EP1455812A4 - Antagonist anti-cd40 monoclonal antibody therapy for multiple sclerosis treatment - Google Patents

Antagonist anti-cd40 monoclonal antibody therapy for multiple sclerosis treatment

Info

Publication number
EP1455812A4
EP1455812A4 EP02784651A EP02784651A EP1455812A4 EP 1455812 A4 EP1455812 A4 EP 1455812A4 EP 02784651 A EP02784651 A EP 02784651A EP 02784651 A EP02784651 A EP 02784651A EP 1455812 A4 EP1455812 A4 EP 1455812A4
Authority
EP
European Patent Office
Prior art keywords
monoclonal antibody
multiple sclerosis
antibody therapy
antagonist anti
sclerosis treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02784651A
Other languages
German (de)
French (fr)
Other versions
EP1455812A2 (en
Inventor
Lorianne K Masuoka
Min F Kwan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of EP1455812A2 publication Critical patent/EP1455812A2/en
Publication of EP1455812A4 publication Critical patent/EP1455812A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP02784651A 2001-11-26 2002-11-26 Antagonist anti-cd40 monoclonal antibody therapy for multiple sclerosis treatment Withdrawn EP1455812A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33335501P 2001-11-26 2001-11-26
US333355P 2001-11-26
PCT/US2002/038164 WO2003045978A2 (en) 2001-11-26 2002-11-26 Antagonist anti-cd40 monoclonal antibody therapy for multiple sclerosis treatment

Publications (2)

Publication Number Publication Date
EP1455812A2 EP1455812A2 (en) 2004-09-15
EP1455812A4 true EP1455812A4 (en) 2006-03-22

Family

ID=23302439

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02784651A Withdrawn EP1455812A4 (en) 2001-11-26 2002-11-26 Antagonist anti-cd40 monoclonal antibody therapy for multiple sclerosis treatment

Country Status (5)

Country Link
EP (1) EP1455812A4 (en)
JP (1) JP2005510570A (en)
AU (1) AU2002346581A1 (en)
CA (1) CA2466931A1 (en)
WO (1) WO2003045978A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
PL1682178T3 (en) * 2003-11-04 2010-12-31 Novartis Vaccines & Diagnostics Inc Methods of therapy for cancers expressing the cd40 antigen
JP2009517339A (en) 2005-11-01 2009-04-30 ノバルティス アーゲー Use of anti-CD40 antibodies
NZ571757A (en) 2006-04-21 2012-01-12 Novartis Ag Antagonist anti-CD40 antibody pharmaceutical compositions comprising arginine-HCl and a citrate or citric acid buffer
GB0707208D0 (en) * 2007-04-13 2007-05-23 Istituto Superiore Di Sanito Novel disease treatments
AR083847A1 (en) 2010-11-15 2013-03-27 Novartis Ag FC VARIANTS (CONSTANT FRAGMENT) SILENCERS OF ANTI-CD40 ANTIBODIES
CN102585011A (en) * 2012-02-10 2012-07-18 中国农业大学 Preparation method for dog alpha interferon derivative and application
KR20210035805A (en) 2018-06-15 2021-04-01 플래그쉽 파이어니어링 이노베이션스 브이, 인크. Increased immune activity through regulation of postcellular signaling factors
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity
WO2021127217A1 (en) 2019-12-17 2021-06-24 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
JP2021169423A (en) * 2020-04-15 2021-10-28 洋悦 松川 Method for administering pharmaceutical preparation
CA3184366A1 (en) 2020-06-29 2022-01-06 Darby Rye Schmidt Viruses engineered to promote thanotransmission and their use in treating cancer
US20220233690A1 (en) 2021-01-28 2022-07-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating cytokine release syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037870A1 (en) * 1999-11-25 2001-05-31 Kennedy Rheumatology Inst Treatment of autoimmune diseases by an agonistic cd40-binding protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5906816A (en) * 1995-03-16 1999-05-25 University Of Florida Method for treatment of autoimmune diseases
US6051228A (en) * 1998-02-19 2000-04-18 Bristol-Myers Squibb Co. Antibodies against human CD40
WO2001083755A2 (en) * 2000-04-28 2001-11-08 La Jolla Institute For Allergy And Immunology Human anti-cd40 antibodies and methods of making and using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001037870A1 (en) * 1999-11-25 2001-05-31 Kennedy Rheumatology Inst Treatment of autoimmune diseases by an agonistic cd40-binding protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COMABELLA MANUEL ET AL: "Interferon-beta treatment alters peripheral blood monocytes chemokine production in MS patients", JOURNAL OF NEUROIMMUNOLOGY, vol. 126, no. 1-2, May 2002 (2002-05-01), pages 205 - 212, XP002364117, ISSN: 0165-5728 *
GERRITSE K ET AL: "CD40-CD40 LIGAND INTERACTIONS IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 93, no. 6, 19 March 1996 (1996-03-19), pages 2499 - 2504, XP002013404, ISSN: 0027-8424 *
JEFFERY D R: "Relationship between disease activity and dose-response relationships with beta interferon therapies in the treatment of multiple sclerosis.", JOURNAL OF THE NEUROLOGICAL SCIENCES. 1 SEP 2000, vol. 178, no. 1, 1 September 2000 (2000-09-01), pages 2 - 9, XP002220791, ISSN: 0022-510X *
MAURI CLAUDIA ET AL: "Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 6, no. 6, June 2000 (2000-06-01), pages 673 - 679, XP002157458, ISSN: 1078-8956 *

Also Published As

Publication number Publication date
AU2002346581A1 (en) 2003-06-10
WO2003045978A3 (en) 2003-07-31
WO2003045978A2 (en) 2003-06-05
CA2466931A1 (en) 2003-06-05
AU2002346581A8 (en) 2003-06-10
JP2005510570A (en) 2005-04-21
EP1455812A2 (en) 2004-09-15

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040604

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

A4 Supplementary search report drawn up and despatched

Effective date: 20060208

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20091110