EP1037963A4 - X-ray crystal comprising hiv-1 gp120 - Google Patents

X-ray crystal comprising hiv-1 gp120

Info

Publication number
EP1037963A4
EP1037963A4 EP98959406A EP98959406A EP1037963A4 EP 1037963 A4 EP1037963 A4 EP 1037963A4 EP 98959406 A EP98959406 A EP 98959406A EP 98959406 A EP98959406 A EP 98959406A EP 1037963 A4 EP1037963 A4 EP 1037963A4
Authority
EP
European Patent Office
Prior art keywords
hiv
ray crystal
ray
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98959406A
Other languages
German (de)
French (fr)
Other versions
EP1037963A1 (en
Inventor
Peter D Kwong
Wayne A Hendrickson
Joseph G Sodroski
Richard T Wyatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Dana Farber Cancer Institute Inc
Original Assignee
Columbia University in the City of New York
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York, Dana Farber Cancer Institute Inc filed Critical Columbia University in the City of New York
Publication of EP1037963A1 publication Critical patent/EP1037963A1/en
Publication of EP1037963A4 publication Critical patent/EP1037963A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/207Diffractometry using detectors, e.g. using a probe in a central position and one or more displaceable detectors in circumferential positions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
EP98959406A 1997-11-10 1998-11-10 X-ray crystal comprising hiv-1 gp120 Withdrawn EP1037963A4 (en)

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
US100521 1979-12-05
US96740397A 1997-11-10 1997-11-10
US96698797A 1997-11-10 1997-11-10
US96714897A 1997-11-10 1997-11-10
US96693297A 1997-11-10 1997-11-10
US966932 1997-11-10
US967148 1997-11-10
US967403 1997-11-10
US966987 1997-11-10
US97674197A 1997-11-24 1997-11-24
US976741 1997-11-24
US8958098P 1998-06-17 1998-06-17
US8958198P 1998-06-17 1998-06-17
US89580 1998-06-17
US10063198A 1998-06-18 1998-06-18
US10052998A 1998-06-18 1998-06-18
US10076398A 1998-06-18 1998-06-18
US10052198A 1998-06-18 1998-06-18
US10076298A 1998-06-18 1998-06-18
US100631 1998-06-18
US100529 1998-06-18
US100763 1998-06-18
PCT/US1998/023905 WO1999024553A2 (en) 1997-11-10 1998-11-10 X-ray crystal comprising hiv-1 gp120
US100762 2002-03-19

Publications (2)

Publication Number Publication Date
EP1037963A1 EP1037963A1 (en) 2000-09-27
EP1037963A4 true EP1037963A4 (en) 2004-09-22

Family

ID=27583731

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98959406A Withdrawn EP1037963A4 (en) 1997-11-10 1998-11-10 X-ray crystal comprising hiv-1 gp120

Country Status (2)

Country Link
EP (1) EP1037963A4 (en)
WO (1) WO1999024553A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US20030125518A1 (en) * 2001-12-01 2003-07-03 Crevecoeur Harry F. Surface simulation synthetic peptides useful in the treatment of hyper-variable viral pathogens
WO2007030518A2 (en) 2005-09-06 2007-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Conformationally stabilized hiv envelope immunogens and triggering hiv-1 envelope to reveal cryptic v3-loop epitopes
WO2012003234A2 (en) * 2010-06-30 2012-01-05 Torrey Pines Institute For Molecular Studies Env trimer immunogens
CN114609392A (en) * 2022-03-08 2022-06-10 武汉科技大学 Screening method and application of HIV (human immunodeficiency virus) fully-humanized broad-spectrum neutralizing antibody

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
GHIARA J B ET AL: "Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 266, no. 1, 14 February 1997 (1997-02-14), pages 31 - 39, XP004462201, ISSN: 0022-2836 *
KWONG P D ET AL: "STRUCTURE OF AN HIV gp120 ENVELOPE GLYCOPROTEIN IN COMPLEX WITH THE CD4 RECEPTOR AND A NEUTRALIZING HUMAN ANTIBODY", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 393, 18 June 1998 (1998-06-18), pages 648 - 659, XP002093502, ISSN: 0028-0836 *
OXFORD J S ET AL: "New scientific developments towards an AIDS vaccine: report on a workshop organized by EU programme EVA entitled Novel approaches to AIDS vaccine development held at the Institut Pasteur, Paris", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 14, no. 17, 1 December 1996 (1996-12-01), pages 1712 - 1717, XP004016836, ISSN: 0264-410X *
RINI JAMES M ET AL: "Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 13, 1993, 1993, pages 6325 - 6329, XP002276067, ISSN: 0027-8424 *
SANEJOUAND Y-H: "On the role of CD4 conformational change in the HIV-cell fusion process", COMPTES RENDUS DES SEANCES DE L'ACADEMIE DES SCIENCES. SERIE III: SCIENCES DE LA VIE, ELSEVIER, AMSTERDAM, NL, vol. 320, no. 2, February 1997 (1997-02-01), pages 163 - 170, XP004349275, ISSN: 0764-4469 *
STURA E A ET AL: "CRYSTALLIZATION, SEQUENCE, AND PRELIMINARY CRYSTALLOGRAPHIC DATA FOR AN ANTIPEPTIDE FAB 50.1 AND PEPTIDE COMPLEXES WITH THE PRINCIPAL NEUTRALIZING DETERMINANT OF HIV-1 GP120", PROTEINS: STRUCTURE, FUNCTION AND GENETICS, ALAN R. LISS, US, vol. 14, no. 4, December 1992 (1992-12-01), pages 499 - 508, XP001069692, ISSN: 0887-3585 *
WYATT R ET AL: "THE ANTIGENIC STRUCTURE OF THE HIV gp120 ENVELOPE GLYCOPROTEIN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 393, 18 June 1998 (1998-06-18), pages 705 - 711, XP002093503, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO1999024553A9 (en) 2001-05-31
WO1999024553A8 (en) 1999-07-22
WO1999024553A2 (en) 1999-05-20
EP1037963A1 (en) 2000-09-27
WO1999024553A3 (en) 2003-12-11

Similar Documents

Publication Publication Date Title
EP0955966A4 (en) Lumbo-sacral orthosis
HUP9901089A3 (en) Medical splint
AU1939799A (en) Anti-retroviral immunogens, preparation and use
GB9712696D0 (en) Bandage
IL135769A0 (en) Grip-aid bandage
GB9707997D0 (en) Surgical implement
ZA98873B (en) Medical speculum
HUP0100218A3 (en) Medical spatula
EP1037963A4 (en) X-ray crystal comprising hiv-1 gp120
AU6582098A (en) Medical splint product
ZA954126B (en) Assay for hiv-1 group o
GB9700875D0 (en) Medical devices
GB9720292D0 (en) Medical support
GB2330526B (en) Patient support
EP1023281A4 (en) Hiv integrase inhibitors
GB9708078D0 (en) Bandage
EP0830862A4 (en) Anti-hiv drugs
GB9720073D0 (en) Dental devices
ZA982247B (en) Dental instrument
EP0724882A4 (en) Novel anti-hiv drug
ZA986324B (en) Composition for the treatment of immunodeficiency disease
PL341219A1 (en) Surgical device
GB9701117D0 (en) HIV Treatment
GB9708380D0 (en) HIV treatment
TW357555U (en) Patient trousures

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000609

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

D17D Deferred search report published (deleted)
D17D Deferred search report published (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: 7G 01N 23/207 B

Ipc: 7G 01N 23/201 B

Ipc: 7G 01N 23/20 B

Ipc: 7C 07K 5/00 B

Ipc: 7A 61K 38/00 A

RTI1 Title (correction)

Free format text: X-RAY CRYSTAL COMPRISING HIV-1 GP120

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 38/00 B

Ipc: 7C 07K 16/08 B

Ipc: 7C 07K 14/73 B

Ipc: 7C 07K 14/16 A

A4 Supplementary search report drawn up and despatched

Effective date: 20040805

17Q First examination report despatched

Effective date: 20050215

17Q First examination report despatched

Effective date: 20050215

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20070512