EP1062319A4 - Facteur de croissance endothelial vasculaire 2 - Google Patents

Facteur de croissance endothelial vasculaire 2

Info

Publication number
EP1062319A4
EP1062319A4 EP99912320A EP99912320A EP1062319A4 EP 1062319 A4 EP1062319 A4 EP 1062319A4 EP 99912320 A EP99912320 A EP 99912320A EP 99912320 A EP99912320 A EP 99912320A EP 1062319 A4 EP1062319 A4 EP 1062319A4
Authority
EP
European Patent Office
Prior art keywords
growth factor
vascular endothelial
endothelial growth
vascular
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99912320A
Other languages
German (de)
English (en)
Other versions
EP1062319A1 (fr
Inventor
Craig A Rosen
Liang Cao
Jing-Shan Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/042,105 external-priority patent/US6040157A/en
Priority claimed from US09/107,997 external-priority patent/US7186688B1/en
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of EP1062319A1 publication Critical patent/EP1062319A1/fr
Publication of EP1062319A4 publication Critical patent/EP1062319A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
EP99912320A 1998-03-13 1999-03-10 Facteur de croissance endothelial vasculaire 2 Withdrawn EP1062319A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/042,105 US6040157A (en) 1994-03-08 1998-03-13 Vascular endothelial growth factor 2
US42105 1998-03-13
US09/107,997 US7186688B1 (en) 1994-03-08 1998-06-30 Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
US107997 1998-06-30
PCT/US1999/005021 WO1999046364A1 (fr) 1998-03-13 1999-03-10 Facteur de croissance endothelial vasculaire 2

Publications (2)

Publication Number Publication Date
EP1062319A1 EP1062319A1 (fr) 2000-12-27
EP1062319A4 true EP1062319A4 (fr) 2003-04-23

Family

ID=26718873

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99912320A Withdrawn EP1062319A4 (fr) 1998-03-13 1999-03-10 Facteur de croissance endothelial vasculaire 2

Country Status (7)

Country Link
EP (1) EP1062319A4 (fr)
JP (1) JP2002505873A (fr)
KR (1) KR20010034576A (fr)
CN (1) CN1299407A (fr)
AU (1) AU3072099A (fr)
CA (1) CA2322748A1 (fr)
WO (1) WO1999046364A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186688B1 (en) 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
US6040157A (en) 1994-03-08 2000-03-21 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US7153827B1 (en) 1994-03-08 2006-12-26 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 and methods of use
US6734285B2 (en) 1994-03-08 2004-05-11 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 proteins and compositions
EP0751992B1 (fr) 1994-03-08 2005-11-09 Human Genome Sciences, Inc. Facteur 2 de croissance endotheliale vasculaire
US7109308B1 (en) 1994-03-08 2006-09-19 Human Genome Sciences, Inc. Antibodies to human vascular endothelial growth factor 2
US6608182B1 (en) 1994-03-08 2003-08-19 Human Genome Sciences, Inc. Human vascular endothelial growth factor 2
US5932540A (en) 1994-03-08 1999-08-03 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US6818220B1 (en) 1994-11-14 2004-11-16 Licentia Ltd. Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
US6361946B1 (en) 1997-02-05 2002-03-26 Licentia Ltd Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
US7423125B2 (en) 1995-08-01 2008-09-09 Vegenics Limited Antibodies to VEGF-C
CA2231400A1 (fr) 1995-09-08 1997-03-13 Genentech, Inc. Proteine apparentee au vegf
US7125714B2 (en) 1997-02-05 2006-10-24 Licentia Ltd. Progenitor cell materials and methods
ATE296117T1 (de) 1997-03-07 2005-06-15 Wistar Inst Verwendung von adenoviralen vektoren, die pdgf oder vegf exprimieren, zur heilung von gewebsdefekten und zur induzierung der hypervaskulität in säugergeweben
US6958147B1 (en) 1998-10-26 2005-10-25 Licentia Ltd Use of VEGF-C to prevent restenosis
US7223724B1 (en) 1999-02-08 2007-05-29 Human Genome Sciences, Inc. Use of vascular endothelial growth factor to treat photoreceptor cells
WO2000058511A1 (fr) 1999-03-26 2000-10-05 Ludwig Institute For Cancer Research Dosage et therapie pour les troubles lymphatiques impliquant la tyrosine kinase flt4 (vegfr-3)
US6764820B2 (en) 1999-03-26 2004-07-20 Ludwig Institute For Cancer Research Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3)
DK1272208T3 (da) * 2000-04-12 2011-10-31 Vib Vzw Anvendelse af VEGF 165 og homologer til at behandle neuron-sygdomme
AU8473401A (en) * 2000-08-04 2002-02-18 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
CA2431308C (fr) 2000-12-07 2010-04-13 Sangamo Biosciences, Inc. Regulation de l'angiogenese au moyen de proteines a doigts de zinc
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
KR20030093316A (ko) * 2001-04-13 2003-12-06 휴먼 게놈 사이언시즈, 인코포레이티드 혈관 내피 성장 인자 ２
US7402312B2 (en) 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
US7217570B2 (en) 2001-08-23 2007-05-15 The Wistar Institute Of Anatomy And Biology Organotypic intestinal culture and methods of use thereof
WO2003081201A2 (fr) * 2002-03-21 2003-10-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Marqueurs de cellules sanguines peripheriques utiles pour le diagnostic de la sclerose en plaques et procedes et trousses comprenant de tels marqueurs
ATE500842T1 (de) 2002-05-04 2011-03-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur förderung des neuronalen wachstums
MX348062B (es) 2003-05-16 2017-05-26 Acorda Therapeutics Inc Mutantes que degradan proteoglicanos para tratamiento del snc.
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
MXPA06013345A (es) 2004-05-18 2008-10-31 Acorda Therapeutics Inc Metodos para purificar condrointinasa y sus formulaciones estables.
RS51481B (en) 2004-05-27 2011-04-30 Vib, Vzw TREATMENT OF AMIOTROPHIC LATERAL SCLEROSIS
CA2599004C (fr) 2005-02-28 2015-05-26 Sangamo Biosciences, Inc. Methodes et compostions anti-angiogeniques
EP1928490B8 (fr) 2005-09-26 2012-10-03 Acorda Therapeutics, Inc. Compositions et procedes d'utilisation de mutants des chondroitinases abci
CN100448892C (zh) * 2006-08-02 2009-01-07 中国人民解放军军事医学科学院基础医学研究所 抗肿瘤血管内皮生长因子受体vegf－r2抗原及其编码基因与应用
AU2007307736C1 (en) 2006-10-10 2014-04-10 Acorda Therapeutics, Inc. Compositions and methods of using chondroitinase ABCI mutants

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024473A1 (fr) * 1994-03-08 1995-09-14 Human Genome Sciences, Inc. Facteur 2 de croissance endotheliale vasculaire
WO1996039515A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Facteur de croissance endotheliale vasculaire 2 humain
WO1997005250A2 (fr) * 1995-08-01 1997-02-13 Helsinki University Licensing Ltd. Oy Facteur de croissance endothelial vasculaire (vegf-c) en tant que ligand de recepteur
WO1997009427A1 (fr) * 1995-09-08 1997-03-13 Genentech, Inc. Proteine apparentee au vegf
WO1997017442A1 (fr) * 1995-11-08 1997-05-15 Immunex Corporation Proteine de liaison flk-1
WO1998033917A1 (fr) * 1994-11-14 1998-08-06 The Ludwig Institute For Cancer Research Proteine et gene du facteur de croissance vasculaire endothelial c (vegf-c), mutants de ce dernier et utilisations
WO1998049300A2 (fr) * 1997-04-25 1998-11-05 Collateral Therapeutics Formes tronquees de proteines apparentees au facteur vegf

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000029986A (ko) * 1996-08-13 2000-05-25 벤슨 로버트 에이치. 각질세포성장인자-2(케이쥐에프-2또는섬유아세포성장인자-12,에프쥐에프-12)

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995024473A1 (fr) * 1994-03-08 1995-09-14 Human Genome Sciences, Inc. Facteur 2 de croissance endotheliale vasculaire
WO1998033917A1 (fr) * 1994-11-14 1998-08-06 The Ludwig Institute For Cancer Research Proteine et gene du facteur de croissance vasculaire endothelial c (vegf-c), mutants de ce dernier et utilisations
WO1996039515A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Facteur de croissance endotheliale vasculaire 2 humain
WO1997005250A2 (fr) * 1995-08-01 1997-02-13 Helsinki University Licensing Ltd. Oy Facteur de croissance endothelial vasculaire (vegf-c) en tant que ligand de recepteur
WO1997009427A1 (fr) * 1995-09-08 1997-03-13 Genentech, Inc. Proteine apparentee au vegf
WO1997017442A1 (fr) * 1995-11-08 1997-05-15 Immunex Corporation Proteine de liaison flk-1
WO1998049300A2 (fr) * 1997-04-25 1998-11-05 Collateral Therapeutics Formes tronquees de proteines apparentees au facteur vegf

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9946364A1 *

Also Published As

Publication number Publication date
KR20010034576A (ko) 2001-04-25
CA2322748A1 (fr) 1999-09-16
JP2002505873A (ja) 2002-02-26
CN1299407A (zh) 2001-06-13
WO1999046364A9 (fr) 1999-11-18
WO1999046364A1 (fr) 1999-09-16
AU3072099A (en) 1999-09-27
EP1062319A1 (fr) 2000-12-27

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Legal Events

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