EP1531690A2 - Nutraceutic compositions and food supplements containing nadh - Google Patents

Nutraceutic compositions and food supplements containing nadh

Info

Publication number
EP1531690A2
EP1531690A2 EP03760616A EP03760616A EP1531690A2 EP 1531690 A2 EP1531690 A2 EP 1531690A2 EP 03760616 A EP03760616 A EP 03760616A EP 03760616 A EP03760616 A EP 03760616A EP 1531690 A2 EP1531690 A2 EP 1531690A2
Authority
EP
European Patent Office
Prior art keywords
nadh
compositions
atp
lycopene
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03760616A
Other languages
German (de)
French (fr)
Inventor
Aldo Perani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dietetic SpA
Original Assignee
Dietetic SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dietetic SpA filed Critical Dietetic SpA
Publication of EP1531690A2 publication Critical patent/EP1531690A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention refers to nutraceutic compositions and food supplements comprising NADH, ATP and antioxidants, in particular resveratrol and lycopene.
  • the compositions according to the invention are capable of stimulating the physiological production of energy (pro-energetic and anti-asthenic activity).
  • Nicotinamide adenine dinucelotide (NAD) in its reduced form (NADH) is a physiological substance which is found in all living cells; NAD is also defined as coenzyme I, as it is cofactor of several enzymes, which catalyze oxidoreduction reactions.
  • NAD coupled to dehydrogenase, oxidizes biological media by accepting hydrogen and it is then re-oxidized by flavoproteins.
  • NADH The most important role of NADH is the energy production through a mitochondrial process, the "oxidative phosphorylation", in which 3 ATP molecules are formed for every single NADH molecule and half oxygen molecule.
  • NADH is formed from glycolysis metabolites (lactate and pyruvate) and is carried into the mitochondrion thanks to two "shuttle” systems, glycerol phosphate and malate - aspartate.
  • NADH a tyrosine hydroxylase cofactor, the enzyme which converts L-Dopa in dopamine; further NADH has a direct stimulation action of tyrosine hydroxylase activity.
  • NADH also stimulates the endogenous adrenaline and noradrenaline bio-synthesis, thus it is effective in the therapy of depression (Birkmayer, J.G.D., Birkmayer W. New Trends in Clinical Neuropharmacology, Vol. 5 - n. 3 / 4 - 1991).
  • NADH is essential to poly (ADP-ribose) polymerase enzyme, its administration prevents DNA breaking processes and it inhibits stress oxidative phenomena (Adams et al. Annali New York Academy of Sciences, 1996, 786-135-131) and thanks to its anti-oxidative action, it may regenerate other important antioxidants thus protecting from damages caused by free radicals.
  • NADH is unstable to the pH of gastric juices, it may be orally administered only in gastro-protected form, preferably associated with vitamin E, sodium bicarbonate, ascorbic acid, sodium ascorbate, as disclosed in US 5,332,727 and in US 5,712,259.
  • Adenosine triphosphate is the coenzyme which is found in high concentration in mammal muscles, and it is required for high energy phosphates bonds.
  • the conversion of ATP in ADP (adenosine diphosphate) provides the energy required for most physiological processes of the organism.
  • exogenous ATP restores physiological ATP levels in myosin fibers, when they are lowered below a certain threshold (Chaudry IH, Yale J. Biol. Med. 1982; 55:1-10).
  • ATP oral pharmaceutical compositions have already been suggested for muscular and cerebral fatigue treatment.
  • Lycopene is a carotenoid, which is contained in high quantities in tomato skins and is characterized by high anti-oxidative properties. As it can be seen from more and more clinical studies, lycopene involves a series of advantages for health and, in particular, it provides valid protection against several epithelial tumours and cardiovascular diseases and it delayes body cells ageing.
  • Resveratrol (3,4,5-trihydroxystilbene) is a polyphenol to which anti- tumoural, anti-oxidant, anti-inflammatory and anti-thrombotic properties are ascribed. In particular, it has been shown that resveratrol modulates lipid metabolism and inhibits low-density lipoproteins LDL oxidation and platelets aggregation through copper capture. It is found in grapefruits, raisins, blackberries, peanuts, but especially in grape skin and in particular in red wine.
  • Zinc acts as regulator of enzymatic systems. Recent studies underline its fundamental role in cerebral functions and treatment of schizophrenia. Further, it improves reflex and mental quickness. DESCRIPTION OF THE INVENTION
  • the association of NADH, adenosine triphosphate (ATP) and antioxidants, in particular resveratrol, lycopene and optionally zinc is particularly advantageous, thanks to proenergetic synergistic effects between NADH and ATP and to the enhancement of the antioxidant/antiradical effect obtainable through the association of lycopene, resveratrol and zinc.
  • the present invention provides nutraceutic compositions and food supplements comprising NADH, ATP and antioxidants, preferably resveratrol and lycopene, and optionally zinc, useful for stimulating the organism to produce energy in physical fatigue states, while practicing sports and/or anyhow under all circumstances where energy consumption is expected and in the conditions under which the administering of NADH brings advantages.
  • compositions according to the invention preferably have the following percentage composition (by weight on the total composition):
  • Zinc will preferably be in the form of salts with organic acids, in particular lactate.
  • compositions according to the invention may be administered with the addition of suitable excipients, in form of hard capsules, soft capsules and tablets.
  • Tablets with gastroenteral coating which can be accomplished by conventional methods and excipients, are preferred.
  • Shellac Rubber a natural polymer, is applied on tablets by spraying in aqueous solution, further containing one or more plasticizing agents (glycerine, lauric acid, oleic acid, polyvinyl pyrrolidone in an amount comprised in the range from 0.5 to 4%, one or more anti-adhesive agents (talcum, silicon dioxide / colloidal silica), in an amount comprised in the range from 2 to 8%, and optionally one or more dye or opacifying agents.
  • plasticizing agents glycol, lauric acid, oleic acid, polyvinyl pyrrolidone
  • anti-adhesive agents talcum, silicon dioxide / colloidal silica
  • Shellac Rubber is used for tablet gastro-protection in an amount ranging from 2 to 8% by weight of the tablet itself.
  • the coating process occurs preferably through a rotating coating pan, at a temperature not above 34-35°C.
  • a cooling step is carried out at the end of the drying process.
  • a fluidized bed granulator-coater apparatus in which the solution to be applied is sprayed from one or more nozzles on the tablet mass kept in motion in a basket (or granulator bucket) by an air stream, which dries the tablets themselves at the same time, can be used as alternative to the rotating coating pan.
  • the tablets thus coated should be kept intact for at least 30 minutes in an aqueous solution at a pH of 1.5 at 37°C.
  • the formulations according to the invention preferably contain for each unitary dose from 1 to 10 mg NADH, preferably from 2 to 5 mg; from 1 to 10 mg resveratrol, preferably from 2 to 5 mg; from 1 to 10 mg lycopene, preferably from 2 to 5 mg; from 1 to 5 mg ATP, preferably from 2 to 4 mg; from 10 to 20 mg zinc, preferably from 15 to 17 mg.
  • compositions according to the invention administered once or twice a day, produce advantageous effects when a restoration of the energy store in fatigued, immuno-depressed organisms and in organisms, which underwent physiological disequilibria induced by the development of free radicals, is convenient.
  • the compositions according to the invention are particularly suitable for persons undertaking intensive trainings, for cognitive and mnemonic skills and in the treatment or prevention of depressions, fatigue, stress and in the ageing processes.
  • Example 1 formulation for 300 mg tablet
  • Example 2 formulation for 300 mg tablet
  • Example 3 formulation for 300 mg tablet
  • Example 4 formulation for 300 mg tablet

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention refers to nutraceutic compositions and food supplements comprising NADH, ATP and antioxidants, in particular resveratrol and lycopene. The compositions according to the invention are capable of stimulating the physiological production of energy (pro-energetic and antiasthenic activity).

Description

NUTRACEUTIC COMPOSITIONS AND FOOD SUPPLEMENTS CONTAINING NADH
The present invention refers to nutraceutic compositions and food supplements comprising NADH, ATP and antioxidants, in particular resveratrol and lycopene. The compositions according to the invention are capable of stimulating the physiological production of energy (pro-energetic and anti-asthenic activity).
BACKGROUND OF THE INVENTION
Nicotinamide adenine dinucelotide (NAD) in its reduced form (NADH) is a physiological substance which is found in all living cells; NAD is also defined as coenzyme I, as it is cofactor of several enzymes, which catalyze oxidoreduction reactions.
NAD, coupled to dehydrogenase, oxidizes biological media by accepting hydrogen and it is then re-oxidized by flavoproteins.
The most important role of NADH is the energy production through a mitochondrial process, the "oxidative phosphorylation", in which 3 ATP molecules are formed for every single NADH molecule and half oxygen molecule. NADH is formed from glycolysis metabolites (lactate and pyruvate) and is carried into the mitochondrion thanks to two "shuttle" systems, glycerol phosphate and malate - aspartate.
The energy production is favoured when NADH is supplied from the outside; it has thus been observed that the administration of NADH is useful in the therapy of chronic fatigue syndrome (Forsyth M.L. et al., Annalis of
Allergy, Asthma, and Immunology, February 1999, vol. 82, n. 2 US
5,712,259) and it improves physical and psychomotor functions in athlets.
Further, an additional NADH supply produces good results in the therapy of Parkinson's disease (Vrecko K. Et al. J. Neural Transm. [P-D Sect] 1993 5:147-156 and EP 0772-734). This is due to the fact that NADH regenerates the biopterin, a tyrosine hydroxylase cofactor, the enzyme which converts L-Dopa in dopamine; further NADH has a direct stimulation action of tyrosine hydroxylase activity. NADH also stimulates the endogenous adrenaline and noradrenaline bio-synthesis, thus it is effective in the therapy of depression (Birkmayer, J.G.D., Birkmayer W. New Trends in Clinical Neuropharmacology, Vol. 5 - n. 3 / 4 - 1991).
Finally, since NADH is essential to poly (ADP-ribose) polymerase enzyme, its administration prevents DNA breaking processes and it inhibits stress oxidative phenomena (Adams et al. Annali New York Academy of Sciences, 1996, 786-135-131) and thanks to its anti-oxidative action, it may regenerate other important antioxidants thus protecting from damages caused by free radicals. Since NADH is unstable to the pH of gastric juices, it may be orally administered only in gastro-protected form, preferably associated with vitamin E, sodium bicarbonate, ascorbic acid, sodium ascorbate, as disclosed in US 5,332,727 and in US 5,712,259.
Recently, the association of NADH with vitamin E and octacosanol, a 28 carbon atoms alcohol contained in several vegetables, especially in wheat germ oil (EP 11641884), has been described.
Adenosine triphosphate (ATP) is the coenzyme which is found in high concentration in mammal muscles, and it is required for high energy phosphates bonds. The conversion of ATP in ADP (adenosine diphosphate) provides the energy required for most physiological processes of the organism.
The administration of exogenous ATP restores physiological ATP levels in myosin fibers, when they are lowered below a certain threshold (Chaudry IH, Yale J. Biol. Med. 1982; 55:1-10). ATP oral pharmaceutical compositions have already been suggested for muscular and cerebral fatigue treatment.
Lycopene is a carotenoid, which is contained in high quantities in tomato skins and is characterized by high anti-oxidative properties. As it can be seen from more and more clinical studies, lycopene involves a series of advantages for health and, in particular, it provides valid protection against several epithelial tumours and cardiovascular diseases and it delayes body cells ageing. Resveratrol (3,4,5-trihydroxystilbene) is a polyphenol to which anti- tumoural, anti-oxidant, anti-inflammatory and anti-thrombotic properties are ascribed. In particular, it has been shown that resveratrol modulates lipid metabolism and inhibits low-density lipoproteins LDL oxidation and platelets aggregation through copper capture. It is found in grapefruits, raisins, blackberries, peanuts, but especially in grape skin and in particular in red wine.
The use of resveratrol in nutraceutic formulations has already been suggested for example in WO 99/64282 and WO 99/01148.
Zinc acts as regulator of enzymatic systems. Recent studies underline its fundamental role in cerebral functions and treatment of schizophrenia. Further, it improves reflex and mental quickness. DESCRIPTION OF THE INVENTION
It has now been found that the association of NADH, adenosine triphosphate (ATP) and antioxidants, in particular resveratrol, lycopene and optionally zinc, is particularly advantageous, thanks to proenergetic synergistic effects between NADH and ATP and to the enhancement of the antioxidant/antiradical effect obtainable through the association of lycopene, resveratrol and zinc. Thus, the present invention provides nutraceutic compositions and food supplements comprising NADH, ATP and antioxidants, preferably resveratrol and lycopene, and optionally zinc, useful for stimulating the organism to produce energy in physical fatigue states, while practicing sports and/or anyhow under all circumstances where energy consumption is expected and in the conditions under which the administering of NADH brings advantages.
The compositions according to the invention preferably have the following percentage composition (by weight on the total composition):
NADH: 1.66% 3.33%
ATP: 0.66% 1.32%
Lycopene: 0.66% 1.32%
Zinc: 5% 10%
Resveratrol: 0.66% 1.32%
Zinc will preferably be in the form of salts with organic acids, in particular lactate.
The compositions according to the invention may be administered with the addition of suitable excipients, in form of hard capsules, soft capsules and tablets.
Tablets with gastroenteral coating, which can be accomplished by conventional methods and excipients, are preferred.
According to a preferred embodiment of the invention, dewaxed, bleached and purified Shellac Rubber (Dewaxed Orange Shellac; Shellac, E 904) is used. Shellac Rubber, a natural polymer, is applied on tablets by spraying in aqueous solution, further containing one or more plasticizing agents (glycerine, lauric acid, oleic acid, polyvinyl pyrrolidone in an amount comprised in the range from 0.5 to 4%, one or more anti-adhesive agents (talcum, silicon dioxide / colloidal silica), in an amount comprised in the range from 2 to 8%, and optionally one or more dye or opacifying agents. Shellac Rubber is used for tablet gastro-protection in an amount ranging from 2 to 8% by weight of the tablet itself.
The coating process occurs preferably through a rotating coating pan, at a temperature not above 34-35°C. A cooling step is carried out at the end of the drying process.
A fluidized bed granulator-coater apparatus, in which the solution to be applied is sprayed from one or more nozzles on the tablet mass kept in motion in a basket (or granulator bucket) by an air stream, which dries the tablets themselves at the same time, can be used as alternative to the rotating coating pan.
The tablets thus coated should be kept intact for at least 30 minutes in an aqueous solution at a pH of 1.5 at 37°C.
The formulations according to the invention preferably contain for each unitary dose from 1 to 10 mg NADH, preferably from 2 to 5 mg; from 1 to 10 mg resveratrol, preferably from 2 to 5 mg; from 1 to 10 mg lycopene, preferably from 2 to 5 mg; from 1 to 5 mg ATP, preferably from 2 to 4 mg; from 10 to 20 mg zinc, preferably from 15 to 17 mg.
The compositions according to the invention, administered once or twice a day, produce advantageous effects when a restoration of the energy store in fatigued, immuno-depressed organisms and in organisms, which underwent physiological disequilibria induced by the development of free radicals, is convenient. The compositions according to the invention are particularly suitable for persons undertaking intensive trainings, for cognitive and mnemonic skills and in the treatment or prevention of depressions, fatigue, stress and in the ageing processes.
The present invention is now shown in greater details by some examples. EXAMPLES
Example 1: formulation for 300 mg tablet
NADH 5 mg
Resveratrol 2 mg ATP 2 mg
Zinc (in form of lactate) 15 mg
Example 2: formulation for 300 mg tablet
NADH 5 mg
Lycopene 2 mg ATP 2 mg
Example 3: formulation for 300 mg tablet
NADH 5 mg
ATP 2.5 mg
Resveratrol 2 mg Lycopene 2 mg
Example 4; formulation for 300 mg tablet
NADH 5 mg
ATP 3 mg
Lycopene 2 mg Zinc (in form of lactate) 15 mg

Claims

1. Nutraceutic compositions and food supplements containing NADH, ATP, anti-oxidants and optionally zinc, in a mixture with suitable excipients and/or carriers.
2. Compositions and supplements according to claim 1 wherein the antioxidants comprise resveratrol and lycopene.
3. Compositions according to claims 1 or 2 further containing zinc.
4. Compositions and supplements according to claim 3 having the following percentage composition (by weight on the total composition):
NADH: 1.66% 3.33%
ATP: 0.66% 1.32%
Lycopene: 0.66% , 1.32%
Resveratrol: 0.66% 1.32%
Zinc: 5% 10%
5. Composition according to one of claims 1 to 4 in the form of hard or soft gelatin capsules, tablets.
6. Composition according to claim 5 in the form of tablet with gastro- resistant coating.
7. Composition according to claim 6 wherein the coating is accomplished by Shellac Rubber.
8. Composition according to claim 7 wherein the Shellac Rubber amount used for coating is in a range comprised from 2 to 8% of the tablet weight.
9. Use of NADH in association with ATP, lycopene, resveratrol and zinc for the preparation of compositions having proenergetic activity.
EP03760616A 2002-06-21 2003-06-13 Nutraceutic compositions and food supplements containing nadh Withdrawn EP1531690A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2002MI001366A ITMI20021366A1 (en) 2002-06-21 2002-06-21 NUTRACEUTICAL COMPOSITIONS AND FOOD SUPPLEMENTS CONTAINING NADH
ITMI20021366 2002-06-21
PCT/EP2003/006256 WO2004000043A2 (en) 2002-06-21 2003-06-13 Nutraceutic compositions and food supplements containing nadh

Publications (1)

Publication Number Publication Date
EP1531690A2 true EP1531690A2 (en) 2005-05-25

Family

ID=11450057

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03760616A Withdrawn EP1531690A2 (en) 2002-06-21 2003-06-13 Nutraceutic compositions and food supplements containing nadh

Country Status (4)

Country Link
EP (1) EP1531690A2 (en)
AU (1) AU2003246430A1 (en)
IT (1) ITMI20021366A1 (en)
WO (1) WO2004000043A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG166688A1 (en) 2009-05-14 2010-12-29 Hsiehs Biotech Singapore Pte Ltd Lycopene and resveratrol dietary supplement
SG166716A1 (en) * 2009-05-14 2010-12-29 Hsiehs Biotech Singapore Pte Ltd Lycopene and resveratrol compositions for nk cell activation resulting in anti-neoplastic effect
WO2018148930A1 (en) * 2017-02-17 2018-08-23 纯菁生物科技（美国）有限公司 Use of nadh or fadh2 in nutritional intervention for cancer patient
CN115299534A (en) * 2022-09-14 2022-11-08 泓博元生命科技（深圳）有限公司 NADH composition for quickly supplementing energy and relieving fatigue of pets and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712259A (en) * 1996-04-22 1998-01-27 Birkmayer Pharmaceuticals NADH and NADPH pharmaceuticals for treating chronic fatigue syndrome
CH692837A5 (en) * 1997-07-02 2002-11-29 Lisapharma Spa A pharmaceutical composition for use in foodstuffs, dietetic or medicinal product suitable to improve the oral absorption of the polyphenols and particularly of resveratrol present in grapes and in its p
IT1318565B1 (en) * 2000-06-09 2003-08-27 World Pharma Tech Ltd NADH OCTOCOSANOL EVITAMIN E PROENERGETIC FOOD SUPPLEMENT
TR200202175T1 (en) * 2001-02-14 2003-10-21 Rath Matthias Compositions of biochemical compounds found in bioenergy metabolism of cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2004000043A2 *

Also Published As

Publication number Publication date
ITMI20021366A1 (en) 2003-12-22
AU2003246430A1 (en) 2004-01-06
WO2004000043A3 (en) 2004-03-04
AU2003246430A8 (en) 2004-01-06
WO2004000043A2 (en) 2003-12-31
ITMI20021366A0 (en) 2002-06-21

Similar Documents

Publication Publication Date Title
Sharma et al. A comprehensive review of free radicals, antioxidants, and their relationship with human ailments
US11331363B2 (en) Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations
JP2022176979A (en) CRYSTAL FORMS OF β-NICOTINAMIDE MONONUCLEOTIDE
EP3359259B1 (en) Resetting biological pathways for defending against and repairing deterioration from human aging
JP6919099B2 (en) VMAT2 inhibitors for treating neurological disorders or disorders
Qiao et al. Antioxidant activities of polysaccharides from Hyriopsis cumingii
CN104997803B (en) Comprising the treatment using magnetic dipole stabilizing solutions or improves disease and enhance the method and composition of performance
Roberts et al. Vitamin C consumption does not impair training-induced improvements in exercise performance
US20090104171A1 (en) Metabolic Enhancement Therapy
Lin et al. Protective effect of green tea (-)-epigallocatechin-3-gallate against the monoamine oxidase B enzyme activity increase in adult rat brains
CN107847513B (en) Composition for preventing and treating obesity or impaired glucose tolerance comprising nicotinamide adenine dinucleotide
ITMI20001285A1 (en) PROENERGETIC FOOD SUPPLEMENT BASED ON NADH OCTOCOSANOL AND VITAMIN E
US20020025310A1 (en) Compositions and methods for promoting healthy joints
RU2270008C1 (en) Agent and method for enhancing human and animal resistance to hypothermia by activation of vital essential biochemical processes
EP1531690A2 (en) Nutraceutic compositions and food supplements containing nadh
Sudheesh et al. Palladium α-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I–IV in the heart of aged rats
NO20054380L (en) Arylic cycloalkyl derivatives with branched side chains as PPAR receptor modulators, their preparation and their use as a drug
CA3145853A1 (en) Compositions and methods using trigonelline to produce intracellular nicotinamide adenine dinucleotide (nad+) for treating or preventing physiological disorders or states
WO2016027837A1 (en) Oral beauty care agent
JP6824746B2 (en) Antioxidants and Antioxidants / UV Care Cosmetics
CN113615833A (en) Mitochondrial nutrient composition for improving cardiovascular disease and application thereof
CA3157712C (en) Synergistic nutritional compositions for enhancing atp efficiency
WO2012080952A1 (en) Composition containing resveratrol, l-tryptophan, l-aspartic acid and vitamin b3 for use in the pharmaceutical, nutritional and cosmetic fields
WO2011091299A1 (en) Composition for perinatal and neonatal stroke
Pawlas et al. Neuroprotective effect of N-acetylcysteine in neurons exposed to arachidonic acid during simulated ischemia in vitro

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20041223

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20070530

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071211