EP1324985A4 - Inhibiteurs de la prenyl-proteine transferase - Google Patents
Inhibiteurs de la prenyl-proteine transferaseInfo
- Publication number
- EP1324985A4 EP1324985A4 EP01979912A EP01979912A EP1324985A4 EP 1324985 A4 EP1324985 A4 EP 1324985A4 EP 01979912 A EP01979912 A EP 01979912A EP 01979912 A EP01979912 A EP 01979912A EP 1324985 A4 EP1324985 A4 EP 1324985A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- prenyl
- inhibitors
- protein transferase
- transferase
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23724100P | 2000-10-02 | 2000-10-02 | |
US237241P | 2000-10-02 | ||
PCT/US2001/042389 WO2002028831A1 (fr) | 2000-10-02 | 2001-09-28 | Inhibiteurs de la prenyl-proteine transferase |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1324985A1 EP1324985A1 (fr) | 2003-07-09 |
EP1324985A4 true EP1324985A4 (fr) | 2004-10-06 |
Family
ID=22892897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01979912A Withdrawn EP1324985A4 (fr) | 2000-10-02 | 2001-09-28 | Inhibiteurs de la prenyl-proteine transferase |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1324985A4 (fr) |
JP (1) | JP2004510762A (fr) |
AU (1) | AU2002211828A1 (fr) |
CA (1) | CA2424222A1 (fr) |
WO (1) | WO2002028831A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ20031910A3 (cs) | 2000-12-11 | 2003-12-17 | Tularik Inc. | Sloučenina s antagonistickými účinky na CXCR3 a farmaceutický postředek |
US6794379B2 (en) | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
CN100522150C (zh) | 2001-11-30 | 2009-08-05 | 参天制药株式会社 | 血管生成抑制剂 |
CA2508290C (fr) * | 2002-12-20 | 2017-02-28 | Ciba Specialty Chemicals Holding Inc. | Synthese d'amines et intermediaires pour cette synthese |
CA2562783A1 (fr) * | 2004-04-26 | 2005-12-01 | Vanderbilt University | Derives d'acides indoleacetique et indenacetique comme agents therapeutiques a toxicite gastrointestinale reduite |
TW200611695A (en) | 2004-06-09 | 2006-04-16 | Glaxo Group Ltd | Pyrrolopyridine derivatives |
US7271271B2 (en) | 2004-06-28 | 2007-09-18 | Amgen Sf, Llc | Imidazolo-related compounds, compositions and methods for their use |
EP2040699A4 (fr) | 2006-06-19 | 2013-03-13 | Vanderbilt University Medical Ct | Méthodes et compositions de diagnostic et de ciblage thérapeutique de cox-2 |
CL2007002617A1 (es) | 2006-09-11 | 2008-05-16 | Sanofi Aventis | Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto. |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
EP2768499A4 (fr) | 2011-10-17 | 2015-08-26 | Univ Vanderbilt | Analogues de l'indométacine destinés au traitement du cancer de la prostate résistant à la castration |
US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
LT3137078T (lt) * | 2014-05-01 | 2019-06-25 | Eiger Biopharmaceuticals, Inc. | Virusinio hepatito delta infekcijos gydymas |
WO2016054807A1 (fr) * | 2014-10-10 | 2016-04-14 | Merck Sharp & Dohme Corp. | Inhibiteurs de la kinase trka, compositions en contenant et méthodes associées |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
WO2016172342A1 (fr) | 2015-04-21 | 2016-10-27 | Eiger Biopharmaceuticals, Inc. | Compositions pharmaceutiques comprenant du lonafarnib et du ritonavir |
US11547706B2 (en) | 2016-06-08 | 2023-01-10 | President And Fellows Of Harvard College | Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and Fragile X syndrome |
WO2019210223A1 (fr) | 2018-04-26 | 2019-10-31 | Adt Pharmaceuticals, Llc | Indènes, indanes, azaindènes, azaindanes anticancéreux, compositions pharmaceutiques et utilisations |
EP3801512A4 (fr) | 2018-05-29 | 2022-01-19 | President and Fellows of Harvard College | Compositions et méthodes pour réduire un dysfonctionnement tactile, l'anxiété et une déficience sociale |
CR20210383A (es) | 2018-12-17 | 2021-09-22 | Vertex Pharma | Inhibidores de apol 1 y sus métodos de uso |
WO2021178768A1 (fr) | 2020-03-06 | 2021-09-10 | Vertex Pharmaceuticals Incorporated | Méthodes de traitement de la glomérulosclérose segmentaire et focale dépendante de l'apol -1 |
WO2021252849A1 (fr) * | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Inhibiteurs d'apol1 et leur utilisation |
WO2022047031A1 (fr) | 2020-08-26 | 2022-03-03 | Vertex Pharmaceuticals Incorporated | Inhibiteurs d'apol1 et leurs méthodes d'utilisation |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3314964A (en) * | 1964-01-16 | 1967-04-18 | Warner Lambert Pharmaceutical | Trans indolomorphinans and process for their production |
US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
WO1992004321A1 (fr) * | 1990-09-10 | 1992-03-19 | Rhone-Poulenc Rorer International (Holdings) Inc. | Composes aryles bicycliques substitues presentant une activite selective antagoniste contre les leucotrienes b4 |
WO1998001428A1 (fr) * | 1996-07-08 | 1998-01-15 | Du Pont Pharmaceuticals Company | AMIDINOINDOLES, AMIDINOAZOLES ET LEURS ANALOGUES AGISSANT EN TANT QU'INHIBITEURS DU FACTEUR Xa ET DE LA THROMBINE |
JP2001089448A (ja) * | 1999-09-24 | 2001-04-03 | Yamanouchi Pharmaceut Co Ltd | アミド誘導体 |
WO2001055107A2 (fr) * | 2000-01-28 | 2001-08-02 | Melacure Therapeutics Ab | Nouveaux amines et amides aromatiques agissant sur les recepteurs de la melanocortine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2183731C (fr) * | 1994-02-22 | 2000-03-21 | Alan J. Bitonti | Nouveaux derives d'indole utilises pour traiter des neoplasmes et des troubles associes aux oestrogenes |
-
2001
- 2001-09-28 CA CA002424222A patent/CA2424222A1/fr not_active Abandoned
- 2001-09-28 WO PCT/US2001/042389 patent/WO2002028831A1/fr not_active Application Discontinuation
- 2001-09-28 JP JP2002532417A patent/JP2004510762A/ja not_active Withdrawn
- 2001-09-28 AU AU2002211828A patent/AU2002211828A1/en not_active Abandoned
- 2001-09-28 EP EP01979912A patent/EP1324985A4/fr not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3314964A (en) * | 1964-01-16 | 1967-04-18 | Warner Lambert Pharmaceutical | Trans indolomorphinans and process for their production |
US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
WO1992004321A1 (fr) * | 1990-09-10 | 1992-03-19 | Rhone-Poulenc Rorer International (Holdings) Inc. | Composes aryles bicycliques substitues presentant une activite selective antagoniste contre les leucotrienes b4 |
WO1998001428A1 (fr) * | 1996-07-08 | 1998-01-15 | Du Pont Pharmaceuticals Company | AMIDINOINDOLES, AMIDINOAZOLES ET LEURS ANALOGUES AGISSANT EN TANT QU'INHIBITEURS DU FACTEUR Xa ET DE LA THROMBINE |
JP2001089448A (ja) * | 1999-09-24 | 2001-04-03 | Yamanouchi Pharmaceut Co Ltd | アミド誘導体 |
WO2001055107A2 (fr) * | 2000-01-28 | 2001-08-02 | Melacure Therapeutics Ab | Nouveaux amines et amides aromatiques agissant sur les recepteurs de la melanocortine |
Non-Patent Citations (4)
Title |
---|
CHEM. COMM., 2001, pages 209 - 210, XP002291111 * |
See also references of WO0228831A1 * |
TETRAHEDRON LETT., vol. 25, no. 14, 1984, pages 1513 - 1516, XP002291110 * |
TROTTER B W ET AL: "2-Arylindole-3-acetamides - FPP-Competitive inhibitors of farnesyl protein transferase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 11, no. 7, 9 April 2001 (2001-04-09), pages 865 - 869, XP004232512, ISSN: 0960-894X * |
Also Published As
Publication number | Publication date |
---|---|
EP1324985A1 (fr) | 2003-07-09 |
JP2004510762A (ja) | 2004-04-08 |
AU2002211828A1 (en) | 2002-04-15 |
WO2002028831A1 (fr) | 2002-04-11 |
CA2424222A1 (fr) | 2002-04-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030502 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61P 35/00 B Ipc: 7C 07D 401/04 B Ipc: 7C 07D 403/12 B Ipc: 7C 07D 405/12 B Ipc: 7C 07D 401/14 B Ipc: 7C 07D 209/18 B Ipc: 7C 07D 471/04 B Ipc: 7C 07D 401/12 B Ipc: 7A 61K 31/4045 B Ipc: 7C 07D 209/12 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040819 |
|
18D | Application deemed to be withdrawn |
Effective date: 20040401 |