EP1399745A2 - Valve block - Google Patents

Valve block

Info

Publication number
EP1399745A2
EP1399745A2 EP02732306A EP02732306A EP1399745A2 EP 1399745 A2 EP1399745 A2 EP 1399745A2 EP 02732306 A EP02732306 A EP 02732306A EP 02732306 A EP02732306 A EP 02732306A EP 1399745 A2 EP1399745 A2 EP 1399745A2
Authority
EP
European Patent Office
Prior art keywords
valve block
plates
plate
channels
openings
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02732306A
Other languages
German (de)
French (fr)
Inventor
Ernst BÜRGISSER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EPR Labautomation AG
Original Assignee
EPR Labautomation AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EPR Labautomation AG filed Critical EPR Labautomation AG
Publication of EP1399745A2 publication Critical patent/EP1399745A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0011—Gate valves or sliding valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/86493—Multi-way valve unit
    • Y10T137/86879—Reciprocating valve unit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/87249—Multiple inlet with multiple outlet
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/87917—Flow path with serial valves and/or closures

Definitions

  • the invention is in the field of microanalysis and relates to a valve block according to the preamble of the independent claim.
  • the valve block can be used, for example, in a metering device, with which a large number of small quantities of liquid can be handled in parallel, with which, for example, small quantities of liquids can be simultaneously metered into a plurality of cavities on a test plate or can also be removed from the cavities.
  • Such a metering device is described in the patent EP-0363450 (or US-5193403, Bürgisser). It has a plurality of piston pipettes or similar dosing means which are equipped for the dosed suction or ejection of liquid through a distal end. Furthermore, the device has a valve plate, one surface of which is directed against the distal ends of the piston pipettes and is pressed against them, for example, by means of spring force.
  • the valve plate has a pattern of through openings which is adapted to the arrangement of the piston pipettes in such a way that a distal end of the pipette can be aligned with a through opening.
  • hollow metering tips advantageously adjoin the mouths of the through openings.
  • the valve plate has two channel systems, each of which has a main connection and a plurality of orifices connected to the main connection by channels at the end facing the distal pipette ends. th side of the valve plate.
  • the mouths of each channel system in turn form a pattern that is adapted to the pipette arrangement.
  • one of the duct systems is connected to a liquid source via the main connection and the other to a drain.
  • the distal ends of the piston pipettes are optionally connected to the through openings or to the orifices of one or the other of the channel systems, which enables a multitude of metering functions.
  • the dosing device briefly described above is simple and robust and can be operated at satisfactory speeds.
  • orifices must be provided for each channel system on the surface of the valve plate directed against the piston pipettes and must be accommodated within a grid determined by the through openings, the number of possible channel systems for a given grid of the through openings is limited.
  • the same limitation also applies to the valve plate for manufacturing reasons, because the valve plate is • essentially made from one piece.
  • valve block for a metering device, as briefly described above, the valve block should be easy to manufacture regardless of the number of channel systems, the valve block should also be easy to implement with a small pitch and the grid dimension in this valve block should in no way limit the possible number of channel systems.
  • the valve block according to the invention is modularly composed of plates.
  • the valve block has a connection plate and a plurality of preferably identical channel plates, each of which represents one of the channel systems.
  • the plates are arranged in a stack adjacent to one another and are displaceable to a limited extent.
  • the connection plate is directed against the distal ends of an arrangement of piston pipettes or other dosing means and has a plurality of through openings aligned with these distal ends.
  • the channel plates also have through openings, the through openings of the connection plate and the channel plates being able to be aligned with one another, that is to say all are arranged in the same grid.
  • each channel plate has a channel system that is open at least to one plate side, which is matched to the grid of the through openings, but is laterally displaced relative to this.
  • the duct system advantageously has at least one main connection on the narrow side of the plate.
  • each channel plate is displaceable in relation to each other and relative to the connection plate in the plate stack in such a way that each channel plate can have essentially two positions: a first position in which its through openings face the outgoing openings of the connection plate are aligned, and a second position in which their channel system is aligned with the through openings of the connection plate.
  • connection plate and the channel plates of the valve block according to the invention consist of a material whose surfaces (if appropriate processed accordingly) can seal against one another on the one hand and can still be moved against one another in a sealing manner. Furthermore, the material should of course not be attacked by the liquids used. It is known from valve technology, ⁇ in particular from the widespread single-lever mixers, that ceramic materials are advantageously used for such applications.
  • valve block according to the invention is described in more detail with reference to the following figures. Show:
  • FIGS. 1 to 3 an exemplary embodiment of the valve block according to the invention in section with different positions of channel plates;
  • FIG. 4 shows a top view of the connection plate of an exemplary embodiment of the valve block according to the invention
  • Figure 5 is a plan view of a channel plate of the same embodiment of the valve block according to the invention
  • FIG. 6 shows a detail of the channels of the channel plate according to FIG. 5.
  • FIG. 1 shows a very schematic and incomplete section through a metering device as described at the beginning.
  • the metering device shows a valve block 1 according to the invention, an arrangement of metering means (e.g. piston pipettes 2) arranged on one side of the valve block and an arrangement of metering tips 3 arranged on the opposite side of the valve block.
  • the valve block has a connecting plate 10 and a first, second and third (outermost) channel plate 11, 12 and 13 adjoining the connecting plate 10, the plates being held together in a stack by means of suitable means (not shown) in such a way that the connection plate 10 forms one end face of the stack and the outermost channel plate 13 the other.
  • connection plate 10 and the channel plates 11, 12 and 13 have the same through-openings 14, which are advantageously arranged in a regular pattern, which pattern is adapted to the arrangement of the piston pipettes.
  • these through openings form first orifices 15 and second orifices 16 to which, with suitable means, the piston pipettes 2 or other suitable dosing means or the dosing tips or other suitable connecting means are connected.
  • the channel plates have a channel system 20. This is designed such that there are all openings of an opening arranged in the same pattern with at least one main connection connects, but it is laterally shifted from the pattern of the through openings. If the through openings are arranged, for example, in straight rows, the channels of the channel system run parallel to these rows and at a constant distance therefrom. Furthermore, collecting channels are advantageously provided outside the pattern of openings and connect the channels to the at least one main connection.
  • Figure 1 shows such channels 21 arranged between rows of through openings in section.
  • a not visible, parallel to the section plane collecting channel 22 is indicated by broken lines.
  • a main connection 23 is indicated in the same way.
  • the channels 21 are arranged, for example, centrally between the rows of through openings 14, so that a lateral displacement of two adjacent plates by half the grid size means switching between the position with aligned through openings and a position with channels aligned with through openings.
  • the channel systems 20 of the channel plates 11, 12 and 13 according to FIG. 1 have a depth that is smaller than the plate thickness (trough-shaped channels).
  • the channels are closed off on one side in the stack of plates by an adjacent plate. It is also possible to give the channels a depth that is the same as the plate thickness (slot-shaped channels). Such slot-like channels are closed on both sides in the stack of plates by adjacent plates.
  • a further connection plate is to be arranged on the end face of the valve block opposite the connection plate 10.
  • the plates which together form the valve block according to the invention preferably consist of a ceramic material, for example of aluminum oxide. As shown in Figure 1, it is advantageous to design the channel plates 11, 12 and 13 all the same, which keeps the price of the valve block low. If the channels are trough-shaped, it is obviously also possible to use a channel plate as the connection plate, the channels of this plate then having no functional meaning.
  • valve block is held, for example, between two holding plates, for example made of steel, perforated accordingly for the first and second orifices, the two plates being pressed lightly against one another.
  • appropriate servomotors are to be installed on two sides of the plate stack. When actuated appropriately, they act on one of the channel plates.
  • FIG. 1 the metering device is shown in a state in which the piston pipettes are connected to the metering tips via the aligned, continuous openings of all plates.
  • FIG. 2 which only shows the valve block 1
  • the piston pipettes are connected to the channel system of the third channel plate 13 via the through openings 14 in the connecting plate 10 and the first two channel plates 11 and 12.
  • FIG. 3 which also only shows the valve block 1, the piston pipettes are connected to the channel system of the first channel plate 11 via the through openings 14 of the connection plate 10.
  • FIGS. 1, 2 and 3 show that for a changeover of the valve block 1 from a state in which the first and second orifices 15 and 16 are each connected to one another in a state in which the first orifices 15 are connected are connected to a selected duct system, a displacement of the corresponding duct plate by half a grid dimension is sufficient (FIG. 2: third duct plate 13, FIG. 3: first duct plate 11).
  • FIG. 4 shows a top view of an exemplary embodiment of a connecting plate 10.
  • the through openings 14 or first openings 15 are arranged in rows with a distance d.
  • the pattern of the through openings corresponds, for example, to the cavity pattern of standardized microtest plates (with 96, 384 or 1536 cavities).
  • FIG. 5 shows a channel plate 11 which can be used together with the connection plate 10 of FIG. 4 in a valve block according to the invention.
  • the channel plate 11 has channels 21 which run centrally between the rows of through openings, ie have a distance d / 2 from them.
  • the channels 21 open into common channels 22, which run outside the pattern of through openings and which in turn open into the main connection 23.
  • FIG. 6 shows in a three-dimensional detail the channels 21 of the channel plate 11 according to FIG. 5.
  • These channels 21 run centrally between the rows of through openings 14 and are trough-shaped, as is also shown in FIGS. 1 to 3.
  • the channels 21 are advantageously designed in such a way that their cross section increases towards the mouth into a collecting channel 22. This is realized, for example, as can be seen from FIG. 6, by increasing the depth of the trough-shaped channels.

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  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

A valve block (1) for a dosing device, with an arrangement of piston pipettes (2) or other dosing means, comprises, on the one side thereof, a pattern of openings (15) which may be placed on the arrangement of piston pipettes (2) and, on the opposite side thereof, a second opening (16) corresponding to each first opening (15). The valve block (1) further comprises a number of channel systems (20), each with a main connector (23). The valve block essentially comprises a number of plates (10, 11, 12, 13), arranged in a stack. All plates have through holes (14), arranged in the pattern of the first holes (15). At least a part of the plates (11, 12, 13) additionally comprises a channel system (20) with channels (21), connected to the main connector (23), whereby said channels (21) form a pattern which matches the pattern of the through holes (14) and is laterally displaced relative thereto. In order to optionally connect the first openings (15) to the corresponding second opening (16) or to a selected channel system (20), said plates (11, 12, 13) with the channel system are optionally laterally displaced.

Description

VENTILBLOCK VALVE BLOCK
Die Erfindung liegt auf dem Gebiete der Mikroanalytik und betrifft einen Ventilblock nach dem Oberbegriff des unabhängigen Patentanspruchs. Der Ventilblock ist anwendbar beispielsweise in einer Dosiervorrichtung, mit der eine grosse Zahl von kleinen Flüssigkeitsmengen parallel handhabbar ist, mit der also beispielsweise gleichzeitig kleine Mengen von Flüssigkeiten einer Mehrzahl von Kavitäten einer Testplatte zudosiert oder auch aus den Kavitäten entnommen werden können.The invention is in the field of microanalysis and relates to a valve block according to the preamble of the independent claim. The valve block can be used, for example, in a metering device, with which a large number of small quantities of liquid can be handled in parallel, with which, for example, small quantities of liquids can be simultaneously metered into a plurality of cavities on a test plate or can also be removed from the cavities.
In der Patentschrift EP-0363450 (oder US-5193403, Bürgisser) ist eine derartige Dosiervorrichtung beschrieben. Sie weist eine Mehrzahl von Kolbenpipetten oder von ähnlichen Dosiermitteln auf, die für das dosierte Ansaugen oder Ausstossen von' Flüssigkeit durch ein distales Ende ausgerüstet sind. Ferner weist die Vorrichtung eine Ventilplatte auf, deren eine Oberfläche gegen die distalen Enden der Kolbenpipetten gerichtet ist und beispielsweise mittels Federkraft gegen diese gepresst wird.Such a metering device is described in the patent EP-0363450 (or US-5193403, Bürgisser). It has a plurality of piston pipettes or similar dosing means which are equipped for the dosed suction or ejection of liquid through a distal end. Furthermore, the device has a valve plate, one surface of which is directed against the distal ends of the piston pipettes and is pressed against them, for example, by means of spring force.
Die Ventilplatte weist ein Muster von durchgehenden Öffnungen auf, das derart an die Anordnung der Kolbenpipetten angepasst ist, dass je ein distales Pipettenende auf eine durchgehende Öffnung ausrichtbar ist. Auf der anderen Seite der Ventilplatte schliessen vorteilhafterweise hohle Dosierspitzen an die Mündungen der durchgehenden Öffnungen an. Ferner weist die Ventilplatte zwei Kanalsysteme auf, die je einen Hauptanschluss aufweisen und je eine Mehrzahl von mit dem Hauptanschluss durch Kanäle verbundene Mündungen an der den distalen Pipettenenden zugewand- ten Seite der Ventilplatte. Die Mündungen jedes Kanalsystems bilden wiederum ein Muster, das an die Pipettenanordnung angepasst ist. Von den Kanalsystemen ist beispielsweise das eine via Hauptanschluss an eine Flüssigkeitsquelle angeschlossen und das andere an einen Ablauf.The valve plate has a pattern of through openings which is adapted to the arrangement of the piston pipettes in such a way that a distal end of the pipette can be aligned with a through opening. On the other side of the valve plate, hollow metering tips advantageously adjoin the mouths of the through openings. Furthermore, the valve plate has two channel systems, each of which has a main connection and a plurality of orifices connected to the main connection by channels at the end facing the distal pipette ends. th side of the valve plate. The mouths of each channel system in turn form a pattern that is adapted to the pipette arrangement. For example, one of the duct systems is connected to a liquid source via the main connection and the other to a drain.
Durch Verschieben der Pipettenanordnung relativ zur Ventilplatte werden die distalen Enden der Kolbenpipetten wahlweise mit den durchgehenden Öffnungen oder mit den Mündungen des einen oder anderen der Kanalsysteme verbunden, wodurch eine Vielzahl von Dosierfunktionen ermöglicht wird.By moving the pipette arrangement relative to the valve plate, the distal ends of the piston pipettes are optionally connected to the through openings or to the orifices of one or the other of the channel systems, which enables a multitude of metering functions.
Die oben kurz beschriebene Dosiervorrichtung ist einfach und robust und kann mit befriedigenden Geschwindigkeiten betrieben werden. Da aber für jedes Kanalsystem an der gegen die Kolbenpipetten gerichteten Oberfläche der Ventilplatte Mündungen vorzusehen und innerhalb eines durch die durchgehenden Öffnungen bestimmten Rasters unterzubringen sind, ist die Anzahl der möglichen Kanalsysteme bei vorgegebenem Raster der durchgehenden Öffnungen beschränkt. Dieselbe Beschränkung be- steht für die Ventilplatte auch aus herstellungstechnischen Gründen, denn die Ventil- • platte ist im wesentlichen aus einem Stück gefertigt.The dosing device briefly described above is simple and robust and can be operated at satisfactory speeds. However, since orifices must be provided for each channel system on the surface of the valve plate directed against the piston pipettes and must be accommodated within a grid determined by the through openings, the number of possible channel systems for a given grid of the through openings is limited. The same limitation also applies to the valve plate for manufacturing reasons, because the valve plate is • essentially made from one piece.
Sollen aber zum Beispiel für einen Anschluss an verschiedene Flüssigkeitsquellen eine grössere Anzahl von Kanalsystemen zur Verfügung gestellt werden, wird es für die oben beschriebene Vorrichtung notwendig, die Distanzen zwischen den durchge- henden Öffnungen in der Ventilplatte zu vergrössern und damit auch für die Pipettenanordnung einen gröberen Raster zu verwenden. Dies bedeutet aber, dass die Kavitäten von gleichen Testplatten nicht mehr alle parallel bedient werden können, was zu einer unerwünschten Verlängerung der für die Bedienung notwendigen Zeit führt. Die Erfindung stellt sich nun die Aufgabe, einen Ventilblock für eine Dosiervorrichtung, wie sie oben kurz beschrieben ist, zu schaffen, wobei der Ventilblock unabhängig von der Anzahl von Kanalsystemen einfach herstellbar sein soll, wobei der Ventilblock auch mit einem kleinen Rastermass einfach realisierbar sein soll und wobei in diesem Ventilblock das Rastermass die mögliche Anzahl von Kanalsystemen in keiner Weise begrenzen soll.However, if, for example, a larger number of channel systems are to be made available for connection to different liquid sources, it becomes necessary for the device described above to increase the distances between the through openings in the valve plate and thus to make the pipette arrangement coarser Grid to use. However, this means that the cavities of the same test plates can no longer all be operated in parallel, which leads to an undesirable increase in the time required for operation. The object of the invention is now to create a valve block for a metering device, as briefly described above, the valve block should be easy to manufacture regardless of the number of channel systems, the valve block should also be easy to implement with a small pitch and the grid dimension in this valve block should in no way limit the possible number of channel systems.
Diese Aufgabe wird gelöst durch den Ventilblock, wie er in den Patentansprüchen definiert ist.This object is achieved by the valve block as defined in the claims.
Der erfindungsgemässe Ventilblock ist aus Platten modular zusammengesetzt. Der Ventilblock weist eine Anschlussplatte auf und eine Mehrzahl von vorzugsweise identischen Kanalplatten, die je eines der Kanalsysteme darstellen. Die Platten sind in einem Stapel aneinander anliegend und beschränkt gegeneinander verschiebbar angeordnet. Die Anschlussplatte ist gegen die distalen Enden einer Anordnung von Kolbenpipetten oder anderen Dosiermitteln gerichtet und weist eine Mehrzahl von auf diese distalen Enden ausgerichteten, durchgehenden Öffnungen auf. Die Kanal-- platten weisen ebenfalls durchgehende Öffnungen auf, wobei die durchgehenden Öffnungen der Anschlussplatte und der Kanalplatten aufeinander ausrichtbar sind, das heisst alle im gleichen Raster angeordnet sind. Ferner weist jede Kanalplatte ein mindestens gegen die eine Plattenseite offenes Kanalsystem auf, das auf den Raster der durchgehenden Öffnungen abgestimmt ist, gegenüber diesem aber lateral verschoben angeordnet ist. Das Kanalsystem weist vorteilhafterweise an der Platten- Schmalseite mindestens einen Hauptanschluss auf.The valve block according to the invention is modularly composed of plates. The valve block has a connection plate and a plurality of preferably identical channel plates, each of which represents one of the channel systems. The plates are arranged in a stack adjacent to one another and are displaceable to a limited extent. The connection plate is directed against the distal ends of an arrangement of piston pipettes or other dosing means and has a plurality of through openings aligned with these distal ends. The channel plates also have through openings, the through openings of the connection plate and the channel plates being able to be aligned with one another, that is to say all are arranged in the same grid. Furthermore, each channel plate has a channel system that is open at least to one plate side, which is matched to the grid of the through openings, but is laterally displaced relative to this. The duct system advantageously has at least one main connection on the narrow side of the plate.
Die Kanalplatten sind im Plattenstapel derart gegeneinander und relativ zur Anschlussplatte verschiebbar, dass jede Kanalplatte im wesentlichen zwei Positionen haben kann: eine erste Position, in der ihre durchgehenden Öffnungen auf die durch- gehenden Öffnungen der Anschlussplatte ausgerichtet sind, und eine zweite Position, in der ihr Kanalsystem auf die durchgehenden Öffnungen der Anschlussplatte ausgerichtet ist.The channel plates are displaceable in relation to each other and relative to the connection plate in the plate stack in such a way that each channel plate can have essentially two positions: a first position in which its through openings face the outgoing openings of the connection plate are aligned, and a second position in which their channel system is aligned with the through openings of the connection plate.
Durch entsprechende Positionierung der Kanalplatten ist es sehr einfach möglich, die distalen Enden der Kolbenpipetten entweder mit den Dosierspitzen auf der anderen Seite des Ventilblocks zu verbinden oder aber wahlweise mit dem Kanalsystem einer der Kanalplatten bzw. mit deren Hauptanschluss. Wie noch zu zeigen ist, genügt es für die Verbindung der distalen Pipettenenden mit dem Hauptanschluss einer vorgegebenen Kanalplatte, diese vorgegebene Kanalplatte in die zweite Position zu brin- gen und alle anderen Kanalplatten in der ersten Position zu belassen.By appropriately positioning the channel plates, it is very easy to either connect the distal ends of the piston pipettes to the dosing tips on the other side of the valve block, or alternatively to the channel system of one of the channel plates or its main connection. As is still to be shown, it is sufficient for the connection of the distal pipette ends to the main connection of a predetermined channel plate, to bring this predetermined channel plate into the second position and to leave all other channel plates in the first position.
Die Anschlussplatte und die Kanalplatten des erfindungsgemässen Ventilblocks bestehen aus einem Material, dessen Oberflächen (gegebenenfalls entsprechend bearbeitet) einerseits gegeneinander dichten und andererseits immer noch dichtend gegeneinander verschoben werden können. Ferner soll das Material von den verwen- deten Flüssigkeiten natürlich nicht angegriffen werden. Es ist aus der Ventiltechnik, ■ insbesondere von den weit verbreiteten Einhebelmischera bekannt, dass für derartige Anwendungen vorteilhafterweise Keramikmaterialien eingesetzt werden.The connection plate and the channel plates of the valve block according to the invention consist of a material whose surfaces (if appropriate processed accordingly) can seal against one another on the one hand and can still be moved against one another in a sealing manner. Furthermore, the material should of course not be attacked by the liquids used. It is known from valve technology, ■ in particular from the widespread single-lever mixers, that ceramic materials are advantageously used for such applications.
Der erfindungsgemässe Ventilblock wird anhand der folgenden Figuren mehr im Detail beschrieben. Dabei zeigen:The valve block according to the invention is described in more detail with reference to the following figures. Show:
Figuren 1 bis 3 eine beispielhafte Ausführungsform des erfindungsgemässen Ventilblocks im Schnitt mit verschiedenen Positionen von Kanalplatten;Figures 1 to 3 an exemplary embodiment of the valve block according to the invention in section with different positions of channel plates;
Figur 4 eine Draufsicht auf die Anschlussplatte einer beispielhaften Ausführungsform des erfindungsgemässen Ventilblocks; Figur 5 eine Draufsicht auf eine Kanalplatte derselben Ausführungsform des erfindungsgemässen Ventilblocks;FIG. 4 shows a top view of the connection plate of an exemplary embodiment of the valve block according to the invention; Figure 5 is a plan view of a channel plate of the same embodiment of the valve block according to the invention;
Figur 6 ein Detail der Kanäle der Kanalplatte gemäss Figur 5.FIG. 6 shows a detail of the channels of the channel plate according to FIG. 5.
Figur 1 zeigt einen sehr schematischen und nicht vollständigen Schnitt durch eine Dosiervorrichtung, wie sie eingangs beschrieben wurde. Von der Dosiervorrichtung sind ein erfindungsgemässer Ventilblock 1, eine auf der einen Seite des Ventilblocks angeordnete Anordnung von Dosiermitteln (z.B. Kolbenpipetten 2) und eine auf der gegenüberliegenden Seite des Ventilblocks angeordnete Anordnung von Dosierspitzen 3 dargestellt. Der Ventilblock weist eine Anschlussplatte 10 und an die An- schlussplatte 10 anschliessend eine erste, zweite und dritte (äusserste) Kanalplatte 11, 12 und 13 auf, wobei die Platten mit Hilfe geeigneter Mittel (nicht dargestellt) derart in einem Stapel zusammengehalten sind, dass die Anschlussplatte 10 die eine Stirnseite des Stapels bildet und die äusserste Kanalplatte 13 die andere.FIG. 1 shows a very schematic and incomplete section through a metering device as described at the beginning. The metering device shows a valve block 1 according to the invention, an arrangement of metering means (e.g. piston pipettes 2) arranged on one side of the valve block and an arrangement of metering tips 3 arranged on the opposite side of the valve block. The valve block has a connecting plate 10 and a first, second and third (outermost) channel plate 11, 12 and 13 adjoining the connecting plate 10, the plates being held together in a stack by means of suitable means (not shown) in such a way that the connection plate 10 forms one end face of the stack and the outermost channel plate 13 the other.
Die Anschlussplatte 10 und die Kanalplatten 11, 12 und 13 weisen in einem gleichen, • vorteilhafterweise regelmässigen Muster angeordnete, durchgehende Öffnungen 14 auf, welches Muster an die Anordnung der Kolbenpipetten angepasst ist. An den Stirnseiten des Plattenstapels, also an der Anschlussplatte 10 bzw. der letzten Kanalplatte 13 bilden diese durchgehenden Öffnungen erste Mündungen 15 und zweite Mündungen 16 an die mit geeigneten Mitteln die Kolbenpipetten 2 oder andere ge- eignete Dosiermittel bzw. die Dosierspitzen oder andere geeignete Anschlussmittel angeschlossen sind.The connection plate 10 and the channel plates 11, 12 and 13 have the same through-openings 14, which are advantageously arranged in a regular pattern, which pattern is adapted to the arrangement of the piston pipettes. On the end faces of the plate stack, that is to say on the connecting plate 10 or the last channel plate 13, these through openings form first orifices 15 and second orifices 16 to which, with suitable means, the piston pipettes 2 or other suitable dosing means or the dosing tips or other suitable connecting means are connected.
Die Kanalplatten weisen zusätzlich zum Muster der durchgehenden Öffnungen ein Kanalsystem 20 auf. Dieses ist derart ausgelegt, dass es alle Öffnungen eines in einem gleichen Muster angeordneten Öffnungen mit mindestens einem Hauptanschluss verbindet, wobei es gegenüber dem Muster der durchgehenden Öffnungen aber lateral verschoben ist. Sind die durchgehenden Öffnungen beispielsweise in geradlinigen Reihen angeordnet, verlaufen die Kanäle des Kanalsystems parallel zu diesen Reihen und mit konstantem Abstand dazu. Ferner sind vorteilhafterweise ausserhalb des Musters von Öffnungen Sammelkanäle vorgesehen, die die Kanäle mit dem mindestens einem Hauptanschluss verbinden.In addition to the pattern of the through openings, the channel plates have a channel system 20. This is designed such that there are all openings of an opening arranged in the same pattern with at least one main connection connects, but it is laterally shifted from the pattern of the through openings. If the through openings are arranged, for example, in straight rows, the channels of the channel system run parallel to these rows and at a constant distance therefrom. Furthermore, collecting channels are advantageously provided outside the pattern of openings and connect the channels to the at least one main connection.
Figur 1 zeigt solche zwischen Reihen von durchgehenden Öffnungen angeordnete Kanäle 21 im Schnitt. Ein nicht sichtbarer, parallel zur Schnittebene verlaufender Sammelkanal 22 ist mit unterbrochenen Linien angedeutet. In derselben Weise ange- deutet ist ein Hauptanschluss 23. Die Kanäle 21 sind beispielsweise mittig zwischen den Reihen von durchgehenden Öffnungen 14 angeordnet, so dass eine laterale Verschiebung von zwei benachbarten Platten um das halbe Rastermass ein Schalten zwischen der Position mit aufeinander ausgerichteten, durchgehenden Öffnungen und einer Position mit auf durchgehende Öffnungen ausgerichteten Kanälen bewirkt.Figure 1 shows such channels 21 arranged between rows of through openings in section. A not visible, parallel to the section plane collecting channel 22 is indicated by broken lines. A main connection 23 is indicated in the same way. The channels 21 are arranged, for example, centrally between the rows of through openings 14, so that a lateral displacement of two adjacent plates by half the grid size means switching between the position with aligned through openings and a position with channels aligned with through openings.
Die Kanalsysteme 20 der Kanalplatten 11, 12 und 13 gemäss Figur 1 weisen eine - Tiefe auf, die kleiner ist als die Plattendicke (trogförmige Kanäle). Die Kanäle werden im Plattenstapel auf einer Seite durch eine benachbarte Platte abgeschlossen. Es ist auch möglich, den Kanälen eine Tiefe zu geben, die gleich gross ist wie die Plattendicke (schlitzförmige Kanäle). Solche schlitzförmigen Kanäle werden im Platten- Stapel beidseitig durch benachbarte Platten abgeschlossen. In diesem Falle ist auf der der Anschlussplatte 10 gegenüberliegenden Stirnseite des Ventilblockes eine weitere Anschlussplatte anzuordnen.The channel systems 20 of the channel plates 11, 12 and 13 according to FIG. 1 have a depth that is smaller than the plate thickness (trough-shaped channels). The channels are closed off on one side in the stack of plates by an adjacent plate. It is also possible to give the channels a depth that is the same as the plate thickness (slot-shaped channels). Such slot-like channels are closed on both sides in the stack of plates by adjacent plates. In this case, a further connection plate is to be arranged on the end face of the valve block opposite the connection plate 10.
Die Platten, die zusammen den erfindungsgemässen Ventilblock bilden, bestehen vorzugsweise aus einem keramischem Material, beispielsweise aus Aluminiumoxid. Wie dies in der Figur 1 dargestellt ist, ist es vorteilhaft, die Kanalplatten 11, 12 und 13 alle gleich auszugestalten, was den Preis des Ventilblocks niedrig hält. Wenn die Kanäle trogförmig sind, ist es offensichtlich auch möglich, als Anschlussplatte eine Kanalplatte zu verwenden, wobei die Kanäle dieser Platte dann keine funktioneile Bedeutung haben.The plates which together form the valve block according to the invention preferably consist of a ceramic material, for example of aluminum oxide. As shown in Figure 1, it is advantageous to design the channel plates 11, 12 and 13 all the same, which keeps the price of the valve block low. If the channels are trough-shaped, it is obviously also possible to use a channel plate as the connection plate, the channels of this plate then having no functional meaning.
Der Ventilblock wird beispielsweise zwischen zwei, für die ersten und zweiten Mündungen entsprechend gelochten Halteplatten, beispielsweise aus Stahl, gehalten, wobei die beiden Platten leicht gegeneinander gepresst werden. Zur Verschiebung einzelner Kanalplatten im Ventilblock sind auf zwei Seiten des Plattenstapels entspre- chende Stellmotoren anzubringen, die bei einer entsprechenden Ansteuerung schiebend auf eine der Kanalplatten wirken.The valve block is held, for example, between two holding plates, for example made of steel, perforated accordingly for the first and second orifices, the two plates being pressed lightly against one another. To move individual channel plates in the valve block, appropriate servomotors are to be installed on two sides of the plate stack. When actuated appropriately, they act on one of the channel plates.
In Figur 1 ist die Dosiervorrichtung in einem Zustand dargestellt, in dem die Kolbenpipetten über die aufeinander ausgerichteten, durchgehenden Öffnungen aller Platten mit den Dosierspitzen verbunden sind. In Figur 2, die nur noch den Ven- tilblock 1 zeigt, sind die Kolbenpipetten über die durchgehenden Öffnungen 14 der- Anschlussplatte 10 und der ersten zwei Kanalplatten 11 und 12 mit dem Kanalsystem der dritten Kanalplatte 13 verbunden. In Figur 3, die ebenfalls nur den Ventilblock 1 zeigt, sind die Kolbenpipetten über die durchgehenden Öffnungen 14 der Anschlussplatte 10 mit dem Kanalsystem der ersten Kanalplatte 11 verbunden.In Figure 1, the metering device is shown in a state in which the piston pipettes are connected to the metering tips via the aligned, continuous openings of all plates. In FIG. 2, which only shows the valve block 1, the piston pipettes are connected to the channel system of the third channel plate 13 via the through openings 14 in the connecting plate 10 and the first two channel plates 11 and 12. In FIG. 3, which also only shows the valve block 1, the piston pipettes are connected to the channel system of the first channel plate 11 via the through openings 14 of the connection plate 10.
Ein Vergleich der Figuren 1, 2 und 3 zeigt, dass für eine Umstellung des Ventilblok- kes 1 von einem Zustand, in dem die ersten und zweiten Mündungen 15 und 16 je miteinander verbunden sind, zu einem Zustand, in dem die ersten Mündungen 15 mit einem ausgewählten Kanalsystem verbunden sind, eine Verschiebung der entsprechenden Kanalplatte um ein halbes Rastermass genügt (Figur 2: dritte Kanalplatte 13, Figur 3 : erste Kanalplatte 11). Figur 4 zeigt als Draufsicht eine beispielhafte Ausführungsform einer Anschlussplatte 10. Die durchgehenden Öffnungen 14 bzw. ersten Mündungen 15 sind in Reihen mit einem Abstand d angeordnet. Das Muster der durchgehenden Öffnungen entspricht beispielsweise dem Kavitätenmuster von genormten Mikrotestplatten (mit 96 , 384 oder 1536 Kavitätten) .A comparison of FIGS. 1, 2 and 3 shows that for a changeover of the valve block 1 from a state in which the first and second orifices 15 and 16 are each connected to one another in a state in which the first orifices 15 are connected are connected to a selected duct system, a displacement of the corresponding duct plate by half a grid dimension is sufficient (FIG. 2: third duct plate 13, FIG. 3: first duct plate 11). FIG. 4 shows a top view of an exemplary embodiment of a connecting plate 10. The through openings 14 or first openings 15 are arranged in rows with a distance d. The pattern of the through openings corresponds, for example, to the cavity pattern of standardized microtest plates (with 96, 384 or 1536 cavities).
Figur 5 zeigt eine Kanalplatte 11, die zusammen mit der Anschlussplatte 10 der Figur 4 in einem erfindungsgemässen Ventilblock anwendbar ist. Die Kanalplatte 11 weist Kanäle 21 auf, die mittig zwischen den Reihen von durchgehenden Öffnungen verlaufen, von diesen also einen Abstand d/2 haben. Die Kanäle 21 münden in Sam- meikanäle 22, die ausserhalb des Musters von durchgehenden Öffnungen verlaufen und die ihrerseits in den Hauptanschluss 23 münden.FIG. 5 shows a channel plate 11 which can be used together with the connection plate 10 of FIG. 4 in a valve block according to the invention. The channel plate 11 has channels 21 which run centrally between the rows of through openings, ie have a distance d / 2 from them. The channels 21 open into common channels 22, which run outside the pattern of through openings and which in turn open into the main connection 23.
Figur 6 zeigt in einem dreidimensional dargestellten Detail die Kanäle 21 der Kanalplatte 11 gemäss Figur 5. Diese Kanäle 21 verlaufen mittig zwischen den Reihen von durchgehenden Öffnungen 14 und sind trogförmig, wie dies auch in den Fi- guren 1 bis 3 dargestellt ist. Um eine regelmässige Flüssigkeitsverteilung auf an die- Kanäle 21 anschliessende, durchgehenden Öffnungen zu garantieren, sind die Kanäle 21 vorteilhafterweise derart ausgestaltet, dass sich ihr Querschnitt gegen die Mündung in einen Sammelkanal 22 vergrössert. Dies wird beispielsweise, wie aus der Figur 6 ersichtlich durch eine grösser werdende Tiefe der trogförmigen Kanäle reali- siert. 6 shows in a three-dimensional detail the channels 21 of the channel plate 11 according to FIG. 5. These channels 21 run centrally between the rows of through openings 14 and are trough-shaped, as is also shown in FIGS. 1 to 3. In order to guarantee a regular distribution of liquid to through-openings adjoining the channels 21, the channels 21 are advantageously designed in such a way that their cross section increases towards the mouth into a collecting channel 22. This is realized, for example, as can be seen from FIG. 6, by increasing the depth of the trough-shaped channels.

Claims

PATENTANSPRÜCHE
1. Ventilblock für eine Dosiervorrichtung mit einer Anordnung von Dosiermitteln, welcher Ventilblock auf seiner einen Seite ein erstes Muster von ersten, auf die Dosiermittel ausrichtbaren Mündungen (15), auf seiner gegenüberlie- genden Seite je einer ersten Mündung entsprechende zweite Mündungen (16) und eine Mehrzahl von Kanalsystemen (20) mit je mindestens einem Hauptanschluss (23) aufweist, dadurch gekennzeichnet, dass der Ventilblock (1) eine Mehrzahl von in einem Stapel angeordneten Platten (10, 11, 12, 13) aufweist, dass alle Platten (10, 11, 12, 13, 14) eine Mehrzahl von im ersten Muster ange- ordneten, durchgehenden Öffnungen (14) aufweisen, dass mindestens ein Teil der Platten (11, 12, 13) zusätzlich je ein Kanalsystem (20) mit Kanälen (21), die mit dem Hauptanschluss (23) verbunden sind, aufweisen, wobei die Kanäle (21) in einem zweiten Muster angeordnet sind, das auf das erste Muster abgestimmt und gegenüber diesem lateral verschoben ist, und dass zur wahlweisen Verbindung der ersten Mündungen (15) mit je einer zweiten Mündung (16) oder mit einem der Kanalsysteme (20) mindestens die Platten (11, 12, 13) mit Kanalsystem lateral einzeln gegeneinander verschiebbar sind.1. Valve block for a dosing device with an arrangement of dosing means, which valve block has on its one side a first pattern of first orifices (15) that can be aligned with the dosing means, on the opposite side of each second orifice corresponding to a first orifice (16) and has a plurality of channel systems (20), each with at least one main connection (23), characterized in that the valve block (1) has a plurality of plates (10, 11, 12, 13) arranged in a stack, that all plates (10 , 11, 12, 13, 14) have a plurality of through openings (14) arranged in the first pattern such that at least some of the plates (11, 12, 13) each additionally have a channel system (20) with channels (21 ), which are connected to the main connection (23), the channels (21) being arranged in a second pattern which is matched to the first pattern and laterally displaced with respect to it, and that for the optional V Connection of the first mouths (15) with a second mouth (16) or with one of the channel systems (20) at least the plates (11, 12, 13) with the channel system are laterally individually displaceable.
2. Ventilblock nach Anspruch 1, dadurch gekennzeichnet, dass die durchgehenden Öffnungen (14) in Reihen angeordnet sind und die Kanäle (21) zwischen den Reihen und mit einem konstanten Abstand von diesen verlaufen.2. Valve block according to claim 1, characterized in that the through openings (14) are arranged in rows and the channels (21) between the rows and at a constant distance from them.
3. Ventilblock nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, dass die Kanalsysteme (20) zusätzlich Sammelkanäle (22) aufweisen, die ausserhalb des Musters von durchgehenden Öffnungen (14) verlaufen. 3. Valve block according to one of claims 1 or 2, characterized in that the channel systems (20) additionally have collecting channels (22) which run outside the pattern of through openings (14).
Ventilblock nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass die Hauptanschlüsse (23) an den Plattenschmalseiten angeordnet sind. Valve block according to one of claims 1 to 3, characterized in that the main connections (23) are arranged on the narrow sides of the plate.
5. Ventilblock nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass die Kanäle (21) trogförmig sind.5. Valve block according to one of claims 1 to 4, characterized in that the channels (21) are trough-shaped.
6. Ventilblock nach Anspruch 5, dadurch gekennzeichnet, dass eine im Plattenstapel aussen angeordnete Platte eine Anschlussplatte (10) ohne Kanalsystem (20) ist.6. Valve block according to claim 5, characterized in that a plate arranged on the outside in the plate stack is a connecting plate (10) without a channel system (20).
7. Ventilblock nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass die Kanäle (21) einen gegen ihre Mündungen sich vergrössernden Querschnitt aufweisen.7. Valve block according to one of claims 1 to 6, characterized in that the channels (21) have a cross-section which enlarges towards their mouths.
8. Ventilblock nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass die Platten (10, 11, 12, 13) aus einem Keramikmaterial bestehen. 8. Valve block according to one of claims 1 to 7, characterized in that the plates (10, 11, 12, 13) consist of a ceramic material.
EP02732306A 2001-06-26 2002-06-10 Valve block Withdrawn EP1399745A2 (en)

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CH117101 2001-06-26
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PCT/CH2002/000306 WO2003001215A2 (en) 2001-06-26 2002-06-10 Valve block for an arrangement of piston pipettes

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US11035480B2 (en) 2016-02-24 2021-06-15 Leanna Levine and Aline, Inc. Mechanically driven sequencing manifold
CN109074062B (en) * 2016-02-24 2023-02-17 琳娜·莱文 Mechanically driven sequencing manifold
EP4308685A1 (en) * 2021-04-12 2024-01-24 Octane Biotech Inc. Combinatorial fluid switch for use in automated cell engineering systems

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US2904070A (en) * 1955-06-06 1959-09-15 Ibm Multi-port selector
US2857082A (en) * 1957-04-19 1958-10-21 Nat Equip Corp Pump construction for candy depositing machines
FR1586152A (en) * 1968-07-26 1970-02-13
DE3813671A1 (en) * 1988-04-22 1989-11-02 Europ Lab Molekularbiolog DEVICE FOR CARRYING OUT CHEMICAL REACTIONS
DE4206488C2 (en) * 1992-03-02 1993-12-23 Deutsches Krebsforsch Device for carrying out chemical reactions taking place simultaneously or sequentially
JP2002504018A (en) * 1997-06-16 2002-02-05 ケムスピード・リミテッド Devices that perform multiple chemical, biochemical or physical processes in parallel

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