EP1112100A1 - Pompe volumetrique a perfusion avec commande par servovanne - Google Patents

Pompe volumetrique a perfusion avec commande par servovanne

Info

Publication number
EP1112100A1
EP1112100A1 EP00942820A EP00942820A EP1112100A1 EP 1112100 A1 EP1112100 A1 EP 1112100A1 EP 00942820 A EP00942820 A EP 00942820A EP 00942820 A EP00942820 A EP 00942820A EP 1112100 A1 EP1112100 A1 EP 1112100A1
Authority
EP
European Patent Office
Prior art keywords
reservoir
liquid
outlet
pressure
bladder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00942820A
Other languages
German (de)
English (en)
Inventor
Hal Danby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9916111A external-priority patent/GB2352974B/en
Priority claimed from US09/410,676 external-priority patent/US6398760B1/en
Application filed by Baxter International Inc filed Critical Baxter International Inc
Publication of EP1112100A1 publication Critical patent/EP1112100A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A61M5/16881—Regulating valves

Definitions

  • the present invention is directed toward volumetric infusion pumps, and more particularly toward a self-regulating servo valve for use with a volumetric infusion pump.
  • Another similar apparatus for infusing therapeutic liquids to a patient includes a collapsible bag containing the therapeutic liquid juxtaposed with an inflatable bladder, with the bladder and the collapsible bag being contained within a rigid housing.
  • the bladder is inflated, for example with compressed air, to apply pressure to the collapsible bag and thus expel therapeutic liquid from it.
  • the therapeutic liquid is expelled through an outlet tube having a fixed cross-sectional area or which includes a flow restrictor of a fixed cross-sectional area. Fluid is provided to the bladder at a controlled rate with the intent that fluid is thus forced through the outlet tube at an approximate flow rate.
  • the present invention is directed toward overcoming one or more of the problems discussed above.
  • a first aspect of the present invention is an infusion pump including a reservoir containing a therapeutic liquid to be infused.
  • the reservoir includes an outlet for the liquid.
  • a volumetric air pump is operatively associated with the reservoir to pressurize the reservoir.
  • a valve is operatively associated with the liquid outlet and prevents liquid flow through the liquid outlet until a select pressure is obtained in the outlet. The valve thereafter maintains an opening in the outlet that keeps the pressure in the reservoir at substantially the select pressure, whereby the volumetric flow rate of liquid through the outlet is proportional to the volumetric flow rate of air from the volumetric air pump.
  • the valve varies the opening in the outlet so as to maintain the select pressure.
  • the outlet may consist of a flexible conduit having a select undeformed inner cross- sectional area and the valve varies the opening in the outlet by pinching a segment of the conduit to vary the inner cross-sectional area of the segment of the conduit.
  • the reservoir comprises a collapsible wall and the infusion pump further comprises an inflatable bladder juxtaposed with the collapsible wall of the reservoir.
  • the volumetric air pump is in fluid communication with the bladder. The volumetric air pump provides gas to the bladder at a first rate until the select pressure is applied to the reservoir and thereafter provides gas to the bladder at a second substantially uniform rate less than the first rate.
  • a second aspect of the present invention is an infusion pump including a collapsible bag defining a therapeutic liquid reservoir, the collapsible bag having a resilient tubing defining a reservoir outlet extending therefrom.
  • An inflatable bladder is juxtaposed with the collapsible bag.
  • a rigid housing defines a chamber receiving the collapsible bag and the inflatable bladder and includes a port receiving the resilient tubing.
  • a volumetric air pump is in fluid communication with the bladder to inflate the bladder and thereby apply pressure to the collapsible bag.
  • a valve is operatively associated with the resilient tubing to variably restrict the flow of liquid through the resilient tubing as a function of the pressure applied to the collapsible bag to maintain the substantially constant select pressure in the collapsible bag.
  • the valve preferably prevents the flow of liquid through the resilient tubing until application of the select pressure to the collapsible bag.
  • the valve may consist of a blade and anvil receiving the resilient tubing therebetween. The blade is biased toward the anvil to restrict the flow of liquid through the resilient tubing and the blade is operatively associated with the collapsible bag to bias the blade away from the anvil as pressure within the collapsible bag increases.
  • the volumetric air pump preferably provides gas to the bladder at a first rate until the select pressure sufficient to overcome the biasing force on the blade so as to initially move the arm and the blade away from the anvil is applied to the reservoir and thereafter provides gas to the bladder at a second substantially uniform rate less than the first rate.
  • a detector may be operatively associated with the arm and the volumetric air pump with the detector detecting the initial movement of the arm and sending a first signal to the volumetric air pump.
  • the sensor may further detect if the blade moves more than a select distance from the anvil, at which point a second signal is sent to the volumetric air pump.
  • a third aspect of the present invention is a method of infusing therapeutic liquid to a patient.
  • the method includes providing a reservoir containing a therapeutic liquid and having a liquid outlet, providing a volumetric air pump in operative association with the reservoir to pressurize the reservoir and maintaining the select pressure in the reservoir so that liquid through the liquid outlet is proportional to the volumetric flow rate of the volumetric air pump.
  • the liquid outlet may comprise a resilient tube and the method may further comprise applying a pinching force to a segment of the resilient tube and decreasing the pinching force as the pressure in the reservoir increases to increase an effective inner cross-sectional area of the segment of the resilient tube.
  • the method may further comprise pressurizing the reservoir by providing a bladder juxtaposed with the reservoir in fluid communication with the volumetric air pump and preventing flow of liquid through the liquid outlet if the pressure in the reservoir is less than the select pressure.
  • the method may further include inflating the bladder at a first rate until the select pressure is reached in the reservoir and thereafter inflating the bladder at a second substantially constant rate less than the first rate.
  • a select pressure at the outlet can be accurately maintained, thereby insuring a substantially constant flow rate by keeping the liquid volumetric flow rate proportional to the volumetric rate of air provided by the volumetric air pump. If the pressure in a line to a patient increases, for example, due to lowering of the pump relative to the point of infusion, pressure will build within the bag which will thereby cause the valve to open further, allowing for a gradually increasing flow rate until the pressure in the bag returns to the select pressure. In this manner, the pump is self regulating. If the valve opens beyond a select amount, indicating a downstream occlusion, the volumetric air pump stops operating, preventing an excessive pressure build up.
  • Fig 1 is a schematic cross-sectional, elevational representation of the volumetric infusion with servo valve control of the present invention.
  • a volumetric infusion pump 10 including a servo valve 12 of the present invention is illustrated schematically in Fig. 1.
  • the volumetric infusion pump 10 consists of a housing 14 defining a chamber 16 of a fixed volume. Within the chamber 16 is a collapsible bag 18 defining a reservoir for a therapeutic liquid. Also within the chamber 16 juxtaposed with the collapsible bag 18 is an inflatable bladder 20 in fluid communication by conduit 22 with a volumetric gas source 24.
  • the volumetric gas source 24 consists of a volumetric air pump 26 driven by an encoded electric motor 27.
  • the encoded electric motor 27 is coupled to a control circuit or microprocessor 28 by a connector 29.
  • the microprocessor 28 may be preprogrammed or alternatively reprogramable through input station 30.
  • the microprocessor 28 and electric motor 27 are preferably powered from a single power supply 31 which distributes power via lines 32 and 33.
  • the power supply 31 may be an internal battery which can be replaceable, rechargeable or disposable along with the entire infusion pump 10. Alternatively, the power supply can be external to the pump 10. such as a common household current.
  • a resilient outlet tube 36 having a select undefo ⁇ ned inner cross-sectional area extends from the collapsible bag 18 and a port 38 in the housing 14 and is in fluid communication with a patient administration set (not shown) to deliver therapeutic liquid from the collapsible bag 18 to a patient.
  • liquid flows from the resilient outlet tube 36 by application of pressure from the inflatable bladder 20 upon the collapsible bag 18 within the chamber 16 of fixed volume.
  • the servo valve 12 consists of an anvil 40 and a blade 42 which receive a segment of the resilient outlet tube 36 therebetween.
  • the anvil 40 consists of a portion of the wall of the housing 14 which defines the port 38 for the resilient outlet tube 36.
  • the blade 42 is on the distal end 46 of an arm 48.
  • the proximal end 50 of the arm 48 is pivotally attached to the housing 14.
  • arm 48 is rigid and the pivotal attachment is by a hinge 52.
  • the housing and arm 14 could be integrally made of a suitable thermoplastic and the pivotal attachment could be a living hinge.
  • a pressure pad 54 intermediate the proximal 50 and distal 46 ends of the arm 48 extends through an orifice 56 in the housing 14.
  • the face of the pressure pad 54 has a defined surface area which is in contact with the collapsible bag 18.
  • a spring 58 is located at the distal end of the arm 48 and biases the blade toward the anvil 40 so as to collapse and therefore to close the interior of the resilient outlet tube 36 by applying a select force. As an alternative to the spring 58, if the pump is maintained in the orientation illustrated in Fig. 1, the weight of the arm can apply the select force.
  • a sensor 60 is operatively associated with the arm 48 to detect movement of the arm 48, and thus the blade 42. The sensor 60 is connected by connector 62 to the microprocessor 30. In operation, the inflatable bladder 20 is inflated by air delivered from the volumetric air pump 26 through the conduit 22 to the bladder 20.
  • a threshold pressure preferably 9 psi
  • the surface area of the pressure pad 54 is selected so that the select force is overcome when a desired threshold pressure is achieved in the collapsible bag 18.
  • gas is supplied to the inflatable bladder 20 at a substantially constant rate sufficient to provide a desired rate of flow to the patient through the resilient outlet tube. Assuming a 9 psi threshold pressure, the flow of air to the inflatable bladder 20 necessary to sustain a desired flow rate can be calculated as follows:
  • the microprocessor Upon entry of the desired flow rate by a user, through the input station 30, the microprocessor calculates the required air flow in accordance with this equation. In application, depending on how smooth flow rate from the air pump is, the valve tends to "float" in a position which maintains an equilibrium.
  • the volumetric air pump 26 is operated at a maximum rate to inflate the bladder until sufficient pressure develops within the collapsible bag 18 that the arm 48 and therefore the blade 42 are caused to lift relative to the anvil 40.
  • the initial movement of the arm is detected by the sensor 60 which sends a signal to the microprocessor 28 which in turn sends a signal to the encoded electric motor drive 27 which slows the encoded electronic motor to slow the delivery of gas to the bladder to the necessary rate calculated to provide the desired flow rate entered in the input station 30 through the resilient outlet tube.
  • the pump works similarly to a pressure regulator in which the valve 12 opens and closes to maintain a desired pressure at the outlet tube 36.
  • the blade 42 will move further away from the anvil 40, thereby temporarily increasing the effective inner cross-sectional area of the resilient tube 36 to allow more flow until the system pressure returns to the desired pressure at the outlet tube and the flow rate returns to the desired flow rate.
  • the pump is self regulated. If an obstruction occurs in the patient administration set or blood vessel of the patient such that pressure builds on the system above a select maximum, the sensor 60 will detect corresponding movement of the arm 48 and send a signal to the microprocessor which in turn will stop the electric motor 27 and sound an alarm.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Compressors, Vaccum Pumps And Other Relevant Systems (AREA)

Abstract

Cette invention concerne une pompe à perfusion (10) munie d'un réservoir (18) pour liquide de perfusion. Ce réservoir (18) comporte une sortie (36) pour le liquide. Une pompe à air volumétrique (24) couplée fonctionnel au réservoir (18) met ledit réservoir sous pression et chasse le liquide par la sortie (36). Une vanne (12) associée de manière fonctionnelle à la sortie (36) empêche le liquide de s'écouler par la sortie tant qu'une pression de seuil donnée ne s'est pas établie dans cette sortie. Dès lors, la vanne maintient dans la sortie une ouverture qui stabilise la pression dans le réservoir (18) à une valeur correspondant sensiblement à la pression de seuil, le débit volumétrique de liquide au niveau de la sortie (36) étant proportionnel au débit volumétrique de l'air débité par la pompe (24). La vanne (12) fait varier l'ouverture dans la sortie pour maintenir la pression voulue. La sortie est constituée de préférence par un conduit souple (36) présentant avant déformation une section intérieure donnée. La vanne (12) réduit plus ou moins le débit de liquide au niveau de la sortie par pincement d'un tronçon du conduit, ce qui fait varier la section intérieure dudit conduit au niveau de ce tronçon. L'invention concerne une méthode de perfusion d'un liquide thérapeutique chez un patient qui fait intervenir un réservoir (18) renfermant le liquide thérapeutique, une pompe à air volumétrique (24) qui met ce réservoir sous pression et chasse le liquide du réservoir par une sortie (36) en maintenant dans le réservoir une pression donnée telle que le débit du liquide au niveau de la sortie est proportionnel au débit volumétrique de la pompe à air.
EP00942820A 1999-07-10 2000-06-15 Pompe volumetrique a perfusion avec commande par servovanne Withdrawn EP1112100A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9916111A GB2352974B (en) 1999-07-10 1999-07-10 Volumetric infusion pump with servo valve control
GB9916111 1999-07-10
US410676 1999-10-01
US09/410,676 US6398760B1 (en) 1999-10-01 1999-10-01 Volumetric infusion pump with servo valve control
PCT/US2000/016394 WO2001003758A1 (fr) 1999-07-10 2000-06-15 Pompe volumetrique a perfusion avec commande par servovanne

Publications (1)

Publication Number Publication Date
EP1112100A1 true EP1112100A1 (fr) 2001-07-04

Family

ID=26315750

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00942820A Withdrawn EP1112100A1 (fr) 1999-07-10 2000-06-15 Pompe volumetrique a perfusion avec commande par servovanne

Country Status (9)

Country Link
EP (1) EP1112100A1 (fr)
JP (1) JP2003504125A (fr)
KR (1) KR20010075031A (fr)
CN (1) CN1315876A (fr)
AR (1) AR024698A1 (fr)
AU (1) AU5739000A (fr)
BR (1) BR0006913A (fr)
CA (1) CA2341745A1 (fr)
WO (1) WO2001003758A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1221991B1 (fr) * 1999-10-13 2005-01-26 Göran EWERLÖF Infuseur destine a etre utilise avec un sac pour perfusion intraveineuse

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2850027B1 (fr) * 2003-01-21 2005-09-16 Medex Sa Dispositif d'injection de liquide medical
CN101087625B (zh) 2004-11-22 2012-02-22 因特利杰克特有限公司 用于药物供给的装置和***
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
EP2432525A1 (fr) * 2009-05-20 2012-03-28 Sanofi-Aventis Deutschland GmbH Dispositif d'administration de médicament
KR101127126B1 (ko) * 2011-08-31 2012-03-21 서현배 압전 작동 인퓨전펌프
WO2014106056A2 (fr) 2012-12-27 2014-07-03 Kaleo, Inc. Dispositifs, systèmes et procédés de localisation et d'interaction avec des systèmes d'administration de médicament
CA3046354A1 (fr) 2017-01-17 2018-07-26 Kaleo, Inc. Dispositifs d'administration de medicament a connectivite sans fil et a detection d'evenement
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
CN109498896A (zh) * 2018-12-28 2019-03-22 山东华亿医疗科技有限公司 一种无重力控制输液装置
CN113697885B (zh) * 2021-08-31 2022-03-08 湖州恒辉科技有限公司 一种大跨度伸缩移动顶棚

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Publication number Priority date Publication date Assignee Title
ES2004595A6 (es) * 1987-04-09 1989-01-16 Ruano Marco Miguel Bomba volumetrica para perfusion parenteral
US5090963A (en) * 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser
USRE35501E (en) * 1991-06-25 1997-05-06 Medication Delivery Devices Infusion pump, treatment fluid bag therefor, and method for the use thereof
US5681284A (en) * 1994-10-31 1997-10-28 Glenn Herskowitz Infusion pump with tube spike holder

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0103758A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1221991B1 (fr) * 1999-10-13 2005-01-26 Göran EWERLÖF Infuseur destine a etre utilise avec un sac pour perfusion intraveineuse

Also Published As

Publication number Publication date
JP2003504125A (ja) 2003-02-04
CA2341745A1 (fr) 2001-01-18
WO2001003758A1 (fr) 2001-01-18
AU5739000A (en) 2001-01-30
BR0006913A (pt) 2001-07-31
CN1315876A (zh) 2001-10-03
KR20010075031A (ko) 2001-08-09
AR024698A1 (es) 2002-10-23

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