EP1071765A4 - Alk-1 responds to tgf-beta and signals through smad-1 and smad-5 - Google Patents

Alk-1 responds to tgf-beta and signals through smad-1 and smad-5

Info

Publication number
EP1071765A4
EP1071765A4 EP99912583A EP99912583A EP1071765A4 EP 1071765 A4 EP1071765 A4 EP 1071765A4 EP 99912583 A EP99912583 A EP 99912583A EP 99912583 A EP99912583 A EP 99912583A EP 1071765 A4 EP1071765 A4 EP 1071765A4
Authority
EP
European Patent Office
Prior art keywords
smad
alk
tgf
responds
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99912583A
Other languages
German (de)
French (fr)
Other versions
EP1071765A1 (en
Inventor
Kohei Miyazono
Takeshe Imamura
Dijke Peter Ten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Institute for Cancer Research Ltd
Ludwig Institute for Cancer Research New York
Original Assignee
Ludwig Institute for Cancer Research Ltd
Ludwig Institute for Cancer Research New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Institute for Cancer Research Ltd, Ludwig Institute for Cancer Research New York filed Critical Ludwig Institute for Cancer Research Ltd
Priority to EP09156929A priority Critical patent/EP2078752A3/en
Publication of EP1071765A1 publication Critical patent/EP1071765A1/en
Publication of EP1071765A4 publication Critical patent/EP1071765A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP99912583A 1998-03-13 1999-03-12 Alk-1 responds to tgf-beta and signals through smad-1 and smad-5 Withdrawn EP1071765A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09156929A EP2078752A3 (en) 1998-03-13 1999-03-12 ALK-1 responds to TGF-beta and signals through SMAD-1 and SMAD-5

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3917798A 1998-03-13 1998-03-13
US39177 1998-03-13
PCT/US1999/005735 WO1999046386A1 (en) 1998-03-13 1999-03-12 ALK-1 RESPONDS TO TGF-β AND SIGNALS THROUGH SMAD-1 AND SMAD-5

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP09156929A Division EP2078752A3 (en) 1998-03-13 1999-03-12 ALK-1 responds to TGF-beta and signals through SMAD-1 and SMAD-5

Publications (2)

Publication Number Publication Date
EP1071765A1 EP1071765A1 (en) 2001-01-31
EP1071765A4 true EP1071765A4 (en) 2003-01-15

Family

ID=21904084

Family Applications (2)

Application Number Title Priority Date Filing Date
EP09156929A Withdrawn EP2078752A3 (en) 1998-03-13 1999-03-12 ALK-1 responds to TGF-beta and signals through SMAD-1 and SMAD-5
EP99912583A Withdrawn EP1071765A4 (en) 1998-03-13 1999-03-12 Alk-1 responds to tgf-beta and signals through smad-1 and smad-5

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP09156929A Withdrawn EP2078752A3 (en) 1998-03-13 1999-03-12 ALK-1 responds to TGF-beta and signals through SMAD-1 and SMAD-5

Country Status (3)

Country Link
EP (2) EP2078752A3 (en)
AU (1) AU3092899A (en)
WO (1) WO1999046386A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ502058A (en) * 1999-12-23 2003-11-28 Ovita Ltd Isolated mutated nucleic acid molecule for regulation of ovulation rate
UA94060C2 (en) 2005-09-07 2011-04-11 Эмджен Фримонт Инк. Monoclonal antibodies that specifically binds alk-1
US10059756B2 (en) 2006-11-02 2018-08-28 Acceleron Pharma Inc. Compositions comprising ALK1-ECD protein
EP2087001B1 (en) 2006-11-02 2016-10-26 Acceleron Pharma, Inc. Alk1 receptor and ligand antagonists and uses thereof
US8642031B2 (en) 2006-11-02 2014-02-04 Acceleron Pharma, Inc. Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
WO2008128559A1 (en) * 2007-04-20 2008-10-30 Stichting Katholieke Universiteit Method for providing a compound capable of interfering with a distorted chondrocyte phenotype
TW201609138A (en) 2008-05-02 2016-03-16 艾西利羅製藥公司 Methods and compositions for modulating angiogenesis and pericyte composition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007135A2 (en) * 1995-08-14 1997-02-27 Creative Biomolecules, Inc. Binding of osteogenic protein-i (op-1) and analogs thereof to the cell surface receptor alk-1 and analogs thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994011502A2 (en) * 1992-11-17 1994-05-26 Ludwig Institute For Cancer Research Activin receptor-like kinases, proteins having serine threonine kinase domains and their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007135A2 (en) * 1995-08-14 1997-02-27 Creative Biomolecules, Inc. Binding of osteogenic protein-i (op-1) and analogs thereof to the cell surface receptor alk-1 and analogs thereof

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ATTISANO L ET AL: "IDENTIFICATION OF HUMAN ACTIVIN AND TGFBETA TYPE I RECEPTORS THAT FORM HETEROMERIC KINASE COMPLEXES WITH TYPE II RECEPTORS", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 75, 19 November 1993 (1993-11-19), pages 671 - 680, XP000611962, ISSN: 0092-8674 *
DIJKE TEN P ET AL: "CHARACTERIZATION OF TYPE I RECEPTORS FOR TRANSFORMING GROWTH FACTOR-B AND ACTIVIN", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 264, no. 5155, 1 April 1994 (1994-04-01), pages 101 - 104, XP000561968, ISSN: 0036-8075 *
FENG X H ET AL: "A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity.", THE EMBO JOURNAL. ENGLAND 1 JUL 1997, vol. 16, no. 13, 1 July 1997 (1997-07-01), pages 3912 - 3923, XP002219537, ISSN: 0261-4189 *
KRETZSCHMAR M ET AL: "SMADS: MEDIATORS AND REGULATORS OF TGF-BETA SIGNALING", CURRENT OPINION IN GENETICS & DEVELOPMENT, CURRENT BIOLOGY LTD, XX, vol. 8, no. 8, February 1998 (1998-02-01), pages 103 - 111, XP000857433, ISSN: 0959-437X *
KRETZSCHMAR M ET AL: "THE TGF-BETA FAMILY MEDIATOR SMAD1 IS PHOSPHORYLATED DIRECTLY AND ACTIVATED FUNCTIONALLY BY THE BMP RECEPTOR KINASE", GENES AND DEVELOPMENT, COLD SPRING HARBOR, NY, US, vol. 11, no. 8, 15 April 1997 (1997-04-15), pages 984 - 995, XP002911614, ISSN: 0890-9369 *
LECHLEIDER R J ET AL: "SERINE PHOSPHORYLATION, CHROMOSOMAL LOCALIZATION, AND TRANSFORMING GROWTH FACTOR-BETA SIGNAL TRANSDUCTION BY HUMAN BSP-1", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 30, 26 July 1996 (1996-07-26), pages 17617 - 17620, XP002030329, ISSN: 0021-9258 *
PERSSON U ET AL: "TRANSFORMING GROWTH FACTOR (TGF-BETA)-SPECIFIC SIGNALING BY CHIMERIC TGF-BETA TYPE II RECEPTOR WITH INTRACELLULAR DOMAIN OF ACTIVIN TYPE IIB RECEPTOR", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 34, 22 August 1997 (1997-08-22), pages 21187 - 21194, XP002934435, ISSN: 0021-9258 *
See also references of WO9946386A1 *
TAKASE M ET AL: "Induction of Smad6 mRNA by bone morphogenetic proteins.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 6 MAR 1998, vol. 244, no. 1, 6 March 1998 (1998-03-06), pages 26 - 29, XP002219536, ISSN: 0006-291X *
YINGLING J M ET AL: "Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 20 AUG 1996, vol. 93, no. 17, 20 August 1996 (1996-08-20), pages 8940 - 8944, XP002219535, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
AU3092899A (en) 1999-09-27
EP1071765A1 (en) 2001-01-31
EP2078752A3 (en) 2009-09-23
WO1999046386B1 (en) 1999-10-21
WO1999046386A1 (en) 1999-09-16
EP2078752A2 (en) 2009-07-15

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