EP1012073B1 - Rigid container for transporting a bag containing bio-pharmaceutical fluid products - Google Patents
Rigid container for transporting a bag containing bio-pharmaceutical fluid products Download PDFInfo
- Publication number
- EP1012073B1 EP1012073B1 EP99929376A EP99929376A EP1012073B1 EP 1012073 B1 EP1012073 B1 EP 1012073B1 EP 99929376 A EP99929376 A EP 99929376A EP 99929376 A EP99929376 A EP 99929376A EP 1012073 B1 EP1012073 B1 EP 1012073B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- sachet
- container
- container according
- plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67D—DISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
- B67D7/00—Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
- B67D7/02—Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
- B67D7/0216—Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants by squeezing collapsible or flexible storage containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D88/00—Large containers
- B65D88/54—Large containers characterised by means facilitating filling or emptying
- B65D88/58—Large containers characterised by means facilitating filling or emptying by displacement of walls
- B65D88/60—Large containers characterised by means facilitating filling or emptying by displacement of walls of internal walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D90/00—Component parts, details or accessories for large containers
- B65D90/02—Wall construction
- B65D90/04—Linings
- B65D90/046—Flexible liners, e.g. loosely positioned in the container
- B65D90/047—Flexible liners, e.g. loosely positioned in the container comprising rigid bracing, e.g. bulkheads
Definitions
- the present invention relates to new rigid containers of transport for bags of bio-pharmaceutical fluids.
- US-A-5 350 080 describes pouches which can be used for cell culture and their rigid transport container.
- BE 539 623 A described a container according to the preamble of claim 1.
- the wider bio-pharmaceutical industry is using more and more often flexible bags of 20 to 2,000 L and more, in particular biocompatible, to transport fluids used in this industry, such as culture media, cell cultures, buffer solutions, liquids artificial nutrition, blood products or derivatives such as plasma.
- fluids used in this industry such as culture media, cell cultures, buffer solutions, liquids artificial nutrition, blood products or derivatives such as plasma.
- these pockets intended to contain the above-mentioned media and liquid products are by nature provided with a certain number access doors allowing for example filling, racking, mixing, etc. of their content, as well as usually a number of pipes installed on all or part of these doors.
- These tubes are themselves often provided with one or more rigid material devices such as valves or clamps which can contribute to the abrasion of the part upper pockets when transported over long distances. A piercing on the top of a pocket can be just as serious as elsewhere by example in the case of transporting sterile contents.
- such a container once emptied from its pocket, should have a volume smaller than that which it occupies during the transport of the pocket, in order to reduce the volume occupied by the container when it returns to its destination original. It should also be simple and inexpensive, without compromised with efficiency.
- the containment plate fills in particular two functions: on the one hand it maintains firmly by pressure the pocket installed in the container, and on the other hand it protects the top of the abrasion pocket due to friction from connection elements such as pipes and taps installed on the doors on the top of the poached.
- the containment plate is adjustable to press more or less on said pocket. Under preferential conditions of implementation of the invention, this adjustment is carried out continuously.
- This continuous adjustment can be obtained for example using a pneumatic system, using for example inflatable bags or mechanical or hydraulic cylinders supported on beams or on a cover installed on the top of the container, but in entirely preferred conditions of realization, this adjustment is obtained using of a screw jack system.
- a pneumatic system using for example inflatable bags or mechanical or hydraulic cylinders supported on beams or on a cover installed on the top of the container, but in entirely preferred conditions of realization, this adjustment is obtained using of a screw jack system.
- the above adjustment device advantageously takes support on removable side rails preferably installed parallel to the wall bottom of the container.
- a simple and efficient way to install these beams is to spare at the top of the container, for example in two opposite side walls of a parallelepiped container, slots passage for inserting the ends of said beams.
- the fine adjustment of the compression is then obtained using the adjustment system, in particular continuously, such as the cylinders mentioned above.
- the shape of the container can be varied and especially cylindrical. In such a case, the side members are advantageously installed parallel to a diameter.
- the beams are for example at number two or three.
- a preferred container according to the invention has a shape generally parallelepiped
- the compression plate is provided with a through hole for the door (s) installed on the top of the poached.
- the passage opening (s) are in number corresponding to the door systems installed on the top of the pocket. So the plate of restraint allows the passage of doors and possibly tubing, and prevents direct contact of these on the pocket by totally reducing the risks of abrasion and rupture due to this effect.
- the above containment orifice (s) are provided with a guillotine adjustable door lock installed on the top of the pocket.
- This guillotine adjustable can be adjusted to the dimensions and location of the pocket and, a once the system is in place, can be blocked using a simple means, such as a screw installed perpendicular to the containment plate, blocking after screwing the sliding part (s) of the guillotine against the slides of sliding.
- the containment plate has its surface facing the interior of the container substantially flat, and advantageously has a surface greater than or equal to 80% of that of the internal surface delimited by the side walls of the rigid container, preferably greater than 90%, in particular greater than 95% and very particularly 98% of this surface.
- the play of the edges of the containment plate is very limited compared to the sides of the rigid container.
- the containment plate is substantially adjusted to the internal dimension container.
- edges of the containment plate directed towards the inside of the container are preferably blunt to avoid risk of damage a pocket during transport.
- the container is foldable or removable, especially for taking a parallelepiped shape of low height.
- foldable preferably, a parallelepiped container is produced, and two side walls, preferably of smaller surface and opposite, are removable, while two other side walls, preferably those of larger area remain integral with the lower wall and are foldable one on the other.
- the bottom of the container is not flat but slightly flared towards the high to facilitate the reflux of the liquid towards the bottom of the bag at the end of emptying.
- the bottom of the container is provided, preferably towards its middle, with a at least opening allowing the correct centering of the pocket with respect to the container. Therefore, in the case of a non-cylindrical pocket, this orifice has any form of preferably other than round, like elongated oval, triangular, square, hexagonal, etc. allowing, by cooperation with a shape protuberance complementary and corresponding location at the bottom of the pocket, of course center it before filling and at the same time constitute a point anchoring at the bottom of the container, and thereby improving the quality of transport.
- This orifice can also be used for the circulation of fluids if for example the protrusion of the pocket is constituted by the base of a plug for example emptying.
- the containers of the invention are used with flexible pockets made of plastic.
- the present invention also relates to a above container, fitted with a bio-pharmaceutical liquid transport pocket of 50 liters and more, preferably a bellows pocket, the shape is substantially rectangular rectangle once this pocket filled.
- the above pocket is advantageously a monofilm pocket multilayer.
- This multi-layer monofilm pocket is preferably three-layer, particularly four-layer and very particularly of the PET (Polyester) / Polyamide / EvOH (Ethylene-Vinyl Alcohol Copolymer) / PE (Polyethylene) type.
- Figure 1 shows is a top view of a container rigid according to the invention provided with a system for continuously adjusting the pressure the compression plate on the pocket, resting on two side members, said pocket being provided with four upper access doors installed side by side side.
- FIG. 2 represents a partially exploded view along AA 'of Figure 1.
- FIG. 3 represents a perspective view of FIG. 1, with a variant of the screw actuation system.
- the side walls 1, 2, 3, 4 are distinguished from a rigid container according to the invention of rectangular parallelepiped shape. Between these side walls 1, 2, 3, 4 is installed a containment plate 5, installed over more than 98% of the surface available between the side walls 1, 2, 3, 4.
- Two beams 6, 7 are installed parallel to each other, parallel to the bottom and top of the container and parallel to the side walls 2 and 4. These beams 6, 7 have their ends inserted into slots formed in the larger opposite side walls 1, 3, of the container.
- These beams 6, 7 each include two threads for screwing a compression screw 8 installed vertically, perpendicular to said side members 6, 7. This compression screw 8 is provided at one end with a crank to facilitate its screwing. Its other end rests on the containment plate 5.
- This crank comprises an arm 9 extending from each side of the axis of the screw, with a sliding pin 10 perpendicular to arm 9 of the crank so that this crankpin 10 is substantially located above the arm during screwing and unscrewing, and substantially located below the arm, as shown here during transport.
- the crank pin 10 is of sufficient length to come in support against the beam 7 during transport. Under these conditions, everything accidental unscrewing is impossible since the rotational movement of the crank arm must be less than 180 °. Only one crank has been shown in this figure. On the other hand, we have represented the circles of revolution of the four cranks.
- a guillotine 12, 13 consisting of two parts 12, 13.
- the two parts 12, 13 of the guillotine are a larger area than the window in the plate allowing the exit of the doors. They are not guided and are simply installed between the pocket and containment plate 5, which allows on the realization illustrated here a displacement of the two parts 12, 13 of the guillotine in all freedom parallel to the compression plate 5.
- Such a system allows the efficient locking of the doors, limiting as much as possible the waivers at this level.
- the two parts 12, 13 of the guillotine are more particularly installed between a foam plate protecting the pocket and the compression plate 5.
- FIG. 2 a detail of the embodiment of the adjustment of Figure 1.
- a screw 8 adjustment provided at its end upper of a crank arm 9 in which a crank pin 10 is installed sliding, held by an O-ring 14.
- the other end of the screw 8 comes take support in a recess 15 formed on the top of the plate support 5.
- the bottom of the support plate 5 is provided with a plate foam 16 to better protect the pocket.
- Slots 17 are provided in the side walls 1.3 of the container to insert the ends of the side members 6, 7.
- the container is also provided with a cover 18.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Packages (AREA)
- Bag Frames (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Closures For Containers (AREA)
Abstract
Description
La présente invention concerne de nouveaux conteneurs rigides de transport pour poches de produits fluides bio-pharmaceutiques.The present invention relates to new rigid containers of transport for bags of bio-pharmaceutical fluids.
US-A-5 350 080 décrit des poches utilisables pour des milieux de
culture cellulaires ainsi que leur conteneur de transport rigide. BE 539 623 A décrit
un conteneur selon le préambule de la revendication 1.US-A-5 350 080 describes pouches which can be used for
cell culture and their rigid transport container. BE 539 623 A described
a container according to the preamble of
L'industrie bio-pharmaceutique au sens large utilise de plus en plus souvent des poches souples de 20 à 2.000 L et plus, notamment biocompatibles, pour transporter des fluides utilisés dans cette industrie, tels des milieux de cultures, des cultures cellulaires, des solutions tampon, des liquides de nutrition artificielle, des produits sanguins ou dérivés comme le plasma.The wider bio-pharmaceutical industry is using more and more often flexible bags of 20 to 2,000 L and more, in particular biocompatible, to transport fluids used in this industry, such as culture media, cell cultures, buffer solutions, liquids artificial nutrition, blood products or derivatives such as plasma.
Parfois les produits renfermés dans ces poches sont utilisés à des milliers de kilomètres de l'endroit où les poches ont été remplies. Ces produits sont souvent d'une haute valeur financière, voire souvent d'une haute valeur pour la santé des individus puisqu'ils peuvent servir par exemple à la fabrication de médicaments destinés à la santé humaine. Il est donc essentiel que ces poches parviennent sûrement à leur destination, pleines du liquide avec lequel elles ont été remplies à l'origine et non contaminées.Sometimes the products in these pockets are used for thousands of miles from where the pockets were filled. These products are often of high financial value, or even often of high value for the health of individuals since they can be used for example in the manufacture of medicines intended for human health. It is therefore essential that these pockets surely reach their destination, full of the liquid with which they have originally filled and uncontaminated.
Or ces poches souples sont soumises à de nombreuses contraintes pendant leur transport : accélérations, freinages, ballottements, secousses, vibrations, etc. et donc à de nombreuses forces dont des forces de cisaillement qui ont tendance à altérer le film qui les constitue, notamment aux endroits sensibles comme les pliures, Toutes ces contraintes en conséquence occasionnent fréquemment des affaiblissements, ruptures ou des percements de ces poches.These flexible pockets are subject to numerous constraints during their transport: acceleration, braking, sloshing, shaking, vibrations, etc. and therefore to many forces including shear forces which tend to alter the film that constitutes them, especially in places sensitive like folds, All of these constraints as a result frequently cause weakening, ruptures or breakthroughs these pockets.
Il y a lieu de rappeler que ces poches destinées à contenir les milieux et produits liquides précités sont par nature dotées d'un certain nombre de portes d'accès permettant par exemple le remplissage, le soutirage, le mélange, etc. de leur contenu, ainsi qu'habituellement un certain nombre de tubulures installées sur tout ou partie de ces portes. Ces tubulures sont elles-mêmes munies souvent d'un ou plusieurs dispositifs en matériau rigide comme des vannes ou des clamps qui peuvent contribuer à l'abrasion de la partie supérieure des poches lors de leur transport sur de longues distances. Un percement sur le dessus d'une poche peut être tout aussi sérieux qu'ailleurs par exemple dans le cas du transport d'un contenu stérile.It should be recalled that these pockets intended to contain the above-mentioned media and liquid products are by nature provided with a certain number access doors allowing for example filling, racking, mixing, etc. of their content, as well as usually a number of pipes installed on all or part of these doors. These tubes are themselves often provided with one or more rigid material devices such as valves or clamps which can contribute to the abrasion of the part upper pockets when transported over long distances. A piercing on the top of a pocket can be just as serious as elsewhere by example in the case of transporting sterile contents.
C'est pourquoi il serait souhaitable de disposer d'un conteneur rigide de transport de poches de liquides bio-pharmaceutiques de volume de 50 litres et plus, permettant le transport sûr de celles-ci sur de longues distances.This is why it would be desirable to have a container rigid transport of bags of bio-pharmaceutical liquids with a volume of 50 liters and more, allowing the safe transport of these over long distances.
En outre, un tel conteneur, une fois vidé de sa poche, devrait avoir un volume inférieur à celui qu'il occupe pendant le transport de la poche, afin de diminuer le volume occupé par le conteneur lors de son retour à sa destination d'origine. Il devrait aussi être de réalisation simple et bon marché, sans compromis avec l'efficacité.In addition, such a container, once emptied from its pocket, should have a volume smaller than that which it occupies during the transport of the pocket, in order to reduce the volume occupied by the container when it returns to its destination original. It should also be simple and inexpensive, without compromised with efficiency.
C'est pourquoi la présente demande a pour objet un conteneur
rigide pour poche souple de transport de fluide bio-pharmaceutique tel que défini par la revendication 1.This is why the present application relates to a container.
rigid for flexible pocket for transporting bio-pharmaceutical fluid as defined by
Il est d'ores et déjà à noter que la plaque de contention remplit notamment deux fonctions : d'une part elle maintient fermement par pression la poche installée dans le conteneur, et d'autre part elle protège le dessus de la poche de l'abrasion due aux frottements des éléments de connectique tels que tubulures et robinets installés sur les portes ménagées sur le dessus de la poche.It should already be noted that the containment plate fills in particular two functions: on the one hand it maintains firmly by pressure the pocket installed in the container, and on the other hand it protects the top of the abrasion pocket due to friction from connection elements such as pipes and taps installed on the doors on the top of the poached.
La plaque de contention est réglable pour appuyer plus ou moins sur ladite poche. Dans des conditions préférentielles de mise en oeuvre de l'invention, ce réglage est réalisé en continu.The containment plate is adjustable to press more or less on said pocket. Under preferential conditions of implementation of the invention, this adjustment is carried out continuously.
Ce réglage en continu peut être obtenu par exemple à l'aide d'un système pneumatique, utilisant par exemple des poches gonflables ou des vérins mécaniques ou hydrauliques prenant appui sur des longerons ou sur un couvercle installé sur la partie supérieure du conteneur, mais dans des conditions tout à fait préférées de réalisation, ce réglage est obtenu à l'aide d'un système à vérins à vis. Ces vérins sont au nombre de 1 ou plus, de préférence au nombre de 3 ou 4.This continuous adjustment can be obtained for example using a pneumatic system, using for example inflatable bags or mechanical or hydraulic cylinders supported on beams or on a cover installed on the top of the container, but in entirely preferred conditions of realization, this adjustment is obtained using of a screw jack system. There are 1 or more of these cylinders, preferably 3 or 4 in number.
Le dispositif de réglage ci-dessus prend avantageusement appui sur des longerons amovibles installés de préférence parallèlement à la paroi inférieure du conteneur. Un moyen simple et efficace d'installer ces longerons consiste à ménager à la partie supérieure du conteneur, par exemple dans deux parois latérales opposées d'un conteneur parallélépipédique, des fentes de passage permettant d'y insérer les extrémités desdits longerons. On peut prévoir de telles fentes à différents niveaux afin d'utiliser les mêmes conteneurs pour différents volumes de poches. Le réglage fin de la contention est alors obtenu à l'aide du système de réglage, notamment en continu, tel que les vérins évoqués ci-dessus. La forme du conteneur peut être variée et notamment cylindrique. Dans un tel cas, les longerons sont avantageusement installés parallèlement à un diamètre. Les longerons sont par exemple au nombre de deux ou trois. Un conteneur préféré selon l'invention a une forme généralement parallélépipédiqueThe above adjustment device advantageously takes support on removable side rails preferably installed parallel to the wall bottom of the container. A simple and efficient way to install these beams is to spare at the top of the container, for example in two opposite side walls of a parallelepiped container, slots passage for inserting the ends of said beams. We can provide such slots at different levels in order to use the same containers for different pocket volumes. The fine adjustment of the compression is then obtained using the adjustment system, in particular continuously, such as the cylinders mentioned above. The shape of the container can be varied and especially cylindrical. In such a case, the side members are advantageously installed parallel to a diameter. The beams are for example at number two or three. A preferred container according to the invention has a shape generally parallelepiped
Dans la mesure où les poches à transporter peuvent être munies de portes et d'une connectique situées sur le haut de la poche, dans des conditions préférentielles de réalisation de l'invention, la plaque de contention est munie d'un orifice de passage pour la ou les portes installées sur le dessus de la poche. Le ou les orifices de passage sont en nombre correspondant aux systèmes de portes installées sur le haut de la poche. Ainsi, la plaque de contention permet le passage des portes et éventuellement des tubulures, et prévient le contact direct de celles-ci sur la poche en réduisant totalement les risques d'abrasion et de rupture dus à cet effet.Insofar as the pockets to be transported can be fitted of doors and a connector located on the top of the pocket, in preferential conditions for carrying out the invention, the compression plate is provided with a through hole for the door (s) installed on the top of the poached. The passage opening (s) are in number corresponding to the door systems installed on the top of the pocket. So the plate of restraint allows the passage of doors and possibly tubing, and prevents direct contact of these on the pocket by totally reducing the risks of abrasion and rupture due to this effect.
Dans d'autres conditions préférentielles de mise en oeuvre de l'invention, le ou les orifices de contention ci-dessus sont munis d'une guillotine réglable de blocage des portes installée sur le haut de la poche. Cette guillotine réglable peut être ajustée aux dimensions et emplacement de la poche et, une fois le système en place, peut être bloquée à l'aide d'un moyen simple, tel une vis installée perpendiculairement à la plaque de contention, bloquant après vissage la ou les parties coulissantes de la guillotine contre les glissières de coulissement.In other preferential conditions of implementation of the invention, the above containment orifice (s) are provided with a guillotine adjustable door lock installed on the top of the pocket. This guillotine adjustable can be adjusted to the dimensions and location of the pocket and, a once the system is in place, can be blocked using a simple means, such as a screw installed perpendicular to the containment plate, blocking after screwing the sliding part (s) of the guillotine against the slides of sliding.
La plaque de contention a sa surface dirigée vers l'intérieur du conteneur substantiellement plate, et a avantageusement une surface supérieure ou égale à 80 % de celle de la surface interne délimitée par les parois latérales du conteneur rigide, de préférence supérieure à 90 %, notamment supérieure à 95 % et tout particulièrement 98 % de cette surface. Ainsi, le jeu des bords de la plaque de contention est très limité par rapport aux côtés du conteneur rigide.The containment plate has its surface facing the interior of the container substantially flat, and advantageously has a surface greater than or equal to 80% of that of the internal surface delimited by the side walls of the rigid container, preferably greater than 90%, in particular greater than 95% and very particularly 98% of this surface. Thus, the play of the edges of the containment plate is very limited compared to the sides of the rigid container.
Dans des conditions tout à fait préférentielles de réalisation, la plaque de contention est sensiblement ajustée à la dimension intérieure correspondante du conteneur.Under entirely preferential conditions of realization, the containment plate is substantially adjusted to the internal dimension container.
Les arêtes de la plaque de contention dirigées vers l'intérieur du conteneur sont de préférence émoussées pour éviter de risquer d'endommager une poche pendant son transport.The edges of the containment plate directed towards the inside of the container are preferably blunt to avoid risk of damage a pocket during transport.
Le conteneur est repliable ou démontable, notamment pour prendre une forme parallélépipédique de faible hauteur. Lorsqu'il est repliable, de préférence, on réalise un conteneur parallélépipédique, et deux parois latérales, de préférence de plus faible surface et opposées, sont amovibles, tandis que deux autres parois latérales, de préférence celles de plus grande surface restent solidaires de la paroi inférieure et sont repliables l'une sur l'autre.The container is foldable or removable, especially for taking a parallelepiped shape of low height. When foldable, preferably, a parallelepiped container is produced, and two side walls, preferably of smaller surface and opposite, are removable, while two other side walls, preferably those of larger area remain integral with the lower wall and are foldable one on the other.
Lorsque le conteneur ci-dessus est démontable, on peut par exemple obtenir séparément trois faces latérales, la base d'une face latérale restant jointive, ou séparément quatre faces latérales et la base.When the container above is removable, you can for example get three sides separately lateral, the base of one lateral face remaining contiguous, or separately four faces side and base.
Dans encore d'autres conditions préférentielles de mise en oeuvre de l'invention, le fond du conteneur n'est pas plat mais légèrement évasé vers le haut pour faciliter le reflux du liquide vers le fond de la poche en fin de vidange. In still other preferential conditions of implementation of the invention, the bottom of the container is not flat but slightly flared towards the high to facilitate the reflux of the liquid towards the bottom of the bag at the end of emptying.
Dans toujours d'autres conditions préférentielles de mise en oeuvre de l'invention, le fond du conteneur est muni, de préférence vers son milieu, d'un orifice au moins permettant le bon centrage de la poche vis-à-vis du conteneur. De ce fait, dans le cas d'unu poche non-cylindrique, cet orifice a toute forme de préférence autre que ronde, comme ovale allongé, triangulaire, carrée, hexagonale, etc.. permettant, par coopération avec une protubérance de forme complémentaire et localisation correspondante au fond de la poche, de bien centrer celle-ci avant le remplissage et en même temps constituer un point d'ancrage au fond du conteneur, et améliorant de ce fait la qualité du transport. Cet orifice peut de plus être utilisé pour la circulation de fluides si par exemple la protubérance de la poche est constituée par l'embase d'une bonde par exemple de vidange.In always other preferential conditions of implementation of the invention, the bottom of the container is provided, preferably towards its middle, with a at least opening allowing the correct centering of the pocket with respect to the container. Therefore, in the case of a non-cylindrical pocket, this orifice has any form of preferably other than round, like elongated oval, triangular, square, hexagonal, etc. allowing, by cooperation with a shape protuberance complementary and corresponding location at the bottom of the pocket, of course center it before filling and at the same time constitute a point anchoring at the bottom of the container, and thereby improving the quality of transport. This orifice can also be used for the circulation of fluids if for example the protrusion of the pocket is constituted by the base of a plug for example emptying.
Comme on l'a vu, les conteneurs de l'invention sont utilisés avec des poches souples réalisées en matière plastique.As we have seen, the containers of the invention are used with flexible pockets made of plastic.
C'est pourquoi la présente invention a également pour objet un conteneur ci-dessus, muni d'une poche de transport de liquide bio-pharmaceutique de 50 litres et plus, de préférence une poche à soufflet, dont la forme est sensiblement parallélépipédique rectangle une fois cette poche remplie.This is why the present invention also relates to a above container, fitted with a bio-pharmaceutical liquid transport pocket of 50 liters and more, preferably a bellows pocket, the shape is substantially rectangular rectangle once this pocket filled.
Dans d'autres conditions préférentielles de mise en oeuvre de l'invention, la poche ci-dessus est avantageusement une poche monofilm multicouche.In other preferential conditions of implementation of the invention, the above pocket is advantageously a monofilm pocket multilayer.
Cette poche monofilm multicouche est de préférence tricouche, particulièrement quadricouche et tout particulièrement de type PET (Polyester) / Polyamide / EvOH (Copolymère Ethylène-Alcool vinylique) / PE (Polyéthylène).This multi-layer monofilm pocket is preferably three-layer, particularly four-layer and very particularly of the PET (Polyester) / Polyamide / EvOH (Ethylene-Vinyl Alcohol Copolymer) / PE (Polyethylene) type.
L'invention sera mieux décrite si l'on se réfère aux dessins annexés sur lesquels :The invention will be better described if reference is made to the accompanying drawings on which ones :
La figure 1 représente est une vue de dessus d'un conteneur rigide selon l'invention muni d'un système de réglage en continu de la pression de la plaque de contention sur la poche, prenant appui sur deux longerons, ladite poche étant munie de quatre portes d'accès supérieur installées côte à côte.Figure 1 shows is a top view of a container rigid according to the invention provided with a system for continuously adjusting the pressure the compression plate on the pocket, resting on two side members, said pocket being provided with four upper access doors installed side by side side.
La figure 2 représente une vue partiellement éclatée selon AA' de la figure 1.FIG. 2 represents a partially exploded view along AA 'of Figure 1.
La figure 3 représente une vue en perspective de la figure 1, avec une variante du système d'actionnement de la vis.FIG. 3 represents a perspective view of FIG. 1, with a variant of the screw actuation system.
Sur la figure 1, on distingue les parois latérales 1, 2, 3, 4, d'un
conteneur rigide selon l'invention de forme parallélépipédique rectangle. Entre
ces parois latérales 1, 2, 3, 4 est installée une plaque de contention 5, installée
sur plus de 98 % de la surface disponible entre les parois latérales 1, 2, 3, 4.
Deux longerons 6, 7, sont installés parallèlement entre eux, parallèlement au
fond et à la partie supérieure du conteneur et parallèlement aux parois latérales
2 et 4. Ces longerons 6, 7, ont leurs extrémités insérées dans des fentes
ménagées dans les plus grandes parois latérales opposées 1, 3, du conteneur.
Ces longerons 6, 7, comprennent chacun deux filetages permettant le vissage
d'une vis 8 de contention installée verticalement, perpendiculairement auxdits
longerons 6, 7. Cette vis 8 de contention est munie à une extrémité d'une
manivelle pour faciliter son vissage. Son autre extrémité prend appui sur la
plaque de contention 5. Cette manivelle comprend un bras 9 s'étendant de
chaque côté de l'axe de la vis, doté d'un maneton 10 coulissant
perpendiculairement au bras 9 de la manivelle de telle sorte que ce maneton
10 soit substantiellement située au dessus du bras lors du vissage et du
dévissage, et substantiellement située au dessous du bras, comme représenté
ici, lors du transport. Le maneton 10 est d'une longueur suffisante pour venir en
appui contre le longeron 7 lors du transport. Dans ces conditions, tout
dévissage accidentel est impossible puisque le déplacement en rotation du
bras de la manivelle est obligatoirement inférieur à 180°. Une seule manivelle a
été représentée sur cette figure. On a par contre représenté les cercles de
révolution des quatre manivelles.In FIG. 1, the
Sur cette figure 1, on distingue également les embases 11 de
quatre portes efficacement bloquées par l'usage d'une guillotine 12, 13
constituée de deux parties 12, 13. Les deux parties 12, 13 de la guillotine sont
d'une surface plus étendue que la fenêtre ménagée dans la plaque permettant
la sortie des portes. Elles ne sont pas guidées et sont simplement installées
entre la poche et plaque de contention 5, ce qui permet sur la réalisation
illustrée ici un déplacement des deux parties 12, 13 de la guillotine en toute
liberté parallèlement à la plaque de contention 5. Un tel système permet le
blocage efficace des portes en limitant au maximum les possibilités de
ballottage à ce niveau. Les deux parties 12, 13 de la guillotine sont plus
particulièrement installées entre une plaque de mousse protégeant la poche et
la plaque de contention 5.In this figure 1, there are also the
Les tubulures et leurs accessoires installés sur les portes n'ont
pas été représentés ici. On comprend toutefois que les tubulures et leurs
accessoires ne peuvent en aucun cas venir frotter sur la partie supérieure de la
poche, complètement protégée par la plaque de contention 5.Tubing and its accessories installed on the doors have
not been represented here. It is understood, however, that the tubes and their
accessories can in no case come to rub on the upper part of the
pocket, completely protected by the
Sur la figure 2, on a illustré un détail de réalisation du système de
réglage de la figure 1. On distingue une vis 8 de réglage munie à son extrémité
supérieure d'un bras 9 de manivelle dans lequel est installé un maneton 10
coulissant, maintenu par un joint torique 14. L'autre extrémité de la vis 8 vient
prendre appui dans une alvéole 15 ménagée sur le haut de la plaque de
contention 5. Le dessous de la plaque de contention 5 est muni d'une plaque
de mousse 16 pour mieux protéger la poche. Des fentes 17 sont prévues dans
les parois latérales 1,3 du conteneur pour y insérer les extrémités des
longerons 6, 7. Le conteneur est aussi muni d'un couvercle 18.In FIG. 2, a detail of the embodiment of the
adjustment of Figure 1. There is a
Sur la figure 3, on observe que les manivelles ont été remplacées
par des poignées. Le dévissage accidentel est prévenu par l'utilisation de
rondelles déformables. On observe en outre la plaque de mousse 16 d'environ
15 mm d'épaisseur et les leviers 18 d'actionnement des extrémités des
longerons 6,7 pour les insérer dans les fentes 17In Figure 3, we see that the cranks have been replaced
by handles. Accidental unscrewing is prevented by the use of
deformable washers. We also observe the
On peut opérer comme suit pour bloquer efficacement une poche installée en place, par référence à la figure 2 : We can operate as follows to effectively block a pocket installed in place, with reference to Figure 2:
La vis 8 étant en position remontée, on installe les longerons 6,7
en insérant leurs extrémités dans les fentes 17 prévues dans les parois
latérales 1,3 du conteneur. A l'aide des manetons 10, installés en position
haute contrairement à cette illustration, on visse alors chaque vérin à vis 8 de
manière à venir en contact avec le fond des alvéoles 15 de la plaque de
contention 5, ce qui met la poche sous pression. On règle alors les deux parties
12, 13 de la guillotine par glissement pour les placer en position de blocage des
portes. On établit alors la pression finale et on équilibre comme désiré. Ce
réglage étant fait, on redescend les manetons 10 dans la position représentée
sur la figure 2, de manière à empêcher un dévissage accidentel du vérin à vis
8. Dans la version présentée à la figure 3, l'utilisation de rondelles déformables
suffit à assurer la protection contre un dévissage accidentel ; on visse à fond
jusqu'au blocage de la poignée sur le longeron. Sur la figure 2, on n'a
représenté qu'une fente 17 dans la paroi latérale 1 du conteneur. Toutefois,
afin de pouvoir utiliser le dispositif selon l'invention pour différentes hauteurs de
poches, on peut prévoir un certain nombre de fentes superposées pour parer à
toutes les dimensions possibles.The
Claims (10)
- A rigid container for flexible sachets used to transport bio-pharmaceutical fluid consisting of a bottom wall, one or more side walls (1,2,3,4) and a contention plate (5), arranged in the upper part of the container, adjustable in height to compress said sachet and the surface of which facing towards the inside of the container is substantially flat, characterised in that said container can be folded or dismantled and in that said container allows the transportation of a flexible sachet with a minimum volume of 50 litres.
- A container according to claim 1, characterised in that the compression regulating device of the sachet comprises a screw actuator system (8).
- A container according to one of claims 1 and 2, characterised in that the regulating device for the compression of the sachet presses against moveable bars (6,7).
- A container according to one of claims 1 to 3, characterised in that the contention plate (5) is provided with one or more access orifices for one or more ports (11) fitted on top of the sachet.
- A container according to one of claims 1 to 4, characterised in that the contention plate (5) of the sachet is continuously adjustable in order to compress said sachet.
- A container according to claim 4, characterised in that the access orifice(s) are equipped with an adjustable guillotine (12,13) to block ports (11) fitted on top of the sachet.
- A container according to one of claims 1 to 6 characterised in that the surface of the contention plate (5) is greater than or equal to 90% of that of the internal surface delimited by the lateral wall(s) (1,2,3,4) of the rigid container.
- A container according to one of claims 1 to 7, characterised in that the bottom of the container is provided with an orifice at least allowing the proper centring of the sachet vis-à-vis the container, by cooperation with a protuberance with a complementary shape and location corresponding to the bottom of the sachet.
- A container according to one of claims 1 to 8 equipped with a sachet for the transportation of 50 litres of bio-pharmaceutical liquid or more, said sachet being a gusseted sachet with an approximately parallelepipedic rectangular shape once filled.
- A container according to claim 9, characterised in that the sachet is a multilayer monofilm sachet.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9808644A FR2780708B1 (en) | 1998-07-02 | 1998-07-02 | RIGID TRANSPORT CONTAINERS FOR POUCHES OF BIO-PHARMACEUTICAL FLUID PRODUCTS |
FR9808644 | 1998-07-02 | ||
PCT/FR1999/001582 WO2000001596A1 (en) | 1998-07-02 | 1999-07-01 | Rigid container for transporting a bag containing bio-pharmaceutical fluid products |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1012073A1 EP1012073A1 (en) | 2000-06-28 |
EP1012073B1 true EP1012073B1 (en) | 2002-03-06 |
Family
ID=9528324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99929376A Expired - Lifetime EP1012073B1 (en) | 1998-07-02 | 1999-07-01 | Rigid container for transporting a bag containing bio-pharmaceutical fluid products |
Country Status (14)
Country | Link |
---|---|
US (1) | US6076457A (en) |
EP (1) | EP1012073B1 (en) |
JP (1) | JP4316807B2 (en) |
KR (1) | KR100531696B1 (en) |
CN (1) | CN1168645C (en) |
AT (1) | ATE214027T1 (en) |
AU (1) | AU764887B2 (en) |
CA (1) | CA2302826C (en) |
DE (1) | DE69900968T2 (en) |
DK (1) | DK1012073T3 (en) |
ES (1) | ES2172336T3 (en) |
FR (1) | FR2780708B1 (en) |
PT (1) | PT1012073E (en) |
WO (1) | WO2000001596A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9005978B2 (en) | 2010-09-30 | 2015-04-14 | Sartorius Stedim Fmt Sas | Detection of the integrity of a tight, closed, soft plastic pouch for receiving and protecting a product or a biopharmaceutical device |
US9266657B2 (en) | 2009-05-27 | 2016-02-23 | Sartorius Stedim Fmt Sas | Rigid container for a flexible pouch for holding a biopharmaceutical fluid, assembly comprising such a flexible pouch and such a container, and method for using such a container |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6837613B2 (en) * | 2001-04-10 | 2005-01-04 | Levtech, Inc. | Sterile fluid pumping or mixing system and related method |
US7762716B2 (en) * | 2000-10-09 | 2010-07-27 | Levtech, Inc. | Mixing vessel with a fluid-agitating element supported by a roller bearing |
US20020131654A1 (en) * | 2001-03-19 | 2002-09-19 | Smith Sidney T. | Large volume flexible container |
US6659132B2 (en) | 2001-03-19 | 2003-12-09 | Baxter International Inc. | Gas permeable sterile closure |
US7025318B2 (en) * | 2001-03-19 | 2006-04-11 | Baxter International Inc. | Container support |
CA2444590C (en) | 2001-04-18 | 2009-12-01 | Robert L. Mcginnis | Stabilized hemoglobin solutions |
CA2462309C (en) * | 2001-10-03 | 2010-12-14 | Levtech, Inc. | Mixing bag or vessel having a receiver for a fluid-agitating element |
US6981794B2 (en) * | 2002-04-12 | 2006-01-03 | Hynetics Llc | Methods for mixing solutions |
US6908223B2 (en) * | 2002-04-12 | 2005-06-21 | Hynetics Llc | Systems for mixing liquid solutions and methods of manufacture |
US6923567B2 (en) * | 2002-04-12 | 2005-08-02 | Hynetics Llc | Mixing tank assembly |
US6837610B2 (en) * | 2002-09-27 | 2005-01-04 | Ilc Dover Lpp | Bioprocess container, bioprocess container mixing device and method of use thereof |
EP1592437A4 (en) * | 2003-01-29 | 2007-12-26 | Northfield Lab | Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing |
FR2851242B1 (en) * | 2003-02-13 | 2005-10-21 | Rhodia Chimie Sa | METHOD FOR DRAINING A SOFT CONTAINER COMPRISING A VISCOUS PRODUCT |
CA2514196A1 (en) * | 2003-02-13 | 2004-08-26 | Ilc Dover, Inc. | Flexible disposable vessel |
FR2851241B1 (en) * | 2003-02-13 | 2005-11-11 | Rhodia Chimie Sa | METHOD FOR DRAINING A SOFT CONTAINER COMPRISING A VISCOUS PRODUCT |
US7431837B2 (en) * | 2003-02-13 | 2008-10-07 | Ilc Dover Lp | Mixing vessel and method of use |
US7284579B2 (en) * | 2003-03-28 | 2007-10-23 | Hyclone Laboratories, Inc. | Fluid dispensing bins and related methods |
CN1946835A (en) | 2004-04-27 | 2007-04-11 | 巴克斯特国际公司 | Stirred-tank reactor system |
US20050249033A1 (en) * | 2004-05-04 | 2005-11-10 | Krause Richard J | Disposable reciprocating bag mixing systems |
US7410155B2 (en) | 2004-07-28 | 2008-08-12 | Spain Iii Charles J | Clamp and sealer for use on flexible conduits in biopharmaceutical applications |
FR2880339A1 (en) * | 2004-12-31 | 2006-07-07 | Rhodia Chimie Sa | PROCESS FOR PACKAGING A FLEXIBLE CONTAINER CONTAINING A VISCOUS PRODUCT |
US7682067B2 (en) * | 2005-04-22 | 2010-03-23 | Hyclone Laboratories, Inc. | Mixing systems and related mixers |
US20070196810A1 (en) * | 2006-01-24 | 2007-08-23 | Northfield Laboratories Inc. | Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells |
US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
US8146762B2 (en) * | 2006-03-09 | 2012-04-03 | Nalge Nunc International Corporation | Flexible container handling system |
WO2008103857A1 (en) * | 2007-02-21 | 2008-08-28 | Levtech, Inc. | Roller bearing for a fluid-agitating element and associated vessel |
US9090398B2 (en) | 2007-05-04 | 2015-07-28 | Emd Millipore Corporation | Disposable processing bag with alignment feature |
US8177123B2 (en) * | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
US9301520B2 (en) | 2007-12-21 | 2016-04-05 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
US7740212B2 (en) * | 2008-04-17 | 2010-06-22 | ConeCraft, Inc, | Apparatus to retain and position tubing of media bags |
FR2946868B1 (en) | 2009-06-18 | 2011-07-22 | Sartorius Stedim Biotech Sa | DETECTION OF LOSS OF INTEGRITY OF A FLEXIBLE POCKET, OF NON-POROUS PLASTIC MATERIAL, CLOSED. |
US8608369B2 (en) | 2011-01-07 | 2013-12-17 | Hyclone Laboratories, Inc. | Methods and systems for heating and mixing fluids |
US9314751B2 (en) | 2011-01-07 | 2016-04-19 | Life Technologies Corporation | Methods and apparatus for mixing and shipping fluids |
US9376655B2 (en) | 2011-09-29 | 2016-06-28 | Life Technologies Corporation | Filter systems for separating microcarriers from cell culture solutions |
FR3017122B1 (en) * | 2014-02-06 | 2016-02-26 | Sartorius Stedim Fmt Sas | METHOD FOR LOADING A FLEXIBLE 3D POCKET TO BE EMPLOYED, A SYSTEM FOR LOADING AND STORING THIS FLEXIBLE POCKET AND ASSOCIATED SUPPORT DEVICE |
US8979357B1 (en) | 2014-03-17 | 2015-03-17 | Advanced Scientifics, Inc. | Transportable mixing system for biological and pharmaceutical materials |
EP3266727B1 (en) | 2016-07-07 | 2020-10-21 | Sartorius Stedim Fmt Sas | System for expanding or collapsing a pouch comprising a shape memory material and method for receiving and transporting biopharmaceutical fluid |
EP3266726B1 (en) | 2016-07-07 | 2019-08-21 | Sartorius Stedim Fmt Sas | Container for transporting a biopharmaceutical fluid comprising a shape memory material and method for transporting a biopharmaceutical fluid |
FR3055317B1 (en) * | 2016-08-23 | 2020-12-25 | Sartorius Stedim Fmt Sas | SOFT POCKET CONTAINER WITH TWO OPERATING POSITIONS |
KR20200138242A (en) | 2018-03-02 | 2020-12-09 | 라이프 테크놀로지스 코포레이션 | Port and tube holder assembly attachment systems and methods of use |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US597236A (en) * | 1898-01-11 | Press for forming bank-bills into packages | ||
BE539623A (en) * | ||||
US754297A (en) * | 1903-08-12 | 1904-03-08 | Gustave Freysleben | Meat-press. |
US1161540A (en) * | 1915-05-07 | 1915-11-23 | Peter Smagel | Household-press. |
US1552754A (en) * | 1923-06-29 | 1925-09-08 | Petersen Armand | Meat press |
FR932321A (en) * | 1945-06-30 | 1948-03-18 | Improvement in the transport of liquids, gases, pulverulent substances, granules or the like | |
BE541428A (en) * | 1953-03-21 | |||
US3565292A (en) * | 1969-03-03 | 1971-02-23 | Walter J Jinotti | Blood-profusing apparatus |
US3937363A (en) * | 1973-11-05 | 1976-02-10 | Anderson Alfred F | Collapsible liquid container for use with plastic liners |
US4166537A (en) * | 1977-11-07 | 1979-09-04 | Fortunato Samuel F | Waterproof pill container |
CH657354A5 (en) * | 1984-07-04 | 1986-08-29 | Battelle Memorial Institute | BEVERAGE DISPENSER CONTAINER LIKELY TO RELEASE GAS SOLUTION. |
US5139169A (en) * | 1991-02-21 | 1992-08-18 | Boyer Richard L | Carbonated beverage dispensing system |
US5100025A (en) * | 1991-03-04 | 1992-03-31 | Mcgraw Kim A | Pump dispensing apparatus |
US5350080A (en) * | 1993-02-10 | 1994-09-27 | Hyclone Laboratories | Multi-access port for use in a cell culture media system |
US5361940A (en) * | 1993-05-28 | 1994-11-08 | Graco Inc. | Pump evacuation system for bulk containers of high viscosity fluids |
WO1997031832A1 (en) * | 1996-03-01 | 1997-09-04 | Cfs Developments Cc | A collapsible container |
WO1997048623A1 (en) * | 1996-06-20 | 1997-12-24 | Versa Pak Pty Ltd | Beverage dispenser |
-
1998
- 1998-07-02 FR FR9808644A patent/FR2780708B1/en not_active Expired - Fee Related
- 1998-08-05 US US09/128,929 patent/US6076457A/en not_active Expired - Lifetime
-
1999
- 1999-07-01 DK DK99929376T patent/DK1012073T3/en active
- 1999-07-01 AT AT99929376T patent/ATE214027T1/en not_active IP Right Cessation
- 1999-07-01 CN CNB998011622A patent/CN1168645C/en not_active Expired - Lifetime
- 1999-07-01 WO PCT/FR1999/001582 patent/WO2000001596A1/en active IP Right Grant
- 1999-07-01 DE DE69900968T patent/DE69900968T2/en not_active Expired - Lifetime
- 1999-07-01 PT PT99929376T patent/PT1012073E/en unknown
- 1999-07-01 ES ES99929376T patent/ES2172336T3/en not_active Expired - Lifetime
- 1999-07-01 JP JP2000558009A patent/JP4316807B2/en not_active Expired - Lifetime
- 1999-07-01 AU AU46212/99A patent/AU764887B2/en not_active Ceased
- 1999-07-01 EP EP99929376A patent/EP1012073B1/en not_active Expired - Lifetime
- 1999-07-01 KR KR10-2000-7002123A patent/KR100531696B1/en not_active IP Right Cessation
- 1999-07-01 CA CA002302826A patent/CA2302826C/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9266657B2 (en) | 2009-05-27 | 2016-02-23 | Sartorius Stedim Fmt Sas | Rigid container for a flexible pouch for holding a biopharmaceutical fluid, assembly comprising such a flexible pouch and such a container, and method for using such a container |
EP3106408A3 (en) * | 2009-05-27 | 2017-01-11 | Sartorius Stedim Fmt Sas | Rigid container for a flexible bag intended for holding a biopharmaceutical fluid and implementation method |
US9005978B2 (en) | 2010-09-30 | 2015-04-14 | Sartorius Stedim Fmt Sas | Detection of the integrity of a tight, closed, soft plastic pouch for receiving and protecting a product or a biopharmaceutical device |
Also Published As
Publication number | Publication date |
---|---|
ES2172336T3 (en) | 2002-09-16 |
JP4316807B2 (en) | 2009-08-19 |
ATE214027T1 (en) | 2002-03-15 |
CN1168645C (en) | 2004-09-29 |
CN1274332A (en) | 2000-11-22 |
KR100531696B1 (en) | 2005-11-29 |
DK1012073T3 (en) | 2002-07-01 |
WO2000001596A1 (en) | 2000-01-13 |
KR20010023478A (en) | 2001-03-26 |
AU4621299A (en) | 2000-01-24 |
CA2302826A1 (en) | 2000-01-13 |
DE69900968T2 (en) | 2002-11-28 |
DE69900968D1 (en) | 2002-04-11 |
AU764887B2 (en) | 2003-09-04 |
JP2002519263A (en) | 2002-07-02 |
EP1012073A1 (en) | 2000-06-28 |
US6076457A (en) | 2000-06-20 |
PT1012073E (en) | 2002-07-31 |
CA2302826C (en) | 2007-04-03 |
FR2780708A1 (en) | 2000-01-07 |
FR2780708B1 (en) | 2001-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1012073B1 (en) | Rigid container for transporting a bag containing bio-pharmaceutical fluid products | |
BE1004754A6 (en) | Grand container for bulk empilable, reusable, walled folding. | |
FR2734250A1 (en) | MODULAR BAC FOR RECOVERY OF SPREADED SUBSTANCES | |
WO2000004131A1 (en) | Flexible bags for transporting biopharmaceutical fluid products | |
FR2932459A1 (en) | CONTAINER, IN PARTICULAR BOTTLE, WITH AT LEAST ONE VARIABLE DEPTH ROD | |
EP3268291B1 (en) | Device for conveying a bag comprising a biopharmaceutical fluid and systems and a method using same | |
EP1554180B1 (en) | Device which is used to transport a container in the vertical position, comprising packaging containing a gyroscopic system | |
EP0122864A1 (en) | Method for parallelepipedic packing, and package obtained by this method | |
EP2605906A1 (en) | Single-use biopharmaceutical device for producing, storing, and transporting a biopharmaceutical material, and corresponding multilayer tube | |
FR2946032A1 (en) | RIGID CONTAINER FOR A 3D POCKET POCKET FOR CONTAINING A BIOPHARMACEUTICAL FLUID; 3D POCKET FOR SUCH A CONTAINER; METHOD OF IMPLEMENTATION | |
FR2952357A1 (en) | FLUID CONTAINER COMPRISING A POCKET INTENDED TO CONTAIN SUCH FLUID, AND IS ASSOCIATED | |
EP1939358A1 (en) | Mobile, stackable device for channel separation | |
FR2557544A1 (en) | Method and device for protecting perishable substances contained in containers from the effect of harmful gases, for example atmospheric air | |
EP1412263B1 (en) | Device with rigid container and soft cylindrical pouch for packaging fluids | |
EP2429925A1 (en) | Flexible container for packaging solid particulate materials in bulk, and use thereof | |
FR2608138A1 (en) | Auxiliary device for flexible containers | |
EP2203360A2 (en) | Container for the transport, storage and transfer between vessels of food-grade liquid | |
EP3126258A1 (en) | Container for liquid comprising a bag | |
FR3016348A1 (en) | MAINTENANCE AND PROTECTION FOR BOTTLES IN BOTH VIS-A-VIS. | |
EP2909104B1 (en) | Container for a liquid, comprising a pouch | |
CA2515241A1 (en) | Interior safety capsules | |
FR2915966A1 (en) | Multiple opening and closing device for reclosable pouch package, has connection element fixed on interior of opening/closing unit and covering part of width of opening/closing unit corresponding to width of package parallel to unit | |
FR2739610A1 (en) | Handle for plastic container holding hazardous material | |
FR2740117A1 (en) | Wedge for transport boxes | |
FR2686582A1 (en) | Device for the storage, warehousing and handling of tanks |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000328 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
17Q | First examination report despatched |
Effective date: 20010314 |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: IF02 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
REF | Corresponds to: |
Ref document number: 214027 Country of ref document: AT Date of ref document: 20020315 Kind code of ref document: T |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REF | Corresponds to: |
Ref document number: 69900968 Country of ref document: DE Date of ref document: 20020411 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: KIRKER & CIE SA |
|
GBT | Gb: translation of ep patent filed (gb section 77(6)(a)/1977) |
Effective date: 20020517 |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 |
|
REG | Reference to a national code |
Ref country code: PT Ref legal event code: SC4A Free format text: AVAILABILITY OF NATIONAL TRANSLATION Effective date: 20020408 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2172336 Country of ref document: ES Kind code of ref document: T3 |
|
REG | Reference to a national code |
Ref country code: GR Ref legal event code: EP Ref document number: 20020402240 Country of ref document: GR |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20021209 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CY Payment date: 20050627 Year of fee payment: 7 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20060701 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: PT Payment date: 20070627 Year of fee payment: 9 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: LU Payment date: 20070730 Year of fee payment: 9 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: MC Payment date: 20070816 Year of fee payment: 9 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FI Payment date: 20070716 Year of fee payment: 9 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: SE Payment date: 20070731 Year of fee payment: 9 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PFA Owner name: SARTORIUS STEDIM BIOTECH Free format text: STEDIM S.A.#Z.I. DES PALUDS, AVENUE DE JOCQUES, BOITE POSTALE 1051#13781 AUBAGNE CEDEX (FR) -TRANSFER TO- SARTORIUS STEDIM BIOTECH#ZONE INDUSTRIELLE DES PALUDS AVENUE DE JOUQUES#13400 AUBAGNE (FR) Ref country code: CH Ref legal event code: NV Representative=s name: BUGNION S.A. |
|
NLT1 | Nl: modifications of names registered in virtue of documents presented to the patent office pursuant to art. 16 a, paragraph 1 |
Owner name: SARTORIUS STEDIM BIOTECH |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GR Payment date: 20070629 Year of fee payment: 9 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: CD |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: ES Payment date: 20080821 Year of fee payment: 10 Ref country code: DK Payment date: 20080721 Year of fee payment: 10 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: AT Payment date: 20080711 Year of fee payment: 10 Ref country code: NL Payment date: 20080703 Year of fee payment: 10 Ref country code: IT Payment date: 20080730 Year of fee payment: 10 Ref country code: IE Payment date: 20080714 Year of fee payment: 10 |
|
REG | Reference to a national code |
Ref country code: PT Ref legal event code: MM4A Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20090102 |
|
EUG | Se: european patent has lapsed | ||
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20080731 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: PT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090102 Ref country code: FI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20080701 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090204 |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: EBP |
|
NLV4 | Nl: lapsed or anulled due to non-payment of the annual fee |
Effective date: 20100201 |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: MM4A |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20080701 Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090701 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20080702 Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090701 Ref country code: DK Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090731 |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FD2A Effective date: 20090702 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: ES Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090702 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20090701 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20100201 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PUE Owner name: SARTORIUS STEDIM FMT SAS, FR Free format text: FORMER OWNER: SARTORIUS STEDIM BIOTECH, FR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E Free format text: REGISTERED BETWEEN 20140320 AND 20140326 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 69900968 Country of ref document: DE Representative=s name: GRUENECKER, KINKELDEY, STOCKMAIR & SCHWANHAEUS, DE |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: TP Owner name: SARTORIUS STEDIM FMT SAS, FR Effective date: 20140602 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 69900968 Country of ref document: DE Representative=s name: GRUENECKER PATENT- UND RECHTSANWAELTE PARTG MB, DE Effective date: 20140630 Ref country code: DE Ref legal event code: R082 Ref document number: 69900968 Country of ref document: DE Representative=s name: GRUENECKER, KINKELDEY, STOCKMAIR & SCHWANHAEUS, DE Effective date: 20140630 Ref country code: DE Ref legal event code: R081 Ref document number: 69900968 Country of ref document: DE Owner name: SARTORIUS STEDIM FMT SAS, FR Free format text: FORMER OWNER: SARTORIUS STEDIM BIOTECH, AUBAGNE, FR Effective date: 20140630 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 18 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 19 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 20 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: BE Payment date: 20180614 Year of fee payment: 20 Ref country code: FR Payment date: 20180612 Year of fee payment: 20 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20180619 Year of fee payment: 20 Ref country code: GB Payment date: 20180627 Year of fee payment: 20 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20180713 Year of fee payment: 20 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R071 Ref document number: 69900968 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
REG | Reference to a national code |
Ref country code: BE Ref legal event code: MK Effective date: 20190701 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: PE20 Expiry date: 20190630 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION Effective date: 20190630 |