EP1329262B1 - Pipette et procédé pour sa production - Google Patents

Pipette et procédé pour sa production Download PDF

Info

Publication number
EP1329262B1
EP1329262B1 EP03000390A EP03000390A EP1329262B1 EP 1329262 B1 EP1329262 B1 EP 1329262B1 EP 03000390 A EP03000390 A EP 03000390A EP 03000390 A EP03000390 A EP 03000390A EP 1329262 B1 EP1329262 B1 EP 1329262B1
Authority
EP
European Patent Office
Prior art keywords
pipette
section
shaft
sealing section
pipette shaft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP03000390A
Other languages
German (de)
English (en)
Other versions
EP1329262A2 (fr
EP1329262A3 (fr
Inventor
Peter Mahler
Renate Rempt
Peter Prokopp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brand GmbH and Co KG
Original Assignee
Brand GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10211794A external-priority patent/DE10211794A1/de
Application filed by Brand GmbH and Co KG filed Critical Brand GmbH and Co KG
Publication of EP1329262A2 publication Critical patent/EP1329262A2/fr
Publication of EP1329262A3 publication Critical patent/EP1329262A3/fr
Application granted granted Critical
Publication of EP1329262B1 publication Critical patent/EP1329262B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means

Definitions

  • the invention relates to a pipette with a pipette shaft made of preferably thermoplastic material for attaching a likewise made of plastic pipette tip with the features of the preamble of claim 1.
  • the invention also provides a method for producing such a pipette having the features of the preamble of claim 11th
  • the sealing portion is located at the attachment portion of the pipette shaft with inserted pipette tip deep within the pipette tip.
  • the sealing section is located in a circumferential recess extending from the end of the pipette shaft, in which this sealing section is formed in an immediately adhesive manner from an elastically yielding, well-sealing elastomeric material.
  • the teaching is based on the problem, a pipette of the type in question to design and further that a tolerance insensitive pipette shaft is realized, low withdrawal forces when discarding the pipette tip present and yet the previously described problems with cleaning options and contamination risk are eliminated.
  • the sealing portion is not executed separately, but formed directly adherent to the thermoplastic resin of the pipette shaft. This has the advantage that the sealing portion is held captive and not displaced when attaching the pipette tip. This avoids a spongy touch feeling for the user. Also, no gap is created by a displacement of the Abdichtabiteses, so that contamination is avoided. It eliminates the second sealing between the recess of the pipette shaft and the Abdichtabites. The boundary layer is sealed and neither dirt nor liquid can penetrate.
  • the invention also provides a process for producing a pipette having the features of the preamble of claim 11, which is described in more detail by the features of the characterizing part of claim 11.
  • advantageous embodiments are the subject of the subsequent dependent claims.
  • Fig. 1 shows a pipette 1 as a single-channel pipette.
  • the teaching of the present invention is not limited to a single-channel pipette. It is equally usable for multichannel pipettes (cf. DE 100 13 511 A1 ) as well as for mechanical pipetting devices.
  • the teaching of the invention involves the coupling of a pipette tip to the pipette shaft of a pipette.
  • the DE 100 13 511 A1 deals with constructive solutions of the interchangeability of the pipette shaft in a multi-channel pipetting device. These design solutions can also be used in a multi-channel pipette, which is designed according to the teaching of the present patent application.
  • Fig. 1 shows the pipette 1 with a handle 2, a manual control button as Pipettierbettechnik 3 and an adjustment 4 for adjusting the volume to be pipetted and / or for calibration of the pipette 1.
  • a pipette shaft 5 At the bottom is indicated a pipette shaft 5, the in Fig. 1 is covered by an ejector 6.
  • the Abwerferhülse 6 is a Abwerbet2011 Trent 7, which is also designed as a push button, in Fig. 1 be pushed axially down to drop a bottom of the pipette shaft 5 plugged pipette tip 8 after performing the pipetting process or the multiple desired pipetting.
  • Fig. 2 shows now in an enlarged and sectional view of the lower end of the pipette shaft 5 with an axially recognizable axial flow channel 9 for performing the pipetting process, and from below on the pipette shaft 5 plugged a pipette tip 8.
  • the pipette shaft 5 is of the in Fig. 1 already identified ejector sleeve 6 surrounded.
  • the invention thus relates to a pipette 1 with a pipette shaft 5 made of preferably thermoplastic material for attaching a pipette tip 8, which is also preferably made of thermoplastic material, which has a plug-on section 10 which opens at least slightly conically, with a fastening section formed on the lower end of the pipette shaft 5 11, onto which the slip-on section 10 of the pipette tip 8 is slipped, wherein a sealing section 12 consisting of elastically yielding plastic material which already seals well with low withdrawal forces is provided on the fastening section 11.
  • a sealing section 12 consisting of elastically yielding plastic material which already seals well with low withdrawal forces is provided on the fastening section 11.
  • it is additionally provided that at the attachment portion 11 axially offset to the sealing portion 12 a formed on the plastic material of the pipette shaft 5 fixing portion 13 is provided. The latter will be explained later in more detail.
  • sealing portion 12 of elastic-flexible plastic material on the plastic of the pipette shaft 5 is formed directly adherent. In the illustrated embodiment, this is realized so that the sealing portion 12 is integrally formed on the pipette shaft 5.
  • the illustrated and preferred embodiment is particularly characterized by the fact that the pipette shaft 5 is designed with the sealing portion 12 as a two-component plastic injection molded part, wherein the one component is the material of the pipette shaft 5 and the other component is the material of the Abdichtabiteses 12.
  • the elastic and flexible plastic material, on which or in which the sealing portion 12 is formed, can be implemented particularly expedient in two-component plastic injection molding.
  • the compound of the materials is particularly intimate, it leaves create a perfect material connection of the plastic materials.
  • the plastic of the pipette shaft 5 is a polypropylene, which is preferably carried talumver prisone.
  • this material selection then fits that the plastic material of the Abdichtabiteses 12 is a mixture polypropylene / ethylene-propylene-diene terpolymer (PP / EPDM blend).
  • PP / EPDM blend polypropylene / ethylene-propylene-diene terpolymer
  • a likewise compatible with polypropylene material choice is, for example, a thermoplastic elastomer (TPE).
  • the pipette shaft 5 of the pipette 1 there are now various ways to equip the pipette shaft 5 of the pipette 1 with the sealing portion 12.
  • the forces directed in the axial direction when attaching and dropping the pipette tip 8 can lead to problems here.
  • the pipette shaft 5 in the region of the Abdichtabiteses 12 has a circumferential, ringnutieri recess 14 of a certain axial extent and that the sealing portion 12 is formed in the recess 14.
  • the sealing portion 12th is incorporated in the two-component plastic injection molding process, the sealing portion 12th
  • the sealing portion 12 may be extended in the upper region to below the ejector sleeve 6.
  • the transition from the sealing portion 12 to the surface of the pipette shaft 5 is not critical and need not be made flush.
  • the pipette shaft 5 protrudes a little further radially outwards, forms a ring-like shoulder and represents the guide for the ejector sleeve 6.
  • the illustrated embodiment of the pipette 1 according to the invention is optimally sealable, the junction sealing portion 12 / pipette shaft 5 is in the region of the recess 14 on all sides gap-free and completely sealed.
  • the seal for Aufsteckabêt 10 of the pipette tip 8 is in elastic-compliant plastic material realized and optimally functional.
  • the plastic material of the sealing portion 12 is set conflicting demands that must be reconciled with each other. It is necessary to choose the plastic material of the Abdichtabiteses 12 so that deformability and wear resistance in a balanced relationship to each other. Abrasive surface wear, which becomes particularly strong when the plastic material of the Abdichtabiteses 12, for example, the thermoplastic elastomer, is greatly compressed, can be counteracted by increasing the flexibility of the plastic material.
  • the plastic material of the sealing portion 12 in turn with a low-wear and / or low-friction protective layer or protective modification of the surface.
  • this additional protective layer is in Fig. 2 not shown in the drawing. In Fig. 3 However, this is indicated at 12 '.
  • the plastic material of the Abdichtabiteses 12 is provided at least in the main investment area with this protective layer, which in turn is directly adherent, in particular material-locking, formed on the plastic material of the Abdichtabiteses 12.
  • the elastomeric material core of the sealing section 12 which provides the necessary and desired deformability of the sealing section 12, is then coated with a thin, flexible, sleeve-like layer of preferably thermoplastic material, which gives the desired wear resistance.
  • An example is a coating of PTFE (polytetrafluoroethylene).
  • PTFE polytetrafluoroethylene
  • FEP a copolymer of hexafluoropropylene and tetrafluoroethylene
  • annular region 15 of larger diameter there are also special variants for the design of the annular region 15 of larger diameter.
  • two successive rings or specially shaped rings as in the case of DE 38 87 205 T2 or lip-shaped ring-like shapes as in the DE 100 13 511 A1 realize in the region of the tip seal, if the application has been found to be appropriate.
  • the illustrated embodiment shows that at the attachment portion 11 axially offset from the sealing portion 12 a formed on the plastic material of the pipette shaft 5 fixing portion 13 is provided. It is expedient in this case that the fixing section 13 is formed at the lower end of the pipette shaft 5 and the sealing section 12 is arranged at an axial distance from the lower end of the pipette shaft 5.
  • the fixing portion 13 serves as a stop in the dulling inner cone of the slip-on section 10 of the pipette tip 8.
  • FIG. 2 illustrated preferred embodiment further shows that the attachment portion 11 of the pipette shaft 5 has a broken here from the annular portion 15 of the Abdichtabiteses 12 cylindrical outer contour or a less conical contour than the Aufsteckabrough 10 of the pipette tip 8, so that the lower edge of the pipette shaft 5, the fixing portion 13 forms.
  • Fig. 3 shows a further preferred embodiment of a pipette 1.
  • a circumferential annular flange 16 is provided at a distance from the end of the pipette shaft 5 on the pipette shaft 5, which optionally serves as a Aufsteckanschlag for the Aufsteckabêt 10 of the pipette tip 8.
  • Such an annular flange 16 can be seen already at the lower end of the ejector 6 in Fig. 1 , The lower edge of the Abwerferhülse 6 forms this annular flange 16, which ultimately performs the ejector function.
  • Fig. 3 shows a modification that extends the scope of the claimed pipette 1 again significantly. It is namely provided that at the lower end of the ejector 6, a spacer element 17 of certain axial length is interchangeably arranged, which forms the annular flange 16 so that pipette tips 8 different effective axial length of the Aufsteckabêtes 10 together with the pipette shaft 5 can be used.
  • the illustrated embodiment shows that here the spacer 17 is designed as a kind of spacer sleeve made of plastic. This spacer 17 is not only simply plugged onto the pipette shaft 5, but it is attached to the ejector 6, namely attached to this. It therefore forms with the Abwerferhülse 6 a total by means of the Abwerferbetuschist 7 movable unit.
  • the present variant serves to realize different distances between the lower edge of the ejector 6 and the upper edge of the Aufsteckabiteses 10 a plugged-pipette tip 8. So you can use different pipette tips 8. It is therefore expedient that a plurality of spacer elements 17 of different axial length can be arranged on the ejector sleeve 6, in particular attachable.
  • the illustrated embodiment also shows that the spacer 17 on the outside with a Manipulationsausformung 18, in particular in the form of an annular recess or Ring groove, provided.
  • a manipulation tool that is to say a pull-off and plug-on tool, can act on the manipulation formation 18 in order to remove or place the spacer 17.
  • Another, also manufacturing technically expedient alternative is to work with two injection molds, ie first to form the pipette shaft in a first injection mold and then introduce after sufficient cooling the semi-finished molding "pipette shaft" in a second injection mold and to form the Abdichtabrough therein.
  • the two last-mentioned process techniques make it possible to work with different materials for the pipette shaft on the one hand and the sealing section on the other hand, which only have to fulfill a sufficient adhesion of the sealing section formed in the second step to the surface of the pipette shaft formed in the first step.
  • a far-reaching material connection as in a classic two-component injection molding process is so difficult to achieve.
  • the use of one or the other method is so a corresponding analysis of the withdrawal forces and sealing forces occurring in practice on the finished part.
  • the applied two-component plastic injection molding process as a manufacturing method at the present location of a pipette unfolds various effects, which results in a particularly expedient and unpredictable synergetic result.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)

Claims (15)

  1. Pipette comprenant une tige de pipette (5) en plastique, une douille de dispositif d'éjection (6) entourant la tige de pipette (5) et un actionnement du dispositif d'éjection (7), la tige de pipette (5) étant réalisée pour permettre d'enficher une pointe de pipette (8) également constituée de plastique, qui présente une portion d'enfichage (10) s'ouvrant de préférence de manière légèrement conique, avec une portion de fixation (11) réalisée à l'extrémité inférieure de la tige de pipette (5), sur laquelle est enfichée la portion d'enfichage (10) de la pointe de pipette (8),
    une portion d'étanchéité (12) constituée d'un matériau en plastique flexible élastiquement et déjà bien hermétique pour de faibles forces de traction étant prévue sur la portion de fixation (11) et la douille de dispositif d'éjection (6) étant poussée axialement vers le bas par l'actionnement du dispositif d'éjection (7) par rapport à la tige de pipette (5), afin d'éjecter une pointe de pipette (8) enfichée par le bas sur la tige de pipette (5) après la mise en oeuvre de l'opération de pipetage ou de plusieurs opérations de pipetage,
    caractérisée en ce que
    la portion d'étanchéité (12) en matériau en plastique élastiquement flexible et bien hermétique est moulée sur le plastique de la tige de pipette (5) en adhérant fixement directement, la portion d'étanchéité (12) s'étend dans la région supérieure jusqu'à la douille du dispositif d'éjection (6) et
    à l'extrémité inférieure de la douille du dispositif d'éjection (6) est disposé, de manière remplaçable, un élément d'espacement (17) de longueur axiale déterminée, qui forme une bride annulaire périphérique (16), de sorte que des pointes de pipette (8) de différente longueur axiale active de la portion d'enfichage (10) puissent être utilisées conjointement avec la tige de pipette (5).
  2. Pipette selon la revendication 1, caractérisée en ce que la portion d'étanchéité (12) est moulée par liaison de matière sur la tige de pipette (5), et de préférence la tige de pipette (5) est réalisée avec la portion d'étanchéité (12) sous forme de pièce moulée par injection de plastique à deux composants, l'un des composants étant le matériau de la tige de pipette (5) et l'autre composant étant le matériau de la portion d'étanchéité (12).
  3. Pipette selon la revendication 1 ou 2,
    caractérisée en ce que le plastique de la tige de pipette (5) est de préférence un polypropylène renforcé par du talc et en ce que le matériau en plastique de la portion d'étanchéité (12) est un mélange de polypropylène/terpolymère d'éthylène-propylène-diène (mélange PP/EPDM) ou un élastomère thermoplastique (TPE).
  4. Pipette selon l'une quelconque des revendications 1 à 3, caractérisée en ce que la tige de pipette (5) présente, dans la région de la portion d'étanchéité (12), un évidement périphérique de type rainure annulaire (14) d'une étendue axiale déterminée, la portion d'étanchéité (12) étant disposée dans l'évidement (14) et le matériau en plastique de la portion d'étanchéité (12) se terminant sans fente avec tous les bords de l'évidement (14) et/ou se terminant en affleurement au moins avec les bords de l'évidement (14) associés à l'extrémité de la tige de pipette (5), de préférence avec tous les bords de l'évidement (14).
  5. Pipette selon l'une quelconque des revendications 1 à 4, caractérisée en ce que le matériau en plastique de la portion d'étanchéité (12), au moins dans la région d'appui principale, est pourvu d'une couche de protection (12') à faible usure et/ou à faible friction ou d'une modification protectrice de la surface, qui est pour sa part moulée directement et fixement par adhérence, notamment par liaison de matière, au matériau en plastique de la portion d'étanchéité (12).
  6. Pipette selon l'une quelconque des revendications 1 à 5, caractérisée en ce qu'au moins une région de type annulaire (15) de relativement plus grand diamètre est moulée sur la portion d'étanchéité (12) .
  7. Pipette selon l'une quelconque des revendications 1 à 6, dans laquelle une portion de fixation (13) réalisée sur le matériau en plastique de la tige de la pipette (5) est prévue sur la portion de fixation (11) de manière décalée axialement par rapport à la portion d'étanchéité (12), caractérisée en ce que la portion de fixation (13) est réalisée sur la tige de la pipette (5) à l'extrémité inférieure de la tige de la pipette (5) et la portion d'étanchéité (12) est disposée à distance axiale de l'extrémité inférieure de la tige de la pipette (5),
    et de préférence la portion de fixation (11) de la tige de la pipette (5) a un contour extérieur cylindrique interrompu éventuellement par une région de type annulaire (15) de la portion d'enfichage (10) ou un contour moins fortement conique en tant que portion d'enfichage (10) de la pointe de la pipette (8), de sorte que le bord inférieur de la tige de la pipette (5) forme la portion de fixation (13).
  8. Pipette selon l'une quelconque des revendications 1 à 7, caractérisée en ce que l'élément d'espacement (17) est monté sur la douille du dispositif d'éjection (6), notamment est enfiché sur celle-ci, et de préférence plusieurs éléments d'espacement (17) de longueur axiale différente peuvent être disposés, notamment montés, sur la douille du dispositif d'éjection (6).
  9. Pipette selon l'une quelconque des revendications 1 à 8, caractérisée en ce que l'extrémité inférieure de la douille du dispositif d'éjection (6) forme elle-même, sans élément d'espacement (17), également la bride annulaire (16) pour une pointe de pipette (8) avec une longueur axiale efficace déterminée de la portion d'enfichage (10).
  10. Pipette selon l'une quelconque des revendications 1 à 9, caractérisée en ce que l'élément d'espacement (17) est pourvu sur son côté extérieur d'une formation de manipulation (18), en particulier en forme d'évidement annulaire ou de rainure annulaire.
  11. Procédé de fabrication d'une pipette selon la revendication 1, comprenant une tige de pipette en plastique, une douille de dispositif d'éjection entourant la tige de pipette et un actionnement du dispositif d'éjection, une portion d'enfichage étant réalisée à l'extrémité inférieure de la tige de pipette, sur laquelle est enfichée une portion d'enfichage d'une pointe de pipette,
    dans lequel, sur la portion de fixation, est montée une portion d'étanchéité constituée de matériau en plastique flexible élastiquement déjà bien hermétique pour de faibles forces de traction, qui, lorsque la pointe de pipette est enfichée, s'applique hermétiquement sur le côté intérieur de la portion d'enfichage,
    caractérisé en ce que
    la portion d'étanchéité est formée en matériau en plastique flexible élastiquement conjointement avec la tige de pipette dans un procédé de moulage par injection de plastique à deux composants,
    le matériau en plastique de la portion d'étanchéité étant moulé sans fente dans un évidement périphérique de type rainure annulaire avec une étendue axiale déterminée sur la tige de pipette avec tous les bords de l'évidement.
  12. Procédé selon la revendication 11, caractérisé en ce que l'on utilise en tant que plastique de la tige de pipette un polypropylène, qui est de préférence renforcé par du talc, et/ou en ce que l'on utilise comme matériau en plastique de la portion d'étanchéité un mélange de polypropylène/terpolymère d'éthylène-propylènediène (mélange PP/EPDM) ou un élastomère thermoplastique (TPE).
  13. Procédé selon la revendication 11 ou 12, caractérisé en ce que le matériau en plastique de la portion d'étanchéité est moulé en affleurement au moins avec les bords de l'évidement associés à l'extrémité de la tige de pipette, de préférence avec tous les bords de l'évidement.
  14. Procédé selon l'une quelconque des revendications 11 à 13, caractérisé en ce qu'au moins une région de type annulaire de relativement grand diamètre est formée sur la portion d'étanchéité.
  15. Procédé selon l'une quelconque des revendications 11 à 14, caractérisé en ce que sur le matériau en plastique de la portion d'étanchéité, au moins dans la région d'appui principale, est appliquée une couche de protection à faible usure et/ou à faible friction directement et fixement par adhérence, notamment par liaison de matière, ou en ce que la surface du matériau en plastique est modifiée de manière à lui conférer une faible usure et/ou un faible frottement,
    et de préférence, on applique en tant que couche protectrice, un revêtement de PTFE sous forme pulvérulente dans une suspension d'huile, sur le matériau en plastique de la portion d'étanchéité, ou en ce qu'une très fine dispersion de poudre de PTFE est répartie sur le matériau en plastique de la portion d'étanchéité et est ensuite fondue thermiquement pour donner un revêtement.
EP03000390A 2002-01-16 2003-01-10 Pipette et procédé pour sa production Expired - Lifetime EP1329262B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10201615 2002-01-16
DE10201615 2002-01-16
DE10211794A DE10211794A1 (de) 2002-01-16 2002-03-16 Pipette und Verfahren zur Herstellung einer Pipette
DE10211794 2002-03-16

Publications (3)

Publication Number Publication Date
EP1329262A2 EP1329262A2 (fr) 2003-07-23
EP1329262A3 EP1329262A3 (fr) 2004-04-07
EP1329262B1 true EP1329262B1 (fr) 2009-08-19

Family

ID=26010935

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03000390A Expired - Lifetime EP1329262B1 (fr) 2002-01-16 2003-01-10 Pipette et procédé pour sa production

Country Status (3)

Country Link
US (1) US7344680B2 (fr)
EP (1) EP1329262B1 (fr)
PL (1) PL202190B1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1185368B1 (fr) * 1999-05-18 2003-09-17 Socorex Isba S.A. Pipette avec ejecteur d'embouts
US7641859B2 (en) 2004-02-11 2010-01-05 Matrix Technologies Corporation Pipette tip mounting and ejection assembly and associated pipette tip
CH708024B8 (de) * 2005-12-20 2015-01-15 Tpp Techno Plastic Products Ag Verfahren zur Herstellung einer Pipette.
US20080078258A1 (en) * 2006-09-28 2008-04-03 Price West L Multi-component pipette tip and associated methods
US20090071267A1 (en) * 2007-09-17 2009-03-19 Greg Mathus Pipette tip ejection mechanism
US20100166616A1 (en) * 2007-09-19 2010-07-01 Price West L Pipette tip rack and associated methods
FI121457B (fi) * 2009-03-24 2010-11-30 Thermo Fisher Scientific Oy Kärkiosapipetti
US9486803B2 (en) 2010-01-22 2016-11-08 Biotix, Inc. Pipette tips
US8795606B2 (en) * 2012-05-30 2014-08-05 Biotix, Inc. Integrated pipette tip devices
DE102012016020A1 (de) * 2012-08-13 2014-02-13 Eppendorf Ag Pipettiervorrichtung, Pipettierbehälter und Verfahren zu dessen Herstellung
DE102015213005A1 (de) * 2015-07-10 2017-01-12 Hamilton Bonaduz Ag Pipettiervorrichtung mit ausstülpbarer Kopplungsformation zur Ankopplung einer Pipettierspitze sowie hierfür ausgebildete Pipettierspitze
US11065614B2 (en) 2016-06-15 2021-07-20 Hamilton Company Pipetting device, pipette tip coupler, and pipette tip: devices and methods
US10898892B2 (en) 2016-06-15 2021-01-26 Hamilton Company Pipetting device, pipette tip coupler, and pipette tip: devices and methods
US11235318B2 (en) 2016-06-15 2022-02-01 Hamilton Company Pipetting device, pipette tip coupler, and pipette tip: devices and methods
JP2019518220A (ja) 2016-06-15 2019-06-27 ハミルトン カンパニーＨａｍｉｌｔｏｎ Ｃｏｍｐａｎｙ ピペット装置、ピペットチップカプラ、およびピペットチップ、装置および方法
US20200122136A1 (en) 2017-05-17 2020-04-23 Biotix, Inc. Ergonomic pipette tips
JP7316276B2 (ja) * 2017-11-30 2023-07-27 コーニング インコーポレイテッド 封入されたまたは一体型のフィルタを備えるピペットおよびピペットを成形するための方法および装置
EP3932557B1 (fr) * 2020-07-02 2023-11-15 Eppendorf SE Tête de pipetage à canaux multiples
CN114409949A (zh) * 2022-02-21 2022-04-29 浙江赛宁生物科技有限公司 一种止溢型血清移液管的制造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369665A (en) 1978-01-11 1983-01-25 Indicon Inc. Manually holdable automatic pipette
US4187724A (en) * 1978-01-11 1980-02-12 Indicon Inc. Replaceable tip for a pipette
FI843976L (fi) * 1983-10-13 1985-04-14 Cetus Corp Utbytbar pipettspets.
US4863695A (en) 1987-04-28 1989-09-05 Hewlett-Packard Company Pipette assembly
US4965050A (en) * 1989-01-18 1990-10-23 Ballard Medical Products Adaptation of pipetter
DE4036361A1 (de) * 1989-12-30 1991-07-04 Josef Gleixner Verfahren zur herstellung eines medizinischen anschlusselementes zur verwendung bei transfusionsleitungen, infusionsleitungen und dgl. medizinischen leitungen sowie nach diesem verfahren hergestelltes anschlusselement
CA2015571A1 (fr) * 1990-04-26 1991-10-26 Samco Scientific, Inc. Obturateur pouvant etre reinsere dans les tubes pour la collecte de specimens
FI84789C (fi) * 1990-05-04 1994-01-12 Biohit Oy Faestsystem och -anordning
JPH09127130A (ja) 1995-08-31 1997-05-16 Teruaki Ito 検体分取分注用ノズル装置
DE19643120A1 (de) * 1996-10-21 1998-04-23 Rolf Oppermann Kunststoffschalen zum Aufbewahren und Erwärmen von flüssigen und festen Nahrungsmitteln
DE19917375C2 (de) * 1999-04-16 2001-09-27 Hamilton Bonaduz Ag Bonaduz Pipettiereinheit
EP1185368B1 (fr) * 1999-05-18 2003-09-17 Socorex Isba S.A. Pipette avec ejecteur d'embouts
US6532837B1 (en) * 2000-02-03 2003-03-18 Rainin Instrument, Llc Pipette device with tip ejector utilizing stored energy
DE10013511A1 (de) 2000-03-20 2001-10-11 Brand Gmbh & Co Kg Mehrkanal-Pipettiereinrichtung sowie Pipettenschaft dafür
DE10056095A1 (de) 2000-11-13 2002-05-23 Gert Schlueter Saugtubus

Also Published As

Publication number Publication date
EP1329262A2 (fr) 2003-07-23
EP1329262A3 (fr) 2004-04-07
PL202190B1 (pl) 2009-06-30
PL358247A1 (en) 2003-07-28
US7344680B2 (en) 2008-03-18
US20030156994A1 (en) 2003-08-21

Similar Documents

Publication Publication Date Title
EP1329262B1 (fr) Pipette et procédé pour sa production
EP2024090B1 (fr) Dispositif de maintien de pointes de pipette, pointe de pipette ainsi que dispositif de pipettage
EP2030524B1 (fr) Essoreur d'une unité cosmétique
EP3265239B1 (fr) Pistolet de pulvérisation
EP2092843B1 (fr) Applicateur doté d'éléments en saillie de maintien de type col, notamment pour du mascara ou des cosmétiques analogues
DE7518809U (de) Pipettenspitze
DE3526632C2 (fr)
EP2731647B1 (fr) Seringue multichambre
EP2071977A1 (fr) Applicateur destiné à l'application de cosmétiques, en particulier du mascara et du produit de teinture capillaire
DE10301029B4 (de) Kartuschenverschluß mit Öffnungs-/Schließ-Funktion
EP2624722B1 (fr) Applicateur pour un fluide à appliquer
EP2158136B1 (fr) Dispositif de déversement d'une substance apte à l'écoulement
DE202007017136U1 (de) Verschlussnadel für eine Nadelverschlussdüse
EP2522438B1 (fr) Pistons de fermeture et d'impression pour cartouches pour masses plastiques et procédé d'insertion d'un tel piston dans une cartouche
EP4116210A1 (fr) Capuchon, ainsi que récipient doté d'un tel capuchon et procédé de fabrication du capuchon
EP2365878B1 (fr) Pipette
DE10229788B4 (de) Pipettenspitze
EP3888791A1 (fr) Point de pipette
DE10211794A1 (de) Pipette und Verfahren zur Herstellung einer Pipette
DE4214634C1 (de) Pipettierhilfe
WO1993022057A1 (fr) Dispositif auxiliaire de pipetage et procede pour sa fabrication
EP2548468A1 (fr) Essoreur réglable
EP1588770B1 (fr) Tête de décharge pour dispositif de dosage
EP2006021A1 (fr) Partie supérieure de pipetage
DE202021103665U1 (de) Bohreinsatz sowie Bohrfutteraufsatz für den Bohreinsatz

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO

RIC1 Information provided on ipc code assigned before grant

Ipc: 7B 29C 45/16 B

Ipc: 7B 01L 3/02 A

17P Request for examination filed

Effective date: 20040920

AKX Designation fees paid

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 50311818

Country of ref document: DE

Date of ref document: 20091001

Kind code of ref document: P

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20091130

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

REG Reference to a national code

Ref country code: IE

Ref legal event code: FD4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20091221

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20091119

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20100520

BERE Be: lapsed

Owner name: BRAND G.M.B.H. + CO KG

Effective date: 20100131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20100131

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20100110

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20091120

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20100110

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20100131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20100110

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20110124

Year of fee payment: 9

Ref country code: FI

Payment date: 20110113

Year of fee payment: 9

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100220

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20100110

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120131

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120131

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20090819

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120110

REG Reference to a national code

Ref country code: DE

Ref legal event code: R082

Ref document number: 50311818

Country of ref document: DE

Representative=s name: VON ROHR PATENTANWAELTE PARTNERSCHAFT MBB, DE

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20140123

Year of fee payment: 12

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20150930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150202

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20200120

Year of fee payment: 18

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 50311818

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210803