EP1037963A4 - X-ray crystal comprising hiv-1 gp120 - Google Patents
X-ray crystal comprising hiv-1 gp120Info
- Publication number
- EP1037963A4 EP1037963A4 EP98959406A EP98959406A EP1037963A4 EP 1037963 A4 EP1037963 A4 EP 1037963A4 EP 98959406 A EP98959406 A EP 98959406A EP 98959406 A EP98959406 A EP 98959406A EP 1037963 A4 EP1037963 A4 EP 1037963A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- hiv
- ray crystal
- ray
- crystal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013078 crystal Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
- G01N23/207—Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Virology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US100521 | 1979-12-05 | ||
US96740397A | 1997-11-10 | 1997-11-10 | |
US96698797A | 1997-11-10 | 1997-11-10 | |
US96714897A | 1997-11-10 | 1997-11-10 | |
US96693297A | 1997-11-10 | 1997-11-10 | |
US966932 | 1997-11-10 | ||
US967148 | 1997-11-10 | ||
US967403 | 1997-11-10 | ||
US966987 | 1997-11-10 | ||
US97674197A | 1997-11-24 | 1997-11-24 | |
US976741 | 1997-11-24 | ||
US8958098P | 1998-06-17 | 1998-06-17 | |
US8958198P | 1998-06-17 | 1998-06-17 | |
US89580 | 1998-06-17 | ||
US10063198A | 1998-06-18 | 1998-06-18 | |
US10052998A | 1998-06-18 | 1998-06-18 | |
US10076398A | 1998-06-18 | 1998-06-18 | |
US10052198A | 1998-06-18 | 1998-06-18 | |
US10076298A | 1998-06-18 | 1998-06-18 | |
US100631 | 1998-06-18 | ||
US100529 | 1998-06-18 | ||
US100763 | 1998-06-18 | ||
PCT/US1998/023905 WO1999024553A2 (en) | 1997-11-10 | 1998-11-10 | X-ray crystal comprising hiv-1 gp120 |
US100762 | 2002-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1037963A1 EP1037963A1 (en) | 2000-09-27 |
EP1037963A4 true EP1037963A4 (en) | 2004-09-22 |
Family
ID=27583731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98959406A Withdrawn EP1037963A4 (en) | 1997-11-10 | 1998-11-10 | X-ray crystal comprising hiv-1 gp120 |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1037963A4 (en) |
WO (1) | WO1999024553A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
US20030125518A1 (en) * | 2001-12-01 | 2003-07-03 | Crevecoeur Harry F. | Surface simulation synthetic peptides useful in the treatment of hyper-variable viral pathogens |
WO2007030518A2 (en) | 2005-09-06 | 2007-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Conformationally stabilized hiv envelope immunogens and triggering hiv-1 envelope to reveal cryptic v3-loop epitopes |
WO2012003234A2 (en) * | 2010-06-30 | 2012-01-05 | Torrey Pines Institute For Molecular Studies | Env trimer immunogens |
CN114609392A (en) * | 2022-03-08 | 2022-06-10 | 武汉科技大学 | Screening method and application of HIV (human immunodeficiency virus) fully-humanized broad-spectrum neutralizing antibody |
-
1998
- 1998-11-10 EP EP98959406A patent/EP1037963A4/en not_active Withdrawn
- 1998-11-10 WO PCT/US1998/023905 patent/WO1999024553A2/en not_active Application Discontinuation
Non-Patent Citations (7)
Title |
---|
GHIARA J B ET AL: "Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 266, no. 1, 14 February 1997 (1997-02-14), pages 31 - 39, XP004462201, ISSN: 0022-2836 * |
KWONG P D ET AL: "STRUCTURE OF AN HIV gp120 ENVELOPE GLYCOPROTEIN IN COMPLEX WITH THE CD4 RECEPTOR AND A NEUTRALIZING HUMAN ANTIBODY", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 393, 18 June 1998 (1998-06-18), pages 648 - 659, XP002093502, ISSN: 0028-0836 * |
OXFORD J S ET AL: "New scientific developments towards an AIDS vaccine: report on a workshop organized by EU programme EVA entitled Novel approaches to AIDS vaccine development held at the Institut Pasteur, Paris", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 14, no. 17, 1 December 1996 (1996-12-01), pages 1712 - 1717, XP004016836, ISSN: 0264-410X * |
RINI JAMES M ET AL: "Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 13, 1993, 1993, pages 6325 - 6329, XP002276067, ISSN: 0027-8424 * |
SANEJOUAND Y-H: "On the role of CD4 conformational change in the HIV-cell fusion process", COMPTES RENDUS DES SEANCES DE L'ACADEMIE DES SCIENCES. SERIE III: SCIENCES DE LA VIE, ELSEVIER, AMSTERDAM, NL, vol. 320, no. 2, February 1997 (1997-02-01), pages 163 - 170, XP004349275, ISSN: 0764-4469 * |
STURA E A ET AL: "CRYSTALLIZATION, SEQUENCE, AND PRELIMINARY CRYSTALLOGRAPHIC DATA FOR AN ANTIPEPTIDE FAB 50.1 AND PEPTIDE COMPLEXES WITH THE PRINCIPAL NEUTRALIZING DETERMINANT OF HIV-1 GP120", PROTEINS: STRUCTURE, FUNCTION AND GENETICS, ALAN R. LISS, US, vol. 14, no. 4, December 1992 (1992-12-01), pages 499 - 508, XP001069692, ISSN: 0887-3585 * |
WYATT R ET AL: "THE ANTIGENIC STRUCTURE OF THE HIV gp120 ENVELOPE GLYCOPROTEIN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 393, 18 June 1998 (1998-06-18), pages 705 - 711, XP002093503, ISSN: 0028-0836 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999024553A9 (en) | 2001-05-31 |
WO1999024553A8 (en) | 1999-07-22 |
WO1999024553A2 (en) | 1999-05-20 |
EP1037963A1 (en) | 2000-09-27 |
WO1999024553A3 (en) | 2003-12-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000609 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
D17D | Deferred search report published (deleted) | ||
D17D | Deferred search report published (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7G 01N 23/207 B Ipc: 7G 01N 23/201 B Ipc: 7G 01N 23/20 B Ipc: 7C 07K 5/00 B Ipc: 7A 61K 38/00 A |
|
RTI1 | Title (correction) |
Free format text: X-RAY CRYSTAL COMPRISING HIV-1 GP120 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 38/00 B Ipc: 7C 07K 16/08 B Ipc: 7C 07K 14/73 B Ipc: 7C 07K 14/16 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040805 |
|
17Q | First examination report despatched |
Effective date: 20050215 |
|
17Q | First examination report despatched |
Effective date: 20050215 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070512 |