EP1012150A4 - Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders - Google Patents
Heteroarylcarboxamide compounds active against protein tyrosine kinase related disordersInfo
- Publication number
- EP1012150A4 EP1012150A4 EP98924794A EP98924794A EP1012150A4 EP 1012150 A4 EP1012150 A4 EP 1012150A4 EP 98924794 A EP98924794 A EP 98924794A EP 98924794 A EP98924794 A EP 98924794A EP 1012150 A4 EP1012150 A4 EP 1012150A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- tyrosine kinase
- related disorders
- protein tyrosine
- active against
- against protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4694597P | 1997-05-19 | 1997-05-19 | |
US4708497P | 1997-05-19 | 1997-05-19 | |
US47084P | 1997-05-19 | ||
US46945P | 1997-05-19 | ||
US5662397P | 1997-08-20 | 1997-08-20 | |
US56623P | 1997-08-20 | ||
US6159097P | 1997-10-10 | 1997-10-10 | |
US61590P | 1997-10-10 | ||
PCT/US1998/010174 WO1998052944A1 (en) | 1997-05-19 | 1998-05-18 | Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1012150A1 EP1012150A1 (en) | 2000-06-28 |
EP1012150A4 true EP1012150A4 (en) | 2002-05-29 |
Family
ID=27489113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98924794A Withdrawn EP1012150A4 (en) | 1997-05-19 | 1998-05-18 | Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1012150A4 (en) |
AR (1) | AR015685A1 (en) |
AU (1) | AU7687998A (en) |
CA (1) | CA2302438A1 (en) |
WO (1) | WO1998052944A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2362883A1 (en) * | 1999-02-12 | 2000-08-17 | Quanam Medical Corporation | Alkylating agents for treatment of cellular proliferation |
GB9904103D0 (en) | 1999-02-24 | 1999-04-14 | Zeneca Ltd | Quinoline derivatives |
WO2000062778A1 (en) | 1999-04-15 | 2000-10-26 | Bristol-Myers Squibb Co. | Cyclic protein tyrosine kinase inhibitors |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
US6689883B1 (en) | 1999-09-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US7977333B2 (en) | 2000-04-20 | 2011-07-12 | Bayer Healthcare Llc | Substituted pyridines and pyridazines with angiogenesis inhibiting activity |
US6903101B1 (en) | 2000-08-10 | 2005-06-07 | Bayer Pharmaceuticals Corporation | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity |
GB0322012D0 (en) * | 2003-09-19 | 2003-10-22 | Syngenta Participations Ag | Chemical compounds |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
EP1990048A3 (en) * | 2007-05-08 | 2009-05-06 | Ulrike Wiebelitz | Therapy of benign prostatic hyperplasia (bph) |
CA2716448A1 (en) | 2008-03-17 | 2009-09-24 | Patrick Brossard | Dosing regimen for a selective s1p1 receptor agonist |
US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
CN108929271B (en) * | 2018-06-29 | 2021-08-31 | 中国药科大学 | Tyrosinase inhibitor and preparation method and application thereof |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0073973A1 (en) * | 1981-08-24 | 1983-03-16 | BASF Aktiengesellschaft | Thiazolyl and isothiazolyl-carboxylic-acid anilides, process for their preparation and their utilization as fungicides |
EP0418667A2 (en) * | 1989-09-22 | 1991-03-27 | BASF Aktiengesellschaft | Carboxylic acid amides |
WO1991017748A1 (en) * | 1990-05-18 | 1991-11-28 | Hoechst Aktiengesellschaft | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs |
WO1994001408A1 (en) * | 1992-07-10 | 1994-01-20 | Laboratoires Glaxo S.A. | Anilide derivatives |
US5342851A (en) * | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
WO1995019169A2 (en) * | 1994-01-07 | 1995-07-20 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancer using inhibitors of platelet derived growth factor receptor |
JPH07196637A (en) * | 1993-11-24 | 1995-08-01 | Mitsui Toatsu Chem Inc | Production of isothiazolecarboxymide derivative |
US5476866A (en) * | 1993-10-01 | 1995-12-19 | Roussel Uclaf | Isoxazoles |
WO1996033179A1 (en) * | 1995-04-21 | 1996-10-24 | Sugen, Inc. | Thioamides derivates and their use as inhibitors of hyper-proliferative cell growth |
WO1997011690A2 (en) * | 1995-09-29 | 1997-04-03 | Microcide Pharmaceuticals, Inc. | Inhibitors of regulatory pathways |
EP0769296A1 (en) * | 1995-10-25 | 1997-04-23 | Hoechst Aktiengesellschaft | Use of isoxazole- and crotonamide derivatives for the manufacture of a medicament for the treatment of cancers |
WO1997040019A1 (en) * | 1996-04-24 | 1997-10-30 | Celltech Therapeutics Limited | 5-aminopyrazoles useful as selective inhibitors of the protein tyrosine kinase p56ick |
WO1998028269A1 (en) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS |
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
WO1999024404A1 (en) * | 1997-11-07 | 1999-05-20 | Amgen Inc. | Substituted pyridine compounds as anti-inflammatory agents |
WO1999043657A1 (en) * | 1998-02-27 | 1999-09-02 | F. Hoffmann-La Roche Ag | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives as muscarinic receptor antagonists |
EP0990645A1 (en) * | 1997-05-30 | 2000-04-05 | Nippon Kayaku Kabushiki Kaisha | Novel sulfonamide derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995024190A2 (en) * | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
-
1998
- 1998-05-18 CA CA002302438A patent/CA2302438A1/en not_active Abandoned
- 1998-05-18 WO PCT/US1998/010174 patent/WO1998052944A1/en not_active Application Discontinuation
- 1998-05-18 AU AU76879/98A patent/AU7687998A/en not_active Abandoned
- 1998-05-18 EP EP98924794A patent/EP1012150A4/en not_active Withdrawn
- 1998-05-19 AR ARP980102308 patent/AR015685A1/en unknown
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0073973A1 (en) * | 1981-08-24 | 1983-03-16 | BASF Aktiengesellschaft | Thiazolyl and isothiazolyl-carboxylic-acid anilides, process for their preparation and their utilization as fungicides |
EP0418667A2 (en) * | 1989-09-22 | 1991-03-27 | BASF Aktiengesellschaft | Carboxylic acid amides |
WO1991017748A1 (en) * | 1990-05-18 | 1991-11-28 | Hoechst Aktiengesellschaft | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs |
WO1994001408A1 (en) * | 1992-07-10 | 1994-01-20 | Laboratoires Glaxo S.A. | Anilide derivatives |
US5342851A (en) * | 1992-10-07 | 1994-08-30 | Mcneil-Ppc, Inc. | Substituted thiazole derivatives useful as platelet aggregation inhibitors |
US5476866A (en) * | 1993-10-01 | 1995-12-19 | Roussel Uclaf | Isoxazoles |
JPH07196637A (en) * | 1993-11-24 | 1995-08-01 | Mitsui Toatsu Chem Inc | Production of isothiazolecarboxymide derivative |
WO1995019169A2 (en) * | 1994-01-07 | 1995-07-20 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancer using inhibitors of platelet derived growth factor receptor |
WO1996033179A1 (en) * | 1995-04-21 | 1996-10-24 | Sugen, Inc. | Thioamides derivates and their use as inhibitors of hyper-proliferative cell growth |
WO1997011690A2 (en) * | 1995-09-29 | 1997-04-03 | Microcide Pharmaceuticals, Inc. | Inhibitors of regulatory pathways |
EP0769296A1 (en) * | 1995-10-25 | 1997-04-23 | Hoechst Aktiengesellschaft | Use of isoxazole- and crotonamide derivatives for the manufacture of a medicament for the treatment of cancers |
WO1997040019A1 (en) * | 1996-04-24 | 1997-10-30 | Celltech Therapeutics Limited | 5-aminopyrazoles useful as selective inhibitors of the protein tyrosine kinase p56ick |
WO1998028269A1 (en) * | 1996-12-23 | 1998-07-02 | Du Pont Pharmaceuticals Company | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS |
EP0990645A1 (en) * | 1997-05-30 | 2000-04-05 | Nippon Kayaku Kabushiki Kaisha | Novel sulfonamide derivatives |
WO1998057937A2 (en) * | 1997-06-19 | 1998-12-23 | The Du Pont Merck Pharmaceutical Company | Inhibitors of factor xa with a neutral p1 specificity group |
WO1999024404A1 (en) * | 1997-11-07 | 1999-05-20 | Amgen Inc. | Substituted pyridine compounds as anti-inflammatory agents |
WO1999043657A1 (en) * | 1998-02-27 | 1999-09-02 | F. Hoffmann-La Roche Ag | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives as muscarinic receptor antagonists |
Non-Patent Citations (4)
Title |
---|
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002192888, Database accession no. 1576091 (BRN) * |
DATABASE WPI Week 9539, Derwent World Patents Index; AN 1995-299548, XP002192889 * |
J. CHEM. SOC. C (1968), (5), 611-14 * |
See also references of WO9852944A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU7687998A (en) | 1998-12-11 |
CA2302438A1 (en) | 1998-11-26 |
WO1998052944A1 (en) | 1998-11-26 |
AR015685A1 (en) | 2001-05-16 |
EP1012150A1 (en) | 2000-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000303 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07D 413/02 A, 7C 07D 231/12 B, 7C 07D 261/18 B, 7C 07D 261/08 B, 7C 07D 413/12 B, 7C 07D 231/14 B, 7C 07D 401/12 B, 7C 07D 407/12 B, 7C 07D 275/02 B, 7C 07D 417/12 B, 7A 61K 31/42 B, 7A 61K 31/415 B, 7A 61K 31/44 B, 7A 61K 31/425 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020411 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20040204 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: SUGEN, INC. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060927 |