EP1009404A4 - METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS - Google Patents
METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORSInfo
- Publication number
- EP1009404A4 EP1009404A4 EP98922359A EP98922359A EP1009404A4 EP 1009404 A4 EP1009404 A4 EP 1009404A4 EP 98922359 A EP98922359 A EP 98922359A EP 98922359 A EP98922359 A EP 98922359A EP 1009404 A4 EP1009404 A4 EP 1009404A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- inflammatory diseases
- treating inflammation
- padprt
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/855,616 US5908861A (en) | 1997-05-13 | 1997-05-13 | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors |
US855616 | 1997-05-13 | ||
US09/056,396 US6303629B1 (en) | 1997-05-13 | 1998-04-06 | Methods for treating inflammation, inflammatory diseases, arthritis and stroke using pADPRT inhibitors |
US56396 | 1998-04-06 | ||
PCT/US1998/010033 WO1998051308A1 (en) | 1997-05-13 | 1998-05-13 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1009404A1 EP1009404A1 (en) | 2000-06-21 |
EP1009404A4 true EP1009404A4 (en) | 2009-07-01 |
Family
ID=26735288
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98922359A Ceased EP1009404A4 (en) | 1997-05-13 | 1998-05-13 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1009404A4 (en) |
JP (1) | JP4362638B2 (en) |
CN (1) | CN1198614C (en) |
AU (2) | AU7484798A (en) |
BR (1) | BR9809115A (en) |
CA (1) | CA2289119C (en) |
IL (1) | IL132758A0 (en) |
NZ (1) | NZ501650A (en) |
WO (2) | WO1998051307A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1140936B1 (en) | 1999-01-11 | 2004-03-17 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
ECSP003637A (en) | 1999-08-31 | 2002-03-25 | Agouron Pharma | TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES |
US6664269B2 (en) | 2001-05-08 | 2003-12-16 | Maybridge Plc | Isoquinolinone derivatives |
ES2357057T3 (en) | 2002-04-30 | 2011-04-15 | Kudos Pharmaceuticals Limited | DERIVATIVES OF FTALAZINONA. |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
TW200536830A (en) | 2004-02-06 | 2005-11-16 | Chugai Pharmaceutical Co Ltd | 1-(2H)-isoquinolone derivative |
TWI389897B (en) | 2005-02-22 | 2013-03-21 | Chugai Pharmaceutical Co Ltd | 1- (2H) -isoquinolinone derivatives |
CA2612979A1 (en) * | 2005-06-10 | 2006-12-21 | Bipar Sciences, Inc. | Parp modulators and treatment of cancer |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
WO2008030887A2 (en) * | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Methods for designing parp inhibitors and uses thereof |
JP2010502731A (en) * | 2006-09-05 | 2010-01-28 | バイパー サイエンシズ,インコーポレイティド | Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof |
CN101641013B (en) | 2007-01-22 | 2014-07-30 | Gtx公司 | Nuclear receptor binding agents |
US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
PT2118074E (en) | 2007-02-01 | 2014-03-20 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular diseases |
KR20100059950A (en) | 2007-09-14 | 2010-06-04 | 아스트라제네카 아베 | Phthalazinone derivatives |
UY31603A1 (en) | 2008-01-23 | 2009-08-31 | DERIVATIVES OF FTALAZINONA | |
CA2711103C (en) | 2008-06-26 | 2016-08-09 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
CN102238945B (en) | 2008-10-07 | 2014-10-29 | 阿斯利康(英国)有限公司 | Pharmaceutical formulation 514 |
JPWO2010061908A1 (en) | 2008-11-28 | 2012-04-26 | 中外製薬株式会社 | 1- (2H) -Isoquinolone derivatives |
WO2010079431A2 (en) | 2009-01-08 | 2010-07-15 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
EP2408454A2 (en) | 2009-03-18 | 2012-01-25 | Resverlogix Corp. | Novel anti-inflammatory agents |
KR101892987B1 (en) | 2009-04-22 | 2018-08-30 | 리스버로직스 코퍼레이션 | Novel anti-inflammatory agents |
JP5992049B2 (en) | 2011-11-01 | 2016-09-14 | レスバーロジックス コーポレイション | Oral immediate release formulations for substituted quinazolinones |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
JP2016507496A (en) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
CN107530356A (en) | 2015-03-13 | 2018-01-02 | 雷斯韦洛吉克斯公司 | For treating the composition and treatment method of complement-associated disease |
EP3655418A4 (en) | 2017-06-22 | 2021-05-19 | Triact Therapeutics, Inc. | Methods of treating glioblastoma |
WO2019067991A1 (en) | 2017-09-29 | 2019-04-04 | Triact Therapeutics, Inc. | Iniparib formulations and uses thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992006687A1 (en) * | 1990-10-19 | 1992-04-30 | The Regents Of The University Of California | Novel 5-iodo-6-amino-1,2-benzopyrones and their analogs useful as cytostatic and antiviral agents |
WO1996031206A2 (en) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of atherosclerosis |
US5583155A (en) * | 1989-09-26 | 1996-12-10 | Octamer, Inc. | 6-amino-1,2-benzopyrones useful for treatment of viral diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516941A (en) | 1991-10-22 | 1996-05-14 | Octamer, Inc. | Specific inactivators of "retroviral" (asymmetric) zinc fingers |
US5473074A (en) | 1991-10-22 | 1995-12-05 | Octamer, Incorporated | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents-54 |
US5482975A (en) | 1991-10-22 | 1996-01-09 | Octamer, Inc. | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents |
US5464871A (en) | 1993-05-12 | 1995-11-07 | Octamer, Inc. | Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents |
DE4436127A1 (en) | 1994-09-27 | 1996-03-28 | Deutsches Rheumaforschungszent | Use of benzoic or pyridine:carboxylic acid or amide cpds. |
US10766598B2 (en) | 2017-06-14 | 2020-09-08 | The Boeing Company | Wing-to-fuselage joints and aircraft including the same |
-
1998
- 1998-05-13 WO PCT/US1998/009768 patent/WO1998051307A1/en active Application Filing
- 1998-05-13 EP EP98922359A patent/EP1009404A4/en not_active Ceased
- 1998-05-13 BR BR9809115-8A patent/BR9809115A/en not_active Application Discontinuation
- 1998-05-13 NZ NZ501650A patent/NZ501650A/en not_active IP Right Cessation
- 1998-05-13 WO PCT/US1998/010033 patent/WO1998051308A1/en not_active Application Discontinuation
- 1998-05-13 CA CA2289119A patent/CA2289119C/en not_active Expired - Fee Related
- 1998-05-13 IL IL13275898A patent/IL132758A0/en unknown
- 1998-05-13 JP JP54960898A patent/JP4362638B2/en not_active Expired - Fee Related
- 1998-05-13 CN CNB988063891A patent/CN1198614C/en not_active Expired - Fee Related
- 1998-05-13 AU AU74847/98A patent/AU7484798A/en not_active Abandoned
- 1998-05-13 AU AU74926/98A patent/AU745790B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583155A (en) * | 1989-09-26 | 1996-12-10 | Octamer, Inc. | 6-amino-1,2-benzopyrones useful for treatment of viral diseases |
WO1992006687A1 (en) * | 1990-10-19 | 1992-04-30 | The Regents Of The University Of California | Novel 5-iodo-6-amino-1,2-benzopyrones and their analogs useful as cytostatic and antiviral agents |
WO1996031206A2 (en) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of atherosclerosis |
Non-Patent Citations (12)
Title |
---|
BAUER P I ET AL: "REVERSION OF MALIGNANT PHENOTYPE BY 5-IODO-6-AMINO-1,2-BENZOPYRONE A NON-COVALENTLY BINDING LIGAND OF POLY(ADP-RIBOSE) POLYMERASE", BIOCHIMIE, MASSON, PARIS, FR, vol. 77, no. 5, 1 January 1995 (1995-01-01), pages 374 - 377, XP000573099, ISSN: 0300-9084 * |
KR\GER H ET AL: "SYNERGISTIC EFFECTS OF THALIDOMIDE AND POLY(ADP-RIBOSE) POLYMERASE INHIBITION ON TYPE II COLLAGEN-INDUCED ARTHRITIS IN MICE", INFLAMMATION, PLENUM PRESS, NEW YORK, NY, US, vol. 20, no. 2, 1 January 1996 (1996-01-01), pages 203 - 215, XP002954235, ISSN: 0360-3997 * |
KRÖGER H ET AL: "The influence of antagonists of poly(ADP-ribose)polymerase on the activity of antirheumatic drugs on the development of adjuvant arthritis in rats and on the induction of tyrosine aminotransferase in the liver of rats", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRING ST., NY, vol. 398, 1 January 1996 (1996-01-01), pages 523 - 526, XP009116003, ISSN: 0065-2598 * |
MIESEL R KURPISZ M KR\GER H: "MODULATION OF INFLAMMATORY ARTHRITIS BY INHIBITION OF POLY(ADP RIBOSE) POLYMERASE", INFLAMMATION, PLENUM PRESS, NEW YORK, NY, US, vol. 19, no. 3, 1 January 1995 (1995-01-01), pages 379 - 387, XP002954234, ISSN: 0360-3997 * |
SCHRAUFSTATTER I U ET AL: "HYDROGEN PEROXIDE-INDUCED INJURY OF CELLS AND ITS PREVENTION BY INHIBITORS OF POLY-ADP-RIBOSE POLYMERASE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 83, no. 13, 1986, pages 4908 - 4912, XP002526047, ISSN: 0027-8424 * |
See also references of WO9851308A1 * |
SZABO C ET AL: "DNA STRAND BREAKAGE, ACTIVATION OF POLY(ADP-RIBOSE) SYNTHETASE, ANDCELLULAR ENERGY DEPLETION ARE INVOLVED IN THE CYTOTOXICITY IN MACROPHAGES AND SMOOTH MUSCLE CELLS EXPOSED TO PEROXYNITRITE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 93, 1 March 1996 (1996-03-01), pages 1753 - 1758, XP000960495, ISSN: 0027-8424 * |
SZABO CSABA ET AL: "Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 10, no. 6, 20 May 1997 (1997-05-20), pages 1093 - 1101, XP009116048, ISSN: 1019-6439 * |
SZABO CSABA ET AL: "Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite", CIRCULATION RESEARCH, vol. 78, no. 6, 1996, pages 1051 - 1063, XP002526068, ISSN: 0009-7330 * |
THIEMERMANN C ET AL: "Inhibition of the Activity of Poly(ADP Ribose) Synthetase Reduces Ischemia-Reperfusion Injury in the Heart and Skeletal Muscle", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 94, no. 2, 21 January 1997 (1997-01-21), pages 679 - 683, XP002080575, ISSN: 0027-8424 * |
ZINGARELLI B ET AL: "Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase", SHOCK (PHILADELPHIA): INJURY, INFLAMMATION, AND SEPSIS: LABORATORY AND CLINICAL APPROACHES, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 5, no. 4, 1 April 1996 (1996-04-01), pages 258 - 264, XP009116150, ISSN: 1073-2322 * |
ZINGARELLI BASILIA ET AL: "Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide", JOURNAL OF IMMUNOLOGY, vol. 156, no. 1, 1996, pages 350 - 358, XP002526046, ISSN: 0022-1767 * |
Also Published As
Publication number | Publication date |
---|---|
JP4362638B2 (en) | 2009-11-11 |
CN1261278A (en) | 2000-07-26 |
IL132758A0 (en) | 2001-03-19 |
BR9809115A (en) | 2002-01-02 |
WO1998051307A1 (en) | 1998-11-19 |
WO1998051308A1 (en) | 1998-11-19 |
EP1009404A1 (en) | 2000-06-21 |
CA2289119A1 (en) | 1998-11-19 |
AU745790B2 (en) | 2002-03-28 |
AU7492698A (en) | 1998-12-08 |
JP2002502367A (en) | 2002-01-22 |
CA2289119C (en) | 2011-03-15 |
AU7484798A (en) | 1998-12-08 |
CN1198614C (en) | 2005-04-27 |
NZ501650A (en) | 2001-11-30 |
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Legal Events
Date | Code | Title | Description |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 29/00 20060101ALI20090506BHEP Ipc: A61K 31/165 20060101ALI20090506BHEP Ipc: A61K 31/35 20060101ALI20090506BHEP Ipc: A61K 31/47 20060101AFI19990219BHEP |
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Effective date: 20120124 |