EP1194768A4 - Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database - Google Patents

Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database

Info

Publication number
EP1194768A4
EP1194768A4 EP00923511A EP00923511A EP1194768A4 EP 1194768 A4 EP1194768 A4 EP 1194768A4 EP 00923511 A EP00923511 A EP 00923511A EP 00923511 A EP00923511 A EP 00923511A EP 1194768 A4 EP1194768 A4 EP 1194768A4
Authority
EP
European Patent Office
Prior art keywords
metabolic profiling
fingerprinting methods
bioinformatics database
polypeptide
polypeptide fingerprinting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00923511A
Other languages
German (de)
French (fr)
Other versions
EP1194768A1 (en
Inventor
Luke V Schneider
Michael P Hall
Robert Petesch
Jeffrey N Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Target Discovery Inc
Original Assignee
Target Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/513,395 external-priority patent/US6379971B1/en
Priority claimed from US09/513,907 external-priority patent/US6677114B1/en
Priority claimed from US09/513,486 external-priority patent/US6537432B1/en
Application filed by Target Discovery Inc filed Critical Target Discovery Inc
Priority to EP10180277A priority Critical patent/EP2293056A3/en
Publication of EP1194768A1 publication Critical patent/EP1194768A1/en
Publication of EP1194768A4 publication Critical patent/EP1194768A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44795—Isoelectric focusing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP00923511A 1999-04-20 2000-04-19 Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database Withdrawn EP1194768A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10180277A EP2293056A3 (en) 1999-04-20 2000-04-19 A method for analysing a metabolic pathway

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US13023899P 1999-04-20 1999-04-20
US130238P 1999-04-20
US513486 2000-02-25
US513395 2000-02-25
US513907 2000-02-25
US09/513,395 US6379971B1 (en) 1998-02-24 2000-02-25 Methods for sequencing proteins
US09/513,907 US6677114B1 (en) 1999-04-20 2000-02-25 Polypeptide fingerprinting methods and bioinformatics database system
US09/513,486 US6537432B1 (en) 1998-02-24 2000-02-25 Protein separation via multidimensional electrophoresis
PCT/US2000/010504 WO2000063683A1 (en) 1999-04-20 2000-04-19 Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database

Publications (2)

Publication Number Publication Date
EP1194768A1 EP1194768A1 (en) 2002-04-10
EP1194768A4 true EP1194768A4 (en) 2008-03-26

Family

ID=27494844

Family Applications (2)

Application Number Title Priority Date Filing Date
EP00923511A Withdrawn EP1194768A4 (en) 1999-04-20 2000-04-19 Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
EP10180277A Withdrawn EP2293056A3 (en) 1999-04-20 2000-04-19 A method for analysing a metabolic pathway

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10180277A Withdrawn EP2293056A3 (en) 1999-04-20 2000-04-19 A method for analysing a metabolic pathway

Country Status (6)

Country Link
EP (2) EP1194768A4 (en)
JP (2) JP4723725B2 (en)
AU (2) AU774662B2 (en)
CA (1) CA2370749A1 (en)
IL (1) IL146093A0 (en)
WO (1) WO2000063683A1 (en)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
EP2479578A1 (en) 2000-10-19 2012-07-25 Target Discovery, Inc. Mass defect labeling for the determination of oligomer sequences
DE10123711A1 (en) * 2001-05-15 2003-02-27 Wolfgang Altmeyer Procedure for determining the origin of biological materials
US6800449B1 (en) 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
JP4873801B2 (en) * 2001-08-10 2012-02-08 サントリーホールディングス株式会社 Structural analysis method for organic compounds
DK1437966T3 (en) 2001-10-24 2011-07-04 Univ California Measurement of protein synthesis rates in humans and in experimental systems using isotopically labeled water
CA2475924C (en) 2002-02-12 2016-03-29 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
EP2299274A1 (en) * 2002-03-07 2011-03-23 Medical Research Council SCD fingerprints
EP1361438A1 (en) * 2002-05-10 2003-11-12 Proteome Factory AG Solid-phase assisted spectroscopic and spectrometric analysis of complex peptide mixes
EP1504267B1 (en) * 2002-05-10 2007-12-12 Proteome Factory AG Solid-phase assisted spectroscopic and spectrometric analysis of complex biopolymer mixtures
AU2003256819B2 (en) * 2002-07-30 2009-11-12 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
ATE415486T1 (en) 2002-09-13 2008-12-15 Univ California METHOD FOR MEASURING SPEEDS OF CHOLESTEROL REVERSE TRANSPORT IN VIVO AS AN INDEX OF ANTI-ARTHEROGENESIS
JP4795688B2 (en) * 2002-10-09 2011-10-19 ウオーターズ・テクノロジーズ・コーポレイシヨン Method and apparatus for identifying compounds in a sample
JP4611025B2 (en) 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Deuterated glucose or fat tolerance test for high-throughput measurement of glucose or fatty acid metabolism in the body
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
WO2005006988A1 (en) 2003-06-19 2005-01-27 Everest Biomedical Instruments Breath end-tidal gas monitor
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
US7598033B2 (en) * 2003-12-15 2009-10-06 University Of Pennsylvania Method and devices for running reactions on a target plate for MALDI mass spectrometry
US8510054B2 (en) 2004-02-05 2013-08-13 Ajinomoto Co., Inc. Intracellular metabolic flux analysis method using substrate labeled with isotope
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
EP1723252A4 (en) * 2004-03-11 2009-07-29 Univ California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
KR100611313B1 (en) * 2004-06-30 2006-08-10 고려대학교 산학협력단 Compound for derivatizing polypeptides, method for sequencing and quantifying aminoacids in polypeptides using the same
JP4512745B2 (en) * 2004-10-29 2010-07-28 独立行政法人産業技術総合研究所 Cell separation and identification apparatus and method
JP2008064459A (en) * 2004-12-24 2008-03-21 Univ Kurume Method of quantitative determination for factor derived from pigment epithelium
JP2006308523A (en) * 2005-05-02 2006-11-09 Ebara Corp Method for coating inside of microchannel for microchip for electrophoresis, and coated microchip for electrophoresis prepared by the method
CA2772688A1 (en) 2005-09-12 2007-03-22 Phenomenome Discoveries Inc. Methods for the diagnosis of colorectal cancer and ovarian cancer health states
JP2007163423A (en) * 2005-12-16 2007-06-28 Ajinomoto Co Inc Amino acid analytical method by mass spectrometer
US8626449B2 (en) 2006-10-17 2014-01-07 The Regents Of The University Of California Biological cell sorting and characterization using aerosol mass spectrometry
US20100312487A1 (en) * 2006-11-15 2010-12-09 Shimadzu Corporation Mass analysis data analyzing method and apparatus thereof
FR2936316B1 (en) * 2008-09-25 2015-05-01 Etat Francais Dga DEVICE FOR SELECTIVE PRECONCENTRATION / DETECTION OF CHARGED ANALYTES CONTAINED IN AN ELECTROLYTE AND ASSOCIATED METHOD.
CA2794248C (en) * 2010-03-24 2018-02-20 Glendon John Parker Methods for conducting genetic analysis using protein polymorphisms
GB201019337D0 (en) 2010-11-16 2010-12-29 Micromass Ltd Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
WO2013036885A1 (en) 2011-09-08 2013-03-14 The Regents Of The University Of California Metabolic flux measurement, imaging and microscopy
JP6294233B2 (en) 2011-12-07 2018-03-14 グラクソスミスクライン エルエルシー Quantification method for whole body skeletal muscle mass
EP2794033B1 (en) 2011-12-21 2021-08-18 Capnia, Inc. Analysis of exhaled gas with breathing parameter frequency compensation
WO2013163451A1 (en) 2012-04-27 2013-10-31 Bio-Rad Laboratories, Inc. Stain-free protein quantification and normalization
KR20150104607A (en) 2013-01-08 2015-09-15 카프니아, 인코포레이티드 Breath selection for analysis
JP5977269B2 (en) 2013-01-22 2016-08-24 アークレイ株式会社 Sample analysis method and solution used therefor
MX2015010391A (en) * 2013-02-12 2015-10-29 Capnia Inc Sampling and storage registry device for breath gas analysis.
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
RU2016111654A (en) 2013-08-30 2017-10-05 Кэпниа, Инк. CARBON GAS MEASUREMENT SYSTEM IN NEWBORNS
JP6281349B2 (en) * 2014-03-19 2018-02-21 株式会社島津製作所 Method for preparing a peptide mixture sample for mass spectrometry
WO2016033382A1 (en) 2014-08-27 2016-03-03 Capnia, Inc. Methods for immune globulin administration
JP6264595B2 (en) 2015-03-09 2018-01-24 パナソニックＩｐマネジメント株式会社 Microfluidic device
PL3294775T3 (en) * 2015-05-12 2021-12-13 Regeneron Pharmaceuticals, Inc. Multimeric protein purity determination
WO2017163413A1 (en) * 2016-03-25 2017-09-28 科健化学株式会社 Hollow-column liquid chromatography system and substance separation using said system
JP2022519246A (en) * 2019-01-31 2022-03-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Native microfluidic CE-MS analysis method for antibody charge heterogeneity
EP4010456A4 (en) 2019-08-05 2023-09-13 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
CN113433200A (en) * 2021-06-16 2021-09-24 华南农业大学 Method for identifying cross-linked polymer by electrospray mass spectrometry technology
CN114935609A (en) * 2021-06-17 2022-08-23 上海阿趣生物科技有限公司 High-throughput target detection method for biological sample polyamine and related metabolites
CN115097038B (en) * 2022-06-22 2023-08-01 山东国仓健生物科技有限公司 Screening and identifying method and application of metabolite related to soybean phytophthora resistance
CN117169317B (en) * 2023-10-30 2024-01-19 内蒙古蒙牛乳业（集团）股份有限公司 Alpha-s 1 casein phosphorylation degree detection method, sample buffer solution and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0653631A2 (en) * 1993-11-11 1995-05-17 Ciba-Geigy Ag Apparatus and method for the electrophoretical separation of mixtures of fluid substances
WO1996033405A1 (en) * 1995-04-17 1996-10-24 Mayo Foundation For Medical Education And Research Sample preprocessor

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4656133A (en) 1983-09-29 1987-04-07 Board Of Regents, University Of Texas System Method for enzymatic synthesis of isotopically labeled carbohydrates
JPH0828934B2 (en) 1984-07-31 1996-03-21 株式会社東芝 Protection control device
US4830010A (en) 1986-04-04 1989-05-16 Marshall Barry J Methods for the diagnosis of gastrointestinal disorders
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4994165A (en) * 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
US5059702A (en) * 1989-09-29 1991-10-22 The United States Of America As Represented By The Secretary Of The Navy 124 Sn-labelled tetra-n-butyltin and tri-n-butyltin bromide
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5935401A (en) 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US5133844A (en) 1990-03-15 1992-07-28 United States Department Of Energy Method of electric field flow fractionation wherein the polarity of the electric field is periodically reversed
SE9002480D0 (en) 1990-07-23 1990-07-23 Hans Lilja ASSAY OF FREE AND COMPLEXED PROSTATE-SPECIFIC ANTIGEN
US5295261A (en) 1990-07-27 1994-03-15 Pacific Bell Corporation Hybrid database structure linking navigational fields having a hierarchial database structure to informational fields having a relational database structure
US5534440A (en) 1991-02-22 1996-07-09 Biomedical Research Centre Limited Compounds and methods for sequencing amino acids
WO1992021138A1 (en) * 1991-05-21 1992-11-26 Analytica Of Brandford, Inc. Method and apparatus for improving electrospray ionization of solute species
JP2844503B2 (en) 1991-11-20 1999-01-06 東京瓦斯株式会社 Gas measurement device
US5140993A (en) 1991-12-27 1992-08-25 Baylor College Of Medicine Device for collecting a breath sample
US5317156A (en) 1992-01-29 1994-05-31 Sri International Diagnostic tests using near-infrared laser absorption spectroscopy
US5338686A (en) * 1992-04-29 1994-08-16 Hellerstein Marc K Method for measuring in vivo synthesis of biopolymers
AU687358B2 (en) * 1992-07-24 1998-02-26 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The Peptides useful as internal standards for microsequencing and methods for their use
ES2111289T5 (en) 1993-01-21 2005-07-16 President And Fellows Of Harvard College METHODS AND DIAGNOSIS KITS THAT USE STRESS PROMOTERS IN MAMMALS TO DETERMINE THE TOXICITY OF A COMPOUND.
US5439803A (en) 1993-08-13 1995-08-08 The Regents Of The University Of Michigan Isotope and assay for glycolysis and the pentose phosphate pathway
JPH0793370A (en) 1993-09-27 1995-04-07 Hitachi Device Eng Co Ltd Gene data base retrieval system
US5599677A (en) 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
US5542419A (en) 1994-02-28 1996-08-06 Boston University Noninvasive method to detect gastric Helicobacter pylori
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
DE4415480C2 (en) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Device and method for the mass spectrometric analysis of substance mixtures by coupling capillary electrophoretic separation (CE) with electrospray ionization (ESI)
US5856082A (en) * 1994-08-31 1999-01-05 University Of British Columbia Devices and methods for characterizing proteins and peptides
DE4433384C2 (en) * 1994-09-09 1996-12-19 Ufz Leipzighalle Gmbh Ecotoxicological metabolism test with stable isotopes
US5628328A (en) * 1995-04-25 1997-05-13 Iowa State University Research Foundation Method for measuring muscle mass
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5710007A (en) 1995-09-29 1998-01-20 Luderer; Albert A. Methods for diagnosing prostatic adenocarcinoma
JPH10291955A (en) * 1997-04-22 1998-11-04 Sagami Chem Res Center 13c-labeled docosahexaenoic acid and its production
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
US5953727A (en) 1996-10-10 1999-09-14 Incyte Pharmaceuticals, Inc. Project-based full-length biomolecular sequence database
US6023659A (en) 1996-10-10 2000-02-08 Incyte Pharmaceuticals, Inc. Database system employing protein function hierarchies for viewing biomolecular sequence data
US5966712A (en) 1996-12-12 1999-10-12 Incyte Pharmaceuticals, Inc. Database and system for storing, comparing and displaying genomic information
CN1217007C (en) * 1997-02-14 2005-08-31 乔治华盛顿大学 Assay for measurement of DNA synthesis rates
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US5910403A (en) 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
US5926818A (en) 1997-06-30 1999-07-20 International Business Machines Corporation Relational database implementation of a multi-dimensional database
JP3862366B2 (en) * 1997-07-01 2006-12-27 東京瓦斯株式会社 Liver function diagnostic agent
US6001231A (en) 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5924995A (en) 1997-11-10 1999-07-20 Meretek Diagnostics Non-invasive method for the functional assessment of infants and children with an inherited metabolic disorder

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0653631A2 (en) * 1993-11-11 1995-05-17 Ciba-Geigy Ag Apparatus and method for the electrophoretical separation of mixtures of fluid substances
WO1996033405A1 (en) * 1995-04-17 1996-10-24 Mayo Foundation For Medical Education And Research Sample preprocessor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FIGEYS D ET AL: "PROTEIN IDENTIFICATION BY SOLID PHASE MICROEXTRACTION-CAPILLARY ZONE ELECTROPHORESIS-MICROELECTROSPRAY-TANDEM MASS SPECTROMETRY", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 14, no. 11, 1996, pages 1579 - 1583, XP001041771, ISSN: 0733-222X *
MANN M ET AL: "ERROR-TOLERANT IDENTIFICATION OF PEPTIDES IN SEQUENCE DATABASES BY PEPTIDE SEQUENCE TAGS", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 66, no. 24, 15 December 1994 (1994-12-15), pages 4390 - 4399, XP000573399, ISSN: 0003-2700 *
See also references of WO0063683A1 *

Also Published As

Publication number Publication date
JP4723725B2 (en) 2011-07-13
JP2010249831A (en) 2010-11-04
AU2004216642B2 (en) 2007-05-10
AU4362400A (en) 2000-11-02
WO2000063683A1 (en) 2000-10-26
AU774662B2 (en) 2004-07-01
JP2003529044A (en) 2003-09-30
AU2004216642A1 (en) 2004-10-28
EP1194768A1 (en) 2002-04-10
EP2293056A3 (en) 2011-06-29
CA2370749A1 (en) 2000-10-26
IL146093A0 (en) 2002-07-25
EP2293056A2 (en) 2011-03-09

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