EP1535610A4 - Therapeutic agent for cancer - Google Patents

Therapeutic agent for cancer

Info

Publication number
EP1535610A4
EP1535610A4 EP03730832A EP03730832A EP1535610A4 EP 1535610 A4 EP1535610 A4 EP 1535610A4 EP 03730832 A EP03730832 A EP 03730832A EP 03730832 A EP03730832 A EP 03730832A EP 1535610 A4 EP1535610 A4 EP 1535610A4
Authority
EP
European Patent Office
Prior art keywords
cancer
therapeutic agent
therapeutic
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03730832A
Other languages
German (de)
French (fr)
Other versions
EP1535610A1 (en
Inventor
Susumu Muto
A Itai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Medicinal Molecular Design Inc IMMD
Original Assignee
Institute of Medicinal Molecular Design Inc IMMD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Medicinal Molecular Design Inc IMMD filed Critical Institute of Medicinal Molecular Design Inc IMMD
Publication of EP1535610A1 publication Critical patent/EP1535610A1/en
Publication of EP1535610A4 publication Critical patent/EP1535610A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
EP03730832A 2002-06-10 2003-06-05 Therapeutic agent for cancer Withdrawn EP1535610A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002168332 2002-06-10
JP2002168332 2002-06-10
PCT/JP2003/007121 WO2003103655A1 (en) 2002-06-10 2003-06-05 Therapeutic agent for cancer

Publications (2)

Publication Number Publication Date
EP1535610A1 EP1535610A1 (en) 2005-06-01
EP1535610A4 true EP1535610A4 (en) 2008-12-31

Family

ID=29727684

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03730832A Withdrawn EP1535610A4 (en) 2002-06-10 2003-06-05 Therapeutic agent for cancer

Country Status (9)

Country Link
US (1) US20060014811A1 (en)
EP (1) EP1535610A4 (en)
JP (1) JPWO2003103655A1 (en)
CN (1) CN100506221C (en)
AU (1) AU2003242108B2 (en)
CA (1) CA2488974A1 (en)
EA (1) EA010835B1 (en)
TW (1) TW200307535A (en)
WO (1) WO2003103655A1 (en)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE553758T1 (en) * 2000-12-18 2012-05-15 Inst Med Molecular Design Inc INHIBITORS FOR THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINE
EP1503986B1 (en) 2001-12-21 2015-09-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
DE10222895A1 (en) * 2002-05-23 2003-12-11 Bosch Gmbh Robert High pressure accumulator for fuel injection systems with integrated pressure control valve
WO2003103647A1 (en) * 2002-06-05 2003-12-18 株式会社医薬分子設計研究所 Inhibitors against the activation of ap-1 and nfat
TW200407112A (en) * 2002-06-05 2004-05-16 Inst Med Molecular Design Inc Immunity-related protein kinase inhibitors
CN101103977A (en) * 2002-06-05 2008-01-16 株式会社医药分子设计研究所 Therapeutic drug for diabetes
WO2003103656A1 (en) 2002-06-06 2003-12-18 株式会社医薬分子設計研究所 O-substituted hydroxyaryl derivatives
WO2003103665A1 (en) * 2002-06-06 2003-12-18 株式会社医薬分子設計研究所 Antiallergic
TW200410675A (en) * 2002-06-10 2004-07-01 Inst Med Molecular Design Inc An NF-κB activation inhibitor
US20060035944A1 (en) * 2002-06-11 2006-02-16 Susumu Muto Remedies for neurodegenerative diseases
CN1681487A (en) 2002-07-15 2005-10-12 美瑞德生物工程公司 Compounds, compositions, and methods for employing the same
KR20050074949A (en) * 2002-11-12 2005-07-19 엔오케이 가부시키가이샤 Rubber-like elastic part
EP1590318A2 (en) * 2002-12-12 2005-11-02 Jawaharlal Nehru Centre For Advanced Scientific Research Modulators (inhibitors/activators) of histone acetyltransferases
US7332629B2 (en) 2002-12-12 2008-02-19 Jawaharlal Nehru Centre For Advanced Scientific Research Modulators (inhibitors/activators) of histone acetyltransferases
KR20060054308A (en) * 2003-07-16 2006-05-22 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 Chromatosis remedies
AU2004282162B2 (en) * 2003-10-14 2012-01-19 X-Ceptor Therapeutics, Inc. Bridged ring structures as pharmaceutical agents
EP1689700A1 (en) * 2003-11-25 2006-08-16 Novo Nordisk A/S Novel salicylic anilides
TW200529812A (en) 2003-12-26 2005-09-16 Chugai Pharmaceutical Co Ltd Benzamide derivatives
WO2006013873A1 (en) * 2004-08-05 2006-02-09 Institute Of Medicinal Molecular Design. Inc. Drugs having cyclooxygenase inhibiting activity
WO2006051808A1 (en) * 2004-11-09 2006-05-18 Kyowa Hakko Kogyo Co., Ltd. Hsp90 FAMILY PROTEIN INHIBITORS
US8541879B2 (en) * 2007-12-13 2013-09-24 Tela Innovations, Inc. Super-self-aligned contacts and method for making the same
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
GB0612713D0 (en) * 2006-06-27 2006-08-09 Syngenta Participations Ag Insecticidal compounds
CN101842093B (en) * 2007-10-23 2012-08-22 株式会社医药分子设计研究所 PAI-1 production inhibitor
JP5501226B2 (en) * 2008-04-24 2014-05-21 Ｍｓｄ株式会社 Long-chain fatty acid elongation enzyme inhibitor comprising an arylsulfonyl derivative as an active ingredient
JP5322527B2 (en) * 2008-07-17 2013-10-23 浜松ホトニクス株式会社 Compounds suitable for detecting apoptosis
US10640457B2 (en) 2009-12-10 2020-05-05 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase activators and uses thereof
CN102249945A (en) * 2010-05-21 2011-11-23 复旦大学 Salicyloyl anilines compound as well as preparation method and application thereof
CN103180316A (en) 2010-08-27 2013-06-26 钙医学公司 Compounds that modulate intracellular calciu
EP3323813B1 (en) 2010-12-22 2020-08-26 The Trustees of Columbia University in the City of New York Histone acetyltransferase modulators and uses thereof
KR101434461B1 (en) * 2011-10-21 2014-09-01 한국생명공학연구원 2-hydroxyarylamide derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof, and pharmaceutical composition for the prevention and treatment of cancers containing the same as an active ingredient
WO2013058613A2 (en) * 2011-10-21 2013-04-25 한국생명공학연구원 2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient
JP6238969B2 (en) 2012-05-08 2017-11-29 エアロミクス・インコーポレイテッドＡｅｒｏｍｉｃｓ，Ｉｎｃ． New method
EP2852439A1 (en) 2012-05-23 2015-04-01 Stemergie Biotechnology SA Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof
WO2014052831A1 (en) * 2012-09-28 2014-04-03 Xavier University Of Louisiana Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103304438B (en) * 2013-06-18 2015-12-02 山东大学 N-substituted salicylamide compounds, preparation method and application
WO2015037659A1 (en) 2013-09-13 2015-03-19 株式会社医薬分子設計研究所 Aqueous solution formulation, and manufacturing method for same
RU2691951C2 (en) 2013-11-06 2019-06-19 Аэромикс, Инк. Novel compounds
WO2019046668A1 (en) * 2017-08-31 2019-03-07 Kezar Life Sciences Amide substituted thiazoles as protein secretion inhibitors
CN117105810B (en) * 2023-10-23 2024-02-09 中国农业大学 Compound with broad-spectrum antibacterial activity and antibacterial composition thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032017A2 (en) * 1997-01-15 1998-07-23 Telik, Inc. Modulators of insulin receptor activity
EP0931544A2 (en) * 1997-12-22 1999-07-28 Kaken Shoyaku Co., Ltd. NF-kB activity inhibitor
WO1999040907A1 (en) * 1998-02-13 1999-08-19 Medinox, Inc. Methods for the controlled delivery of carbon disulfide for the treatment of inflammatory conditions
WO1999046267A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999046244A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999046236A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999065449A2 (en) * 1998-06-19 1999-12-23 Smithkline Beecham Corporation INHIBITORS OF TRANSCRIPTION FACTOR NF-λB
EP1008346A1 (en) * 1998-03-20 2000-06-14 Suntory Limited NF-$g(k)B INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT PHENYLMETHYL BENZOQUINONE
WO2002016633A2 (en) * 2000-08-11 2002-02-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods for identifying inhibitors of ubiquitin-mediated proteolysis of ikb
EP1352650A1 (en) * 2000-12-18 2003-10-15 Institute of Medicinal Molecular Design, Inc. Inhibitors against the production and release of inflammatory cytokines

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US157844A (en) * 1874-12-15 Improvement in steam x c cylinder lubricators
NL292958A (en) * 1962-05-29 1900-01-01
DE2120862A1 (en) * 1971-04-28 1972-11-09 Farbenfabriken Bayer Ag, 5090 Leverkusen 3,5-disubstituted 2-acyloxybenzoic acid anilides, process for their preparation and their insecticidal and acaricidal use
EG10942A (en) * 1972-03-21 1976-11-30 Hoechst Ag Trifluoromethyl salicylanilides and process for preparing them
US4358443A (en) * 1980-04-14 1982-11-09 The Research Foundation Of State University Of New York Method and composition for controlling the growth of microorganisms
JPS59118750A (en) * 1982-12-27 1984-07-09 Eisai Co Ltd Carboxylic acid amide compound and its derivative
US4725590A (en) * 1983-08-24 1988-02-16 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4742083A (en) * 1983-08-24 1988-05-03 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4560549A (en) * 1983-08-24 1985-12-24 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
JPS6230780A (en) * 1985-04-17 1987-02-09 Ss Pharmaceut Co Ltd Naphthyridine derivative and pharmaceutical containing said derivative
US4939133A (en) * 1985-10-01 1990-07-03 Warner-Lambert Company N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade
DE8610394U1 (en) * 1986-04-16 1986-11-13 Kieninger & Obergfell, Fabrik Fuer Technische Laufwerke Und Apparate Gmbh & Co, 7742 St Georgen, De
US4966906A (en) * 1987-11-27 1990-10-30 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-isoquinolinecarboxamides
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
US4952588A (en) * 1987-11-27 1990-08-28 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinoline-and 1-aryl-3-isoquinoline-carboxamides
JP2988739B2 (en) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 1,8-naphthyridin-2-one derivatives
US6159988A (en) * 1992-01-16 2000-12-12 Hoeschst Aktiengesellschaft Arylcycloalkyl derivatives, their production and their use
SK280617B6 (en) * 1992-01-16 2000-05-16 Hoechst Aktiengesellschaft Arylcycloalkyl derivatives, method of their preparation, pharmaceutical compositions them containing, and their use
US5811428A (en) * 1995-12-18 1998-09-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
US5852028A (en) * 1995-12-18 1998-12-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5935966A (en) * 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US6117859A (en) * 1997-11-04 2000-09-12 The Research Foundation Of State University Of New York Method of relieving chronic inflammation by using 5-alkylsulfonylsalicylanilides
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
US6262044B1 (en) * 1998-03-12 2001-07-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPASES)
US6225329B1 (en) * 1998-03-12 2001-05-01 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPases)
AU3665199A (en) * 1998-04-29 1999-11-16 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
EP1018514B1 (en) * 1998-07-22 2004-05-12 Daiichi Suntory Pharma Co., Ltd. NF-$g(k)B INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT
US6653309B1 (en) * 1999-04-26 2003-11-25 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme technical field of the invention
AU774221B2 (en) * 1999-08-11 2004-06-17 Signal Creation Inc. Salicylamide derivatives
US6787652B1 (en) * 1999-09-30 2004-09-07 Pfizer, Inc. 6-Azauracil derivatives as thyroid receptor ligands
US6706766B2 (en) * 1999-12-13 2004-03-16 President And Fellows Of Harvard College Small molecules used to increase cell death
US6414013B1 (en) * 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
AU2002211842A1 (en) * 2000-10-02 2002-04-15 The Research Foundation Of State University Of New York Naphthylsalicylanilides as antimicrobial and antiinflammatory agents
CA2432713C (en) * 2000-12-22 2009-10-27 Ishihara Sangyo Kaisha, Ltd. Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
EP1314712A4 (en) * 2001-03-27 2004-12-15 Daiichi Suntory Pharma Co Ltd Nf-kappa-b inhibitor containing substituted benzoic acid derivative as active ingredient
WO2003103665A1 (en) * 2002-06-06 2003-12-18 株式会社医薬分子設計研究所 Antiallergic
TW200410675A (en) * 2002-06-10 2004-07-01 Inst Med Molecular Design Inc An NF-κB activation inhibitor
KR20060054308A (en) * 2003-07-16 2006-05-22 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 Chromatosis remedies

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032017A2 (en) * 1997-01-15 1998-07-23 Telik, Inc. Modulators of insulin receptor activity
EP0931544A2 (en) * 1997-12-22 1999-07-28 Kaken Shoyaku Co., Ltd. NF-kB activity inhibitor
WO1999040907A1 (en) * 1998-02-13 1999-08-19 Medinox, Inc. Methods for the controlled delivery of carbon disulfide for the treatment of inflammatory conditions
WO1999046267A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999046244A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999046236A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
EP1008346A1 (en) * 1998-03-20 2000-06-14 Suntory Limited NF-$g(k)B INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT PHENYLMETHYL BENZOQUINONE
WO1999065449A2 (en) * 1998-06-19 1999-12-23 Smithkline Beecham Corporation INHIBITORS OF TRANSCRIPTION FACTOR NF-λB
WO2002016633A2 (en) * 2000-08-11 2002-02-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods for identifying inhibitors of ubiquitin-mediated proteolysis of ikb
EP1352650A1 (en) * 2000-12-18 2003-10-15 Institute of Medicinal Molecular Design, Inc. Inhibitors against the production and release of inflammatory cytokines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO03103655A1 *

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JPWO2003103655A1 (en) 2005-10-06
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AU2003242108A1 (en) 2003-12-22
EA200401613A1 (en) 2005-08-25
AU2003242108B2 (en) 2008-09-11
CA2488974A1 (en) 2003-12-18
US20060014811A1 (en) 2006-01-19
CN1658856A (en) 2005-08-24
TW200307535A (en) 2003-12-16
WO2003103655A1 (en) 2003-12-18
EA010835B1 (en) 2008-12-30

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