EP1073460A4 - Nucleic acid encoding hyaluronan synthase and methods of use - Google Patents

Nucleic acid encoding hyaluronan synthase and methods of use

Info

Publication number
EP1073460A4
EP1073460A4 EP99917339A EP99917339A EP1073460A4 EP 1073460 A4 EP1073460 A4 EP 1073460A4 EP 99917339 A EP99917339 A EP 99917339A EP 99917339 A EP99917339 A EP 99917339A EP 1073460 A4 EP1073460 A4 EP 1073460A4
Authority
EP
European Patent Office
Prior art keywords
nucleic acid
methods
acid encoding
hyaluronan synthase
encoding hyaluronan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP99917339A
Other languages
German (de)
French (fr)
Other versions
EP1073460A1 (en
Inventor
Paul Deangelis
Paul H Weigel
Kshama Kumari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Priority to EP07007453A priority Critical patent/EP1832662B1/en
Publication of EP1073460A1 publication Critical patent/EP1073460A1/en
Publication of EP1073460A4 publication Critical patent/EP1073460A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active bacterial multocida , and to the use of this nucleic acid segment in the preparation of recombinant cells which produce chondroitin synthase and chondroitin polymer.
EP99917339A 1998-04-02 1999-04-01 Nucleic acid encoding hyaluronan synthase and methods of use Ceased EP1073460A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07007453A EP1832662B1 (en) 1998-04-02 1999-04-01 DNA encoding chondroitin synthase from Pasteurella multocida and methods of use

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8041498P 1998-04-02 1998-04-02
US80414P 1998-04-02
US17885198A 1998-10-26 1998-10-26
US178851 1998-10-26
PCT/US1999/007289 WO1999051265A1 (en) 1998-04-02 1999-04-01 Nucleic acid encoding hyaluronan synthase and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP07007453A Division EP1832662B1 (en) 1998-04-02 1999-04-01 DNA encoding chondroitin synthase from Pasteurella multocida and methods of use

Publications (2)

Publication Number Publication Date
EP1073460A1 EP1073460A1 (en) 2001-02-07
EP1073460A4 true EP1073460A4 (en) 2001-05-23

Family

ID=26763480

Family Applications (2)

Application Number Title Priority Date Filing Date
EP99917339A Ceased EP1073460A4 (en) 1998-04-02 1999-04-01 Nucleic acid encoding hyaluronan synthase and methods of use
EP07007453A Expired - Lifetime EP1832662B1 (en) 1998-04-02 1999-04-01 DNA encoding chondroitin synthase from Pasteurella multocida and methods of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP07007453A Expired - Lifetime EP1832662B1 (en) 1998-04-02 1999-04-01 DNA encoding chondroitin synthase from Pasteurella multocida and methods of use

Country Status (11)

Country Link
EP (2) EP1073460A4 (en)
JP (2) JP4490581B2 (en)
CN (2) CN1327894C (en)
AT (1) ATE501275T1 (en)
AU (1) AU770903B2 (en)
BR (1) BR9909346A (en)
CA (1) CA2326821C (en)
CZ (1) CZ20003576A3 (en)
DE (1) DE69943276D1 (en)
IL (1) IL138803A0 (en)
WO (1) WO1999051265A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060469B2 (en) 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
DE69940353D1 (en) * 1998-11-11 2009-03-12 Univ Oklahoma Polymerpfropfung mittels polysaccharide-synthase
US7534589B2 (en) 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
WO2001080810A2 (en) * 1999-11-10 2001-11-01 Angelis Paul L De Chondroitin synthase gene and methods of making and using same
WO2001062800A1 (en) 2000-02-24 2001-08-30 Eidgenössische Technische Hochschule Zürich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
JP2005514059A (en) * 2001-06-13 2005-05-19 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ Hyaluronan synthase genes and their expression
CZ2004765A3 (en) 2001-12-21 2004-12-15 Novozymes Biopolymer A/S Processes for producing hyaluronate within a recombinant host cell
US8202986B2 (en) 2006-08-04 2012-06-19 Novozymes Biopolymer AIS Branched hyaluronic acid and method of manufacture
AU2008291695A1 (en) * 2007-08-31 2009-03-05 Sugar Industry Innovation Pty Ltd Production of hyaluronic acid
CN101878230B (en) 2007-12-19 2012-11-21 赢创高施米特有限公司 Crosslinked hyaluronic acid in emulsion
WO2010010631A1 (en) * 2008-07-25 2010-01-28 電気化学工業株式会社 Method for producing hyaluronic acid
WO2012163884A1 (en) 2011-05-30 2012-12-06 Novozymes Biopharma Dk A/S Spray drying of high molecular weight hyaluronic acid
WO2013030348A1 (en) 2011-09-02 2013-03-07 Novozymes Biopharma Dk A/S Oral formulations containing hyaluronic acid for sustained drug release
KR101736790B1 (en) * 2012-02-21 2017-05-17 블루메이지 프레다 바이오팜 컴퍼니 리미티드 Bacillus, hyaluronic acid enzyme, and uses thereof
ITMI20120896A1 (en) 2012-05-23 2013-11-24 Bongulielmi Reto CONDROITIN FOR USE IN MEDICINE
ITMI20121316A1 (en) 2012-07-27 2014-01-28 Altergon Sa CONDROTIC COMPLEXES FOR TRANSCUTANEOUS ABSORPTION
WO2014100837A1 (en) 2012-12-17 2014-06-26 Bui The Duy Computer aided implantation of body implants
ES2824402T3 (en) * 2013-11-01 2021-05-12 Boehringer Ingelheim Animal Health Usa Inc Attenuated vaccines against Pasteurella multocida and procedures for their manufacture and use
RU2719140C1 (en) 2019-07-26 2020-04-17 Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" Bacillus genus bacteria producing hyaluronic acid, and method of producing hyaluronic acid using said bacteria
RU2723722C1 (en) 2019-07-26 2020-06-17 Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" Tandem promoter functioning in bacteria of bacillus genus, transformed bacillus bacterium - target product producer containing said promoter, and method for producing desired product using said bacterium

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003559A1 (en) * 1989-08-29 1991-03-21 Board Of Regents, The University Of Texas System Dna encoding hyaluronate synthase
WO1994000463A2 (en) * 1992-06-19 1994-01-06 M.u.r.s.t. Italian Ministry for Universities and Scientific and Technological Research Production of hyaluronic acid by transeformed microorganisms
WO1997020061A1 (en) * 1995-11-30 1997-06-05 The Scripps Research Institute Synthesis of hyaluronic acid
WO1999023227A2 (en) * 1997-10-31 1999-05-14 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase gene and uses thereof
WO2000027437A2 (en) * 1998-11-11 2000-05-18 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163294A (en) * 1984-09-05 1986-04-01 Chisso Corp Production of hyaluronic acid through fermentation process
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5496726A (en) * 1993-04-16 1996-03-05 Lucky Limited Streptococcus zooepidemicus medium and process for preparing hyaluronic acid
CN1161060A (en) * 1994-09-12 1997-10-01 M·G·伯杰龙 Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis Lab.
JP3638955B2 (en) * 1995-01-30 2005-04-13 トルオク，ペーター Antitumor and anticholesterol formulations containing lipoteichoic acid from Streptococcus
US6086894A (en) * 1996-06-27 2000-07-11 Virginia Tech Intellectual Properties, Inc. Recombinant vaccine for diseases caused by encapsulated organisms

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003559A1 (en) * 1989-08-29 1991-03-21 Board Of Regents, The University Of Texas System Dna encoding hyaluronate synthase
WO1994000463A2 (en) * 1992-06-19 1994-01-06 M.u.r.s.t. Italian Ministry for Universities and Scientific and Technological Research Production of hyaluronic acid by transeformed microorganisms
WO1997020061A1 (en) * 1995-11-30 1997-06-05 The Scripps Research Institute Synthesis of hyaluronic acid
WO1999023227A2 (en) * 1997-10-31 1999-05-14 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase gene and uses thereof
WO2000027437A2 (en) * 1998-11-11 2000-05-18 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEANGELIS PAUL L ET AL: "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 31, 4 August 2000 (2000-08-04), pages 24124 - 24129, XP002163608, ISSN: 0021-9258 *
P H WEIGEL ET AL: "Hyaluronan synthases", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 272, no. 22, 30 May 1997 (1997-05-30), pages 13997 - 14000, XP002105370, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CZ20003576A3 (en) 2001-09-12
BR9909346A (en) 2001-09-11
IL138803A0 (en) 2001-10-31
CN1304317A (en) 2001-07-18
CN1327894C (en) 2007-07-25
AU3548599A (en) 1999-10-25
EP1832662A3 (en) 2007-11-07
EP1832662A2 (en) 2007-09-12
JP4887333B2 (en) 2012-02-29
WO1999051265A9 (en) 2000-04-13
CA2326821A1 (en) 1999-10-14
JP4490581B2 (en) 2010-06-30
EP1832662B1 (en) 2011-03-09
CA2326821C (en) 2010-09-28
ATE501275T1 (en) 2011-03-15
JP2008283974A (en) 2008-11-27
EP1073460A1 (en) 2001-02-07
CN101275143A (en) 2008-10-01
DE69943276D1 (en) 2011-04-21
AU770903B2 (en) 2004-03-04
JP2002510648A (en) 2002-04-09
WO1999051265A1 (en) 1999-10-14

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