EP1037628A4 - METHOD FOR PREVENTING RESTENOSE USING TOCOTRIENOLE - Google Patents

METHOD FOR PREVENTING RESTENOSE USING TOCOTRIENOLE

Info

Publication number
EP1037628A4
EP1037628A4 EP98960259A EP98960259A EP1037628A4 EP 1037628 A4 EP1037628 A4 EP 1037628A4 EP 98960259 A EP98960259 A EP 98960259A EP 98960259 A EP98960259 A EP 98960259A EP 1037628 A4 EP1037628 A4 EP 1037628A4
Authority
EP
European Patent Office
Prior art keywords
tocotrienols
methods
preventing restenosis
restenosis
preventing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98960259A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1037628A1 (en
Inventor
Ronald H Lane
Frederick H Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lipogenics Inc
Original Assignee
Lipogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipogenics Inc filed Critical Lipogenics Inc
Publication of EP1037628A1 publication Critical patent/EP1037628A1/en
Publication of EP1037628A4 publication Critical patent/EP1037628A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Pyrane Compounds (AREA)
EP98960259A 1997-11-17 1998-11-17 METHOD FOR PREVENTING RESTENOSE USING TOCOTRIENOLE Withdrawn EP1037628A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97170397A 1997-11-17 1997-11-17
US971703 1997-11-17
PCT/US1998/024606 WO1999025336A1 (en) 1997-11-17 1998-11-17 Methods for preventing restenosis using tocotrienols

Publications (2)

Publication Number Publication Date
EP1037628A1 EP1037628A1 (en) 2000-09-27
EP1037628A4 true EP1037628A4 (en) 2002-08-21

Family

ID=25518699

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98960259A Withdrawn EP1037628A4 (en) 1997-11-17 1998-11-17 METHOD FOR PREVENTING RESTENOSE USING TOCOTRIENOLE

Country Status (6)

Country Link
EP (1) EP1037628A4 (id)
JP (1) JP2001522880A (id)
AU (1) AU746369B2 (id)
CA (1) CA2310232A1 (id)
ID (1) ID26335A (id)
WO (1) WO1999025336A1 (id)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE470442T1 (de) * 2000-03-31 2010-06-15 Eisai R&D Man Co Ltd Verwendung von gamma-tocotrienol als diuretika
US7713546B1 (en) * 2001-04-03 2010-05-11 Soft Gel Technologies, Inc. Corosolic acid formulation and its application for weight-loss management and blood sugar balance
DE10115740A1 (de) 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
WO2004006976A1 (en) 2002-07-12 2004-01-22 Cook Incorporated Coated medical device
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
JP2007509179A (ja) * 2003-10-21 2007-04-12 メドロジックス・ディバイス・コーポレーション 再狭窄の予防のためのガンマ−トコフェロールの治療
WO2007011385A2 (en) 2004-09-28 2007-01-25 Atrium Medical Corporation Heat cured gel and method of making
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
WO2006036967A1 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Solubilizing a drug for use in a coating
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
PL1888059T3 (pl) 2005-06-01 2015-06-30 Bioelectron Tech Corp Środki terapeutyczne aktywne wobec układów redoks do leczenia chorób mitochondrialnych i innych zaburzeń oraz modulacja biomarkerów energetycznych
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
WO2007047781A2 (en) 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
JP5374162B2 (ja) 2006-02-22 2013-12-25 エジソン ファーマシューティカルズ， インコーポレイテッド ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
EP2083875B1 (en) 2006-11-06 2013-03-27 Atrium Medical Corporation Coated surgical mesh
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
MX2011002318A (es) 2008-09-10 2011-05-10 Edison Pharmaceuticals Inc Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
EP3064230B1 (en) 2009-07-10 2019-04-10 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
WO2011008393A2 (en) 2009-07-17 2011-01-20 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
SI2470168T1 (en) 2009-08-26 2018-05-31 Bioelectron Technology Corporation Procedures for the prevention and treatment of brain ischemia
EP2593141B1 (en) 2010-07-16 2018-07-04 Atrium Medical Corporation Composition and methods for altering the rate of hydrolysis of cured oil-based materials
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
KR20150058157A (ko) * 2012-07-19 2015-05-28 더 오하이오 스테이트 유니버시티 응고 병리상태를 개선시키는 방법 및 관련 물질 및 방법
CA3008849A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4333794A1 (de) * 1993-10-04 1995-04-06 Carl Heinrich Dr Weischer Neue Acetyl-Salicylsäure-Derivate zur Bekämpfung von Entzündungs- und Schmerzzuständen sowie zur Thromboseprophylaxe und -terapie
EP0669132A1 (en) * 1994-02-23 1995-08-30 van der Kraaij, Antonius Marinus Maria Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis
US5591772A (en) * 1991-11-22 1997-01-07 Lipogenics, Inc. Tocotrienols and tocotrienol-like compounds and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591772A (en) * 1991-11-22 1997-01-07 Lipogenics, Inc. Tocotrienols and tocotrienol-like compounds and methods for their use
DE4333794A1 (de) * 1993-10-04 1995-04-06 Carl Heinrich Dr Weischer Neue Acetyl-Salicylsäure-Derivate zur Bekämpfung von Entzündungs- und Schmerzzuständen sowie zur Thromboseprophylaxe und -terapie
EP0669132A1 (en) * 1994-02-23 1995-08-30 van der Kraaij, Antonius Marinus Maria Pharmaceutical composition of vitamin E and acetylsalicylate for treatment and prevention of atherosclerosis

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AZZI A ET AL: "MODULATION OF CELL PROLIFERATION BY TOCOPHEROLS AND TOCOTRIENOLS: ROLE IN ARTERIOSCLEROSIS", LIPID SOLUBLE ANTIOXIDANTS: BIOCHEMISTRY AND CLINICAL APPLICATIONS, BIRKHAEUSER VERLAG, BASEL, CH, 1992, pages 123 - 133, XP008004536 *
GELLER M R ET AL: "Palmvitee-induced carotid plaque regression in humans.", STROKE (26, NO. 1, 162, 1995) CODEN: SJCCA7 ISSN: 0039-2499, XP008004540 *
KARPEN C W ET AL: "TOCOTRIENOL-INDUCED INHIBITION OF PLATELET THROMBUS FORMATION AND PLATELET AGGREGATION IN A STENOSEL CORONARY ARTERY CANINE MODEL", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 4, PART 2, no. 90, 14 November 1994 (1994-11-14), pages 1181, XP008004384, ISSN: 0009-7322 *
KOOYENGA D ET AL: "ANTIOXIDANT EFFECTS OF TOCOTRIENOLS IN PATIENTS WITH CAROTID STENOSIS", JOURNAL OF INVESTIGATIVE MEDICINE, AMERICAN FEDERATION FOR CLINICAL RESEARCH,, US, vol. 3, no. 44, 3 May 1996 (1996-05-03), pages 245A, XP008004383, ISSN: 1081-5589 *
PACKER L: "INTERACTIONS AMONG ANTIOXIDANTS IN HEALTH AND DISEASE: VITAMIN E AND ITS REDOX CYCLE", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY & MEDICINE, ACADEMIC PRESS INC. NEW YORK, US, vol. 2, no. 200, June 1992 (1992-06-01), pages 271 - 276, XP001073940, ISSN: 0037-9727 *
QURESHI A A ET AL: "NOVEL TOCOTRIENOLS OF RICE BRAN MODULATE CARDIOVASCULAR DISEASE RISK PARAMETERS OF HYPERCHOLESTEROLEMIC HUMANS", JOURNAL OF NUTRITIONAL BIOCHEMISTRY, BUTTERWORTH PUBLISHERS, STONEHAM, GB, vol. 8, no. 5, May 1997 (1997-05-01), pages 290 - 298, XP001026694, ISSN: 0955-2863 *
See also references of WO9925336A1 *
TOMEO A C ET AL: "ANTIOXIDANT EFFECTS OF PV IN HYPERLIPIDEMIC SUBJECTS WITH CAROTID ARTERY STENOSIS", CLINICAL RESEARCH, THOROFARE, NJ, US, vol. 2, no. 42, 29 April 1994 (1994-04-29), pages 158A, XP008004385, ISSN: 0009-9279 *
TOMEO ET AL.: "Antioxidant effects of vitamin E and gamma-tocotrienol in hyperlipidemic subjects with carotid artery stenosis - A preliminary report", CLIN. RES., vol. 42, no. 1, - 1994, pages 29a, XP008004386 *

Also Published As

Publication number Publication date
CA2310232A1 (en) 1999-05-27
JP2001522880A (ja) 2001-11-20
AU746369B2 (en) 2002-04-18
AU1590299A (en) 1999-06-07
WO1999025336A1 (en) 1999-05-27
ID26335A (id) 2000-12-14
EP1037628A1 (en) 2000-09-27

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