EP1126833A4 - Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives - Google Patents
Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derivesInfo
- Publication number
- EP1126833A4 EP1126833A4 EP99971314A EP99971314A EP1126833A4 EP 1126833 A4 EP1126833 A4 EP 1126833A4 EP 99971314 A EP99971314 A EP 99971314A EP 99971314 A EP99971314 A EP 99971314A EP 1126833 A4 EP1126833 A4 EP 1126833A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thiadiazole
- oxadiazole
- combinatorial libraries
- triazole derivatives
- triazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US183222 | 1994-01-14 | ||
US18322298A | 1998-10-29 | 1998-10-29 | |
PCT/US1999/025331 WO2000025768A1 (fr) | 1998-10-29 | 1999-10-28 | Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1126833A2 EP1126833A2 (fr) | 2001-08-29 |
EP1126833A4 true EP1126833A4 (fr) | 2004-09-08 |
Family
ID=22671958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99971314A Withdrawn EP1126833A4 (fr) | 1998-10-29 | 1999-10-28 | Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1126833A4 (fr) |
AU (1) | AU1455500A (fr) |
WO (1) | WO2000025768A1 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5891600A (en) * | 1999-07-01 | 2001-01-22 | Chemrx Advanced Technologies, Inc. | Process for synthesizing oxadiazoles |
WO2001054503A1 (fr) * | 2000-01-28 | 2001-08-02 | Akkadix Corporation | Procedes de destruction des nematodes et des oeufs de nematodes a l'aide de derives 4-phenoxy-6-aminopyrimidine |
US6683191B2 (en) | 2000-06-05 | 2004-01-27 | Ortho-Mcneil Pharmaceuticals, Inc. | Method for synthesis of substituted azole libraries |
WO2001094318A2 (fr) * | 2000-06-05 | 2001-12-13 | Ortho-Mcneil Pharmaceutical, Inc. | Procede de synthese de banques d'azoles substitues |
US6482829B2 (en) | 2000-06-08 | 2002-11-19 | Hoffmann-La Roche Inc. | Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor |
US7390813B1 (en) | 2001-12-21 | 2008-06-24 | Xenon Pharmaceuticals Inc. | Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents |
HUE031794T2 (en) | 2003-04-11 | 2017-08-28 | Ptc Therapeutics Inc | 1,2,4-oxadiol-benzoic acid compounds and their use for nonsense suppression and disease treatment |
NZ545265A (en) | 2003-07-30 | 2009-11-27 | Xenon Pharmaceuticals Inc | Pyridazine derivatives and their use for treating diseases mediated by stearoyl-CoA desaturase (SCD) enzymes |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
US7605171B2 (en) | 2003-12-17 | 2009-10-20 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists |
US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US7592343B2 (en) | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
BRPI0515488A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
BRPI0515500A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
EP2266569A3 (fr) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Dérivés hétérocycliques et leur utilisation en tant qu'inhibiteurs de la stearoyl-coa desaturase |
EP1799664A1 (fr) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation en tant qu'inhibiteurs de la stearoyl-coa desaturase |
GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
MX2007015216A (es) | 2005-06-03 | 2008-02-22 | Xenon Pharmaceuticals Inc | Derivados de aminotiazol y sus usos como agentes terapeuticos. |
WO2007117438A2 (fr) | 2006-03-30 | 2007-10-18 | Ptc Therapeutics, Inc. | Méthodes de production d'une protéine fonctionnelle à partir d'un adn présentant une mutation non-sens et traitement des troubles associés |
WO2008013622A2 (fr) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Amides azocycliques fongicides |
US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
KR20090040478A (ko) | 2006-08-24 | 2009-04-24 | 노파르티스 아게 | 2-(피라진-2-일)-티아졸 및 2-(1H-피라졸-3-일)-티아졸 유도체, 및 대사, 심혈관 및 기타 장애의 치료를 위한 스테아로일-CoA 데새투라제(SCD) 억제제로서의 관련 화합물 |
NZ577111A (en) | 2006-12-15 | 2012-05-25 | Abbott Lab | Novel oxadiazole compounds |
WO2010108187A2 (fr) | 2009-03-20 | 2010-09-23 | Brandeis University | Composés et procédés pour traiter les infections microbiennes gastro-intestinales mammaliennes |
EP2560488B1 (fr) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Aminopyridines et aminotriazines, leurs compositions et leurs procédés d'utilisation |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
WO2014028931A2 (fr) | 2012-08-17 | 2014-02-20 | Brandeis University | Composés et procédés de traitement d'infections microbiennes gastro-intestinales de mammifère |
KR102497273B1 (ko) | 2014-03-06 | 2023-02-07 | 피티씨 테라퓨틱스, 인크. | 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염 |
BR112018008838A8 (pt) | 2015-10-30 | 2019-02-26 | Ptc Therapeutics Inc | método para tratar, prevenir, melhorar ou administrar uma doença epiléptica |
CN112010828B (zh) * | 2020-09-27 | 2023-01-31 | 中国医科大学 | Cdk7小分子抑制剂的化合物及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994019330A1 (fr) * | 1993-02-18 | 1994-09-01 | Warner-Lambert Company | AMIDES ALKYLE SUBSTITUES HETEROCYCLIQUES EXERÇANT UNE ACTIVITE INHIBITRICE DE L'ACYLE-CoA: CHOLESTEROL ACYLTRANSFERASE |
WO1996022997A1 (fr) * | 1995-01-27 | 1996-08-01 | Novo Nordisk A/S | Composes ayant des proprietes de liberation de l'hormone de croissance |
WO1997014671A1 (fr) * | 1995-10-18 | 1997-04-24 | Merck & Co., Inc. | Antagonistes des recepteurs de la cyclopentyle-tachykinine |
WO1997016433A1 (fr) * | 1995-10-30 | 1997-05-09 | Smithkline Beecham Corporation | Inhibiteurs de proteases |
WO1998037068A1 (fr) * | 1997-02-21 | 1998-08-27 | Bristol-Myers Squibb Company | Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8801289D0 (en) * | 1988-01-21 | 1988-02-17 | Shell Int Research | Oxadiazole compounds their preparation & their use as pesticides |
US5242890A (en) * | 1988-07-07 | 1993-09-07 | Korea Research Institute Of Chemical Technology | 1,2,4-oxadiazole derivative, useful as selective herbicide |
-
1999
- 1999-10-28 EP EP99971314A patent/EP1126833A4/fr not_active Withdrawn
- 1999-10-28 AU AU14555/00A patent/AU1455500A/en not_active Abandoned
- 1999-10-28 WO PCT/US1999/025331 patent/WO2000025768A1/fr not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994019330A1 (fr) * | 1993-02-18 | 1994-09-01 | Warner-Lambert Company | AMIDES ALKYLE SUBSTITUES HETEROCYCLIQUES EXERÇANT UNE ACTIVITE INHIBITRICE DE L'ACYLE-CoA: CHOLESTEROL ACYLTRANSFERASE |
WO1996022997A1 (fr) * | 1995-01-27 | 1996-08-01 | Novo Nordisk A/S | Composes ayant des proprietes de liberation de l'hormone de croissance |
WO1997014671A1 (fr) * | 1995-10-18 | 1997-04-24 | Merck & Co., Inc. | Antagonistes des recepteurs de la cyclopentyle-tachykinine |
WO1997016433A1 (fr) * | 1995-10-30 | 1997-05-09 | Smithkline Beecham Corporation | Inhibiteurs de proteases |
WO1998037068A1 (fr) * | 1997-02-21 | 1998-08-27 | Bristol-Myers Squibb Company | Derives d'acide benzoïque et composes apparentes utilises comme agents antiarythmiques |
Non-Patent Citations (2)
Title |
---|
See also references of WO0025768A1 * |
SUSANNA BORG: "synthesis of 1,2,4-oxadiazole-", JOURNAL OF ORGANIC CHEMISTRY., vol. 60, no. 10, 1995, USAMERICAN CHEMICAL SOCIETY. EASTON., pages 3112 - 20, XP002288337 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000025768A1 (fr) | 2000-05-11 |
EP1126833A2 (fr) | 2001-08-29 |
WO2000025768A8 (fr) | 2000-08-24 |
AU1455500A (en) | 2000-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010509 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HANNAH, AMY, L. Inventor name: HEBERT, R., NORMAND |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61P 43/00 B Ipc: 7C 07D 271/10 B Ipc: 7C 07D 271/06 B Ipc: 7A 61K 31/10 B Ipc: 7A 61K 31/075 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040723 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040501 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HANNAH, AMY, L. Inventor name: HEBERT, R., NORMAND |