatty acids with alcohols of low C number, e.g. B. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with low C number alkanoic acids or with fatty acids;
- alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or mono butyl ether, diethylene glycol monomethyl or monoethyl ether and analog products.
- Water can also be a component of alcoholic solvents.
- the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the sense of the present invention is advantageously selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms, from the group of the esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms. atoms.
- ester oils can then advantageously be selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl ethylate, 2-ethylhexyl ethylate, 2-ethylhexyl ethylate -Octyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, erucylerucate and synthetic, semi-synthetic and natural mixtures of such esters, e.g. B. Jojoba oil.
- the oil phase can advantageously be chosen from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and also the fatty acid triglycerides, especially the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12 - 18 carbon atoms.
- the fatty acid triglycerides can, for example, advantageously be selected from the group of synthetic, semi-synthetic and natural oils, e.g. B. olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
- oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyldecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12 . 15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.
- hydrocarbons paraffin oil, squalane and squalene can be used advantageously for the purposes of the present invention.
- the oil phase can also advantageously contain cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.
- Cyclomethicone (octamethylcyclotetrasiloxane) is advantageously used as the silicone oil to be used according to the invention.
- other silicone oils can also be used advantageously for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
- the aqueous phase of the preparations according to the invention optionally advantageously contains alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether , Ethylene glycol monomethyl or monoethyl ether and analog products, furthermore alcohols of low C number, e.g.
- isopropanol, 1,2-propanediol, glycerol and in particular one or more thickeners which or which can advantageously be selected from the group consisting of silicon dioxide, aluminum silicates, polysaccharides and their de- derivatives, e.g. B. hyaluronic acid, xanthan gum, hydroxypropylmethyl cellulose, particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopoles, for example carbopoles of types 980, 981, 1382, 2984, 5984, each individually or in combination.
- thickeners which or which can advantageously be selected from the group consisting of silicon dioxide, aluminum silicates, polysaccharides and their de- derivatives, e.g. B. hyaluronic acid, xanthan gum, hydroxypropylmethyl cellulose, particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopoles,
- Gels used according to the invention usually contain alcohols of low C number, e.g. Example, ethanol, isopropanol, 1,2-propanediol, glycerol and water or an oil mentioned above in the presence of a thickener, which is preferably silicon dioxide or an aluminum silicate in the case of oily-alcoholic gels, preferably a polyacrylate in the case of aqueous-alcoholic or alcoholic gels is.
- a thickener which is preferably silicon dioxide or an aluminum silicate in the case of oily-alcoholic gels, preferably a polyacrylate in the case of aqueous-alcoholic or alcoholic gels is.
- Fixed pens contain e.g. B. natural or synthetic waxes, fatty alcohols or fatty acid esters.
- Usual base materials which are suitable for use as cosmetic sticks in the sense of the present invention are liquid oils (e.g. paraffin oils, castor oil, isopropyl myristate), semi-solid components (e.g. petroleum jelly, lanolin), solid components (e.g. beeswax, ceresin and microcrystalline waxes or ozokerite) and high-melting waxes (e.g. carnauba wax, candelilla wax)
- liquid oils e.g. paraffin oils, castor oil, isopropyl myristate
- semi-solid components e.g. petroleum jelly, lanolin
- solid components e.g. beeswax, ceresin and microcrystalline waxes or ozokerite
- high-melting waxes e.g. carnauba wax, candelilla wax
- Suitable blowing agents for cosmetic and / or dermatological preparations which can be sprayed from aerosol containers for the purposes of the present invention are the customarily known volatile, liquefied blowing agents, for example hydrocarbons (propane, butane, isobutane), which can be used alone or in a mixture with one another. Compressed air can also be used advantageously.
- volatile, liquefied blowing agents for example hydrocarbons (propane, butane, isobutane)
- Cosmetic preparations in the sense of the present invention can also be used as gels are present, which in addition to an effective content of the active ingredient according to the invention and solvents usually used for this purpose, preferably water, still organic thickeners, for.
- B. aluminum silicates such as bentonite, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
- the thickener is in the gel e.g. B. in an amount between 0.1 and 30 wt .-%, preferably between 0.5 and 15 wt .-%.
- the cosmetic or dermatological preparations according to the invention contain further active substances, in particular natural active substances and / or their derivatives, such as, for example, B. alpha-lipoic acid, phytoene, D-biotin, coenzyme Q10, alpha glucosylrutin, camitin, carnosine, osmolyte, clover extract, hop or hop malt extract.
- active substances in particular natural active substances and / or their derivatives, such as, for example, B. alpha-lipoic acid, phytoene, D-biotin, coenzyme Q10, alpha glucosylrutin, camitin, carnosine, osmolyte, clover extract, hop or hop malt extract.
- the content of these active ingredients is advantageously selected from the range from 0.0001 to 30% by weight, based on the total weight of the preparations.
- AFP and / or AFGP i.e. anti-freezing proteins and anti-freezing glycoproteins in particular being understood here to mean one or more of the substances mentioned above.
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
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Abstract
Description
Claims
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2002/010044 WO2004022081A1 (de) | 2002-09-07 | 2002-09-07 | Kosmetische oder dermatologische zubereitungen mit einem gehalt an anti-freezing proteinen und/oder anti-freezing glycoproteinen |
Publications (1)
Publication Number | Publication Date |
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EP1539206A1 true EP1539206A1 (de) | 2005-06-15 |
Family
ID=31970251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP02774582A Withdrawn EP1539206A1 (de) | 2002-09-07 | 2002-09-07 | Kosmetische oder dermatologische zubereitungen mit einem gehalt an anti-freezing proteinen und/oder anti-freezing glycoproteinen |
Country Status (3)
Country | Link |
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US (1) | US20060008440A1 (de) |
EP (1) | EP1539206A1 (de) |
WO (1) | WO2004022081A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101700711B1 (ko) * | 2007-11-21 | 2017-01-31 | 로스킬드 유니베르시테트 | 얼음-결합 활성을 포함하는 폴리펩티드 |
CN102112219A (zh) * | 2008-07-31 | 2011-06-29 | 溶胶凝胶技术公司 | 包含有效成分和金属氧化物壳的微胶囊,其制备方法及其用途 |
JP5123333B2 (ja) * | 2010-01-26 | 2013-01-23 | 株式会社 資生堂 | 油中水型乳化日焼け止め化粧料 |
WO2017072103A1 (en) * | 2015-10-26 | 2017-05-04 | Basf Se | Oral care products and methods comprising hlps |
MX2018005201A (es) * | 2015-10-26 | 2018-07-06 | Basf Se | Productos para el cuidado bucal y metodos que comprenden afp. |
KR101678392B1 (ko) | 2016-09-30 | 2016-11-22 | (주)넥스젠바이오텍 | 항산화 기능 및 피부 세포 증식 효과가 증가된 부동화 단백질 및 인간 상피세포성장인자를 포함하는 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선용 화장료 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975272A (en) * | 1976-11-10 | 1990-12-04 | Voyt Walter F | Method of and composition for the prevention of solar radiation exposure-induced formation of carcinogenic skin lipid degradation products |
US4144325A (en) * | 1976-11-10 | 1979-03-13 | Voyt Walter F | Method of and composition for preventing sunburn while affording tanning |
US4248861A (en) * | 1979-02-21 | 1981-02-03 | Schutt Steven R | Skin treatment methods |
US5190762A (en) * | 1988-07-06 | 1993-03-02 | Applied Genetics, Inc. | Method of administering proteins to living skin cells |
US5358931A (en) * | 1990-01-17 | 1994-10-25 | The Regents Of The University Of California | Interaction of thermal hysteresis proteins with cells and cell membranes and associated applications |
ATE165208T1 (de) * | 1990-01-17 | 1998-05-15 | Univ California | Zusammensetzung zur verbesserung der lebenserhaltung biologischer materialien |
GB9110123D0 (en) * | 1991-05-10 | 1991-07-03 | Dow Corning | Organosilicon compounds their preparation and use |
IT1255729B (it) * | 1992-05-19 | 1995-11-15 | Giuseppe Raspanti | Derivati di s-triazina come agenti fotostabilizzanti |
DE19543730A1 (de) * | 1995-11-23 | 1997-05-28 | Ciba Geigy Ag | Bis-Resorcinyl-Triazine |
WO2001094378A1 (en) * | 2000-06-08 | 2001-12-13 | The Research Foundation Of State University Of New York | Nucleic acid sequences encoding type iii tenebrio antifreeze proteins and method for assaying activity |
-
2002
- 2002-09-07 WO PCT/EP2002/010044 patent/WO2004022081A1/de not_active Application Discontinuation
- 2002-09-07 EP EP02774582A patent/EP1539206A1/de not_active Withdrawn
-
2005
- 2005-03-04 US US11/071,259 patent/US20060008440A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO2004022081A1 * |
Also Published As
Publication number | Publication date |
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WO2004022081A1 (de) | 2004-03-18 |
US20060008440A1 (en) | 2006-01-12 |
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