EP1050470A1 - Erfassung von Ophtalmischen Formkörpern in einer Verpackung - Google Patents

Erfassung von Ophtalmischen Formkörpern in einer Verpackung Download PDF

Info

Publication number
EP1050470A1
EP1050470A1 EP00109353A EP00109353A EP1050470A1 EP 1050470 A1 EP1050470 A1 EP 1050470A1 EP 00109353 A EP00109353 A EP 00109353A EP 00109353 A EP00109353 A EP 00109353A EP 1050470 A1 EP1050470 A1 EP 1050470A1
Authority
EP
European Patent Office
Prior art keywords
package
contact lens
moulding
ophthalmic
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00109353A
Other languages
English (en)
French (fr)
Inventor
Achim Müller
Roger Biel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Erfindungen Verwaltungs GmbH
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99108810A external-priority patent/EP1057730A1/de
Application filed by Novartis Erfindungen Verwaltungs GmbH, Novartis AG filed Critical Novartis Erfindungen Verwaltungs GmbH
Priority to EP00109353A priority Critical patent/EP1050470A1/de
Publication of EP1050470A1 publication Critical patent/EP1050470A1/de
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B25/00—Packaging other articles presenting special problems
    • B65B25/008—Packaging other articles presenting special problems packaging of contact lenses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B65B57/10—Automatic control, checking, warning, or safety devices responsive to absence, presence, abnormal feed, or misplacement of articles or materials to be packaged

Definitions

  • the invention relates to a method and a device for registering the presence of an ophthalmic moulding consisting of a biocompatible polymeric material, especially an ophthalmic lens, particularly a contact lens, in a package.
  • a blister package consists of a plastic container, for example of polypropylene (PP), the upper side of which is sealed with film after the moulding has been placed in the plastic container.
  • PP polypropylene
  • Such contact lenses are preferably manufactured by the so-called mould or full-mould process. In this process, the lenses are manufactured into their final shape between two moulds, so that there is no need to subsequently finish the surfaces of the lenses, nor to finish the edges. Moulding processes are described for example in PCT application no. WO/87/04390 or in European patent application EP-A-0 367 513.
  • a contact lens To manufacture a contact lens, first of all a certain amount of a flowable starting material is placed in the female mould half. Afterwards, the mould is closed by placing the male mould half thereon. Normally, a surplus of starting material is used, so that, when the mould is closed, the excess amount is expelled into an overflow area outwardly adjacent to the mould cavity. The subsequent polymerisation or crosslinking of the starting material takes place by radiation with UV light, or by heat action, or by another non-thermal method.
  • the contact lenses produced in this manner are moulded parts having little mechanical stability and a water content of more than 60 % by weight. After manufacture, the lens is inspected, then ed and subjected to heat sterilisation at 121°C in an autoclave.
  • Optical components produced in series e.g. contact lenses
  • the components recognised as faulty are then rejected.
  • empty packages may appear, which are not recognised.
  • the client then discovers the empty package and is of course annoyed.
  • empty packages are recognised by chance or by spot checks, then either the whole batch has to be rejected or all the contact lens packages have to undergo 100% manual testing. Both procedures involve substantial costs.
  • the invention is therefore based on the problem of providing a testing method with which it is possible to inspect, at low cost, whether an ophthalmic moulding is actually present in the package.
  • a spectroscopic method it is possible to determine the presence of ophthalmic mouldings in a package.
  • Packages containing a moulding, especially a contact lens have a characteristic change in their measuring spectrum compared with a package without a contact lens.
  • By evaluating the spectra it is possible to determine whether or not there is a contact lens in a package.
  • the measuring method according to the invention one can determine directly after the filling procedure whether there is a contact lens in the package.
  • the invention is suitable for checking whether contact lenses are contained in the package which has already been sealed. During this procedure, the package remains intact.
  • a measuring device 1 is illustrated.
  • the measuring device comprises a spectrometer 2, which is linked to a fibre optic 3 and is attached to a computer 4 to evaluate the data.
  • measurements are carried out in near infrared (NIR).
  • NIR near infrared
  • An appliance from the company Bruker of the type IFS 28/N is used as the NIR spectrometer.
  • the fibre optic 3 is advantageously set up for measurements in reflection, i.e. one part of the fibres serves to irradiate the sample with NIR light, while another part receives the reflected radiation and passes it to the spectrometer 2.
  • An ophthalmic moulding preferably a contact lens 5 is located in a container 6 and is exposed to rays from the NIR light emerging from the fibre optic 3. The reflected light is similarly received by the fibre optic 3 and passed on to the NIR spectrometer 2 for detection.
  • the container 6 preferably consists of polypropylene (PP). The distance d between the container 6 and the fibre optic 3 can be varied.
  • the measuring process according to the invention is not an imaging process, since no image is made of the moulding 5 to be examined. Instead, resonance vibrations are detected from certain atom groups of the biocompatible polymeric material from which the moulding is made, which have been stimulated by the radiated NIR light. Furthermore, it is also possible to provide the moulding with moistening means which are stimulated by the radiated NIR light. In addition, it is also conceivable in terms of the invention for the ophthalmic moulding to carry out a chemical reaction with a further substance that is filled into the package, this reaction is used for the detection of resonance vibrations. In this case, the resonance vibrations only occur if an ophthalmic moulding, such as a contact lens, is located in the package.
  • contact lenses 5 made of PVA are a prepolymer containing several crosslinkable groups, as well as C-OH groups.
  • the distance between the contact lens 5 and the fibre optic 3 was varied, measurements being made preferably at 10, 20, 30 and 40 mm.
  • a background measurement was made (basic measurement) with an empty, dry PP container. This background measurement is read automatically by the spectrometer from the spectra subsequently received.
  • the received spectra for a distance of 40 mm are illustrated in fig. 3.
  • the absorption was plotted against the wavelength of the radiated NIR light.
  • the measurements show no absorption of the radiated light. If there are water drops in the PP container (fig. 3.2), slight absorption is detected. As the container is increasingly filled with water, the absorption increases, whereby it extends over a broad wavelength area and no specific structure is recognised (fig. 3.3).
  • a contact lens 5 is in the container 6 with or without water drops, a significant peak is established with its maximum at a wavelength of 1.45 ⁇ m (figs.
  • This peak only occurs if a contact lens is present in the package, and it is therefore a suitable characteristic of a filled package.
  • Measurements undertaken on a sealed PP container show that in principle it is possible to detect contact lenses through the PP container.
  • the measurement signal is smaller than in tests on the open container, but still clearly distinguishable.
  • the invention offers the possibility of checking the presence of mouldings, especially ophthalmic lenses, particularly contact lenses, in a package which can be either open or closed.
  • the NIR spectroscopy illustrates a very interesting method of detecting contact lenses in the package.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Eyeglasses (AREA)
EP00109353A 1999-05-04 2000-05-02 Erfassung von Ophtalmischen Formkörpern in einer Verpackung Withdrawn EP1050470A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP00109353A EP1050470A1 (de) 1999-05-04 2000-05-02 Erfassung von Ophtalmischen Formkörpern in einer Verpackung

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99108810 1999-05-04
EP99108810A EP1057730A1 (de) 1999-05-04 1999-05-04 Verfahren und Vorrichtung zum Erfassen von ophthalmischen Formkörpern in einer Verpackung
EP00109353A EP1050470A1 (de) 1999-05-04 2000-05-02 Erfassung von Ophtalmischen Formkörpern in einer Verpackung

Publications (1)

Publication Number Publication Date
EP1050470A1 true EP1050470A1 (de) 2000-11-08

Family

ID=26070888

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00109353A Withdrawn EP1050470A1 (de) 1999-05-04 2000-05-02 Erfassung von Ophtalmischen Formkörpern in einer Verpackung

Country Status (1)

Country Link
EP (1) EP1050470A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6577387B2 (en) 2000-12-29 2003-06-10 Johnson & Johnson Vision Care, Inc. Inspection of ophthalmic lenses using absorption
WO2007082859A1 (en) * 2006-01-17 2007-07-26 Novartis Ag Method and apparatus for detecting presence of an ophthalmic lens in a package

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2709566A1 (de) * 1977-03-04 1978-09-07 Sick Optik Elektronik Erwin Optische ueberwachungsvorrichtung fuer in einer durchsichtigen verpackung angeordnete gegenstaende
EP0070252A1 (de) * 1981-07-08 1983-01-19 Ciba-Geigy Ag Vorrichtung zur Kontrolle von Durchdrückpackungen auf die Vollständigkeit der Füllung der Näpfe mit Tabletten
WO1987004390A1 (en) 1986-01-28 1987-07-30 Coopervision Optics Limited Moulding contact lenses
US4847487A (en) * 1986-12-23 1989-07-11 I.M.A. Industria Macchine Automatiche S.P.A. Device for detecting the presence of products in related seats and any irregularity in the base section of these products when already located in their related seats
EP0367513A2 (de) 1988-11-02 1990-05-09 Btg International Limited Giessen von Kontaktlinsen
EP0685734A1 (de) * 1994-05-31 1995-12-06 JOHNSON & JOHNSON VISION PRODUCTS, INC. Verfahren und System zur Inspektion von Packungen
EP0691273A1 (de) * 1994-05-31 1996-01-10 JOHNSON & JOHNSON VISION PRODUCTS, INC. Automatisches Inspektionssystem mit Transport- und Abgabeförderband
US5508317A (en) 1993-08-06 1996-04-16 Ciba-Geigy Corporation Photocrosslinked polymers

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2709566A1 (de) * 1977-03-04 1978-09-07 Sick Optik Elektronik Erwin Optische ueberwachungsvorrichtung fuer in einer durchsichtigen verpackung angeordnete gegenstaende
EP0070252A1 (de) * 1981-07-08 1983-01-19 Ciba-Geigy Ag Vorrichtung zur Kontrolle von Durchdrückpackungen auf die Vollständigkeit der Füllung der Näpfe mit Tabletten
WO1987004390A1 (en) 1986-01-28 1987-07-30 Coopervision Optics Limited Moulding contact lenses
US4847487A (en) * 1986-12-23 1989-07-11 I.M.A. Industria Macchine Automatiche S.P.A. Device for detecting the presence of products in related seats and any irregularity in the base section of these products when already located in their related seats
EP0367513A2 (de) 1988-11-02 1990-05-09 Btg International Limited Giessen von Kontaktlinsen
US5508317A (en) 1993-08-06 1996-04-16 Ciba-Geigy Corporation Photocrosslinked polymers
EP0685734A1 (de) * 1994-05-31 1995-12-06 JOHNSON & JOHNSON VISION PRODUCTS, INC. Verfahren und System zur Inspektion von Packungen
EP0691273A1 (de) * 1994-05-31 1996-01-10 JOHNSON & JOHNSON VISION PRODUCTS, INC. Automatisches Inspektionssystem mit Transport- und Abgabeförderband

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6577387B2 (en) 2000-12-29 2003-06-10 Johnson & Johnson Vision Care, Inc. Inspection of ophthalmic lenses using absorption
WO2007082859A1 (en) * 2006-01-17 2007-07-26 Novartis Ag Method and apparatus for detecting presence of an ophthalmic lens in a package
US7339171B2 (en) 2006-01-17 2008-03-04 Novartis Ag Method and apparatus for detecting presence of an ophthalmic lens in a package

Similar Documents

Publication Publication Date Title
US5786226A (en) Quantitative transmission spectroscopy using sample carriers with nets
US5633504A (en) Inspection of optical components
US5614718A (en) Apparatus and method for noninvasive assessment of pressurized container properties
EP1973782B1 (de) Verfahren und vorrichtung zur erkennung des vorhandenseins einer ophthalmischen linse in einer verpackung
US6835939B2 (en) Missing lens detection system and method
CA2112953A1 (en) Method of and apparatus for testing containers
CN111492229B (zh) 用于无损识别包装好的药物的***和方法
US6838679B2 (en) Missing lens detection system and method
US20020125436A1 (en) Detection of ophthalmic mouldings in a package
CA2475934C (en) Method of analysing a pharmaceutical sample
EP1050470A1 (de) Erfassung von Ophtalmischen Formkörpern in einer Verpackung
US7145147B1 (en) Apparatus and methods of determining chemical properties of a resin-based material using infrared absorbance
CA2163294A1 (en) Process and apparatus for testing a multi-trip bottle for contamination
JP2000338260A (ja) パッケージ中の眼科用成形品の検出
TWI536004B (zh) 測定用於檢查眼用鏡片之最佳波長的方法
JP2001208860A (ja) パッケージ中の成形物を検出する方法及び装置
US5619038A (en) Method and apparatus for determining the polymer content of a cellulose/polymer mixture and associated calibration
CN113376098A (zh) 一种原位监测半导体材料成膜和结晶的监测装置及使用方法
EP1109011B1 (de) Verfahren zur Feststellung der Anwesenheit von Formkörpern in einer Verpackung
JP2003516537A (ja) 材料層の品質を制御するための方法
JPH07109386B2 (ja) 光ファイバーの弾性特性を測定する方法および装置
US4552847A (en) Visual quality control method for barrier treated containers
Wohlschläger et al. A method for sorting of plastics with an apparatus specific quantum efficiency approach
JP2560927B2 (ja) 積層体を構成する層の厚みの分布を測定する方法
JPH02228559A (ja) 光ファイバ被覆表面の硬化状態測定法

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

17P Request for examination filed

Effective date: 20010417

AKX Designation fees paid

Free format text: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NOVARTIS AG

Owner name: NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20031202