EP1315794A4 - Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation - Google Patents

Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation

Info

Publication number
EP1315794A4
EP1315794A4 EP01968382A EP01968382A EP1315794A4 EP 1315794 A4 EP1315794 A4 EP 1315794A4 EP 01968382 A EP01968382 A EP 01968382A EP 01968382 A EP01968382 A EP 01968382A EP 1315794 A4 EP1315794 A4 EP 1315794A4
Authority
EP
European Patent Office
Prior art keywords
requirement
neuron generation
ventral neuron
demonstration
genetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01968382A
Other languages
German (de)
French (fr)
Other versions
EP1315794A1 (en
Inventor
Thomas M Jessell
James Briscoe
Johan Ericson
John L R Rubenstein
Maike Sander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
University of California
Original Assignee
Columbia University in the City of New York
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/654,462 external-priority patent/US7393686B1/en
Application filed by Columbia University in the City of New York, University of California filed Critical Columbia University in the City of New York
Publication of EP1315794A1 publication Critical patent/EP1315794A1/en
Publication of EP1315794A4 publication Critical patent/EP1315794A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP01968382A 2000-09-01 2001-08-31 Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation Withdrawn EP1315794A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/654,462 US7393686B1 (en) 2000-05-11 2000-09-01 Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation
US654462 2000-09-01
PCT/US2001/027256 WO2002018545A1 (en) 2000-09-01 2001-08-31 Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation

Publications (2)

Publication Number Publication Date
EP1315794A1 EP1315794A1 (en) 2003-06-04
EP1315794A4 true EP1315794A4 (en) 2005-01-26

Family

ID=24624954

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01968382A Withdrawn EP1315794A4 (en) 2000-09-01 2001-08-31 Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation

Country Status (4)

Country Link
EP (1) EP1315794A4 (en)
AU (1) AU2001288634A1 (en)
CA (1) CA2419851A1 (en)
WO (1) WO2002018545A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393686B1 (en) 2000-05-11 2008-07-01 Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation
US7312081B2 (en) 2000-05-11 2007-12-25 The Trustees Of Columbia University In The City Of New York Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
US6955802B1 (en) 2000-05-11 2005-10-18 The Trustees Of Columbia University In The City Of New York Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube
US20100319073A1 (en) * 2005-09-29 2010-12-16 The Johns Hopkins University GDE Compositions and Methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023223A1 (en) * 1994-02-25 1995-08-31 The Trustees Of Columbia University In The City Of New York Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof
WO1999000516A2 (en) * 1997-06-25 1999-01-07 Medical Research Council Neuronal stem cell gene
WO1999000528A1 (en) * 1997-06-25 1999-01-07 Flachglas Aktiengesellschaft Coatings with a silver layer
WO2000009676A2 (en) * 1998-08-14 2000-02-24 California Institute Of Technology Methods of forming neurons
WO2000018884A1 (en) * 1998-09-29 2000-04-06 The Trustees Of Columbia University In The City Of New York Gene encoding mnr2 and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023223A1 (en) * 1994-02-25 1995-08-31 The Trustees Of Columbia University In The City Of New York Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof
WO1999000516A2 (en) * 1997-06-25 1999-01-07 Medical Research Council Neuronal stem cell gene
WO1999000528A1 (en) * 1997-06-25 1999-01-07 Flachglas Aktiengesellschaft Coatings with a silver layer
WO2000009676A2 (en) * 1998-08-14 2000-02-24 California Institute Of Technology Methods of forming neurons
WO2000018884A1 (en) * 1998-09-29 2000-04-06 The Trustees Of Columbia University In The City Of New York Gene encoding mnr2 and uses thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BRISCOE J ET AL: "HOMEOBOX GENE NKX2.2 AND SPECIFICATION OF NEURONAL IDENTITY BY GRADED SONIC HEDGEHOG SIGNALLING", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 398, 15 April 1999 (1999-04-15), pages 622 - 627, XP002944809, ISSN: 0028-0836 *
CAI J ET AL: "EXPRESSION AND REGULATION OF THE CHICKEN NKX-6.2 HOMEOBOX GENE SUGGEST ITS POSSIBLE INVOLVEMENT IN THE VENTRAL NEURAL PATTERNING AND CELL FATE SPECIFICATION", DEVELOPMENTAL DYNAMICS, WILEY-LISS, INC., NEW YORK, NY, US, vol. 216, no. 4/5, December 1999 (1999-12-01), pages 459 - 468, XP009034441, ISSN: 1058-8388 *
CAI JUN ET AL: "Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally", MOLECULAR AND CELLULAR BIOLOGY, vol. 21, no. 13, July 2001 (2001-07-01), pages 4399 - 4403, XP002306958, ISSN: 0270-7306 *
PALMER T D ET AL: "FIBROBLAST GROWTH FACTOR-2 ACTIVATES A LATENT NEUROGENIC PROGRAM IN NEURAL STEM CELLS FROM DIVERSE REGIONS OF THE ADULT CNS", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 19, no. 19, 1 October 1999 (1999-10-01), pages 8487 - 8497, XP001105835, ISSN: 0270-6474 *
QIU MENGSHENG ET AL: "Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx gene during vertebrate CNS development", MECHANISMS OF DEVELOPMENT, vol. 72, no. 1-2, March 1998 (1998-03-01), pages 77 - 88, XP002944806, ISSN: 0925-4773 *
SANDER M ET AL: "Ventral neural patterning by NKX homeobox genes: NKX6.1 controls somatic motor neuron and ventral interneuron fates", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 14, 7 September 2000 (2000-09-07), pages 2134 - 2139, XP002902773, ISSN: 0890-9369 *
See also references of WO0218545A1 *
TANABE Y ET AL: "SPECIFICATION OF MOTOR NEURON IDENTITY BY THE MNR2 HOMEODOMAIN PROTEIN", CELL, MIT PRESS, CAMBRIDGE, MA,, US, vol. 95, 2 October 1998 (1998-10-02), pages 67 - 80, XP002925301, ISSN: 0092-8674 *

Also Published As

Publication number Publication date
CA2419851A1 (en) 2002-03-07
WO2002018545A1 (en) 2002-03-07
AU2001288634A1 (en) 2002-03-13
EP1315794A1 (en) 2003-06-04

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030328

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Owner name: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF

A4 Supplementary search report drawn up and despatched

Effective date: 20041212

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20091030