EP1309718A4 - Neutrokine-alpha et variant d'epissage de neutrokine-alpha - Google Patents
Neutrokine-alpha et variant d'epissage de neutrokine-alphaInfo
- Publication number
- EP1309718A4 EP1309718A4 EP01967981A EP01967981A EP1309718A4 EP 1309718 A4 EP1309718 A4 EP 1309718A4 EP 01967981 A EP01967981 A EP 01967981A EP 01967981 A EP01967981 A EP 01967981A EP 1309718 A4 EP1309718 A4 EP 1309718A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- neutrokine
- alpha
- splice variant
- variant
- alpha splice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Rehabilitation Therapy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Applications Claiming Priority (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22562800P | 2000-08-15 | 2000-08-15 | |
US225628P | 2000-08-15 | ||
US22700800P | 2000-08-23 | 2000-08-23 | |
US227008P | 2000-08-23 | ||
US23433800P | 2000-09-22 | 2000-09-22 | |
US234338P | 2000-09-22 | ||
US24080600P | 2000-10-17 | 2000-10-17 | |
US240806P | 2000-10-17 | ||
US25002000P | 2000-11-30 | 2000-11-30 | |
US250020P | 2000-11-30 | ||
US27624801P | 2001-03-16 | 2001-03-16 | |
US276248P | 2001-03-16 | ||
US29349901P | 2001-05-25 | 2001-05-25 | |
US293499P | 2001-05-25 | ||
US29612201P | 2001-06-07 | 2001-06-07 | |
US296122P | 2001-06-07 | ||
US30480901P | 2001-07-13 | 2001-07-13 | |
US304809P | 2001-07-13 | ||
PCT/US2001/025549 WO2002018620A2 (fr) | 2000-08-15 | 2001-08-15 | Neutrokine-alpha et variant d'epissage de neutrokine-alpha |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1309718A2 EP1309718A2 (fr) | 2003-05-14 |
EP1309718A4 true EP1309718A4 (fr) | 2004-08-25 |
Family
ID=27578713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01967981A Withdrawn EP1309718A4 (fr) | 2000-08-15 | 2001-08-15 | Neutrokine-alpha et variant d'epissage de neutrokine-alpha |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1309718A4 (fr) |
AU (1) | AU2001288260A1 (fr) |
CA (1) | CA2419661A1 (fr) |
WO (1) | WO2002018620A2 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
US6812327B1 (en) | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
EP2974736A1 (fr) | 1999-01-25 | 2016-01-20 | Biogen MA Inc. | Baff, ses inhibiteurs et leur utilisation pour moduler la réponse immunitaire des cellules b |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
MXPA02001665A (es) | 1999-08-17 | 2003-07-14 | Biogen Inc | Receptor de baff (bcma) como agente inmunorregulador. |
UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
EP2281843B1 (fr) | 2000-06-16 | 2016-10-12 | Human Genome Sciences, Inc. | Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte B (BLyS) |
AU2001288301A1 (en) | 2000-08-18 | 2002-03-04 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
CA2476675A1 (fr) * | 2001-10-17 | 2003-04-24 | Human Genome Sciences, Inc. | Neutrokine-alpha et variant d'epissage de neutrokine-alpha |
WO2004081043A2 (fr) * | 2003-01-06 | 2004-09-23 | Xencor, Inc. | Variants de baff et leurs methodes d'utilisation |
US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
US20050130892A1 (en) * | 2003-03-07 | 2005-06-16 | Xencor, Inc. | BAFF variants and methods thereof |
JP5524441B2 (ja) | 2003-03-28 | 2014-06-18 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 短縮されたbaffレセプター |
US6987270B2 (en) | 2003-05-07 | 2006-01-17 | General Electric Company | Method to account for event losses due to positron range in positron emission tomography and assay of positron-emitting isotopes |
EP1629001A2 (fr) | 2003-06-05 | 2006-03-01 | Genentech, Inc. | Antagonistes de blys et leurs utilisations |
CA2583900A1 (fr) * | 2004-10-13 | 2006-04-27 | The Washington University | Utilisation de baff dans le traitement du sepsis |
US9168286B2 (en) | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
US9726673B2 (en) | 2005-11-23 | 2017-08-08 | Genentech, Inc. | Methods and compositions related to B cell assays |
US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998018921A1 (fr) * | 1996-10-25 | 1998-05-07 | Human Genome Sciences, Inc. | Neutrokine alpha |
WO1998027114A2 (fr) * | 1996-12-17 | 1998-06-25 | Schering Corporation | Antigenes de surface mammaliens et reactifs associes |
WO1999012964A2 (fr) * | 1997-09-12 | 1999-03-18 | Biogen, Inc. | Kay, nouvelle proteine du systeme immunitaire |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2212299A (en) * | 1998-01-05 | 1999-07-26 | Genentech Inc. | Compositions and methods for the treatment of tumor |
-
2001
- 2001-08-15 EP EP01967981A patent/EP1309718A4/fr not_active Withdrawn
- 2001-08-15 CA CA002419661A patent/CA2419661A1/fr not_active Abandoned
- 2001-08-15 AU AU2001288260A patent/AU2001288260A1/en not_active Abandoned
- 2001-08-15 WO PCT/US2001/025549 patent/WO2002018620A2/fr not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998018921A1 (fr) * | 1996-10-25 | 1998-05-07 | Human Genome Sciences, Inc. | Neutrokine alpha |
WO1998027114A2 (fr) * | 1996-12-17 | 1998-06-25 | Schering Corporation | Antigenes de surface mammaliens et reactifs associes |
WO1999012964A2 (fr) * | 1997-09-12 | 1999-03-18 | Biogen, Inc. | Kay, nouvelle proteine du systeme immunitaire |
Non-Patent Citations (10)
Title |
---|
DATABASE UNIPROT [online] 16 October 2001 (2001-10-16), "Tumor necrosis factor ligand superfamily member 13B", XP002286038, retrieved from UNIPROT Database accession no. Q9Y275 * |
DENARDO G L ET AL: "Comparison of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''tetraacetic acid (DOTA)-peptide-ChL6, a novel immunoconjugate with catabolizable linker, to 2-iminothiolane-2[p-(bromoacetamido)benzyl]-DOTA-ChL6 in breast cancer xenografts", CLINICAL CANCER RESEARCH 1998 UNITED STATES, vol. 4, no. 10, 1998, pages 2483 - 2490, XP001181898, ISSN: 1078-0432 * |
HEPPELER A ET AL: "RECEPTOR TARGETING FOR TUMOR LOCALISATION AND THERAPY WITH RADIOPEPTIDES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 9, no. 7, 2000, pages 971 - 994, XP000982225, ISSN: 0929-8673 * |
KARPUSAS M ET AL: "Crystal structure of extracellular human BAFF, a TNF family member that stimulates B lymphocytes", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 315, no. 5, 1 February 2002 (2002-02-01), pages 1145 - 1154, XP004470833, ISSN: 0022-2836 * |
LIU YINGFANG ET AL: "Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands", CELL, vol. 108, no. 3, 8 February 2002 (2002-02-08), pages 383 - 394, XP002286032, ISSN: 0092-8674 * |
MOORE P A ET AL: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 285, no. 5425, 9 July 1999 (1999-07-09), pages 260 - 263, XP002142252, ISSN: 0036-8075 * |
OREN DEENA A ET AL: "Structural basis of BLyS receptor recognition.", NATURE STRUCTURAL BIOLOGY, vol. 9, no. 4, April 2002 (2002-04-01), pages 288 - 292, XP002286033, ISSN: 1072-8368 (ISSN print) * |
SCHNEIDER P ET AL: "BAFF, A NOVEL LIGAND OF THE TUMOR NECROSIS FACTOR FAMILY, STIMULATES B CELL GROWTH", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 189, no. 11, 7 June 1999 (1999-06-07), pages 1747 - 1756, XP000915409, ISSN: 0022-1007 * |
SHU H-B ET AL: "TALL-1 IS A NOVEL MEMBER OF THE TNF FAMILY THAT IS DOWN-REGULATED BY MITOGENS", JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL, US, vol. 65, no. 5, May 1999 (1999-05-01), pages 680 - 683, XP000939092, ISSN: 0741-5400 * |
YU G ET AL: "APRIL AND TALL-I AND RECEPTORS BCMA AND TACI: SYSTEM FOR REGULATING HUMORAL IMMUNITY", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP,, GB, vol. 1, no. 3, September 2000 (2000-09-01), pages 252 - 256, XP000982268, ISSN: 1529-2908 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002018620A3 (fr) | 2003-03-20 |
WO2002018620A2 (fr) | 2002-03-07 |
CA2419661A1 (fr) | 2002-03-07 |
EP1309718A2 (fr) | 2003-05-14 |
AU2001288260A1 (en) | 2002-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030305 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 12N 15/64 B Ipc: 7C 12N 15/63 B Ipc: 7C 12N 15/62 B Ipc: 7C 12N 15/13 B Ipc: 7C 12N 15/12 B Ipc: 7C 12N 5/10 B Ipc: 7C 07K 1/24 B Ipc: 7C 07K 16/18 B Ipc: 7C 07K 16/00 B Ipc: 7A 61K 48/00 B Ipc: 7A 61K 39/395 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040715 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 51/08 B Ipc: 7A 61K 38/19 B Ipc: 7C 07K 14/705 A |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060113 |