EP1007051A4 - Integrin receptor antagonists - Google Patents

Integrin receptor antagonists

Info

Publication number: EP1007051A4
Authority: EP; European Patent Office
Prior art keywords: receptor antagonists; integrin receptor; integrin; antagonists; receptor
Prior art date: 1997-08-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP98938357A

Other languages

German (de)

French (fr)

Other versions

EP1007051A1 (en

Inventor

Dirk Heerding

James Martin Samanen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-04

Filing date

1998-08-04

Publication date

2001-08-29

1998-08-04 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

2000-06-14 Publication of EP1007051A1 publication Critical patent/EP1007051A1/en

2001-08-29 Publication of EP1007051A4 publication Critical patent/EP1007051A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

EP98938357A 1997-08-04 1998-08-04 Integrin receptor antagonists Withdrawn EP1007051A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US5470397P	1997-08-04	1997-08-04
US54703P		1997-08-04
US6352697P	1997-10-29	1997-10-29
US63526P		1997-10-29
PCT/US1998/016246 WO1999006049A1 (en)	1997-08-04	1998-08-04	Integrin receptor antagonists

Publications (2)

Publication Number	Publication Date
EP1007051A1 EP1007051A1 (en)	2000-06-14
EP1007051A4 true EP1007051A4 (en)	2001-08-29

Family

ID=26733371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP98938357A Withdrawn EP1007051A4 (en)	1997-08-04	1998-08-04	Integrin receptor antagonists

Country Status (5)

Country	Link
EP (1)	EP1007051A4 (en)
JP (1)	JP2001511452A (en)
AU (1)	AU8689798A (en)
CA (1)	CA2298544A1 (en)
WO (1)	WO1999006049A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548663B1 (en)	1998-03-31	2003-04-15	Bristol-Myers Squibb Pharma Company	Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6524553B2 (en)	1998-03-31	2003-02-25	Bristol-Myers Squibb Pharma Company	Quinolone vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en)	1998-03-31	2003-03-25	Bristol-Myers Squibb Pharma Company	Pharmaceuticals for the imaging of angiogenic disorders
CA2727746A1 (en)	1998-12-18	2000-06-22	Bristol-Myers Squibb Pharma Company	Quinolone vitronectin receptor antagonist pharmaceuticals
WO2000035488A2 (en) *	1998-12-18	2000-06-22	Du Pont Pharmaceuticals Company	Vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en)	1998-12-18	2004-09-21	Bristol-Myers Squibb Pharma Company	Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en)	1998-12-18	2003-01-28	Thomas D. Harris	Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en)	1998-12-18	2003-05-27	Bristol-Myers Squibb Pharma Company	Vitronectin receptor antagonist pharmaceuticals
TR200101757T2 (en) *	1998-12-18	2001-12-21	Dupont Pharmaceuticais Company	Vitronectin receptor antagonist pharmaceuticals
JP2002536370A (en)	1999-02-03	2002-10-29	メルクエンドカムパニーインコーポレーテッド	Benzoazepine derivatives as α-V integrin receptor antagonists
CO5180550A1 (en) *	1999-04-19	2002-07-30	Smithkline Beecham Corp	FAB I INHIBITORS
JP2003506452A (en) *	1999-08-06	2003-02-18	スミスクライン・ビーチャム・コーポレイション	Vitronectin receptor antagonists useful for the treatment of stroke
US6514964B1 (en)	1999-09-27	2003-02-04	Amgen Inc.	Fused cycloheptane and fused azacycloheptane compounds and their methods of use
DE10028575A1 (en) *	2000-06-14	2002-03-14	Basf Ag	integrin
DE10027514A1 (en) *	2000-06-06	2002-01-03	Basf Ag	Ligands of integrin receptors
DE10039998A1 (en) *	2000-08-11	2002-02-21	Basf Ag	New substituted diareno-azepine derivatives as integrin ligands
US6509366B2 (en)	2000-01-18	2003-01-21	Neurogen Corporation	Substituted imidazoles as selective modulators of Bradykinin B2 receptors
EP1341497A4 (en) *	2000-11-02	2005-10-19	Smithkline Beecham Corp	Receptor antagonist-lipid conjugates and delivery vehicles containing same
MXPA03009683A (en)	2001-04-24	2004-02-12	Merck Patent Gmbh	Combination therapy using anti-angiogenic agents and tnfa.
KR20040058229A (en)	2001-10-22	2004-07-03	더 스크립스 리서치 인스티튜트	Antibody targeting compounds
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CA2637387A1 (en)	2006-01-18	2007-07-26	Simon Goodman	Specific therapy using integrin ligands for treating cancer
MX2009007597A (en)	2007-01-18	2009-07-22	Merck Patent Gmbh	Specific therapy and medicament using integrin ligands for treating cancer.
EP2217238B1 (en)	2007-11-08	2014-03-12	The General Hospital Corporation	Methods and compositions for the treatment of proteinuric diseases
EP2221308B1 (en)	2007-11-16	2013-07-10	Ube Industries, Ltd.	Benzazepinone compound
US8518927B2 (en)	2009-02-10	2013-08-27	The Scripps Research Institute	Chemically programmed vaccination
CA2763275A1 (en)	2009-05-25	2010-12-02	Merck Patent Gmbh	Continuous administration of integrin ligands for treating cancer
US10328082B2 (en)	2014-05-30	2019-06-25	Pfizer Inc.	Methods of use and combinations
KR20220115062A (en)	2021-02-09	2022-08-17	(주)오스티오뉴로젠	Pharmaceutical Composition For Treating and Preventing Osteoporosis Comprising Compounds of Chromone Scaffold
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994014776A2 (en) *	1992-12-21	1994-07-07	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
WO1996000574A1 (en) *	1994-06-29	1996-01-11	Smithkline Beecham Corporation	Vitronectin receptor antagonists
WO1996026190A1 (en) *	1995-02-22	1996-08-29	Smithkline Beecham Corporation	Integrin receptor antagonists
WO1997001540A1 (en) *	1995-06-29	1997-01-16	Smithkline Beecham Corporation	Integrin receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ382496A3 (en) *	1994-06-29	1997-12-17	Smithkline Beecham Corp	Compounds representing antagonists of vitronectin receptors, process of their preparation, intermediates of such process, pharmaceutical composition containing the compounds and their use
KR19990076878A (en) *	1995-12-29	1999-10-25	스티븐 베네티아너	Bitronectin receptor antagonist

1998
- 1998-08-04 CA CA002298544A patent/CA2298544A1/en not_active Abandoned
- 1998-08-04 JP JP2000504863A patent/JP2001511452A/en not_active Withdrawn
- 1998-08-04 WO PCT/US1998/016246 patent/WO1999006049A1/en not_active Application Discontinuation
- 1998-08-04 AU AU86897/98A patent/AU8689798A/en not_active Abandoned
- 1998-08-04 EP EP98938357A patent/EP1007051A4/en not_active Withdrawn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994014776A2 (en) *	1992-12-21	1994-07-07	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
WO1996000574A1 (en) *	1994-06-29	1996-01-11	Smithkline Beecham Corporation	Vitronectin receptor antagonists
WO1996026190A1 (en) *	1995-02-22	1996-08-29	Smithkline Beecham Corporation	Integrin receptor antagonists
WO1997001540A1 (en) *	1995-06-29	1997-01-16	Smithkline Beecham Corporation	Integrin receptor antagonists

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
RICHARD M. KEENAN ET AL.: "Discovery of potent nonpeptide Vitronectin Receptor (avb3) Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 15, 18 July 1997 (1997-07-18), pages 2289 - 2292, XP002933333 *
See also references of WO9906049A1 *
WILLIAM E. BONDINELLI ET AL.: "Design of a potent and Orally active Nonpeptide platelet Fibrinogen Receptor (GPIIb/IIIa) Antagonist", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, no. 9, 1994, pages 897 - 908, XP000196285 *
WILLIAM H. MILLER ET AL.: "Structure-Activity Relationships in 3-oxo-1,4-benzodiazepine-2-acetic Acid GPIIb/IIIA antagonists. The 2-benzazepine series", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 21, 1996, pages 2481 - 2486, XP004135899 *

Also Published As

Publication number	Publication date
WO1999006049A1 (en)	1999-02-11
AU8689798A (en)	1999-02-22
EP1007051A1 (en)	2000-06-14
CA2298544A1 (en)	1999-02-11
JP2001511452A (en)	2001-08-14

Legal Events

Date	Code	Title	Description
2000-04-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-06-14	17P	Request for examination filed	Effective date: 20000126
2000-06-14	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL
2001-08-29	A4	Supplementary search report drawn up and despatched	Effective date: 20010712
2001-08-29	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): BE CH DE ES FR GB IT LI NL
2001-08-29	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 31/55 A, 7C 07D 223/16 B, 7C 07D 243/14 B, 7C 07D 267/14 B, 7C 07D 281/10 B, 7C 07D 401/14 B, 7C 07D 403/12 B
2002-12-11	17Q	First examination report despatched	Effective date: 20021023
2004-03-03	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2004-12-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2005-01-26	18D	Application deemed to be withdrawn	Effective date: 20040720

Publication	Publication Date	Title
EP1047425A4 (en)	2009-04-22	Integrin receptor antagonists
EP1007051A4 (en)	2001-08-29	Integrin receptor antagonists
EP1100506A4 (en)	2002-06-26	Integrin receptor antagonists
EP1105389A4 (en)	2001-10-17	Integrin receptor antagonists
EP1007026A4 (en)	2002-08-07	Integrin antagonists
EP0934305A4 (en)	2001-04-11	Integrin antagonists
EP0880511A4 (en)	1999-06-16	Integrin receptor antagonists
IL130760A0 (en)	2001-01-28	Vitronectin receptor antagonists
EP1229910A4 (en)	2003-10-01	Integrin receptor antagonists
EP1194151A4 (en)	2003-01-15	Integrin receptor antagonists
HK1031726A1 (en)	2001-06-22	Thrombin receptor antagonists
IL135028A0 (en)	2001-05-20	Vitronectin receptor antagonists
IL138245A0 (en)	2001-10-31	Vitronectin receptor antagonists
EP1027337A4 (en)	2002-04-03	Integrin receptor antagonists
IL148043A0 (en)	2002-09-12	Novel integrin receptor antagonists
IL146146A0 (en)	2002-07-25	Integrin receptor antagonists
IL141163A0 (en)	2002-02-10	Vitronectin receptor antagonists
ZA986930B (en)	1999-05-13	Integrin receptor antagonists
ZA9811500B (en)	1999-06-17	Integrin receptor antagonists
IL119820A0 (en)	1997-03-18	Integrin receptor antagonists
GB9603373D0 (en)	1996-04-17	Integrin receptor antagonists
ZA988562B (en)	1999-03-19	Vitronectin receptor antagonists
ZA9610690B (en)	1997-10-29	Integrin receptor antagonists.
GB9811283D0 (en)	1998-07-22	Vironectin receptor antagonists
ZA964195B (en)	1997-11-24	Integrin receptor antagonists.