EP1259236A4 - Tyrosine kinase inhibitors - Google Patents

Tyrosine kinase inhibitors

Info

Publication number: EP1259236A4
Authority: EP; European Patent Office
Prior art keywords: tyrosine kinase; kinase inhibitors; inhibitors; tyrosine; kinase
Prior art date: 2000-02-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP01914424A

Other languages

German (de)

French (fr)

Other versions

EP1259236A1 (en

Inventor

Mark E Fraley

George D Hartman

Randall W Hungate

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-25

Filing date

2001-02-21

Publication date

2004-11-03

2001-02-21 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2002-11-27 Publication of EP1259236A1 publication Critical patent/EP1259236A1/en

2004-11-03 Publication of EP1259236A4 publication Critical patent/EP1259236A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

EP01914424A 2000-02-25 2001-02-21 Tyrosine kinase inhibitors Withdrawn EP1259236A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US18502400P	2000-02-25	2000-02-25
US185024P		2000-02-25
PCT/US2001/005567 WO2001062252A1 (en)	2000-02-25	2001-02-21	Tyrosine kinase inhibitors

Publications (2)

Publication Number	Publication Date
EP1259236A1 EP1259236A1 (en)	2002-11-27
EP1259236A4 true EP1259236A4 (en)	2004-11-03

Family

ID=22679242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01914424A Withdrawn EP1259236A4 (en)	2000-02-25	2001-02-21	Tyrosine kinase inhibitors

Country Status (5)

Country	Link
EP (1)	EP1259236A4 (en)
JP (1)	JP2003523390A (en)
AU (1)	AU778417B2 (en)
CA (1)	CA2400923A1 (en)
WO (1)	WO2001062252A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0203895A3 (en)	1999-12-24	2004-09-28	Aventis Pharma Ltd West Mallin	Substituted azaindoles and pharmaceutical compositions containing them and their use
EP1313734B1 (en)	2000-09-01	2009-11-11	Novartis Vaccines and Diagnostics, Inc.	Aza heterocyclic derivatives and their therapeutic use
AP1666A (en)	2000-09-11	2006-09-29	Chiron Corp	Quinolinone derivatives as tyrosine kinase inhibitors.
GB0115109D0 (en)	2001-06-21	2001-08-15	Aventis Pharma Ltd	Chemical compounds
MXPA04003878A (en) *	2001-10-25	2004-07-08	Novartis Ag	Combinations comprising a selective cyclooxygenase-2 inhibitor.
US6797825B2 (en)	2001-12-13	2004-09-28	Abbott Laboratories	Protein kinase inhibitors
US20030187026A1 (en)	2001-12-13	2003-10-02	Qun Li	Kinase inhibitors
US6822097B1 (en)	2002-02-07	2004-11-23	Amgen, Inc.	Compounds and methods of uses
WO2004018419A2 (en)	2002-08-23	2004-03-04	Chiron Corporation	Benzimidazole quinolinones and uses thereof
US20060228331A1 (en)	2003-10-10	2006-10-12	Novo Nordisk A/S	IL-21 Derivatives and variants
JP2007508332A (en) *	2003-10-17	2007-04-05	ノボ　ノルディスク　アクティーゼルスカブ	Combination therapy
EP1682529A4 (en)	2003-11-07	2010-06-30	Novartis Vaccines & Diagnostic	Methods for synthesizing quinolinone compounds
WO2006071035A1 (en) *	2004-12-31	2006-07-06	Lg Life Sciences, Ltd.	Novel ([1,3]thiazolo[5,4-b]pyridin-2-yl)-2-carboxamide derivatives
WO2006081445A2 (en)	2005-01-27	2006-08-03	Novartis Vaccines And Diagnostics Inc.	Treatment of metastasized tumors
JP5545925B2 (en)	2005-05-17	2014-07-09	ノバルティスアーゲー	Method for synthesizing heterocyclic compounds
GB0614471D0 (en)	2006-07-20	2006-08-30	Syngenta Ltd	Herbicidal Compounds
CA2717991A1 (en) *	2008-03-10	2009-09-17	Sanofi-Aventis	Treatment for ocular-related disorders
EP3007689B1 (en)	2013-01-10	2018-03-07	Pulmokine, Inc.	Non-selective kinase inhibitors
ES2959419T3 (en)	2013-10-11	2024-02-26	Pulmokine Inc	Spray Dry Formulations
CN110087653A (en)	2016-10-27	2019-08-02	普尔莫凯恩股份有限公司	For treating the combination treatment of pulmonary hypertension

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001062251A1 (en) *	2000-02-25	2001-08-30	Merck & Co., Inc.	Tyrosine kinase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0584222B1 (en) *	1991-05-10	1997-10-08	Rhone-Poulenc Rorer International (Holdings) Inc.	Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US6162804A (en) *	1997-09-26	2000-12-19	Merck & Co., Inc.	Tyrosine kinase inhibitors

2001
- 2001-02-21 EP EP01914424A patent/EP1259236A4/en not_active Withdrawn
- 2001-02-21 CA CA002400923A patent/CA2400923A1/en not_active Abandoned
- 2001-02-21 AU AU39814/01A patent/AU778417B2/en not_active Ceased
- 2001-02-21 JP JP2001561318A patent/JP2003523390A/en not_active Withdrawn
- 2001-02-21 WO PCT/US2001/005567 patent/WO2001062252A1/en active IP Right Grant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001062251A1 (en) *	2000-02-25	2001-08-30	Merck & Co., Inc.	Tyrosine kinase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO0162252A1 *

Also Published As

Publication number	Publication date
EP1259236A1 (en)	2002-11-27
JP2003523390A (en)	2003-08-05
AU3981401A (en)	2001-09-03
AU778417B2 (en)	2004-12-02
CA2400923A1 (en)	2001-08-30
WO2001062252A1 (en)	2001-08-30

Legal Events

Date	Code	Title	Description
2002-10-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2002-11-27	17P	Request for examination filed	Effective date: 20020925
2002-11-27	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2002-11-27	AX	Request for extension of the european patent	Free format text: AL PAYMENT 20020925;LT PAYMENT 20020925;LV PAYMENT 20020925;MK PAYMENT 20020925;RO PAYMENT 20020925;SI PAYMENT 20020925
2004-11-03	A4	Supplementary search report drawn up and despatched	Effective date: 20040921
2004-11-03	RIC1	Information provided on ipc code assigned before grant	Ipc: 7C 07D 519/00 B Ipc: 7A 61K 31/4355 A Ipc: 7C 07D 209:00 J Ipc: 7A 61K 31/437 B Ipc: 7A 61P 35/00 B Ipc: 7A 61K 31/4375 B Ipc: 7C 07D 471/04 B Ipc: 7A 61K 31/4365 B Ipc: 7C 07D 471/04 J Ipc: 7C 07D 221:00 J
2006-06-28	RIN1	Information on inventor provided before grant (corrected)	Inventor name: HUNGATE, RANDALL, W. Inventor name: HARTMAN, GEORGE, D. Inventor name: FRALEY, MARK, E.
2007-03-03	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2007-04-04	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/4355 20060101AFI20070227BHEP Ipc: C07D 221/00 20060101ALN20070227BHEP Ipc: A61P 35/00 20060101ALI20070227BHEP Ipc: A61K 31/4365 20060101ALI20070227BHEP Ipc: A61K 31/437 20060101ALI20070227BHEP Ipc: C07D 471/04 20060101ALI20070227BHEP Ipc: C07D 519/00 20060101ALI20070227BHEP Ipc: A61K 31/4375 20060101ALI20070227BHEP Ipc: C07D 209/00 20060101ALN20070227BHEP
2008-04-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2008-05-21	18D	Application deemed to be withdrawn	Effective date: 20070724

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AU2003299651A8 (en)	2004-06-30	Tyrosine kinase inhibitors
HK1053644A1 (en)	2003-10-31	Quinolinone derivatives as tyrosine kinase inhibitors
AU2001237041A1 (en)	2001-11-08	Kinase inhibitors
AU2002361577A1 (en)	2003-05-12	Tyrosine kinase inhibitors
AU2003298942A8 (en)	2004-06-30	Tyrosine kinase inhibitors
EP1534268A4 (en)	2006-11-02	Tyrosine kinase inhibitors
EP1259236A4 (en)	2004-11-03	Tyrosine kinase inhibitors
AU2003275282A8 (en)	2004-04-23	Novel tyrosine kinase inhibitors
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AU2002348020A1 (en)	2003-05-06	Tyrosine kinase inhibitors
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GB0201384D0 (en)	2002-03-13	Tyrosine kinase inhibitors
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IL145329A0 (en)	2002-06-30	Protein tyrosine kinase inhibitors
AU2002322568A1 (en)	2003-02-17	Tyrosine kinase inhibitors
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