EP1165146A4 - Lipid soluble radioactive metal chelates for tumor therapy - Google Patents

Lipid soluble radioactive metal chelates for tumor therapy

Info

Publication number
EP1165146A4
EP1165146A4 EP00921373A EP00921373A EP1165146A4 EP 1165146 A4 EP1165146 A4 EP 1165146A4 EP 00921373 A EP00921373 A EP 00921373A EP 00921373 A EP00921373 A EP 00921373A EP 1165146 A4 EP1165146 A4 EP 1165146A4
Authority
EP
European Patent Office
Prior art keywords
tumor therapy
radioactive metal
metal chelates
lipid soluble
soluble radioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00921373A
Other languages
German (de)
French (fr)
Other versions
EP1165146A1 (en
Inventor
Madhukar Mathew L Thakur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of EP1165146A1 publication Critical patent/EP1165146A1/en
Publication of EP1165146A4 publication Critical patent/EP1165146A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP00921373A 1999-03-09 2000-03-09 Lipid soluble radioactive metal chelates for tumor therapy Withdrawn EP1165146A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12348399P 1999-03-09 1999-03-09
US123483P 1999-03-09
PCT/US2000/006207 WO2000053234A1 (en) 1999-03-09 2000-03-09 Lipid soluble radioactive metal chelates for tumor therapy

Publications (2)

Publication Number Publication Date
EP1165146A1 EP1165146A1 (en) 2002-01-02
EP1165146A4 true EP1165146A4 (en) 2003-09-17

Family

ID=22408928

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00921373A Withdrawn EP1165146A4 (en) 1999-03-09 2000-03-09 Lipid soluble radioactive metal chelates for tumor therapy

Country Status (4)

Country Link
EP (1) EP1165146A4 (en)
JP (1) JP2002538225A (en)
CA (1) CA2366593A1 (en)
WO (1) WO2000053234A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059550A2 (en) * 1999-04-02 2000-10-12 Ut-Battelle Llc Indium-114m and related compositions applicable in brachytherapie
WO2019243419A1 (en) * 2018-06-19 2019-12-26 Danmarks Tekniske Universitet Brachygel for treatment of cancer and/or for guidance of surgery

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225409A1 (en) * 1985-12-02 1987-06-16 The Dow Chemical Company Organic amine phosphonic acid complexes for the treatment of calcific tumors
US4925925A (en) * 1988-06-15 1990-05-15 University Of Cincinnati Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use
US5192526A (en) * 1989-05-02 1993-03-09 Mallinckrodt Medical, Inc. Kit for preparation of rhenium therapeutic agents for bone cancer without purification
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
DE19632052A1 (en) * 1996-08-08 1998-02-12 Michael Prof Dr Eisenhut New benzamide compounds which complex to technetium and/or rhenium
US5840859A (en) * 1995-07-06 1998-11-24 Research Corporation Technologies, Inc. (Aminostyryl)pyridinium compounds for radiolabelling cell membranes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017596A (en) * 1975-03-03 1977-04-12 Research Corporation Radiopharmaceutical chelates and method of external imaging
US5130118A (en) * 1987-11-06 1992-07-14 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225409A1 (en) * 1985-12-02 1987-06-16 The Dow Chemical Company Organic amine phosphonic acid complexes for the treatment of calcific tumors
US4925925A (en) * 1988-06-15 1990-05-15 University Of Cincinnati Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use
US5192526A (en) * 1989-05-02 1993-03-09 Mallinckrodt Medical, Inc. Kit for preparation of rhenium therapeutic agents for bone cancer without purification
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5840859A (en) * 1995-07-06 1998-11-24 Research Corporation Technologies, Inc. (Aminostyryl)pyridinium compounds for radiolabelling cell membranes
DE19632052A1 (en) * 1996-08-08 1998-02-12 Michael Prof Dr Eisenhut New benzamide compounds which complex to technetium and/or rhenium

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BERNARD B F ET AL: "Tc-MIBI, Tc-Tetrofosmin and Tc-Q12 In Vitro and In Vivo - Human distribution, dosimetry, safety and preliminary comparison to thallium 201 for myocardial perfusion imaging", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 25, no. 3, 1 April 1998 (1998-04-01), pages 233 - 240, XP004113280, ISSN: 0969-8051 *
DEWANJEE M K ET AL: "TECHNETIUM-99M-LABELED PLATELETS: COMPARISON OF LABELING WITH A NEWLIPID-SOLUBLE SN(II)-MERCAPTOPYRIDINE-N-OXIDE AND 99M TC-HMPAO", INTERNATIONAL JOURNAL OF RADIATION APPLICATIONS AND INSTRUMENTATION PART B: NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 18, no. 5, 1991, pages 461 - 468, XP000827908, ISSN: 0883-2897 *
KOSTARELOS K ET AL: "LIPOSOMES AS CARRIERS OF RADIONUCLIDES: FROM IMAGING TO THERAPY", JOURNAL OF LIPOSOME RESEARCH, MARCEL DEKKER, NEW YORK, US, vol. 9, no. 4, November 1999 (1999-11-01), pages 429 - 460, XP000878065, ISSN: 0898-2104 *
See also references of WO0053234A1 *
VIRGOLINI I ET AL: "INDIUM-111-DOTA-LANREOTIDE: BIODISTRIBUTION, SAFETY AND RADIATION ABSORBED DOSE IN TUMOR PATIENTS", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE. NEW YORK, US, vol. 39, no. 11, November 1998 (1998-11-01), pages 1928 - 1936, XP001073903, ISSN: 0161-5505 *
ZWEIT J: "RADIONUCLIDES AND CARRIER MOLECULES FOR THERAPY", PHYSICS IN MEDICINE AND BIOLOGY, TAYLOR AND FRANCIS LTD. LONDON, GB, vol. 41, 1996, pages 1905 - 1914, XP001079428, ISSN: 0031-9155 *

Also Published As

Publication number Publication date
EP1165146A1 (en) 2002-01-02
JP2002538225A (en) 2002-11-12
WO2000053234A1 (en) 2000-09-14
CA2366593A1 (en) 2000-09-14

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20011009

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 51/00 A

Ipc: 7A 61K 51/04 B

Ipc: 7C 07F 5/00 B

Ipc: 7A 61N 5/00 B

A4 Supplementary search report drawn up and despatched

Effective date: 20030801

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071002