EP0988295A4 - Piperidines a substitution heterocyclique et utilisations de ces dernieres - Google Patents

Piperidines a substitution heterocyclique et utilisations de ces dernieres

Info

Publication number
EP0988295A4
EP0988295A4 EP98931350A EP98931350A EP0988295A4 EP 0988295 A4 EP0988295 A4 EP 0988295A4 EP 98931350 A EP98931350 A EP 98931350A EP 98931350 A EP98931350 A EP 98931350A EP 0988295 A4 EP0988295 A4 EP 0988295A4
Authority
EP
European Patent Office
Prior art keywords
heterocyclic substituted
substituted piperidines
piperidines
heterocyclic
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98931350A
Other languages
German (de)
English (en)
Other versions
EP0988295A1 (fr
Inventor
Bharat Lagu
T G Murali Dhar
Dhanapalan Nagarathnam
Yoon T Jeon
Mohammad R Marzabadi
Wai C Wong
Charles Gluchowski
Dake Tian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synaptic Pharmaceutical Corp
Original Assignee
Synaptic Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synaptic Pharmaceutical Corp filed Critical Synaptic Pharmaceutical Corp
Publication of EP0988295A1 publication Critical patent/EP0988295A1/fr
Publication of EP0988295A4 publication Critical patent/EP0988295A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP98931350A 1997-06-18 1998-06-17 Piperidines a substitution heterocyclique et utilisations de ces dernieres Withdrawn EP0988295A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87784697A 1997-06-18 1997-06-18
US877846 1997-06-18
PCT/US1998/012668 WO1998057940A1 (fr) 1997-06-18 1998-06-17 Piperidines a substitution heterocyclique et utilisations de ces dernieres

Publications (2)

Publication Number Publication Date
EP0988295A1 EP0988295A1 (fr) 2000-03-29
EP0988295A4 true EP0988295A4 (fr) 2003-08-13

Family

ID=25370847

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98931350A Withdrawn EP0988295A4 (fr) 1997-06-18 1998-06-17 Piperidines a substitution heterocyclique et utilisations de ces dernieres

Country Status (5)

Country Link
EP (1) EP0988295A4 (fr)
JP (1) JP2002505683A (fr)
AU (1) AU740064B2 (fr)
CA (1) CA2294549A1 (fr)
WO (1) WO1998057940A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228870B1 (en) 1998-11-10 2001-05-08 Merck & Co., Inc. Oxazolidinones useful as alpha 1a adrenoceptor antagonists
US6319932B1 (en) 1998-11-10 2001-11-20 Merck & Co., Inc. Oxazolidinones useful as alpha 1A adrenoceptor antagonists
US6046331A (en) * 1998-12-17 2000-04-04 Synaptic Pharmaceutical Corporation Imidazolones and their use in treating benign prostatic hyperplasia and other disorders
GB2344821A (en) 1998-12-17 2000-06-21 Merck & Co Inc Crystalline pharmaceutically acceptable salt of an oxazolidinone derivative
US6372911B1 (en) * 1999-02-09 2002-04-16 Merck & Co., Inc. Process for preparing β-hydroxycarbamates and their conversion to oxazolidinones
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
GB2355456A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
GB2355263A (en) 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
US8835426B2 (en) 2007-02-26 2014-09-16 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
EP2229368A1 (fr) 2007-12-11 2010-09-22 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques d'urée de la 11béta-hydroxystéroïde déhydrogénase 1
CA2729998A1 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs de la 11 beta-hydroxysteroide deshydrogenase 1
CA2730499A1 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs cycliques de la 11 beta-hydroxysteroide deshydrogenase 1
US8637505B2 (en) 2009-02-04 2014-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (fr) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
EP2585444B1 (fr) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones comme inhibiteurs de 11-beta -hsd1 pour le traitement de troubles métaboliques
EP2635268A1 (fr) 2010-11-02 2013-09-11 Boehringer Ingelheim International GmbH Combinaisons pharmaceutiques destinées au traitement de troubles du métabolisme
WO2014059265A1 (fr) * 2012-10-11 2014-04-17 Southern Research Institute Dérivés urée et amide d'aminoalkylpipérazines et leur utilisation
CA3120514A1 (fr) * 2018-11-20 2020-05-28 Sironax Ltd Urees cycliques
CN116003380B (zh) * 2023-01-31 2024-07-05 天津大学 指纹识别探针、显影剂和介质表面潜指纹荧光成像方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014846A1 (fr) * 1994-11-16 1996-05-23 Synaptic Pharmaceutical Corporation Dihydropyrimidines et leurs utilisations
WO1997017969A1 (fr) * 1995-11-16 1997-05-22 Synaptic Pharmaceutical Corporation Dihydropirimidines et leurs emplois

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334098A (en) * 1964-05-07 1967-08-01 American Cyanamid Co 1-monocarbocyclic aryl-3-amino-alkanoyl-2-imidazolidinones
CH611898A5 (fr) * 1975-06-06 1979-06-29 Hoffmann La Roche
US4377578A (en) * 1976-12-21 1983-03-22 Janssen Pharmaceutica, N.V. Piperazine derivatives
US4410540A (en) * 1981-11-04 1983-10-18 Merrell Dow Pharmaceuticals Inc. Cardiotonic 4-aroylimidazolidin-2-ones
JPH0713017B2 (ja) * 1986-06-18 1995-02-15 日本ケミファ株式会社 脳細胞保護作用を有する医薬組成物
JPH0755937B2 (ja) * 1986-07-29 1995-06-14 日本曹達株式会社 オキサ（チア）ゾリジン誘導体その製造方法及び殺ダニ剤
US5202345A (en) * 1987-08-19 1993-04-13 Shionogi & Co., Ltd. Carbamoylpyrrolidone derivatives and drugs for senile dementia
FR2698359B1 (fr) * 1992-11-25 1995-10-27 Rhone Poulenc Agrochimie Derives de 2-alkoxy 2-imidazoline-5-ones fongicides.
WO1995007904A1 (fr) * 1993-09-15 1995-03-23 Merck Sharp & Dohme Limited Derives d'imidazolone et d'oxazolone utilises comme antagonistes de la dopamine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014846A1 (fr) * 1994-11-16 1996-05-23 Synaptic Pharmaceutical Corporation Dihydropyrimidines et leurs utilisations
WO1997017969A1 (fr) * 1995-11-16 1997-05-22 Synaptic Pharmaceutical Corporation Dihydropirimidines et leurs emplois

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9857940A1 *

Also Published As

Publication number Publication date
AU8149898A (en) 1999-01-04
AU740064B2 (en) 2001-10-25
JP2002505683A (ja) 2002-02-19
WO1998057940A1 (fr) 1998-12-23
CA2294549A1 (fr) 1998-12-23
EP0988295A1 (fr) 2000-03-29

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 07D 417/14 B

Ipc: 7C 07D 413/14 B

Ipc: 7C 07D 401/14 B

Ipc: 7C 07D 401/12 B

Ipc: 7C 07D 265/10 B

Ipc: 7C 07D 263/26 B

Ipc: 7A 61K 31/495 B

Ipc: 7A 61K 31/445 B

Ipc: 7A 61K 31/425 B

Ipc: 7A 61K 31/42 B

Ipc: 7A 61K 31/415 B

Ipc: 7C 07D 413/12 B

Ipc: 7C 07D 411/12 B

Ipc: 7C 07D 403/06 B

Ipc: 7C 07D 277/14 B

Ipc: 7C 07D 263/20 A

A4 Supplementary search report drawn up and despatched

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