EP1383541A4 - Methods for delivering nucleic acid molecules into cells and assessment thereof - Google Patents

Methods for delivering nucleic acid molecules into cells and assessment thereof

Info

Publication number
EP1383541A4
EP1383541A4 EP02753692A EP02753692A EP1383541A4 EP 1383541 A4 EP1383541 A4 EP 1383541A4 EP 02753692 A EP02753692 A EP 02753692A EP 02753692 A EP02753692 A EP 02753692A EP 1383541 A4 EP1383541 A4 EP 1383541A4
Authority
EP
European Patent Office
Prior art keywords
assessment
cells
methods
nucleic acid
acid molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02753692A
Other languages
German (de)
French (fr)
Other versions
EP1383541A1 (en
Inventor
Gary Dejong
Sandra Louise Vanderbyl
Volker Oberle
Dirk Hoekstra
Jan Drayer
Paul Peter Tak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Chromos Molecular Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/815,979 external-priority patent/US7294511B2/en
Priority claimed from US09/815,981 external-priority patent/US6936469B2/en
Priority claimed from US10/086,745 external-priority patent/US20030186390A1/en
Application filed by Chromos Molecular Systems Inc filed Critical Chromos Molecular Systems Inc
Publication of EP1383541A1 publication Critical patent/EP1383541A1/en
Publication of EP1383541A4 publication Critical patent/EP1383541A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
EP02753692A 2001-03-22 2002-03-22 Methods for delivering nucleic acid molecules into cells and assessment thereof Withdrawn EP1383541A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US815981 1992-01-02
US815979 2001-03-22
US09/815,979 US7294511B2 (en) 2001-03-22 2001-03-22 Methods for delivering nucleic acid molecules into cells and assessment thereof
US09/815,981 US6936469B2 (en) 2001-03-22 2001-03-22 Methods for delivering nucleic acid molecules into cells and assessment thereof
US10/086,745 US20030186390A1 (en) 2001-03-22 2002-02-28 Methods for delivering nucleic acid molecules into cells and assessment thereof
US86745 2002-02-28
PCT/US2002/009262 WO2002076508A1 (en) 2001-03-22 2002-03-22 Methods for delivering nucleic acid molecules into cells and assessment thereof

Publications (2)

Publication Number Publication Date
EP1383541A1 EP1383541A1 (en) 2004-01-28
EP1383541A4 true EP1383541A4 (en) 2009-11-04

Family

ID=27375461

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02753692A Withdrawn EP1383541A4 (en) 2001-03-22 2002-03-22 Methods for delivering nucleic acid molecules into cells and assessment thereof

Country Status (6)

Country Link
EP (1) EP1383541A4 (en)
JP (1) JP2004532205A (en)
CA (1) CA2441535C (en)
IL (1) IL157703A0 (en)
NZ (1) NZ527972A (en)
WO (1) WO2002076508A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
IL157746A0 (en) 2001-05-30 2004-03-28 Chromos Molecular Systems Inc Chromosome-based platforms
JP4676679B2 (en) * 2003-04-02 2011-04-27 帝人株式会社 Artificial cartilage
ES2679282T3 (en) 2004-10-22 2018-08-23 Revivicor Inc. Transgenic pigs that lack endogenous immunoglobulin light chain
JP5115686B2 (en) * 2006-04-17 2013-01-09 学校法人慶應義塾 Drug introduction device to cells
EP2348827B1 (en) 2008-10-27 2015-07-01 Revivicor, Inc. Immunocompromised ungulates
CN109963506B (en) 2016-11-22 2024-05-07 西达-赛奈医疗中心 Novel transfection and drug delivery device
CN117357480B (en) * 2023-12-08 2024-03-29 北京中科利华医药研究院有限公司 Composition for needleless percutaneous injection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000569A1 (en) * 1992-06-18 1994-01-06 Genpharm International, Inc. Methods for producing transgenic non-human animals harboring a yeast artificial chromosome
EP0755924A1 (en) * 1995-07-25 1997-01-29 Stichting voor de Technische Wetenschappen Transportvehicles for macromolecules
WO1999025385A1 (en) * 1997-11-17 1999-05-27 Imarx Pharmaceutical Corp. A method of increasing nucleic acid synthesis with ultrasound
WO2000034436A2 (en) * 1998-12-04 2000-06-15 Genetronics, Inc. Facs assisted methods for introducing individual chromosomes into cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US6184037B1 (en) * 1996-05-17 2001-02-06 Genemedicine, Inc. Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
US6074667A (en) * 1996-11-20 2000-06-13 Kinnunen; Paavo Liposomal transfection method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000569A1 (en) * 1992-06-18 1994-01-06 Genpharm International, Inc. Methods for producing transgenic non-human animals harboring a yeast artificial chromosome
EP0755924A1 (en) * 1995-07-25 1997-01-29 Stichting voor de Technische Wetenschappen Transportvehicles for macromolecules
WO1999025385A1 (en) * 1997-11-17 1999-05-27 Imarx Pharmaceutical Corp. A method of increasing nucleic acid synthesis with ultrasound
WO2000034436A2 (en) * 1998-12-04 2000-06-15 Genetronics, Inc. Facs assisted methods for introducing individual chromosomes into cells

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALLSHIRE R C: "Introduction of large linear minichromosomes into Schizosaccharomyces pombe by an improved transformation procedure", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 87, no. 11, 1 January 1990 (1990-01-01), pages 4043 - 4047, XP002345219, ISSN: 0027-8424 *
CYTOMETRY, vol. 44, no. 2, 1 June 2001 (2001-06-01), pages 100 - 105, ISSN: 0196-4763 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 June 2001 (2001-06-01), VANDERBYL SANDRA ET AL: "A flow cytometry technique for measuring chromosome-mediated gene transfer", XP002546669, Database accession no. PREV200100318894 *
JONG DE G ET AL: "EFFICIENT IN-VITRO TRANSFER OF A 60-MB MAMMALIAN ARTIFICIAL CHROMOSOME INTO MURINE AND HAMSTER CELLS USING CATIONIC LIPIDS AND DENDRIMERS", CHROMOSOME RESEARCH, KLUWER ACADEMIC PUBLISHERS, NL, vol. 9, no. 6, 23 April 2001 (2001-04-23), pages 475 - 485, XP009020460, ISSN: 0967-3849 *
JULICHER K ET AL: "Yeast Artificial Chromosome Transfer into Human Renal Carcinoma Cells by Spheroplast Fusion", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 43, no. 1, 1 July 1997 (1997-07-01), pages 95 - 98, XP004459277, ISSN: 0888-7543 *
LEE J T ET AL: "A method for high efficiency YAC lipofection into murine embryonic stem cells", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 24, no. 24, 1 January 1996 (1996-01-01), pages 5054 - 5055, XP002260393, ISSN: 0305-1048 *
OHSE MORIMASA ET AL: "A new and efficient method for gene transfer into mouse FM3A cells using metaphase chromosomes by electroporation", BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, vol. 60, no. 11, 1996, pages 1879 - 1881, XP002546668, ISSN: 0916-8451 *
RECH E L ET AL: "INTRODUCTION OF YEAST ARTIFICIAL CHROMOSOME VECTOR INTO SACCHAROMYCES-CEREVISIAE CELLS BY ELECTROPORATION", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 18, no. 5, 20 September 1990 (1990-09-20), pages 1313, XP001155836, ISSN: 0305-1048 *
See also references of WO02076508A1 *

Also Published As

Publication number Publication date
WO2002076508B1 (en) 2002-12-12
WO2002076508A1 (en) 2002-10-03
IL157703A0 (en) 2004-03-28
NZ527972A (en) 2006-04-28
JP2004532205A (en) 2004-10-21
CA2441535C (en) 2008-08-26
CA2441535A1 (en) 2002-10-03
EP1383541A1 (en) 2004-01-28

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Inventor name: TAK, PAUL, PETER

Inventor name: DRAYER, JAN

Inventor name: HOEKSTRA, DIRK

Inventor name: OBERLE, VOLKER

Inventor name: VANDERBYL, SANDRA, LOUISE

Inventor name: DEJONG, GARY

A4 Supplementary search report drawn up and despatched

Effective date: 20091002

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Owner name: GLAXO GROUP LIMITED

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